EA201400990A1 - Ингибиторы диацилглицеринацилтрансферазы 2 - Google Patents

Ингибиторы диацилглицеринацилтрансферазы 2

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Publication number
EA201400990A1
EA201400990A1 EA201400990A EA201400990A EA201400990A1 EA 201400990 A1 EA201400990 A1 EA 201400990A1 EA 201400990 A EA201400990 A EA 201400990A EA 201400990 A EA201400990 A EA 201400990A EA 201400990 A1 EA201400990 A1 EA 201400990A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diacylglycerinacyltransferase
inhibitors
dgat2
animals
inhibit
Prior art date
Application number
EA201400990A
Other languages
English (en)
Inventor
Кей Эн
Маркус Боем
Шон Кэбрел
Филип А. Карпино
Кентаро Футатсуги
Дэвид Хепворс
Даниель В. Кунг
Сьюви Орр
Джайан Ванг
Original Assignee
Пфайзер Инк.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48428540&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201400990(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA201400990A1 publication Critical patent/EA201400990A1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Описываются соединения формулы I, ингибирующие активность диацилглицеринацилтрансферазы 2 (DGAT2), и их применение при лечении у животных заболеваний, связанных с ней.
EA201400990A 2012-04-06 2013-03-26 Ингибиторы диацилглицеринацилтрансферазы 2 EA201400990A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261621144P 2012-04-06 2012-04-06
PCT/IB2013/052404 WO2013150416A1 (en) 2012-04-06 2013-03-26 Diacylglycerol acyltransferase 2 inhibitors

Publications (1)

Publication Number Publication Date
EA201400990A1 true EA201400990A1 (ru) 2015-01-30

Family

ID=48428540

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400990A EA201400990A1 (ru) 2012-04-06 2013-03-26 Ингибиторы диацилглицеринацилтрансферазы 2

Country Status (27)

Country Link
US (1) US9296745B2 (ru)
EP (1) EP2834238B1 (ru)
JP (1) JP2015515472A (ru)
KR (1) KR20140137404A (ru)
CN (1) CN104334557A (ru)
AP (1) AP2014007953A0 (ru)
AU (1) AU2013245353A1 (ru)
CA (1) CA2869587A1 (ru)
CL (1) CL2014002541A1 (ru)
CO (1) CO7160030A2 (ru)
CR (1) CR20140468A (ru)
CU (1) CU20140115A7 (ru)
DO (1) DOP2014000225A (ru)
EA (1) EA201400990A1 (ru)
EC (1) ECSP14021251A (ru)
GT (1) GT201400213A (ru)
HK (1) HK1206735A1 (ru)
IL (1) IL234928A0 (ru)
MA (1) MA37385B1 (ru)
MD (1) MD20140103A2 (ru)
MX (1) MX2014011373A (ru)
NI (1) NI201400120A (ru)
PE (1) PE20142164A1 (ru)
PH (1) PH12014502057A1 (ru)
SG (1) SG11201405477XA (ru)
TN (1) TN2014000419A1 (ru)
WO (1) WO2013150416A1 (ru)

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TW202043239A (zh) 2019-01-24 2020-12-01 日商第一三共股份有限公司 具有取代基之脲化合物
TWI771766B (zh) * 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
CN111214449B (zh) * 2020-03-02 2021-09-07 广东彼迪药业有限公司 一种盐酸西替利嗪片剂及其制备方法
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
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TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途
JP2023545741A (ja) 2020-10-08 2023-10-31 メルク・シャープ・アンド・ドーム・エルエルシー 新規なジアシルグリセリドｏ－アシルトランスフェラーゼ２阻害剤としてのベンゾイミダゾロン誘導体の製造
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KR20140137404A (ko) 2014-12-02
MX2014011373A (es) 2014-10-14
MA37385B1 (fr) 2019-09-30
AU2013245353A1 (en) 2014-09-25
SG11201405477XA (en) 2014-11-27
TN2014000419A1 (fr) 2016-03-30
WO2013150416A1 (en) 2013-10-10
CN104334557A (zh) 2015-02-04
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JP2015515472A (ja) 2015-05-28
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ECSP14021251A (es) 2015-09-30
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EP2834238B1 (en) 2017-02-01
DOP2014000225A (es) 2014-11-30
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PH12014502057A1 (en) 2014-12-10
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