EA200970280A1 - Ингибиторы киназ, полезные для лечения пролиферативных заболеваний - Google Patents
Ингибиторы киназ, полезные для лечения пролиферативных заболеванийInfo
- Publication number
- EA200970280A1 EA200970280A1 EA200970280A EA200970280A EA200970280A1 EA 200970280 A1 EA200970280 A1 EA 200970280A1 EA 200970280 A EA200970280 A EA 200970280A EA 200970280 A EA200970280 A EA 200970280A EA 200970280 A1 EA200970280 A1 EA 200970280A1
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- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к новым ингибиторам киназ и соединениям, модулирующим киназы, которые можно применять для лечения различных заболеваний. В частности, изобретение относится к таким соединениям, киназа/соединениям присоединения, способам лечения заболеваний и способам синтеза соединений. Соединения можно применять преимущественно для модуляции киназной активности киназ Raf и различных полиморфных форм Raf-киназ, встречающихся при заболеваниях. Соединения согласно настоящему изобретению находят применение в лечении различных видов рака млекопитающих и, в частности, человека, включая, но не ограничиваясь, злокачественную меланому, рак кишечника, рак яичника, сосочковую карциному щитовидной железы, немелкоклеточный рак легкого и мезотелиому. Соединения согласно настоящему изобретению также находят применение при лечении ревматоидного артрита и ретинопатий, включая диабетическую нейропатию сетчатки и дегенерацию желтого пятна.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84455206P | 2006-09-14 | 2006-09-14 | |
US11/854,354 US8188113B2 (en) | 2006-09-14 | 2007-09-12 | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
PCT/US2007/078408 WO2008034008A2 (en) | 2006-09-14 | 2007-09-13 | Kinase inhibitors useful for the treatment of proliferative diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200970280A1 true EA200970280A1 (ru) | 2009-10-30 |
EA016055B1 EA016055B1 (ru) | 2012-01-30 |
Family
ID=39184593
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201101341A EA026730B1 (ru) | 2006-09-14 | 2007-09-13 | Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе |
EA200970280A EA016055B1 (ru) | 2006-09-14 | 2007-09-13 | Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201101341A EA026730B1 (ru) | 2006-09-14 | 2007-09-13 | Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе |
Country Status (10)
Country | Link |
---|---|
US (2) | US8188113B2 (ru) |
EP (1) | EP2063897A4 (ru) |
JP (1) | JP5265550B2 (ru) |
KR (1) | KR101110530B1 (ru) |
AU (1) | AU2007296450C1 (ru) |
BR (2) | BRPI0716981B8 (ru) |
CA (1) | CA2663577A1 (ru) |
EA (2) | EA026730B1 (ru) |
MX (1) | MX2009002814A (ru) |
WO (1) | WO2008034008A2 (ru) |
Families Citing this family (74)
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EA201101341A1 (ru) | 2012-04-30 |
MX2009002814A (es) | 2009-07-24 |
BRPI0716981B1 (pt) | 2021-02-02 |
EP2063897A2 (en) | 2009-06-03 |
WO2008034008A2 (en) | 2008-03-20 |
JP2010503702A (ja) | 2010-02-04 |
EP2063897A4 (en) | 2010-09-29 |
CA2663577A1 (en) | 2008-03-20 |
AU2007296450B2 (en) | 2012-08-30 |
US8188113B2 (en) | 2012-05-29 |
KR101110530B1 (ko) | 2012-04-24 |
US20080114006A1 (en) | 2008-05-15 |
JP5265550B2 (ja) | 2013-08-14 |
US20120289540A1 (en) | 2012-11-15 |
AU2007296450A1 (en) | 2008-03-20 |
WO2008034008A3 (en) | 2008-07-10 |
KR20090069296A (ko) | 2009-06-30 |
EA026730B1 (ru) | 2017-05-31 |
BR122012012032A2 (pt) | 2015-07-14 |
BRPI0716981B8 (pt) | 2021-05-25 |
AU2007296450C1 (en) | 2013-05-02 |
BR122012012032B1 (pt) | 2021-02-23 |
BRPI0716981A2 (pt) | 2013-10-15 |
EA016055B1 (ru) | 2012-01-30 |
BR122012012032B8 (pt) | 2021-05-25 |
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