EA201070216A1 - Окисленный авидин с большим временем удержания в обработанной им ткани - Google Patents
Окисленный авидин с большим временем удержания в обработанной им тканиInfo
- Publication number
- EA201070216A1 EA201070216A1 EA201070216A EA201070216A EA201070216A1 EA 201070216 A1 EA201070216 A1 EA 201070216A1 EA 201070216 A EA201070216 A EA 201070216A EA 201070216 A EA201070216 A EA 201070216A EA 201070216 A1 EA201070216 A1 EA 201070216A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- avidins
- oxidation
- tissue
- brachytherapy
- groups
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Optics & Photonics (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В настоящем изобретении описаны химически модифицированные авидины, имеющие большую стабильность в обработанной ими ткани по сравнению с авидином дикого типа. Окисление авидина проводят окислением с периодатом в присутствии низкоаффинного лиганда НАВА, который, занимая участки связывания биотина, предупреждает денатурацию белка в ходе стадии окисления. В результате окисления периодатом при разрыве маннозного кольца образуются СНО-группы, которые при инъекции в ткань вступают в реакцию с NH-группами ткани, образуя стабильные шиффовы основания. Заякоренные авидины сохраняют способность связывать биотинилированные агенты, имеющие терапевтическую активность, такие как радиоактивно меченные биотины, стволовые клетки и соматические клетки, используемые для брахитерапии, подобной радионуклидной терапии с интраоперативным авидинированием для (IART®), или для брахитерапии дегенеративных или генетических болезней.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07113733 | 2007-08-02 | ||
EP08157473 | 2008-06-03 | ||
PCT/EP2008/059260 WO2009016031A1 (en) | 2007-08-02 | 2008-07-16 | Oxidized avidin with high residency time in the treated tissues |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201070216A1 true EA201070216A1 (ru) | 2010-08-30 |
EA017017B1 EA017017B1 (ru) | 2012-09-28 |
Family
ID=39734214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070216A EA017017B1 (ru) | 2007-08-02 | 2008-07-16 | Окисленный авидин с большим временем удержания в обработанной им ткани |
Country Status (26)
Country | Link |
---|---|
US (1) | US8562947B2 (ru) |
EP (1) | EP2185203B1 (ru) |
JP (1) | JP5577248B2 (ru) |
KR (1) | KR101544628B1 (ru) |
CN (1) | CN101772353B (ru) |
AR (1) | AR067771A1 (ru) |
AU (1) | AU2008281901B2 (ru) |
BR (1) | BRPI0815050B8 (ru) |
CA (1) | CA2694391C (ru) |
DK (1) | DK2185203T3 (ru) |
EA (1) | EA017017B1 (ru) |
ES (1) | ES2625815T3 (ru) |
HK (1) | HK1145290A1 (ru) |
HR (1) | HRP20170735T1 (ru) |
HU (1) | HUE032093T2 (ru) |
IL (1) | IL203321A (ru) |
LT (1) | LT2185203T (ru) |
MX (1) | MX2010001302A (ru) |
MY (1) | MY155347A (ru) |
NZ (1) | NZ582711A (ru) |
PL (1) | PL2185203T3 (ru) |
PT (1) | PT2185203T (ru) |
SG (1) | SG183076A1 (ru) |
SI (1) | SI2185203T1 (ru) |
TW (1) | TWI441650B (ru) |
WO (1) | WO2009016031A1 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2591524C2 (ru) * | 2010-12-28 | 2016-07-20 | Джапан Тобакко Инк. | Модифицированный тамавидин |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9872831B2 (en) | 2011-08-02 | 2018-01-23 | Alfasigma S.P.A. | Pharmaceutical composition of oxidised avidin suitable for inhalation |
JP2014001204A (ja) * | 2012-05-23 | 2014-01-09 | Kumamoto Univ | 腫瘍細胞選択的抗がん剤 |
EP2941243A4 (en) | 2013-01-04 | 2016-09-14 | Massachusetts Inst Technology | SURFACE BINDING IN THE ADMINISTRATION OF A MEDICAMENT ON NANOPARTICLE BASE IN A TISSUE |
EP3316871A4 (en) | 2015-06-30 | 2019-02-20 | The Trustees of Columbia University in the City of New York | TALKED COMPOSITION AND USES THEREOF |
US20200179530A1 (en) * | 2016-05-19 | 2020-06-11 | University Of Miami | Targeted delivery of therapeutic agents and imaging reagents to pancreatic cancer cells |
EP3857226B1 (en) * | 2018-09-25 | 2023-11-15 | Siemens Healthcare Diagnostics Inc. | Methods and compositions for removing biotin interference from assays using conjugated molecular traps |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0733066B1 (en) * | 1993-12-07 | 2003-11-19 | NeoRx Corporation | Pretargeting methods and compounds |
US5716594A (en) * | 1994-06-06 | 1998-02-10 | The Jmde Trust | Biotin compounds for targetting tumors and sites of infection |
US8021667B2 (en) * | 1994-11-16 | 2011-09-20 | Macfarlane Burnet Institute For Medical Research And Public Health Ltd | Compositions for immunotherapy and uses thereof |
WO2000027814A1 (en) * | 1998-11-10 | 2000-05-18 | Yeda Research And Development Co. Ltd. | Avidin derivatives and uses thereof |
US7001994B2 (en) * | 2001-01-18 | 2006-02-21 | Genzyme Corporation | Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins |
US20040101901A1 (en) * | 2002-11-27 | 2004-05-27 | Piotr Tabaczewski | Novel lipophilic complexes for insertion of receptors into lipid membranes |
ITRM20030196A1 (it) | 2003-04-24 | 2004-10-25 | Sigma Tau Ind Farmaceuti | Uso di reagenti per la preparazione di un medicamento |
-
2008
- 2008-07-16 KR KR1020107004513A patent/KR101544628B1/ko active IP Right Grant
- 2008-07-16 EP EP08775109.5A patent/EP2185203B1/en active Active
- 2008-07-16 CA CA2694391A patent/CA2694391C/en active Active
- 2008-07-16 NZ NZ582711A patent/NZ582711A/en unknown
- 2008-07-16 BR BRPI0815050A patent/BRPI0815050B8/pt active IP Right Grant
- 2008-07-16 JP JP2010518601A patent/JP5577248B2/ja active Active
- 2008-07-16 US US12/670,925 patent/US8562947B2/en active Active
- 2008-07-16 LT LTEP08775109.5T patent/LT2185203T/lt unknown
- 2008-07-16 ES ES08775109.5T patent/ES2625815T3/es active Active
- 2008-07-16 AU AU2008281901A patent/AU2008281901B2/en active Active
- 2008-07-16 PT PT87751095T patent/PT2185203T/pt unknown
- 2008-07-16 WO PCT/EP2008/059260 patent/WO2009016031A1/en active Application Filing
- 2008-07-16 MX MX2010001302A patent/MX2010001302A/es active IP Right Grant
- 2008-07-16 DK DK08775109.5T patent/DK2185203T3/da active
- 2008-07-16 MY MYPI2010000136A patent/MY155347A/en unknown
- 2008-07-16 HU HUE08775109A patent/HUE032093T2/en unknown
- 2008-07-16 PL PL08775109T patent/PL2185203T3/pl unknown
- 2008-07-16 EA EA201070216A patent/EA017017B1/ru unknown
- 2008-07-16 CN CN2008801016692A patent/CN101772353B/zh active Active
- 2008-07-16 SI SI200831808A patent/SI2185203T1/sl unknown
- 2008-07-16 SG SG2012054938A patent/SG183076A1/en unknown
- 2008-07-18 TW TW097127328A patent/TWI441650B/zh active
- 2008-08-01 AR ARP080103343A patent/AR067771A1/es active IP Right Grant
-
2010
- 2010-01-14 IL IL203321A patent/IL203321A/en active IP Right Grant
- 2010-12-16 HK HK10111803.2A patent/HK1145290A1/xx unknown
-
2017
- 2017-05-16 HR HRP20170735TT patent/HRP20170735T1/hr unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2591524C2 (ru) * | 2010-12-28 | 2016-07-20 | Джапан Тобакко Инк. | Модифицированный тамавидин |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201070216A1 (ru) | Окисленный авидин с большим временем удержания в обработанной им ткани | |
NO20070951L (no) | Inhibitorer av angiopoientinlignende-4-protein, kombinasjoner og deres anvendelse. | |
EA201890903A1 (ru) | Соединения пиридиловых ингибиторов передачи сигналов белком hedgehog, способ их получения, композиция и способы лечения рака и ингибирований ангиогенеза и сигнального пути hedgehog в клетках на их основе | |
EA201001695A1 (ru) | Применение эпотилона d для лечения заболеваний, связанных с тау-белком | |
ATE364698T1 (de) | Neues, physiologisch aktives peptid und dessen verwendung | |
EA200501849A1 (ru) | Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ | |
ATE421501T1 (de) | 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck | |
ATE551060T1 (de) | Zusammensetzungen und verfahren zur behandlung von neovaskulären erkrankungen | |
EA200600591A1 (ru) | МОДУЛИРОВАНИЕ ЭКСПРЕССИИ eIF4E | |
WO2006120573A3 (en) | Heterocyclic n-oxides as hypoxic selective protein kinase inhibitors | |
ATE434617T1 (de) | 5-amino-4-hydroxy-7-(imidazo ä1,2-aü pyridin-6- ylmethyl)-8-methylnonamidderivate und verwandte verbindungen als renininhibitoren zur behandlung von bluthochdruck | |
MY140132A (en) | Thiazolidin-4-one derivatives for use in the treatment of anemias | |
EA200601212A1 (ru) | Ингибиторы фосфодиэстеразы, получение и их терапевтическое применение | |
EA200600209A1 (ru) | ПРОИЗВОДНЫЕ ПИРРОЛО[3,4-c]ПИРАЗОЛА, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ КАК ИНГИБИТОРЫ КИНАЗЫ | |
WO2004006838A3 (en) | Novel kinases | |
HK1110802A1 (en) | Use of nucleic acids in the preparation of a medicament for treating melanoma and the composition thereof | |
DE60019318D1 (de) | Zusammensetzungen und verfahren zur inhibierung vom zellulären g2-übergang und sensitisierung von zellen gegen dna-schädigenden wirkstoffe | |
WO2007080194A3 (en) | Use of tpp ii inhibitors in combination with gamma-irradiation for the treatment of cancer | |
WO2004009024A3 (en) | Modulation of protein kinase c-iota expression | |
DK1234025T3 (da) | Humane enzymer fra metalloproteasefamilien | |
EA200702136A1 (ru) | Композиции станнсопорфина и их применение | |
HK1074840A1 (en) | Novel dithiolopyrrolones with therapeutic activity | |
EA200700346A1 (ru) | Бактериофаг- и профаг-специфические протеины в генной терапии рака | |
ATE516038T1 (de) | Metallcluster-nanoverbindungen zur behandlung von tumorerkrankungen | |
ATE522625T1 (de) | Verfahren und zusammensetzungen zur diagnose und behandlung von lungenkrebs mittels pdgfra-, kit- oder kdg-gen als genmarker |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title |