EA201390327A1 - Гетероциклильные соединения в качестве лигандов гистаминовых hрецепторов - Google Patents
Гетероциклильные соединения в качестве лигандов гистаминовых hрецепторовInfo
- Publication number
- EA201390327A1 EA201390327A1 EA201390327A EA201390327A EA201390327A1 EA 201390327 A1 EA201390327 A1 EA 201390327A1 EA 201390327 A EA201390327 A EA 201390327A EA 201390327 A EA201390327 A EA 201390327A EA 201390327 A1 EA201390327 A1 EA 201390327A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- histomine
- hepathogen
- compounds
- receptor ligands
- heterocyclyl compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
Настоящее изобретение относится к гетероциклильным соединениям формулы (I) и их фармацевтически приемлемым солям и к композициям, содержащим такие соединения.Настоящее изобретение также относится к способу получения указанных выше новых соединений и их фармацевтически приемлемых солей. Соединения формулы (I) являются полезными в лечения различных расстройств, которые связаны с гистаминовыми Нрецепторами.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2551CH2010 | 2010-09-02 | ||
PCT/IN2010/000740 WO2012029070A1 (en) | 2010-09-02 | 2010-11-15 | Heterocyclyl compounds as histamine h3 receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201390327A1 true EA201390327A1 (ru) | 2013-08-30 |
EA022746B1 EA022746B1 (ru) | 2016-02-29 |
Family
ID=43608695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201390327A EA022746B1 (ru) | 2010-09-02 | 2010-11-15 | Гетероциклические соединения в качестве лигандов гистаминовых hрецепторов |
Country Status (27)
Country | Link |
---|---|
US (1) | US8912179B2 (ru) |
EP (1) | EP2611444B1 (ru) |
JP (1) | JP5650329B2 (ru) |
KR (1) | KR101538239B1 (ru) |
CN (1) | CN103079566B (ru) |
AU (1) | AU2010360038B2 (ru) |
BR (1) | BR112013005084A2 (ru) |
CA (1) | CA2812970C (ru) |
CY (1) | CY1117096T1 (ru) |
DK (1) | DK2611444T3 (ru) |
EA (1) | EA022746B1 (ru) |
ES (1) | ES2558531T3 (ru) |
HK (1) | HK1180955A1 (ru) |
HR (1) | HRP20151380T1 (ru) |
HU (1) | HUE028435T2 (ru) |
IL (1) | IL224652A (ru) |
ME (1) | ME02320B (ru) |
MX (1) | MX354852B (ru) |
NZ (1) | NZ607658A (ru) |
PL (1) | PL2611444T3 (ru) |
PT (1) | PT2611444E (ru) |
RS (1) | RS54514B1 (ru) |
SG (1) | SG188212A1 (ru) |
SI (1) | SI2611444T1 (ru) |
SM (1) | SMT201600012B (ru) |
WO (1) | WO2012029070A1 (ru) |
ZA (1) | ZA201301143B (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2878217C (en) * | 2012-08-23 | 2016-05-17 | Suven Life Sciences Limited | Acrylamide compounds as histamine h3 receptor ligands |
CN104530088A (zh) * | 2014-12-08 | 2015-04-22 | 苏州施亚生物科技有限公司 | 2-氨基-6,7-二氢-5H-噻唑并[5,4-b]吡啶-4-羧酸叔丁酯及其衍生物,以及它们的合成方法 |
EP3378477A1 (en) * | 2017-03-21 | 2018-09-26 | BIOPROJET Pharma | New therapeutical use of h3-ligands |
KR20200083551A (ko) | 2017-11-02 | 2020-07-08 | 아이쿠리스 게엠베하 운트 코. 카게 | B형 간염 바이러스 (hbv)에 활성인 신규 고활성 아미노-티아졸 치환된 인돌-2-카르복스아미드 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4695575A (en) | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
PH23995A (en) | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
DE60234453D1 (de) | 2001-07-02 | 2009-12-31 | High Point Pharmaceuticals Llc | Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren |
RU2005106274A (ru) | 2002-09-06 | 2005-11-10 | Янссен Фармацевтика, Н.В. (Be) | Гетероциклические соединения |
CN101018769A (zh) * | 2004-07-16 | 2007-08-15 | 詹森药业有限公司 | 二聚哌啶衍生物 |
MX2007000616A (es) * | 2004-07-16 | 2007-03-07 | Janssen Pharmaceutica Nv | Derivados dimericos de piperidina. |
CA2601644A1 (en) * | 2005-03-14 | 2006-09-21 | Glaxo Group Limited | Fused thiazole derivatives having affinity for the histamine h3 receptor |
EP1999120B1 (en) * | 2006-03-28 | 2012-06-27 | High Point Pharmaceuticals, LLC | Benzothiazoles having histamine h3 receptor activity |
EP2049548A1 (en) * | 2006-07-27 | 2009-04-22 | UCB Pharma, S.A. | Fused oxazoles & thiazoles as histamine h3- receptor ligands |
US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
US7557101B2 (en) * | 2006-12-08 | 2009-07-07 | Hoffman-La Roche Inc. | 4,5,6,7-tetrahydro-thieno[3,2-c] pyridine derivatives |
US20080146559A1 (en) * | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
US20100292188A1 (en) * | 2008-01-24 | 2010-11-18 | Ucb Pharma S.A. | Compounds Comprising A Cyclobutoxy Group |
WO2010026113A1 (en) | 2008-09-03 | 2010-03-11 | Evotec Neurosciences Gmbh | Acyl- and sufonyl tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists |
-
2010
- 2010-11-15 US US13/818,152 patent/US8912179B2/en not_active Expired - Fee Related
- 2010-11-15 RS RS20150868A patent/RS54514B1/en unknown
- 2010-11-15 PT PT108033960T patent/PT2611444E/pt unknown
- 2010-11-15 MX MX2013001988A patent/MX354852B/es active IP Right Grant
- 2010-11-15 HU HUE10803396A patent/HUE028435T2/en unknown
- 2010-11-15 JP JP2013526597A patent/JP5650329B2/ja not_active Expired - Fee Related
- 2010-11-15 EP EP10803396.0A patent/EP2611444B1/en active Active
- 2010-11-15 SG SG2013010921A patent/SG188212A1/en unknown
- 2010-11-15 ME MEP-2015-216A patent/ME02320B/me unknown
- 2010-11-15 PL PL10803396T patent/PL2611444T3/pl unknown
- 2010-11-15 CN CN201080068911.8A patent/CN103079566B/zh not_active Expired - Fee Related
- 2010-11-15 EA EA201390327A patent/EA022746B1/ru not_active IP Right Cessation
- 2010-11-15 KR KR1020137005890A patent/KR101538239B1/ko active IP Right Grant
- 2010-11-15 SI SI201031083T patent/SI2611444T1/sl unknown
- 2010-11-15 AU AU2010360038A patent/AU2010360038B2/en not_active Ceased
- 2010-11-15 CA CA2812970A patent/CA2812970C/en not_active Expired - Fee Related
- 2010-11-15 ES ES10803396.0T patent/ES2558531T3/es active Active
- 2010-11-15 WO PCT/IN2010/000740 patent/WO2012029070A1/en active Application Filing
- 2010-11-15 DK DK10803396.0T patent/DK2611444T3/en active
- 2010-11-15 BR BR112013005084-5A patent/BR112013005084A2/pt not_active Application Discontinuation
-
2012
- 2012-12-24 NZ NZ607658A patent/NZ607658A/en not_active IP Right Cessation
-
2013
- 2013-02-10 IL IL224652A patent/IL224652A/en not_active IP Right Cessation
- 2013-02-11 ZA ZA2013/01143A patent/ZA201301143B/en unknown
- 2013-07-15 HK HK13108284.3A patent/HK1180955A1/xx not_active IP Right Cessation
-
2015
- 2015-12-15 HR HRP20151380TT patent/HRP20151380T1/hr unknown
- 2015-12-30 CY CY20151101205T patent/CY1117096T1/el unknown
-
2016
- 2016-01-14 SM SM201600012T patent/SMT201600012B/it unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |