EA201070039A1 - Спироциклы в качестве ингибиторов 11-бета гидроксилстероиддегидрогеназы типа 1 - Google Patents

Спироциклы в качестве ингибиторов 11-бета гидроксилстероиддегидрогеназы типа 1

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Publication number
EA201070039A1
EA201070039A1 EA201070039A EA201070039A EA201070039A1 EA 201070039 A1 EA201070039 A1 EA 201070039A1 EA 201070039 A EA201070039 A EA 201070039A EA 201070039 A EA201070039 A EA 201070039A EA 201070039 A1 EA201070039 A1 EA 201070039A1
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EA
Eurasian Patent Office
Prior art keywords
inhibitors
spirocycles
dehydrogenase type
steroid dehydrogenase
beta hydroxyl
Prior art date
Application number
EA201070039A
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English (en)
Other versions
EA016017B1 (ru
Inventor
Вэньцин Яо
Цзиньцун Чжо
Колин Чжан
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Инсайт Корпорейшн
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39731144&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201070039(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Инсайт Корпорейшн filed Critical Инсайт Корпорейшн
Publication of EA201070039A1 publication Critical patent/EA201070039A1/ru
Publication of EA016017B1 publication Critical patent/EA016017B1/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
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  • Vascular Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к определенным спироциклическим соединениям, которые представляют собой ингибиторы 11-гидроксилстероиддегидрогеназы типа 1 (11HSD1), содержащим их композициям и способам их применения для лечения диабета, ожирения и других заболеваний.
EA201070039A 2007-06-21 2008-06-20 Спироциклы в качестве ингибиторов 11-бета гидроксилстероиддегидрогеназы типа 1 EA016017B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94548707P 2007-06-21 2007-06-21
PCT/US2008/067637 WO2008157752A1 (en) 2007-06-21 2008-06-20 Spirocycles as inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1

Publications (2)

Publication Number Publication Date
EA201070039A1 true EA201070039A1 (ru) 2010-06-30
EA016017B1 EA016017B1 (ru) 2012-01-30

Family

ID=39731144

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070039A EA016017B1 (ru) 2007-06-21 2008-06-20 Спироциклы в качестве ингибиторов 11-бета гидроксилстероиддегидрогеназы типа 1

Country Status (31)

Country Link
US (4) US8278318B2 (ru)
EP (3) EP2918586A1 (ru)
JP (2) JP5364702B2 (ru)
KR (1) KR101554471B1 (ru)
CN (1) CN101815716B (ru)
AR (1) AR067090A1 (ru)
AU (1) AU2008265656B2 (ru)
BR (1) BRPI0812904A2 (ru)
CA (1) CA2691150C (ru)
CL (1) CL2008001839A1 (ru)
CO (1) CO6150151A2 (ru)
CR (1) CR11183A (ru)
CY (2) CY1113212T1 (ru)
DK (2) DK2173750T3 (ru)
EA (1) EA016017B1 (ru)
EC (1) ECSP109844A (ru)
ES (2) ES2531056T3 (ru)
GE (1) GEP20135754B (ru)
HK (2) HK1143156A1 (ru)
HR (2) HRP20120772T1 (ru)
IL (1) IL202842A (ru)
MX (1) MX2009014274A (ru)
NZ (1) NZ582524A (ru)
PL (2) PL2173750T3 (ru)
PT (2) PT2540723E (ru)
RS (2) RS53839B1 (ru)
SI (2) SI2173750T1 (ru)
TW (1) TWI428340B (ru)
UA (1) UA98651C2 (ru)
WO (1) WO2008157752A1 (ru)
ZA (1) ZA201000233B (ru)

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