EA200900709A1 - Способы лечения хронических воспалительных заболеваний с использованием антагониста gm-csf - Google Patents

Способы лечения хронических воспалительных заболеваний с использованием антагониста gm-csf

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Publication number
EA200900709A1
EA200900709A1 EA200900709A EA200900709A EA200900709A1 EA 200900709 A1 EA200900709 A1 EA 200900709A1 EA 200900709 A EA200900709 A EA 200900709A EA 200900709 A EA200900709 A EA 200900709A EA 200900709 A1 EA200900709 A1 EA 200900709A1
Authority
EA
Eurasian Patent Office
Prior art keywords
csf
antagonist
chronic inflammatory
treatment
methods
Prior art date
Application number
EA200900709A
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English (en)
Inventor
Кристофер Р. Беббингтон
Джеффри Т. Яррантон
Original Assignee
Калобиос Фармасьютикалс, Инк.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39386167&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200900709(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Калобиос Фармасьютикалс, Инк. filed Critical Калобиос Фармасьютикалс, Инк.
Publication of EA200900709A1 publication Critical patent/EA200900709A1/ru

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Изобретение основано на открытии, что антагонисты GM-CSF могут быть использованы для лечения хронического воспалительного заболевания, такого как ревматоидный артрит. Соответственно, изобретение предоставляет способы введения антагониста GM-CSF, например антитела против GM-CSF, и антифолатных соединений, например метотрексата, пациенту с RA, и фармацевтические композиции, содержащие такие антагонисты.
EA200900709A 2006-11-21 2007-11-21 Способы лечения хронических воспалительных заболеваний с использованием антагониста gm-csf EA200900709A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86078006P 2006-11-21 2006-11-21
US90274207P 2007-02-21 2007-02-21
PCT/US2007/085402 WO2008064321A2 (en) 2006-11-21 2007-11-21 Methods of treating chronic inflammatory diseases using a gm-csf antagonist

Publications (1)

Publication Number Publication Date
EA200900709A1 true EA200900709A1 (ru) 2009-12-30

Family

ID=39386167

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900709A EA200900709A1 (ru) 2006-11-21 2007-11-21 Способы лечения хронических воспалительных заболеваний с использованием антагониста gm-csf

Country Status (15)

Country Link
US (2) US20080206241A1 (ru)
EP (2) EP2101780B1 (ru)
JP (1) JP5410293B2 (ru)
KR (1) KR101517251B1 (ru)
CN (2) CN101605547A (ru)
AU (1) AU2007323541B2 (ru)
BR (1) BRPI0719109A2 (ru)
CA (1) CA2670288C (ru)
EA (1) EA200900709A1 (ru)
ES (1) ES2432173T3 (ru)
IL (1) IL198829A0 (ru)
MX (1) MX2009005398A (ru)
NZ (1) NZ598345A (ru)
SG (1) SG176503A1 (ru)
WO (1) WO2008064321A2 (ru)

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KR20230124910A (ko) * 2020-12-04 2023-08-28 씨에스엘 이노베이션 피티와이 엘티디 염증성 피부 상태 치료 방법
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