EA200970041A1 - Ингибиторы акт (протеинкиназы в) - Google Patents

Ингибиторы акт (протеинкиназы в)

Info

Publication number
EA200970041A1
EA200970041A1 EA200970041A EA200970041A EA200970041A1 EA 200970041 A1 EA200970041 A1 EA 200970041A1 EA 200970041 A EA200970041 A EA 200970041A EA 200970041 A EA200970041 A EA 200970041A EA 200970041 A1 EA200970041 A1 EA 200970041A1
Authority
EA
Eurasian Patent Office
Prior art keywords
protein kinases
act inhibitors
inhibitors
compounds
act
Prior art date
Application number
EA200970041A
Other languages
English (en)
Other versions
EA015712B1 (ru
Inventor
Саджан Джозеф
Жэньхуа Ли
Майкл Рэй Майерс
Актхам Абуруб
Дженни Пингкви Дай
Кристофер Рэндалл Шмид
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200970041A1 publication Critical patent/EA200970041A1/ru
Publication of EA015712B1 publication Critical patent/EA015712B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к 4-[5-(2-аминэтансульфонил)изохинолин-7-ил]фенолу или его фармацевтически приемлемой соли, или гидрату указанного соединения, или его соли в качестве ингибиторов Akt, которые являются противоопухолевыми и/или противовирусными агентами, а также к композициям, содержащим указанные соединения, и способам применения указанных соединений.
EA200970041A 2006-06-20 2007-06-12 Ингибиторы akt (протеинкиназы в) EA015712B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80526006P 2006-06-20 2006-06-20
US88576507P 2007-01-19 2007-01-19
PCT/US2007/070945 WO2007149730A2 (en) 2006-06-20 2007-06-12 Inhibitors of akt (protein kinase b)

Publications (2)

Publication Number Publication Date
EA200970041A1 true EA200970041A1 (ru) 2009-06-30
EA015712B1 EA015712B1 (ru) 2011-10-31

Family

ID=38834248

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970041A EA015712B1 (ru) 2006-06-20 2007-06-12 Ингибиторы akt (протеинкиназы в)

Country Status (28)

Country Link
US (1) US7998977B2 (ru)
EP (1) EP2035385B1 (ru)
JP (1) JP2009541335A (ru)
KR (1) KR101067551B1 (ru)
AR (1) AR061240A1 (ru)
AT (1) ATE455102T1 (ru)
AU (1) AU2007261120A1 (ru)
BR (1) BRPI0713136A2 (ru)
CA (1) CA2652612A1 (ru)
CL (1) CL2007001752A1 (ru)
DE (1) DE602007004333D1 (ru)
DK (1) DK2035385T3 (ru)
DO (1) DOP2008000053A (ru)
EA (1) EA015712B1 (ru)
EC (1) ECSP088992A (ru)
ES (1) ES2336630T3 (ru)
HR (1) HRP20100147T1 (ru)
IL (1) IL195005A0 (ru)
MA (1) MA30757B1 (ru)
MX (1) MX2008015904A (ru)
NO (1) NO20090289L (ru)
PE (1) PE20080338A1 (ru)
PL (1) PL2035385T3 (ru)
PT (1) PT2035385E (ru)
SI (1) SI2035385T1 (ru)
TN (1) TNSN08529A1 (ru)
TW (1) TW200812970A (ru)
WO (1) WO2007149730A2 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc METHODS AND THERAPEUTIC COMPOUNDS
US8507496B2 (en) 2010-09-07 2013-08-13 Dmi Acquisition Corp. Treatment of diseases
PL2766029T3 (pl) 2011-10-10 2020-08-24 Ampio Pharmaceuticals, Inc. Leczenie choroby zwyrodnieniowej stawów
KR20140075772A (ko) 2011-10-10 2014-06-19 앰피오 파마슈티컬스 인코퍼레이티드 면역 내성을 증가시킨 이식 의료 장비, 및 그의 제조 및 이식 방법
CN103841974A (zh) 2011-10-28 2014-06-04 安皮奥制药股份有限公司 鼻炎的治疗
MX2015010937A (es) 2013-03-15 2015-10-29 Ampio Pharmaceuticals Inc Composiciones para la movilizacion, autodireccion, expansion y diferenciacion de celulas madre y metodos para usar las mismas.
AU2014293011A1 (en) 2013-07-26 2016-03-17 Race Oncology Ltd. Compositions to improve the therapeutic benefit of bisantrene
CA2958080A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
US10123997B2 (en) * 2015-06-15 2018-11-13 Yong Liao Target for treating hepatitis B virus
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW MOLECULAR WEIGHT HUMAN SERUM ALBUMIN FRACTIONS FOR TREATING DISEASES
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
US20230271958A1 (en) * 2020-07-22 2023-08-31 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152807A0 (en) 2000-05-30 2003-06-24 Peptor Ltd Protein kinase inhibitors
WO2004094386A1 (en) 2003-03-28 2004-11-04 Eli Lilly And Company Isoquinoline-5-sulfonic acid amides as inhibitors of akt (protein kinase b)
GB0317315D0 (en) 2003-07-24 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
EP1689719A1 (en) * 2003-11-25 2006-08-16 Eli Lilly And Company 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b)

Also Published As

Publication number Publication date
CA2652612A1 (en) 2007-12-27
MA30757B1 (fr) 2009-10-01
CL2007001752A1 (es) 2008-01-18
IL195005A0 (en) 2009-08-03
PT2035385E (pt) 2010-03-01
SI2035385T1 (sl) 2010-05-31
PL2035385T3 (pl) 2010-06-30
ES2336630T3 (es) 2010-04-14
AR061240A1 (es) 2008-08-13
BRPI0713136A2 (pt) 2012-04-17
ECSP088992A (es) 2009-01-30
JP2009541335A (ja) 2009-11-26
ATE455102T1 (de) 2010-01-15
DE602007004333D1 (de) 2010-03-04
WO2007149730A3 (en) 2008-04-24
NO20090289L (no) 2009-01-19
TW200812970A (en) 2008-03-16
AU2007261120A1 (en) 2007-12-27
DOP2008000053A (es) 2009-01-15
DK2035385T3 (da) 2010-03-22
MX2008015904A (es) 2009-01-12
WO2007149730A2 (en) 2007-12-27
EA015712B1 (ru) 2011-10-31
HRP20100147T1 (hr) 2010-04-30
EP2035385B1 (en) 2010-01-13
PE20080338A1 (es) 2008-04-25
US20090221633A1 (en) 2009-09-03
US7998977B2 (en) 2011-08-16
KR101067551B1 (ko) 2011-09-27
TNSN08529A1 (en) 2010-04-14
KR20090015978A (ko) 2009-02-12
EP2035385A2 (en) 2009-03-18

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU