EA201170079A1 - Кристаллическая форма (2s)-(-)-n-(6-хлор-2,3-дигидробензо[1,4]диоксин-2-илметил)сульфамида - Google Patents

Кристаллическая форма (2s)-(-)-n-(6-хлор-2,3-дигидробензо[1,4]диоксин-2-илметил)сульфамида

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Publication number
EA201170079A1
EA201170079A1 EA201170079A EA201170079A EA201170079A1 EA 201170079 A1 EA201170079 A1 EA 201170079A1 EA 201170079 A EA201170079 A EA 201170079A EA 201170079 A EA201170079 A EA 201170079A EA 201170079 A1 EA201170079 A1 EA 201170079A1
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EA
Eurasian Patent Office
Prior art keywords
crystalline form
dioxin
chloro
disorders
dihydrodibenzo
Prior art date
Application number
EA201170079A
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English (en)
Other versions
EA018567B1 (ru
Inventor
Стивен Дж. Мерман
Вэньцзю Ву
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Янссен Фармацевтика Нв
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Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201170079A1 publication Critical patent/EA201170079A1/ru
Publication of EA018567B1 publication Critical patent/EA018567B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Изобретение относится к новой кристаллической форме (2S)-(-)-N-(6-хлор-2,3-дигидробензо[1,4]диоксин-2-илметил)сульфамида, фармацевтическим композициям, содержащим указанную кристаллическую форму, а также к использованию указанной кристаллической формы для лечения тревожного состояния и сопутствующих расстройств, биполярной депрессии и мании, депрессии, эпилепсии и сопутствующих расстройств, эпилептогенеза, расстройств, связанных с нарушением метаболизма глюкозы, расстройств, связанных с нарушением метаболизма липидов, мигрени, ожирения, болей, злоупотребления психоактивньми веществами, а также в качестве нейропротекторного средства. Настоящее изобретение также относится к созданию процесса получения новой кристаллической формы.
EA201170079A 2008-06-23 2009-06-19 Кристаллическая форма (2s)-(-)-n-(6-хлор-2,3-дигидробензо[1,4]диоксин-2-илметил)сульфамида EA018567B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7478308P 2008-06-23 2008-06-23
PCT/US2009/048026 WO2010008776A2 (en) 2008-06-23 2009-06-19 Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems

Publications (2)

Publication Number Publication Date
EA201170079A1 true EA201170079A1 (ru) 2011-06-30
EA018567B1 EA018567B1 (ru) 2013-08-30

Family

ID=41431873

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170079A EA018567B1 (ru) 2008-06-23 2009-06-19 Кристаллическая форма (2s)-(-)-n-(6-хлор-2,3-дигидробензо[1,4]диоксин-2-илметил)сульфамида

Country Status (22)

Country Link
US (1) US8809385B2 (ru)
EP (1) EP2340246A2 (ru)
JP (1) JP2012530682A (ru)
AR (1) AR072961A1 (ru)
AU (1) AU2009271362B2 (ru)
BR (1) BRPI0915890A2 (ru)
CA (1) CA2729056A1 (ru)
CL (1) CL2010001540A1 (ru)
CO (1) CO6341554A2 (ru)
CR (1) CR20110042A (ru)
EA (1) EA018567B1 (ru)
EC (1) ECSP10010707A (ru)
HN (1) HN2010002735A (ru)
IL (1) IL210138A0 (ru)
MX (1) MX2011000090A (ru)
NI (1) NI201000226A (ru)
NZ (1) NZ590682A (ru)
PE (1) PE20110060A1 (ru)
TW (1) TW201012807A (ru)
UY (1) UY31934A (ru)
WO (1) WO2010008776A2 (ru)
ZA (1) ZA201100570B (ru)

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US8809385B2 (en) 2014-08-19
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