EA201001085A1 - Фармацевтические композиции, содержащие гранулы очищенной микробной липазы, и способы предупреждения или лечения пищеварительных нарушений - Google Patents

Фармацевтические композиции, содержащие гранулы очищенной микробной липазы, и способы предупреждения или лечения пищеварительных нарушений

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Publication number
EA201001085A1
EA201001085A1 EA201001085A EA201001085A EA201001085A1 EA 201001085 A1 EA201001085 A1 EA 201001085A1 EA 201001085 A EA201001085 A EA 201001085A EA 201001085 A EA201001085 A EA 201001085A EA 201001085 A1 EA201001085 A1 EA 201001085A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
prevention
treatment
compositions containing
disabilities
Prior art date
Application number
EA201001085A
Other languages
English (en)
Inventor
Джордж Шлиаут
Флориан Унгер
Андреас Кёрнер
Original Assignee
Абботт Продактс Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Абботт Продактс Гмбх filed Critical Абботт Продактс Гмбх
Publication of EA201001085A1 publication Critical patent/EA201001085A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

В заявке описаны фармацевтические композиции, содержащие гранулы, которые содержат по меньшей мере одну созданную методом рекомбинации очищенную микробную липазу, применение указанных фармацевтических композиций для приготовления лекарственного средства, предназначенного для предупреждения или лечения определенных заболеваний или нарушений типа эндокринной панкреатической недостаточности, и способ изготовления указанных фармацевтических композиций.
EA201001085A 2008-01-03 2009-01-02 Фармацевтические композиции, содержащие гранулы очищенной микробной липазы, и способы предупреждения или лечения пищеварительных нарушений EA201001085A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1883408P 2008-01-03 2008-01-03
EP08150018 2008-01-03
PCT/EP2009/050010 WO2009083607A1 (en) 2008-01-03 2009-01-02 Pharmaceutical compositions comprising granules of purified microbial lipase and methods for preventing or treating digestive disorders

Publications (1)

Publication Number Publication Date
EA201001085A1 true EA201001085A1 (ru) 2011-02-28

Family

ID=39708910

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001085A EA201001085A1 (ru) 2008-01-03 2009-01-02 Фармацевтические композиции, содержащие гранулы очищенной микробной липазы, и способы предупреждения или лечения пищеварительных нарушений

Country Status (11)

Country Link
US (1) US20110008423A1 (ru)
EP (1) EP2237771A1 (ru)
JP (1) JP2011508755A (ru)
KR (1) KR20100101106A (ru)
CN (1) CN101951893A (ru)
AU (1) AU2009203123A1 (ru)
BR (1) BRPI0906439A2 (ru)
CA (1) CA2711187A1 (ru)
EA (1) EA201001085A1 (ru)
MX (1) MX2010007242A (ru)
WO (1) WO2009083607A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2712877C2 (ru) * 2013-05-14 2020-01-31 Новозимс А/С Моющие композиции

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* Cited by examiner, † Cited by third party
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KR101968457B1 (ko) 2010-10-01 2019-04-11 앨러간 파마슈티컬스 인터내셔널 리미티드 장용 코팅된 저 강도 췌장 리파제 제제
CN104080908B (zh) * 2012-02-03 2018-02-06 诺维信公司 脂肪酶变体以及编码它们的多核苷酸
JP2016537387A (ja) 2013-08-09 2016-12-01 アラガン ファーマシューティカルズ インターナショナル リミテッド 経腸投与に適した消化酵素組成物
DE102017104482A1 (de) * 2017-03-03 2018-09-06 Nordmark Arzneimittel Gmbh & Co. Kg Pharmazeutische Zusammensetzung umfassend Pankreatin und einen lipasehaltigen Überzug
DE102017104501A1 (de) 2017-03-03 2018-09-06 Nordmark Arzneimittel Gmbh & Co. Kg Pharmazeutische Zusammensetzung umfassend einen Träger und einen Überzug enthaltend wenigstens eine Lipase
EP3459528B1 (en) 2017-09-20 2022-11-23 Tillotts Pharma Ag Preparation of solid dosage forms comprising antibodies by solution/suspension layering
CA3241218A1 (en) * 2021-12-16 2023-06-22 Dinesh SRINIVASAN Stable lipase formulations and methods thereof
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

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GB1509866A (en) * 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
GB1590432A (en) * 1976-07-07 1981-06-03 Novo Industri As Process for the production of an enzyme granulate and the enzyme granuate thus produced
US4447412A (en) * 1983-02-01 1984-05-08 Bilton Gerald L Enzyme-containing digestive aid compostions
US4689297A (en) * 1985-03-05 1987-08-25 Miles Laboratories, Inc. Dust free particulate enzyme formulation
DK173590D0 (da) * 1990-06-06 1990-07-19 Novo Nordisk As Rekombinante terapeutiske lipaser
US5869438A (en) * 1990-09-13 1999-02-09 Novo Nordisk A/S Lipase variants
US5324649A (en) * 1991-10-07 1994-06-28 Genencor International, Inc. Enzyme-containing granules coated with hydrolyzed polyvinyl alcohol or copolymer thereof
AU677166B2 (en) * 1991-10-07 1997-04-17 Genencor International, Inc. Coated enzyme containing granule
US5879920A (en) * 1991-10-07 1999-03-09 Genencor International, Inc. Coated enzyme-containing granule
DE4322229A1 (de) * 1993-07-05 1995-01-12 Cognis Bio Umwelt Umhüllte Enzymzubereitung für Wasch- und Reinigungsmittel
DE4344215A1 (de) * 1993-12-23 1995-06-29 Cognis Bio Umwelt Silberkorrosionsschutzmittelhaltige Enzymzubereitung
DE69737828T2 (de) * 1996-04-29 2008-03-06 Novozymes A/S Flüssige, nichtwässrige enzyme enthaltende zusammensetzungen
US6268329B1 (en) * 1998-06-30 2001-07-31 Nouozymes A/S Enzyme containing granule
AR032392A1 (es) * 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
AU2006261442A1 (en) * 2005-06-24 2006-12-28 Novozymes A/S Lipases for pharmaceutical use
ATE418329T1 (de) * 2005-08-15 2009-01-15 Solvay Pharm Gmbh Pankreatin-mikropellets geeignet für magensaftresistente überzüge

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2712877C2 (ru) * 2013-05-14 2020-01-31 Новозимс А/С Моющие композиции

Also Published As

Publication number Publication date
JP2011508755A (ja) 2011-03-17
WO2009083607A1 (en) 2009-07-09
EP2237771A1 (en) 2010-10-13
MX2010007242A (es) 2010-10-05
BRPI0906439A2 (pt) 2018-12-04
KR20100101106A (ko) 2010-09-16
CA2711187A1 (en) 2009-07-09
US20110008423A1 (en) 2011-01-13
AU2009203123A1 (en) 2009-07-09
CN101951893A (zh) 2011-01-19

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