EA201001823A1 - Новые гетероциклические карбоксамиды для применения в качестве ингибиторов тромбина - Google Patents

Новые гетероциклические карбоксамиды для применения в качестве ингибиторов тромбина

Info

Publication number
EA201001823A1
EA201001823A1 EA201001823A EA201001823A EA201001823A1 EA 201001823 A1 EA201001823 A1 EA 201001823A1 EA 201001823 A EA201001823 A EA 201001823A EA 201001823 A EA201001823 A EA 201001823A EA 201001823 A1 EA201001823 A1 EA 201001823A1
Authority
EA
Eurasian Patent Office
Prior art keywords
thrombin inhibitors
new heterocyclic
heterocyclic carboxamides
carboxamides
compounds
Prior art date
Application number
EA201001823A
Other languages
English (en)
Other versions
EA018502B1 (ru
Inventor
Йонас Брональт
Давид Густафссон
Ингемар Нильссон
Магнус Полла
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201001823A1 publication Critical patent/EA201001823A1/ru
Publication of EA018502B1 publication Critical patent/EA018502B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к новым фармацевтически полезным соединениям формулы (I), в частности соединениям, которые представляют собой конкурентные ингибиторы трипсиноподобных сериновых протеаз, в частности тромбина, их применению в качестве лекарственных средств, содержащим их фармацевтическим композициям и путям синтеза для их получения.
EA201001823A 2008-06-23 2009-06-22 Новые гетероциклические карбоксамиды и фармацевтические композиции, содержащие их EA018502B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7473608P 2008-06-23 2008-06-23
US10238108P 2008-10-03 2008-10-03
PCT/SE2009/050778 WO2009157860A1 (en) 2008-06-23 2009-06-22 New heterocyclic carboxamides for use as thrombin inhibitors

Publications (2)

Publication Number Publication Date
EA201001823A1 true EA201001823A1 (ru) 2011-06-30
EA018502B1 EA018502B1 (ru) 2013-08-30

Family

ID=41431868

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001823A EA018502B1 (ru) 2008-06-23 2009-06-22 Новые гетероциклические карбоксамиды и фармацевтические композиции, содержащие их

Country Status (20)

Country Link
US (2) US20110130432A1 (ru)
EP (1) EP2321301A4 (ru)
JP (1) JP2011525487A (ru)
KR (1) KR20110025970A (ru)
CN (1) CN102131802A (ru)
AR (1) AR072278A1 (ru)
AU (1) AU2009263076B2 (ru)
BR (1) BRPI0914323A2 (ru)
CA (1) CA2727925A1 (ru)
CO (1) CO6321275A2 (ru)
CR (1) CR11873A (ru)
DO (1) DOP2010000402A (ru)
EA (1) EA018502B1 (ru)
EC (1) ECSP10010710A (ru)
IL (1) IL210076A0 (ru)
MX (1) MX2010014229A (ru)
TW (1) TW201002689A (ru)
UY (1) UY31923A (ru)
WO (1) WO2009157860A1 (ru)
ZA (1) ZA201100568B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2570896C2 (ru) * 2013-04-23 2015-12-20 Общество с ограниченной ответственностью "Химико-фармацевтические технологии" (ООО "ХимФармТех") (4-фтор-бензил)-этил-(2-тетразол-1-ил-фенил)-амин и способ его получения

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354444B2 (en) 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
CN104610184A (zh) * 2015-01-13 2015-05-13 佛山市赛维斯医药科技有限公司 苯二烯四氮唑类化合物、其制备方法和用途
CN104529923B (zh) * 2015-01-13 2016-06-01 佛山市赛维斯医药科技有限公司 二烯四氮唑硝基苯类化合物、其制备方法和用途
EP3672939A1 (en) * 2017-08-21 2020-07-01 Celgene Corporation Processes for preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate
CN113636982A (zh) * 2021-04-28 2021-11-12 合肥工业大学 一种肉桂酸衍生物及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
JPH11503161A (ja) * 1995-04-04 1999-03-23 メルク エンド カンパニー インコーポレーテッド トロンビン阻害剤
AR013084A1 (es) * 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
EP1019364B1 (en) 1997-08-28 2004-06-09 Biovitrum Ab Inhibitors of protein tyrosine phosphatase
BR9907112A (pt) * 1998-01-26 2000-10-24 Basf Ag Composto, medicamento, e, uso de um composto
US6482921B1 (en) 1999-01-28 2002-11-19 Essential Therapeutics, Inc. Uridyl peptide antibiotic (UPA) derivatives, their synthesis and use
FR2793248B1 (fr) * 1999-05-03 2001-06-29 Adir Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SE0001803D0 (sv) * 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6528503B2 (en) * 2000-12-18 2003-03-04 Merck & Co., Inc. Thrombin inhibitors
WO2002050056A1 (en) * 2000-12-18 2002-06-27 Merck & Co., Inc. Benzylamine derivatives and their use as thrombin inhibitors
WO2002064559A2 (en) * 2001-02-09 2002-08-22 Merck & Co., Inc. Thrombin inhibitors
UA78195C2 (ru) * 2001-08-30 2007-03-15 Astrazeneca Ab Производные миндальной кислоты и их применения в качестве ингибиторов тромбина, фармацевтическая композиция на их основе
WO2004032834A2 (en) * 2002-10-04 2004-04-22 Merck & Co., Inc. Thrombin inhibitors
GB0327761D0 (en) 2003-11-29 2003-12-31 Astrazeneca Ab Compounds
EP2104497B1 (de) 2006-12-06 2015-02-25 Sanofi Sulfamidderivate als inhibitoren von tafia
WO2009004383A2 (en) 2007-07-03 2009-01-08 Astrazeneca Ab Aza-bicyclohexane compounds useful as anticoagulants
JP5531011B2 (ja) 2008-06-06 2014-06-25 サノフイ ＴＡＦＩａの阻害剤としての大環状尿素およびスルファミド誘導体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2570896C2 (ru) * 2013-04-23 2015-12-20 Общество с ограниченной ответственностью "Химико-фармацевтические технологии" (ООО "ХимФармТех") (4-фтор-бензил)-этил-(2-тетразол-1-ил-фенил)-амин и способ его получения

Also Published As

Publication number Publication date
ECSP10010710A (es) 2011-01-31
CN102131802A (zh) 2011-07-20
JP2011525487A (ja) 2011-09-22
US20110130432A1 (en) 2011-06-02
MX2010014229A (es) 2011-06-20
EA018502B1 (ru) 2013-08-30
ZA201100568B (en) 2012-06-27
TW201002689A (en) 2010-01-16
AU2009263076B2 (en) 2012-07-26
WO2009157860A1 (en) 2009-12-30
UY31923A (es) 2010-01-29
BRPI0914323A2 (pt) 2017-03-28
CA2727925A1 (en) 2009-12-30
DOP2010000402A (es) 2011-01-15
US20090318517A1 (en) 2009-12-24
CO6321275A2 (es) 2011-09-20
CR11873A (es) 2011-02-28
AR072278A1 (es) 2010-08-18
EP2321301A1 (en) 2011-05-18
US8119673B2 (en) 2012-02-21
AU2009263076A1 (en) 2009-12-30
KR20110025970A (ko) 2011-03-14
EP2321301A4 (en) 2011-09-28
IL210076A0 (en) 2011-02-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU