EA201200560A1 - Специфическая терапия, использующая интегриновые лиганды для лечения рака - Google Patents

Специфическая терапия, использующая интегриновые лиганды для лечения рака

Info

Publication number
EA201200560A1
EA201200560A1 EA201200560A EA201200560A EA201200560A1 EA 201200560 A1 EA201200560 A1 EA 201200560A1 EA 201200560 A EA201200560 A EA 201200560A EA 201200560 A EA201200560 A EA 201200560A EA 201200560 A1 EA201200560 A1 EA 201200560A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ligands
therapy
integrine
cancer treatment
specific therapy
Prior art date
Application number
EA201200560A
Other languages
English (en)
Inventor
Саймон Гудман
Мартин Андреас Пикард
Том Миккелсен
Иоганнес Ниппгрен
Ульрике Гримм
Роже Ступп
Михаэль Веллер
Андреас Харштрик
Маттиас Грелль
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201200560A1 publication Critical patent/EA201200560A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение касается комбинированной терапии для лечения опухолей и опухолевых метастазов, включающей введение интегриновых лигандов, предпочтительно интегриновых антагонистов, вместе с котерапевтическими агентами или формами терапии, которые имеют синергистическую эффективность при последовательном введении с указанными лигандами, такими как химиотерапевтические агенты и/или лучевая терапия. Терапия приводит к синергистическому потенциальному увеличению эффекта ингибирования каждого индивидуального терапевтического средства на пролиферацию опухолевых клеток, приводя к более эффективному лечению, чем обнаружено при введении индивидуального компонента по отдельности, одновременно или не в режиме дозировки настоящего изобретения.
EA201200560A 2006-01-18 2007-01-18 Специфическая терапия, использующая интегриновые лиганды для лечения рака EA201200560A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP06000988 2006-01-18
EP06001044 2006-01-18
EP06006003 2006-01-20
EP06015883 2006-07-31

Publications (1)

Publication Number Publication Date
EA201200560A1 true EA201200560A1 (ru) 2012-09-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
EA201200560A EA201200560A1 (ru) 2006-01-18 2007-01-18 Специфическая терапия, использующая интегриновые лиганды для лечения рака
EA200801671A EA016817B1 (ru) 2006-01-18 2007-01-18 Специфическая терапия, использующая интегриновые лиганды для лечения рака

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200801671A EA016817B1 (ru) 2006-01-18 2007-01-18 Специфическая терапия, использующая интегриновые лиганды для лечения рака

Country Status (10)

Country Link
US (1) US20090130098A1 (ru)
EP (3) EP1973569B1 (ru)
JP (2) JP2009523813A (ru)
KR (1) KR20080089489A (ru)
AU (1) AU2007207465B2 (ru)
BR (1) BRPI0706540A2 (ru)
CA (1) CA2637387A1 (ru)
EA (2) EA201200560A1 (ru)
ES (2) ES2521679T3 (ru)
WO (1) WO2007084670A2 (ru)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008082537A2 (en) 2006-12-19 2008-07-10 The General Hospital Corporation Compounds for modulating integrin cd11b/cd18
BRPI0806596A2 (pt) * 2007-01-18 2013-07-23 Merck Patent Ges Mit Berchraenkter Haftung medicamento e terapia especÍfica usando-se ligantes de integrina para o tratamento de cÂncer
CA2697070A1 (en) * 2007-08-24 2009-03-05 University Health Network Methods of inhibiting tumor growth using beta 5 integrin antagonists
JP2012509287A (ja) * 2008-11-20 2012-04-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌を治療するためのインテグリンリガンドを用いる新規療法および医薬
KR20120116425A (ko) * 2009-11-30 2012-10-22 프로테오로직스 엘티디 작은 피리미딘 유도체 및 이의 사용 방법
US9023876B2 (en) * 2010-07-08 2015-05-05 Adhaere Pharmaceuticals, Inc. Compounds and methods for regulating integrins
SG192667A1 (en) 2011-02-11 2013-09-30 Merck Patent Gmbh Anti-alpha-v integrin antibody for the treatment of prostate cancer
CA2856329A1 (en) 2011-11-17 2013-05-23 Nencki Institute Of Experimental Biology Compositions and methods for treating glioma
AU2013248972A1 (en) 2012-04-20 2014-11-13 Adhaere Pharmaceuticals, Inc. Compounds and methods for regulating integrins
US10960230B2 (en) 2012-10-16 2021-03-30 Nam P. Nguyen Calibration of hypoxic region focused radiotherapy treatment plans
US10166405B2 (en) * 2012-10-16 2019-01-01 Nam Nguyen Image-guided radiotherapy for internal tumor boost
US9895554B2 (en) 2012-10-16 2018-02-20 Nam Nguyen Image-guided radiotherapy for internal tumor boost
WO2016041614A1 (en) 2014-09-17 2016-03-24 Merck Patent Gmbh A method of treating solid cancers and/or metastases thereof, medicaments therefore, and a method of predicting the clinical outcome of treating solid cancers and/or metastases thereof
KR20170055540A (ko) 2014-09-17 2017-05-19 메르크 파텐트 게엠베하 뼈 전이 질환 치료 방법, 그에 따른 약제, 및 뼈 전이 질환 치료의 임상 결과 예측 방법
RU2736045C2 (ru) 2015-03-06 2020-11-11 Бейондспринг Фармасьютикалс, Инк. Способ лечения рака, ассоциированного с мутацией ras
BR112017018964A2 (pt) * 2015-03-06 2018-05-22 Beyondspring Pharmaceuticals Inc uso de plinabulin e métodos para tratar tumor cerebral
KR20180027563A (ko) 2015-07-13 2018-03-14 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린 조성물
SG11201806583XA (en) 2016-02-08 2018-09-27 Beyondspring Pharmaceuticals Inc Compositions containing tucaresol or its analogs
EP3207937A1 (en) 2016-02-17 2017-08-23 Royal College of Surgeons in Ireland A method of treating or preventing sepsis
WO2017182834A1 (en) * 2016-04-19 2017-10-26 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for treating resistant glioblastoma
SG11201810872UA (en) 2016-06-06 2019-01-30 Beyondspring Pharmaceuticals Inc Composition and method for reducing neutropenia
JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド チューブリン結合化合物およびその治療的使用
AU2018217120B2 (en) 2017-02-01 2024-02-08 Beyondspring Pharmaceuticals, Inc. Method of reducing neutropenia
RU2654417C1 (ru) * 2017-05-29 2018-05-17 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ им. Н.Н. Петрова" Минздрава России) Способ расчёта дозы противоопухолевого препарата при выполнении нормотермической изолированной химиоперфузии лёгкого с метастазэктомией
JP7350015B2 (ja) 2018-01-24 2023-09-25 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド プリナブリンの投与による血小板減少症を軽減するための組成物および方法
WO2019208820A1 (ja) * 2018-04-27 2019-10-31 国立大学法人北海道大学 細胞内物質移送システムおよびその利用
MX2022000990A (es) * 2019-08-02 2022-02-16 Univ California Composiciones y metodos que se dirigen y eliminan celulas madre cancerosas (csc) positivas para alfa-v beta-3 (av?3) y tratan canceres resistentes a farmacos y metastasicos.
CA3208998A1 (en) 2021-01-22 2022-07-28 Steven Kerrigan Treatment of coronavirus
CN113289014B (zh) * 2021-05-10 2022-05-17 上海交通大学 超小粒径的两性离子聚肽/没食子酸/铁配位纳米粒子及其制备方法与应用

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3396536A (en) * 1966-08-08 1968-08-13 Cessna Aircraft Co Hydraulic transmission
FR2268956B1 (ru) * 1974-04-24 1977-06-24 Messier Hispano Sa
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4474893A (en) 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US5260291A (en) 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
US4661111A (en) 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
US4517686A (en) 1982-08-04 1985-05-21 La Jolla Cancer Research Foundation Polypeptide
US4578079A (en) 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4589881A (en) 1982-08-04 1986-05-20 La Jolla Cancer Research Foundation Polypeptide
US4792525A (en) 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4614517A (en) 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4754603A (en) * 1987-07-20 1988-07-05 Rosman Allan H Hydraulic-drive system for an intermittent-demand load
DE69029036T2 (de) 1989-06-29 1997-05-22 Medarex Inc Bispezifische reagenzien für die aids-therapie
WO1991003493A1 (en) 1989-08-29 1991-03-21 The University Of Southampton Bi-or trispecific (fab)3 or (fab)4 conjugates
DK0553244T4 (da) 1990-10-05 2005-08-01 Celldex Therapeutics Inc Målrettet immunostimulering med bispecifikke reagenser
CA2097060A1 (en) 1990-12-04 1992-06-05 Peter J. Curtis Bifunctional antibodies and method of preparing same
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
US5932448A (en) 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
EP1997894B1 (en) 1992-02-06 2011-03-30 Novartis Vaccines and Diagnostics, Inc. Biosynthetic binding protein for cancer marker
US5407804A (en) 1992-05-22 1995-04-18 Applied Genetics Inc. Assays for O6 -methylguanine-DNA methyltransferase
GB9224888D0 (en) 1992-11-27 1993-01-13 Univ Singapore Monoclonal antibody
DK0672142T3 (da) 1992-12-04 2001-06-18 Medical Res Council Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse
US5753230A (en) 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US5741796A (en) 1994-05-27 1998-04-21 Merck & Co., Inc. Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption
EP0767792A4 (en) 1994-06-29 2002-11-20 Smithkline Beecham Corp VITRONECTIN RECEPTOR ANTAGONISTS
WO1996000574A1 (en) 1994-06-29 1996-01-11 Smithkline Beecham Corporation Vitronectin receptor antagonists
IT1271688B (it) 1994-08-04 1997-06-04 Menarini Ricerche Sud Spa Molecole ibride per il trattamento antitumorale loro preparazione e loro uso in composizioni farmaceutiche
EP0777657A1 (en) 1994-08-22 1997-06-11 Smithkline Beecham Corporation Bicyclic compounds
WO1996026190A1 (en) 1995-02-22 1996-08-29 Smithkline Beecham Corporation Integrin receptor antagonists
US5780426A (en) 1995-06-07 1998-07-14 Ixsys, Incorporated Fivemer cyclic peptide inhibitors of diseases involving αv β3
ATE238996T1 (de) 1995-06-29 2003-05-15 Smithkline Beecham Corp Integrin-rezeptor-antagonisten
DE19534177A1 (de) 1995-09-15 1997-03-20 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
WO1997024119A1 (en) 1995-12-29 1997-07-10 Smithkline Beecham Corporation Vitronectin receptor antagonists
KR19990076877A (ko) 1995-12-29 1999-10-25 스티븐 베네티아너 비트로넥틴 수용체 길항제
IL125034A0 (en) 1995-12-29 1999-01-26 Smithkline Beecham Corp Vitronectin receptor antagonists
KR20000064710A (ko) 1996-03-20 2000-11-06 제넨테크, 인코포레이티드 인테그린, 특히 ανβ3 인테그린에 대하여 특이 활성을갖는 3환식 화합물, 그 제조방법 및 그 제조를 위한 중간체, 의약으로서의 그 용도 및 그를 포함한 약제 조성물
US5925655A (en) 1996-04-10 1999-07-20 Merck & Co., Inc. αv β3 antagonists
JP2000508319A (ja) 1996-04-10 2000-07-04 メルク エンド カンパニー インコーポレーテッド αｖβ３拮抗薬
WO1997041844A1 (en) 1996-05-09 1997-11-13 Alcon Laboratories, Inc. Combinations of angiostatic compounds
CZ383498A3 (cs) 1996-05-31 1999-05-12 The Scripps Research Institute Průmyslový výrobek, antagonista integrinu alfav beta3, farmaceutický přípravek s obsahem alfav beta3 antagonisty a způsob inhibice angiogeneze ve tkáni
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5981546A (en) 1996-08-29 1999-11-09 Merck & Co., Inc. Integrin antagonists
CA2263999A1 (en) 1996-08-29 1998-03-05 Merck & Co., Inc. Integrin antagonists
JP2001501951A (ja) 1996-10-07 2001-02-13 スミスクライン・ビーチャム・コーポレイション 骨形成刺激方法
AU717283B2 (en) 1996-10-30 2000-03-23 Merck & Co., Inc. Integrin antagonists
US5919792A (en) 1996-10-30 1999-07-06 Merck & Co., Inc. Integrin antagonists
EP0946165B1 (en) 1996-10-30 2003-04-09 Merck & Co., Inc. Integrin antagonists
AU5596298A (en) 1996-12-09 1998-07-03 Cor Therapeutics, Inc. Integrin antagonists
DE19653646A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19653645A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
CO4920232A1 (es) 1997-01-08 2000-05-29 Smithkline Beecham Corp Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin
JP2001509176A (ja) 1997-01-17 2001-07-10 メルク エンド カンパニー インコーポレーテッド インテグリンアンタゴニスト
ES2246069T3 (es) 1997-05-02 2006-02-01 Genentech, Inc. Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos.
WO1999005107A1 (en) 1997-07-25 1999-02-04 Smithkline Beecham Corporation Vitronectin receptor antagonist
WO1999006049A1 (en) 1997-08-04 1999-02-11 Smithkline Beecham Corporation Integrin receptor antagonists
WO1999011626A1 (en) 1997-09-04 1999-03-11 Smithkline Beecham Corporation Integrin receptor antagonists
PE122699A1 (es) 1997-09-19 2000-02-12 Smithkline Beecham Corp Antagonistas de receptores de vitronectina
FR2768734B1 (fr) 1997-09-24 2000-01-28 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2768736B1 (fr) 1997-09-24 2000-05-26 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
EP1017387A4 (en) 1997-09-24 2004-08-18 Smithkline Beecham Corp VITRONEECT RECEPTOR ANTAGONIST
BR9813214A (pt) 1997-09-24 2000-08-29 Smithkline Beecham Corp Antagonista de receptor vitronectina
EP1044001B1 (en) 1997-12-17 2005-07-06 Merck & Co., Inc. Integrin receptor antagonists
US6048861A (en) 1997-12-17 2000-04-11 Merck & Co., Inc. Integrin receptor antagonists
US6017926A (en) 1997-12-17 2000-01-25 Merck & Co., Inc. Integrin receptor antagonists
AU736026B2 (en) 1997-12-17 2001-07-26 Merck & Co., Inc. Integrin receptor antagonists
IL136314A0 (en) 1997-12-17 2001-05-20 Merck & Co Inc Integrin receptor antagonists
EA002822B1 (ru) 1997-12-17 2002-10-31 Мерк Энд Ко., Инк. Антагонисты рецептора интегрина
CA2319160A1 (en) 1998-01-23 1999-07-29 Merck Patent Gesellschaft Mit Beschraenkter Haftung Monoclonal antibody anti .alpha.v-integrin and its use to inhibit .alpha.v.beta.6-integrin attachment to fibronectin
CA2338275A1 (en) 1998-07-29 2000-02-10 Merck & Co., Inc. Integrin receptor antagonists
WO2000009503A1 (en) 1998-08-13 2000-02-24 Merck & Co., Inc. Integrin receptor antagonists
DE19842415A1 (de) * 1998-09-16 2000-03-23 Merck Patent Gmbh Pharmazeutische Zubereitung
US6833373B1 (en) * 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
JP2002533387A (ja) * 1998-12-23 2002-10-08 ジー．ディー．サール ＆ カンパニー 腫瘍治療の複合療法としてインテグリン拮抗物質と一つ以上の抗腫瘍剤を使用する方法
TR200103431T2 (tr) 1999-06-02 2002-06-21 Merck & Co.,Inc. Alfa V integrin reseptör antagonistleri.
JP2004509643A (ja) 2000-09-29 2004-04-02 ザ　ジョンズ　ホプキンス　ユニバーシティー　スクール　オブ　メディシン アルキル化剤を用いた化学療法による治療に対する臨床反応を予測する方法
AU2002219221B2 (en) * 2001-01-09 2007-05-17 Merck Patent Gmbh Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors
CA2478239A1 (en) * 2002-03-04 2003-09-18 Medimmune, Inc. The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
JP2012509287A (ja) * 2008-11-20 2012-04-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌を治療するためのインテグリンリガンドを用いる新規療法および医薬

Also Published As

Publication number Publication date
EA200801671A1 (ru) 2008-12-30
EP2335733B1 (en) 2014-08-06
US20090130098A1 (en) 2009-05-21
EP1973569A2 (en) 2008-10-01
EP2335733A1 (en) 2011-06-22
CA2637387A1 (en) 2007-07-26
WO2007084670A3 (en) 2007-11-22
ES2425396T3 (es) 2013-10-15
ES2521679T3 (es) 2014-11-13
WO2007084670A2 (en) 2007-07-26
EA016817B1 (ru) 2012-07-30
BRPI0706540A2 (pt) 2011-03-29
EP1973569B1 (en) 2013-05-22
EP2338518A1 (en) 2011-06-29
AU2007207465A1 (en) 2007-07-26
WO2007084670A8 (en) 2008-02-28
AU2007207465B2 (en) 2012-12-06
JP2009523813A (ja) 2009-06-25
KR20080089489A (ko) 2008-10-06
JP2013049710A (ja) 2013-03-14

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