EA201070844A1 - ((e)-n-{3-[1-(8-фтор-11h-10-окса-1-аза-дибензо[a,d]циклогептен-5-илиден)пропил]фенил}метансульфонамид) в качестве модулятора рецепторов глюкокортикоидов для лечения ревматизма - Google Patents

((e)-n-{3-[1-(8-фтор-11h-10-окса-1-аза-дибензо[a,d]циклогептен-5-илиден)пропил]фенил}метансульфонамид) в качестве модулятора рецепторов глюкокортикоидов для лечения ревматизма

Info

Publication number
EA201070844A1
EA201070844A1 EA201070844A EA201070844A EA201070844A1 EA 201070844 A1 EA201070844 A1 EA 201070844A1 EA 201070844 A EA201070844 A EA 201070844A EA 201070844 A EA201070844 A EA 201070844A EA 201070844 A1 EA201070844 A1 EA 201070844A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
фтор
окса
methanesulfonamid
iliden
Prior art date
Application number
EA201070844A
Other languages
English (en)
Other versions
EA017288B1 (ru
Inventor
Мэттью Уилльям Карсон
Майкл Джозеф Коулан
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201070844A1 publication Critical patent/EA201070844A1/ru
Publication of EA017288B1 publication Critical patent/EA017288B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Согласно настоящему изобретению предложено соединение (I)или фармацевтически приемлемая соль данного соединения; фармацевтические композиции, содержащие сединение (1) в сочетании с одним или более фармацевтически приемлемыми носителями, эксципиентами или разбавителями; и способы лечения воспалительных и иммунных заболеваний, включающие введение пациенту, нуждающемуся в таком лечении, эффективной дозы соединения (1) или фармацевтически приемлемой соли данного соединения.
EA201070844A 2008-01-11 2009-01-08 (E)-N-{3-[1-(8-ФТОР-11Н-10-ОКСА-1-АЗАДИБЕНЗО[a,d]ЦИКЛОГЕПТЕН-5-ИЛИДЕН)ПРОПИЛ]ФЕНИЛ}МЕТАНСУЛЬФОНАМИД В КАЧЕСТВЕ МОДУЛЯТОРА РЕЦЕПТОРОВ ГЛЮКОКОРТИКОИДОВ ДЛЯ ЛЕЧЕНИЯ РЕВМАТИЗМА EA017288B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2052008P 2008-01-11 2008-01-11
PCT/US2009/030374 WO2009089312A1 (en) 2008-01-11 2009-01-08 (e)-n-{3- [1-(8-fluoro-11h-10-oxa-1-aza-dibenzo [a,d] cycl0hepten-5ylidene)-propyl]-phenyl }-methynsulfon amide as glucocorticoid receptor modulator for the treatment of rheumatoid

Publications (2)

Publication Number Publication Date
EA201070844A1 true EA201070844A1 (ru) 2011-02-28
EA017288B1 EA017288B1 (ru) 2012-11-30

Family

ID=40456776

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070844A EA017288B1 (ru) 2008-01-11 2009-01-08 (E)-N-{3-[1-(8-ФТОР-11Н-10-ОКСА-1-АЗАДИБЕНЗО[a,d]ЦИКЛОГЕПТЕН-5-ИЛИДЕН)ПРОПИЛ]ФЕНИЛ}МЕТАНСУЛЬФОНАМИД В КАЧЕСТВЕ МОДУЛЯТОРА РЕЦЕПТОРОВ ГЛЮКОКОРТИКОИДОВ ДЛЯ ЛЕЧЕНИЯ РЕВМАТИЗМА

Country Status (13)

Country Link
US (1) US8101761B2 (ru)
EP (1) EP2231676B1 (ru)
JP (1) JP2011525474A (ru)
KR (1) KR101237296B1 (ru)
CN (1) CN101910179B (ru)
AT (1) ATE522537T1 (ru)
AU (1) AU2009204155A1 (ru)
BR (1) BRPI0906945A2 (ru)
CA (1) CA2711885A1 (ru)
EA (1) EA017288B1 (ru)
ES (1) ES2370148T3 (ru)
MX (1) MX2010007607A (ru)
WO (1) WO2009089312A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011081173A1 (ja) * 2009-12-29 2011-07-07 協和発酵キリン株式会社 四環系化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2603713B1 (fr) * 1986-09-10 1992-07-24 Canon Kk Derive nouveau de 5h-dibenzo(a,d)cycloheptane-(ene)ylidene, son procede de production et support electrophotographique photosensible le contenant
JPH01161245A (ja) 1987-12-18 1989-06-23 Canon Inc 電子写真感光体
US4999363A (en) * 1988-06-09 1991-03-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
US5093210A (en) * 1989-06-30 1992-03-03 Ricoh Company, Ltd. Electroluminescent device
US5378701A (en) * 1991-12-27 1995-01-03 Kyowa Hakko Kogyo Tricyclic compounds
ZA9811898B (en) 1997-12-29 2000-06-28 Ortho Mcneil Pharm Inc Anti-Inflammatory Compounds.
WO2000059884A1 (en) 1999-01-26 2000-10-12 Dana-Farber Cancer Institute, Inc. Pharmaceutically active compounds and methods of use thereof
TW200400816A (en) 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
CN1918151A (zh) * 2003-12-19 2007-02-21 伊莱利利公司 三环甾类激素核受体调节剂
US8101760B2 (en) * 2006-07-14 2012-01-24 Eli Lilly And Company Glucocorticoid receptor modulator and methods of use

Also Published As

Publication number Publication date
KR101237296B1 (ko) 2013-03-04
BRPI0906945A2 (pt) 2015-07-14
EA017288B1 (ru) 2012-11-30
JP2011525474A (ja) 2011-09-22
EP2231676A1 (en) 2010-09-29
MX2010007607A (es) 2010-08-23
US8101761B2 (en) 2012-01-24
US20100280062A1 (en) 2010-11-04
CN101910179A (zh) 2010-12-08
CA2711885A1 (en) 2009-07-16
CN101910179B (zh) 2013-06-19
WO2009089312A1 (en) 2009-07-16
EP2231676B1 (en) 2011-08-31
KR20100090808A (ko) 2010-08-17
ES2370148T3 (es) 2011-12-13
ATE522537T1 (de) 2011-09-15
AU2009204155A8 (en) 2010-07-08
AU2009204155A1 (en) 2009-07-16

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Designated state(s): AM AZ BY KZ KG MD TJ TM RU