EA201000319A1 - Производные азациклилизохинолинона и изоиндолинона в качестве антагонистов гистаминовых рецепторов подтипа 3 - Google Patents
Производные азациклилизохинолинона и изоиндолинона в качестве антагонистов гистаминовых рецепторов подтипа 3Info
- Publication number
- EA201000319A1 EA201000319A1 EA201000319A EA201000319A EA201000319A1 EA 201000319 A1 EA201000319 A1 EA 201000319A1 EA 201000319 A EA201000319 A EA 201000319A EA 201000319 A EA201000319 A EA 201000319A EA 201000319 A1 EA201000319 A1 EA 201000319A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- subtip
- azacyclilyzyohinolinone
- isoindolinone
- antagonists
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
В настоящем изобретении предложено соединение формулы I и его применение для лечения нарушения центральной нервной системы, связанного с гистаминовым рецептором подтипа 3 или зависимого от него.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99355407P | 2007-09-12 | 2007-09-12 | |
PCT/US2008/075942 WO2009036117A1 (en) | 2007-09-12 | 2008-09-11 | Azacyclylisoquinolinone and isoindolinone derivatives as histamine-3 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201000319A1 true EA201000319A1 (ru) | 2010-10-29 |
Family
ID=40261508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201000319A EA201000319A1 (ru) | 2007-09-12 | 2008-09-11 | Производные азациклилизохинолинона и изоиндолинона в качестве антагонистов гистаминовых рецепторов подтипа 3 |
Country Status (23)
Country | Link |
---|---|
US (1) | US20090069370A1 (ru) |
EP (1) | EP2200998A1 (ru) |
JP (1) | JP2010539178A (ru) |
KR (1) | KR20100054852A (ru) |
CN (1) | CN101842366A (ru) |
AP (1) | AP2010005199A0 (ru) |
AU (1) | AU2008298983A1 (ru) |
BR (1) | BRPI0816806A2 (ru) |
CA (1) | CA2699383A1 (ru) |
CL (1) | CL2008002708A1 (ru) |
CO (1) | CO6300951A2 (ru) |
CR (1) | CR11309A (ru) |
DO (1) | DOP2010000078A (ru) |
EA (1) | EA201000319A1 (ru) |
EC (1) | ECSP10010032A (ru) |
MA (1) | MA31700B1 (ru) |
MX (1) | MX2010002899A (ru) |
NI (1) | NI201000035A (ru) |
PA (1) | PA8795601A1 (ru) |
PE (1) | PE20090679A1 (ru) |
TN (1) | TN2010000107A1 (ru) |
TW (1) | TW200918062A (ru) |
WO (1) | WO2009036117A1 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
JP2011213700A (ja) * | 2010-04-02 | 2011-10-27 | Nishizaki Soyaku Kenkyusho:Kk | 認知症改善用組成物 |
WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
TW201206444A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
TW201206889A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
JP5968307B2 (ja) | 2010-05-11 | 2016-08-10 | サノフイ | 置換フェニルシクロアルキルピロリジン(ピペリジン)スピロラクタム類及びアミド類、それらの製造及び治療的使用 |
AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
JP2013529198A (ja) | 2010-05-11 | 2013-07-18 | サノフイ | 置換されたn−ヘテロシクロアルキルビピロリジニルフェニルアミド誘導体、その製造及び治療上の使用 |
EP2717933B1 (en) | 2011-06-13 | 2019-05-01 | Dentsply IH AB | Collagen coated article |
EP2535062A1 (en) | 2011-06-13 | 2012-12-19 | Dentsply IH AB | Collagen coated article |
WO2013079452A1 (en) * | 2011-11-30 | 2013-06-06 | F. Hoffmann-La Roche Ag | New bicyclic dihydroisoquinoline-1-one derivatives |
JO3442B1 (ar) * | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
AR098215A1 (es) | 2013-10-29 | 2016-05-18 | Takeda Pharmaceuticals Co | Compuesto heterocíclico |
CN112209876B (zh) * | 2020-10-15 | 2022-08-26 | 华侨大学 | 一种3-三氟甲基异喹啉酮衍生物的制备方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3933829A (en) * | 1974-08-22 | 1976-01-20 | John Wyeth & Brother Limited | 4-Aminoquinoline derivatives |
US4166853A (en) * | 1978-05-05 | 1979-09-04 | The Upjohn Company | Antihypertensive 7-trifluoromethyl-4-aminoquinolones |
US4159331A (en) * | 1978-05-05 | 1979-06-26 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
SE7907121L (sv) * | 1979-08-27 | 1981-02-28 | Astra Laekemedel Ab | Ftalimidinderivat |
US5491148A (en) * | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
WO1998013364A1 (fr) * | 1996-09-25 | 1998-04-02 | Yamanouchi Pharmaceutical Co., Ltd. | Derives de 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline ou compositions medicinales obtenues |
AU7270798A (en) * | 1997-05-01 | 1998-11-24 | Eli Lilly And Company | Antithrombotic agents |
US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
EA012112B1 (ru) * | 2004-05-14 | 2009-08-28 | Миллениум Фармасьютикалз, Инк. | Соединения и способы для ингибирования митотической прогрессии |
US20060014733A1 (en) * | 2004-07-19 | 2006-01-19 | Pfizer Inc | Histamine-3 agonists and antagonists |
SE0401970D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Novel compounds |
US7381732B2 (en) * | 2004-10-26 | 2008-06-03 | Bristol-Myers Squibb Company | Pyrazolobenzamides and derivatives as factor Xa inhibitors |
JP2008526895A (ja) * | 2005-01-21 | 2008-07-24 | シェーリング コーポレイション | ヒスタミンh3アンタゴニストとして有用なイミダゾールおよびベンゾイミダゾール誘導体 |
JP2008537953A (ja) * | 2005-04-15 | 2008-10-02 | エラン ファーマシューティカルズ,インコーポレイテッド | ブラジキニンb1受容体拮抗作用に有用な新規化合物 |
US8143284B2 (en) * | 2006-10-05 | 2012-03-27 | Abbott Laboratories | Poly(ADP-ribose)polymerase inhibitors |
US7799806B2 (en) * | 2007-04-04 | 2010-09-21 | Hoffmann-La Roche Inc. | Substituted n-benzyl piperidines as somatostatin receptor modulators |
-
2008
- 2008-09-10 TW TW097134761A patent/TW200918062A/zh unknown
- 2008-09-11 CL CL200802708A patent/CL2008002708A1/es unknown
- 2008-09-11 US US12/208,780 patent/US20090069370A1/en not_active Abandoned
- 2008-09-11 EA EA201000319A patent/EA201000319A1/ru unknown
- 2008-09-11 JP JP2010524972A patent/JP2010539178A/ja not_active Withdrawn
- 2008-09-11 KR KR1020107007636A patent/KR20100054852A/ko not_active Application Discontinuation
- 2008-09-11 PE PE2008001588A patent/PE20090679A1/es not_active Application Discontinuation
- 2008-09-11 AU AU2008298983A patent/AU2008298983A1/en not_active Abandoned
- 2008-09-11 BR BRPI0816806-7A2A patent/BRPI0816806A2/pt not_active IP Right Cessation
- 2008-09-11 EP EP08830104A patent/EP2200998A1/en not_active Withdrawn
- 2008-09-11 CA CA2699383A patent/CA2699383A1/en not_active Abandoned
- 2008-09-11 AP AP2010005199A patent/AP2010005199A0/xx unknown
- 2008-09-11 WO PCT/US2008/075942 patent/WO2009036117A1/en active Application Filing
- 2008-09-11 CN CN200880113557A patent/CN101842366A/zh active Pending
- 2008-09-11 MX MX2010002899A patent/MX2010002899A/es unknown
- 2008-09-12 PA PA20088795601A patent/PA8795601A1/es unknown
-
2010
- 2010-03-11 CR CR11309A patent/CR11309A/es not_active Application Discontinuation
- 2010-03-11 NI NI201000035A patent/NI201000035A/es unknown
- 2010-03-11 TN TNP2010000107A patent/TN2010000107A1/fr unknown
- 2010-03-11 DO DO2010000078A patent/DOP2010000078A/es unknown
- 2010-03-12 EC EC2010010032A patent/ECSP10010032A/es unknown
- 2010-03-12 MA MA32689A patent/MA31700B1/fr unknown
- 2010-03-15 CO CO10030401A patent/CO6300951A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX2010002899A (es) | 2010-04-09 |
US20090069370A1 (en) | 2009-03-12 |
JP2010539178A (ja) | 2010-12-16 |
KR20100054852A (ko) | 2010-05-25 |
ECSP10010032A (es) | 2010-08-31 |
CO6300951A2 (es) | 2011-07-21 |
PE20090679A1 (es) | 2009-05-28 |
CN101842366A (zh) | 2010-09-22 |
TW200918062A (en) | 2009-05-01 |
TN2010000107A1 (fr) | 2011-09-26 |
AU2008298983A1 (en) | 2009-03-19 |
WO2009036117A1 (en) | 2009-03-19 |
CR11309A (es) | 2010-04-07 |
BRPI0816806A2 (pt) | 2015-03-10 |
AP2010005199A0 (en) | 2010-04-30 |
PA8795601A1 (es) | 2009-05-15 |
EP2200998A1 (en) | 2010-06-30 |
DOP2010000078A (es) | 2010-04-15 |
CA2699383A1 (en) | 2009-03-19 |
CL2008002708A1 (es) | 2008-10-10 |
MA31700B1 (fr) | 2010-09-01 |
NI201000035A (es) | 2010-07-15 |
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