TR201905480T4 - Paklitaksel, paklitaksel analogları veya paklitaksel konjugatlarının farmasötik bileşimleri ve ilgili preparasyon ve kullanım yöntemleri. - Google Patents

Paklitaksel, paklitaksel analogları veya paklitaksel konjugatlarının farmasötik bileşimleri ve ilgili preparasyon ve kullanım yöntemleri. Download PDF

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Publication number
TR201905480T4
TR201905480T4 TR2019/05480T TR201905480T TR201905480T4 TR 201905480 T4 TR201905480 T4 TR 201905480T4 TR 2019/05480 T TR2019/05480 T TR 2019/05480T TR 201905480 T TR201905480 T TR 201905480T TR 201905480 T4 TR201905480 T4 TR 201905480T4
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TR
Turkey
Prior art keywords
paclitaxel
conjugates
pharmaceutical compositions
analogs
use methods
Prior art date
Application number
TR2019/05480T
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English (en)
Inventor
Demeule Michel
Che Christian
Regina Anthony
Beliveau Richard
Gagnon Catherine
Castaigne Jean-Paul
Gabathuler Reinhard
Original Assignee
Angiochem Inc
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Filing date
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Application filed by Angiochem Inc filed Critical Angiochem Inc
Publication of TR201905480T4 publication Critical patent/TR201905480T4/tr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Cremophor barındırmayan hidrofobik ajanlar paklitaksel, paklitaksel analogları ve bunların konjugatları (örneğin ANG1005) için faydalı olan farmasötik bileşimler. Bileşimler ayrıca, bir opsiyonel tonisite ajanı, bir tamponlama ajanı, bir hacim artırıcı ajan ve söz konusu bileşimlerin ve hazırlanmasında ve söz konusu bileşimlerin kanser tedavisine aynı zamanda dahil edilmesinin Cremophor Yöntemleri olmayan bir çözücü ajan içermektedir.
TR2019/05480T 2008-04-18 2009-04-20 Paklitaksel, paklitaksel analogları veya paklitaksel konjugatlarının farmasötik bileşimleri ve ilgili preparasyon ve kullanım yöntemleri. TR201905480T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12467708P 2008-04-18 2008-04-18

Publications (1)

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TR201905480T4 true TR201905480T4 (tr) 2019-05-21

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TR2019/05480T TR201905480T4 (tr) 2008-04-18 2009-04-20 Paklitaksel, paklitaksel analogları veya paklitaksel konjugatlarının farmasötik bileşimleri ve ilgili preparasyon ve kullanım yöntemleri.

Country Status (17)

Country Link
US (1) US8710013B2 (tr)
EP (1) EP2279008B1 (tr)
JP (2) JP5860698B2 (tr)
CN (1) CN102026667B (tr)
AU (1) AU2009238187B2 (tr)
BR (1) BRPI0910557A2 (tr)
CA (1) CA2721019C (tr)
DK (1) DK2279008T3 (tr)
ES (1) ES2721148T3 (tr)
HK (1) HK1154795A1 (tr)
MX (1) MX355683B (tr)
PL (1) PL2279008T3 (tr)
PT (1) PT2279008T (tr)
RU (1) RU2518240C2 (tr)
TR (1) TR201905480T4 (tr)
WO (1) WO2009127072A1 (tr)
ZA (1) ZA201007170B (tr)

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CN102026667A (zh) 2011-04-20
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WO2009127072A8 (en) 2009-12-30
US8710013B2 (en) 2014-04-29
CA2721019C (en) 2015-09-15
RU2010146718A (ru) 2012-05-27
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