EA201490175A1 - COMPOSITIONS OF DEOXIC ACID AND ITS SALTS - Google Patents

COMPOSITIONS OF DEOXIC ACID AND ITS SALTS

Info

Publication number
EA201490175A1
EA201490175A1 EA201490175A EA201490175A EA201490175A1 EA 201490175 A1 EA201490175 A1 EA 201490175A1 EA 201490175 A EA201490175 A EA 201490175A EA 201490175 A EA201490175 A EA 201490175A EA 201490175 A1 EA201490175 A1 EA 201490175A1
Authority
EA
Eurasian Patent Office
Prior art keywords
deoxic
salts
compositions
acid
level
Prior art date
Application number
EA201490175A
Other languages
Russian (ru)
Other versions
EA029305B1 (en
Inventor
Роберт Эмил Ходж
Джеффри Дуглас Вебстер
Роберт М. Мориарти
Original Assignee
Китера Биофармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45569726&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201490175(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Китера Биофармасьютикалз, Инк. filed Critical Китера Биофармасьютикалз, Инк.
Publication of EA201490175A1 publication Critical patent/EA201490175A1/en
Publication of EA029305B1 publication Critical patent/EA029305B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Настоящая заявка относится к водной фармацевтической композиции, содержащей от приблизительно 0,4% (мас./об.) до менее чем приблизительно 2% (мас./об.) соли дезоксихолевой кислоты, причем рН указанной композиции сохраняется на уровне от приблизительно 8,1 до приблизительно 8,5, что обеспечивает указанной композиции устойчивость к выпадению в осадок. Также в настоящей заявке предложены способы стабилизации водной фармацевтической композиции, содержащей от приблизительно 0,4% (мас./об.) до менее чем приблизительно 2% (мас./об.) соли дезоксихолевой кислоты, для предотвращения образования осадка, при этом указанный способ включает поддержание рН указанного раствора на уровне от приблизительно 8,1 до приблизительно 8,5.The present application relates to an aqueous pharmaceutical composition containing from about 0.4% (w / v) to less than about 2% (w / v) of a deoxycholic acid salt, wherein the pH of said composition is kept at a level of from about 8, 1 to about 8.5, which provides the specified composition with resistance to precipitation. Also provided in this application are methods for stabilizing an aqueous pharmaceutical composition containing from about 0.4% (w / v) to less than about 2% (w / v) of a deoxycholic acid salt to prevent precipitation, wherein the method comprises maintaining the pH of said solution at a level of from about 8.1 to about 8.5.

EA201490175A 2011-08-23 2011-08-23 Formulations of deoxycholic acid and salts thereof EA029305B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/048806 WO2013028177A1 (en) 2011-08-23 2011-08-23 Formulations of deoxycholic acid and salts thereof

Publications (2)

Publication Number Publication Date
EA201490175A1 true EA201490175A1 (en) 2014-06-30
EA029305B1 EA029305B1 (en) 2018-03-30

Family

ID=45569726

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490175A EA029305B1 (en) 2011-08-23 2011-08-23 Formulations of deoxycholic acid and salts thereof

Country Status (18)

Country Link
JP (1) JP5919597B2 (en)
KR (5) KR101919269B1 (en)
CN (3) CN108619089A (en)
AU (3) AU2011375432B2 (en)
BR (1) BR112014000547B1 (en)
CA (1) CA2842177C (en)
CR (1) CR20140053A (en)
EA (1) EA029305B1 (en)
IL (1) IL230547A (en)
IN (1) IN2014CN02188A (en)
MX (1) MX350390B (en)
MY (1) MY184277A (en)
NZ (1) NZ620040A (en)
PH (1) PH12016501175A1 (en)
SG (1) SG2014013205A (en)
UA (1) UA113522C2 (en)
WO (1) WO2013028177A1 (en)
ZA (1) ZA201401027B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
WO2017079700A1 (en) * 2015-11-04 2017-05-11 Kythera Biopharmaceuticals, Inc. Treatments of accumulated fat with deoxycholic acid and salts thereof
KR101841193B1 (en) * 2016-09-22 2018-03-22 이경락 Composition for hypotonic lipolysis and manufacturing method thereof
US20180078621A1 (en) * 2016-09-22 2018-03-22 Kyoung Lack Lee Composition for hypotonic lipolysis and manufacturing method thereof
KR102051922B1 (en) * 2018-04-16 2019-12-10 주식회사 펜믹스 Pharmaceutical composition containing deoxycholic acid
KR102172439B1 (en) * 2018-12-05 2020-10-30 송미희 Composition for lipolysis and injection composition comprising the same
KR102064864B1 (en) 2019-02-08 2020-01-10 (주)제테마 Topical injectable composition
KR102111346B1 (en) * 2019-08-20 2020-05-22 아영창 Aqueous composition with sodium deoxycholate having improved stability against precipitation
KR20220026068A (en) 2020-08-25 2022-03-04 강명범 Composition for lipolysis and injection composition comprising the same
CN116617160A (en) * 2023-07-25 2023-08-22 山东则正医药技术有限公司 Aqueous suspension, preparation method, freeze-dried powder, application and fat reduction injection

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2754709B1 (en) 1996-10-23 1999-03-05 Sanofi Sa COSMETIC COMPOSITION CONTAINING AN ANTAGONIST OF GAMMA NEUROPEPTIDE RECEPTORS AND ALPHA 2 ANTAGONISTS THAT MAY BE INCORPORATED IN SUCH A COMPOSITION
US6251428B1 (en) * 1998-07-24 2001-06-26 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
US6417179B1 (en) 1998-10-13 2002-07-09 Craig G. Burkhart Ear wax solution
US20050048126A1 (en) * 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
DE10361067A1 (en) * 2003-12-22 2005-07-14 Aventis Pharma Deutschland Gmbh Medicinal lipolysis of fat accumulations
US7754230B2 (en) * 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
US20060127468A1 (en) 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
DK2422789T3 (en) * 2004-05-19 2018-02-26 Los Angeles Biomedical Res Inst Harbor Ucla Medical Ct INJECTABLE COMPOSITION CONTAINING SODIUM DEOXYCHOLATE
WO2006133160A2 (en) 2005-06-06 2006-12-14 Georgetown University Compositions and methods for lipo modeling
TW201011755A (en) 2008-09-10 2010-03-16 Skymedi Corp Flash memory system and its data recovery method
JP5420946B2 (en) * 2009-03-23 2014-02-19 富士フイルム株式会社 Minoxidil aqueous composition containing bile acids
EP2645099A1 (en) * 2012-03-30 2013-10-02 Phares Pharmaceutical Research N.V. Biorelevant compositions

Also Published As

Publication number Publication date
JP2014524467A (en) 2014-09-22
KR101919269B1 (en) 2018-11-15
KR20190119677A (en) 2019-10-22
AU2018202807A1 (en) 2018-05-10
NZ620040A (en) 2016-06-24
AU2011375432A1 (en) 2014-02-06
IN2014CN02188A (en) 2015-05-29
MX2014001495A (en) 2014-04-25
JP5919597B2 (en) 2016-05-18
IL230547A0 (en) 2014-03-31
KR102034606B1 (en) 2019-10-22
KR101751585B1 (en) 2017-06-27
PH12016501175B1 (en) 2017-12-11
CR20140053A (en) 2014-06-12
BR112014000547A2 (en) 2017-02-14
KR102073536B1 (en) 2020-02-04
AU2016202661B2 (en) 2018-02-22
SG2014013205A (en) 2014-05-29
AU2016202661A1 (en) 2016-05-19
IL230547A (en) 2017-02-28
CN108619089A (en) 2018-10-09
UA113522C2 (en) 2017-02-10
CA2842177C (en) 2016-07-19
KR20180123734A (en) 2018-11-19
MY184277A (en) 2021-03-30
CN103826608A (en) 2014-05-28
AU2018202807B2 (en) 2020-01-16
BR112014000547B1 (en) 2021-11-09
MX350390B (en) 2017-09-06
ZA201401027B (en) 2017-09-27
KR20150000448A (en) 2015-01-02
CA2842177A1 (en) 2013-02-28
PH12016501175A1 (en) 2017-12-11
CN108743522A (en) 2018-11-06
KR20200013103A (en) 2020-02-05
KR20170075016A (en) 2017-06-30
AU2011375432B2 (en) 2016-02-04
WO2013028177A1 (en) 2013-02-28
EA029305B1 (en) 2018-03-30

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