EA201400924A1 - Сконструированные пестицидные белки - Google Patents

Сконструированные пестицидные белки

Info

Publication number
EA201400924A1
EA201400924A1 EA201400924A EA201400924A EA201400924A1 EA 201400924 A1 EA201400924 A1 EA 201400924A1 EA 201400924 A EA201400924 A EA 201400924A EA 201400924 A EA201400924 A EA 201400924A EA 201400924 A1 EA201400924 A1 EA 201400924A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polypeptides
organisms
pesticidal
constructed
pesticidal proteins
Prior art date
Application number
EA201400924A
Other languages
English (en)
Other versions
EA031448B1 (ru
Inventor
Микун Ли
Цзэншун Чэнь
Черил Мари Де-Фонте
Джаред Конвилл
Наренда Палекар
Original Assignee
Зингента Партисипейшнс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зингента Партисипейшнс Аг filed Critical Зингента Партисипейшнс Аг
Publication of EA201400924A1 publication Critical patent/EA201400924A1/ru
Publication of EA031448B1 publication Critical patent/EA031448B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8285—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for nematode resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pest Control & Pesticides (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Agronomy & Crop Science (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Раскрыты сконструированные пестицидные полипептиды, являющиеся высокоактивными против широкого спектра вредителей, и способы получения таких полипептидов. Нуклеотидные последовательности, кодирующие пестицидный полипептид, можно применять для трансформации различных прокариотических и эукариотических организмов, при этом организмы можно применять для получения пестицидных полипептидов. Рекомбинантные организмы и/или полипептиды, вырабатываемые рекомбинантными организмами, можно применять для борьбы с вредителями в различных условиях окружающей среды.
EA201400924A 2012-02-16 2013-01-23 Сконструированные пестицидные белки EA031448B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261599583P 2012-02-16 2012-02-16
PCT/US2013/022685 WO2013122720A2 (en) 2012-02-16 2013-01-23 Engineered pesticidal proteins

Publications (2)

Publication Number Publication Date
EA201400924A1 true EA201400924A1 (ru) 2015-07-30
EA031448B1 EA031448B1 (ru) 2019-01-31

Family

ID=47682062

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400924A EA031448B1 (ru) 2012-02-16 2013-01-23 Сконструированные пестицидные белки

Country Status (16)

Country Link
US (2) US10023876B2 (ru)
EP (1) EP2814965B1 (ru)
CN (1) CN104145020B (ru)
AR (1) AR090070A1 (ru)
AU (2) AU2013219927B2 (ru)
BR (1) BR112014020164B1 (ru)
CA (1) CA2860626C (ru)
CL (1) CL2014002148A1 (ru)
EA (1) EA031448B1 (ru)
ES (1) ES2670505T3 (ru)
MX (1) MX356581B (ru)
PH (1) PH12014501854B1 (ru)
PT (1) PT2814965T (ru)
UA (1) UA116881C2 (ru)
WO (1) WO2013122720A2 (ru)
ZA (1) ZA201405056B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6680760B2 (ja) * 2014-07-31 2020-04-15 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ アンタゴニストｉｃ ｐｄ−１アプタマー及びその癌治療関連用途への応用
WO2016033265A1 (en) 2014-08-29 2016-03-03 Syngenta Participations Ag Modified vip3 polypeptides
WO2018048525A1 (en) * 2016-09-09 2018-03-15 Syngenta Participations Ag Insecticidal proteins
CA3077180A1 (en) * 2017-09-26 2019-04-04 Dow Agrosciences Llc Chimeric insecticidal proteins
KR102198072B1 (ko) * 2020-03-04 2021-01-04 씨제이제일제당 주식회사 글루타민 신테타아제 변이형 폴리펩티드 및 이를 이용한 l-글루타민 생산 방법
WO2022144904A1 (en) * 2021-01-04 2022-07-07 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Institute) Anti-pest toxins and cells
AR128208A1 (es) * 2022-01-06 2024-04-10 Dcm Shriram Ltd Proteína insecticida y sus usos
CN114907458B (zh) * 2022-05-10 2023-12-22 山东大学 一种活性提高的Vip3A突变蛋白及其应用
CN117624314A (zh) * 2022-09-01 2024-03-01 青岛清原种子科学有限公司 一种突变杀虫蛋白Vip3及其应用

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535060A (en) 1983-01-05 1985-08-13 Calgene, Inc. Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthetase, production and use
EP0154204B1 (en) 1984-03-06 1994-01-12 Mgi Pharma, Inc. Herbicide resistance in plants
US4761373A (en) 1984-03-06 1988-08-02 Molecular Genetics, Inc. Herbicide resistance in plants
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5036006A (en) 1984-11-13 1991-07-30 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5100792A (en) 1984-11-13 1992-03-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues
US4940835A (en) 1985-10-29 1990-07-10 Monsanto Company Glyphosate-resistant plants
US4810648A (en) 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
EP0242236B2 (en) 1986-03-11 1996-08-21 Plant Genetic Systems N.V. Plant cells resistant to glutamine synthetase inhibitors, made by genetic engineering
US4975374A (en) 1986-03-18 1990-12-04 The General Hospital Corporation Expression of wild type and mutant glutamine synthetase in foreign hosts
NZ221259A (en) 1986-07-31 1990-05-28 Calgene Inc Seed specific transcriptional regulation
US5273894A (en) 1986-08-23 1993-12-28 Hoechst Aktiengesellschaft Phosphinothricin-resistance gene, and its use
US5276268A (en) 1986-08-23 1994-01-04 Hoechst Aktiengesellschaft Phosphinothricin-resistance gene, and its use
US5013659A (en) 1987-07-27 1991-05-07 E. I. Du Pont De Nemours And Company Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase
TR27832A (tr) 1987-04-29 1995-08-31 Monsanto Co Zararli ucucu hasarata mukavim bitkiler.
US6040504A (en) 1987-11-18 2000-03-21 Novartis Finance Corporation Cotton promoter
EP0332104A3 (en) 1988-03-08 1991-03-20 Ciba-Geigy Ag Chemically regulatable dna sequences and genes and uses thereof
US5614395A (en) 1988-03-08 1997-03-25 Ciba-Geigy Corporation Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
ATE112314T1 (de) 1988-05-17 1994-10-15 Lubrizol Genetics Inc Pflanzliches ubiquitinpromotorsystem.
NZ230375A (en) 1988-09-09 1991-07-26 Lubrizol Genetics Inc Synthetic gene encoding b. thuringiensis insecticidal protein
US5162602A (en) 1988-11-10 1992-11-10 Regents Of The University Of Minnesota Corn plants tolerant to sethoxydim and haloxyfop herbicides
EP0413019B1 (en) 1989-02-24 2001-10-04 Monsanto Technology LLC Synthetic plant genes and method for preparation
JP3046063B2 (ja) 1989-03-17 2000-05-29 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 遺伝子の発現の外部の調節
US5641876A (en) 1990-01-05 1997-06-24 Cornell Research Foundation, Inc. Rice actin gene and promoter
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
ATE225853T1 (de) 1990-04-12 2002-10-15 Syngenta Participations Ag Gewebe-spezifische promotoren
US5451513A (en) 1990-05-01 1995-09-19 The State University of New Jersey Rutgers Method for stably transforming plastids of multicellular plants
US5459252A (en) 1991-01-31 1995-10-17 North Carolina State University Root specific gene promoter
US5767366A (en) 1991-02-19 1998-06-16 Louisiana State University Board Of Supervisors, A Governing Body Of Louisiana State University Agricultural And Mechanical College Mutant acetolactate synthase gene from Ararbidopsis thaliana for conferring imidazolinone resistance to crop plants
WO1993004177A1 (en) 1991-08-27 1993-03-04 Agricultural Genetics Company Limited Proteins with insecticidal properties against homopteran insects and their use in plant protection
US5994629A (en) 1991-08-28 1999-11-30 Novartis Ag Positive selection
GB9304200D0 (en) 1993-03-02 1993-04-21 Sandoz Ltd Improvements in or relating to organic compounds
US5304730A (en) 1991-09-03 1994-04-19 Monsanto Company Virus resistant plants and method therefore
UA48104C2 (ru) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, содержащий последовательность, которая кодирует инсектицидный протеин, оптимизированную для кукурузы, фрагмент днк, обеспечивающий направленную желательную для сердцевины стебля экспрессию связанного с ней структурного гена в растении, фрагмент днк, обеспечивающий специфическую для пыльцы экспрессию связанного с ней структурного гена в растении, рекомбинантная молекула днк, способ получения оптимизированной для кукурузы кодирующей последовательности инсектицидного протеина, способ защиты растений кукурузы по меньшей мере от одного насекомого-вредителя
US5877012A (en) 1993-03-25 1999-03-02 Novartis Finance Corporation Class of proteins for the control of plant pests
US5849870A (en) 1993-03-25 1998-12-15 Novartis Finance Corporation Pesticidal proteins and strains
US6291156B1 (en) 1997-04-03 2001-09-18 Syngenta Participations Ag Plant pest control
DE4317845A1 (de) 1993-05-28 1994-12-01 Bayer Ag Desoxyribonukleinsäuren
US5576198A (en) 1993-12-14 1996-11-19 Calgene, Inc. Controlled expression of transgenic constructs in plant plastids
US5545818A (en) 1994-03-11 1996-08-13 Calgene Inc. Expression of Bacillus thuringiensis cry proteins in plant plastids
US5545817A (en) 1994-03-11 1996-08-13 Calgene, Inc. Enhanced expression in a plant plastid
US5437992A (en) 1994-04-28 1995-08-01 Genencor International, Inc. Five thermostable xylanases from microtetraspora flexuosa for use in delignification and/or bleaching of pulp
US6808904B2 (en) 1994-06-16 2004-10-26 Syngenta Participations Ag Herbicide-tolerant protox genes produced by DNA shuffling
WO1996021031A1 (en) 1994-12-30 1996-07-11 Asgrow Seed Company Transgenic plants expressing dna constructs containing a plurality of genes to impart virus resistance
GB9515941D0 (en) 1995-08-03 1995-10-04 Zeneca Ltd DNA constructs
US5853973A (en) 1995-04-20 1998-12-29 American Cyanamid Company Structure based designed herbicide resistant products
US6084155A (en) 1995-06-06 2000-07-04 Novartis Ag Herbicide-tolerant protoporphyrinogen oxidase ("protox") genes
GB9516241D0 (en) 1995-08-08 1995-10-11 Zeneca Ltd Dna constructs
GB9611777D0 (en) * 1996-06-06 1996-08-07 Ciba Geigy Ag Method of controlling insect pests
US5849320A (en) 1996-06-13 1998-12-15 Novartis Corporation Insecticidal seed coating
US5876739A (en) 1996-06-13 1999-03-02 Novartis Ag Insecticidal seed coating
WO1998000546A2 (en) 1996-07-01 1998-01-08 Mycogen Corporation Bacillus thuringiensis toxins active against noctuidae pests
US6369213B1 (en) * 1996-07-01 2002-04-09 Mycogen Corporation Toxins active against pests
US6603063B1 (en) 1999-05-07 2003-08-05 Mycogen Corp. Plants and cells transformed with a nucleic acid from Bacillus thuringiensis strain KB59A4-6 encoding a novel SUP toxin
JP2001502919A (ja) 1996-10-30 2001-03-06 マイコーゲン コーポレーション 新規殺虫性毒素およびこれらの毒素をコードする塩基配列
US7129212B2 (en) 1996-10-30 2006-10-31 Mycogen Corporation Polynucleotides, pesticidal proteins, and novel methods of using them
US6242669B1 (en) 1996-10-30 2001-06-05 Mycogen Corporation Pesticidal toxins and nucleotide sequences which encode these toxins
US6121436A (en) 1996-12-13 2000-09-19 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
SE506835C2 (sv) 1997-01-31 1998-02-16 Lennart Svensson Förankringsanordning samt förfarande vid montering av en sådan
DK1034262T3 (da) 1997-11-18 2005-11-28 Pioneer Hi Bred Int Sammensætninger og fremgangsmåder til genetisk modifikation af planter
AU745960C (en) 1997-11-18 2003-09-18 Pioneer Hi-Bred International, Inc. A novel method for the integration of foreign DNA into eukaryoticgenomes
EP1032692A1 (en) 1997-11-18 2000-09-06 Pioneer Hi-Bred International, Inc. Targeted manipulation of herbicide-resistance genes in plants
ES2338284T3 (es) 1997-11-18 2010-05-05 Pioneer Hi-Bred International, Inc. Movilizacion de genomas viricos a partir de t-adn utilizando sistemas de recombinacion especificos de sitio.
US7166770B2 (en) 2000-03-27 2007-01-23 Syngenta Participations Ag Cestrum yellow leaf curling virus promoters
AR044724A1 (es) 2000-03-27 2005-10-05 Syngenta Participations Ag Promotores del virus de la rizadura amarilla del cestrum
AR035799A1 (es) 2001-03-30 2004-07-14 Syngenta Participations Ag Toxinas insecticidas aisladas de bacillus thuringiensis y sus usos.
DE10138285A1 (de) 2001-08-10 2003-03-06 Akzenta Paneele & Profile Gmbh Paneel sowie Befestigungssystem für Paneele
ATE465628T1 (de) 2002-03-06 2010-05-15 Syngenta Participations Ag Neue vip3-toxine und ihre verwendung
EP2360179A1 (en) 2002-03-22 2011-08-24 Bayer BioScience N.V. Novel bacillus thuringiensis insecticidal proteins
AU2003209748B2 (en) * 2002-03-22 2009-09-10 Bayer Cropscience Nv Novel bacillus thuringiensis insecticidal proteins
US7129397B2 (en) 2003-10-06 2006-10-31 Syngenta Participations Ag Promoters functional in plant plastids
EP1771554A4 (en) 2003-12-19 2008-03-05 Syngenta Participations Ag MICROBIAL EXPRESSED XYLANASES, THEIR USE AS FOOD ADDITIVES AND OTHER APPLICATIONS
WO2009132850A1 (en) * 2008-05-01 2009-11-05 Bayer Bioscience N.V. Armyworm insect resistance management in transgenic plants
CN102066566A (zh) * 2008-06-13 2011-05-18 拜尔生物科学公司 转基因植物中的棉铃虫昆虫抗性管理

Also Published As

Publication number Publication date
AU2013219927B2 (en) 2018-11-08
EA031448B1 (ru) 2019-01-31
WO2013122720A3 (en) 2013-12-19
AR090070A1 (es) 2014-10-15
CN104145020A (zh) 2014-11-12
US10023876B2 (en) 2018-07-17
PT2814965T (pt) 2018-05-23
CN104145020B (zh) 2020-06-02
CL2014002148A1 (es) 2014-11-03
BR112014020164A2 (pt) 2017-08-01
UA116881C2 (uk) 2018-05-25
AU2018253611A1 (en) 2018-11-22
EP2814965A2 (en) 2014-12-24
WO2013122720A2 (en) 2013-08-22
AU2018253611B2 (en) 2021-04-01
ZA201405056B (en) 2015-10-28
AU2013219927A1 (en) 2014-08-07
US20150020236A1 (en) 2015-01-15
PH12014501854A1 (en) 2014-11-17
PH12014501854B1 (en) 2014-11-17
CA2860626C (en) 2021-05-18
CA2860626A1 (en) 2013-08-22
BR112014020164B1 (pt) 2022-09-13
MX2014009282A (es) 2014-08-27
EP2814965B1 (en) 2018-03-21
MX356581B (es) 2018-06-05
ES2670505T3 (es) 2018-05-30
US20180291397A1 (en) 2018-10-11

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