EA200900404A1 - Новые гены, родственные гену глутаминилциклазы - Google Patents

Новые гены, родственные гену глутаминилциклазы

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Publication number
EA200900404A1
EA200900404A1 EA200900404A EA200900404A EA200900404A1 EA 200900404 A1 EA200900404 A1 EA 200900404A1 EA 200900404 A EA200900404 A EA 200900404A EA 200900404 A EA200900404 A EA 200900404A EA 200900404 A1 EA200900404 A1 EA 200900404A1
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EA
Eurasian Patent Office
Prior art keywords
genes
isozymes
glutaminylciclase
glutaminyl
cyclase
Prior art date
Application number
EA200900404A
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English (en)
Other versions
EA016584B1 (ru
Inventor
Штефан Шиллинг
Хольгер Цинис
Йенс-Ульрих Рафельд
Ханс-Ульрих Демут
Original Assignee
Пробиодруг Аг
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Publication date
Application filed by Пробиодруг Аг filed Critical Пробиодруг Аг
Publication of EA200900404A1 publication Critical patent/EA200900404A1/ru
Publication of EA016584B1 publication Critical patent/EA016584B1/ru

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Abstract

В заявке описаны новые белки, напоминающие глутаминилпептидциклотрансферазу (QPCTL), которые являются изозимами глутаминилциклазы (QC, К.Ф. 2.3.2.5), и выделенные нуклеиновые кислоты, кодирующие эти изозимы, которые все можно применять для выявления новых терапевтических агентов, измерения циклазной активности и для определения ингибирующей активности соединений в отношении этих изозимов глутаминилциклазы.
EA200900404A 2006-09-21 2007-09-21 Новые гены, родственные гену глутаминилциклазы EA016584B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84624406P 2006-09-21 2006-09-21
US94778007P 2007-07-03 2007-07-03
PCT/EP2007/060013 WO2008034891A2 (en) 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase

Publications (2)

Publication Number Publication Date
EA200900404A1 true EA200900404A1 (ru) 2009-10-30
EA016584B1 EA016584B1 (ru) 2012-06-29

Family

ID=38779576

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Application Number Title Priority Date Filing Date
EA200900404A EA016584B1 (ru) 2006-09-21 2007-09-21 Новые гены, родственные гену глутаминилциклазы

Country Status (13)

Country Link
US (3) US20080249083A1 (ru)
EP (2) EP2082041B1 (ru)
JP (1) JP2010504088A (ru)
KR (1) KR101432848B1 (ru)
AU (1) AU2007298929B2 (ru)
BR (1) BRPI0718507A2 (ru)
CA (1) CA2663635A1 (ru)
EA (1) EA016584B1 (ru)
HK (1) HK1136603A1 (ru)
IL (2) IL197090A (ru)
MX (1) MX2009003090A (ru)
NZ (2) NZ590631A (ru)
WO (1) WO2008034891A2 (ru)

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EP1961416B1 (en) * 2003-05-05 2013-01-23 Probiodrug AG Use of inhibitors of glutaminyl cyclase for treating psoriasis, rheumatoid arthritis or atherosclerosis.
US8889709B2 (en) 2006-09-21 2014-11-18 Probiodrug Ag Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
KR101432848B1 (ko) * 2006-09-21 2014-08-27 프로비오드룩 아게 글루타미닐 사이클라제에 관련된 신규한 유전자
US9277737B2 (en) 2006-09-21 2016-03-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
JP5379692B2 (ja) * 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
US8420684B2 (en) * 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
ES2481442T3 (es) * 2006-11-09 2014-07-30 Probiodrug Ag Inhibidores novedosos de glutaminil ciclasa
EP2091948B1 (en) * 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
ES2372229T3 (es) * 2007-01-19 2012-01-17 Probiodrug Ag Modelos de selección in vivo para el tratamiento de la enfermedad de alzheimer y otros trastornos relacionados con qpct.
WO2008110523A1 (en) * 2007-03-09 2008-09-18 Probiodrug Ag Imidazo [1,5-a] pyridine derivatives as inhibitors of glutaminyl cyclase
EP2142513B1 (en) * 2007-04-18 2014-03-12 Probiodrug AG Nitrovinyl-diamine derivatives as glutaminyl cyclase inhibitors
ES2533484T3 (es) * 2007-04-18 2015-04-10 Probiodrug Ag Derivados de tiourea como inhibidores de la glutaminil ciclasa
JP5675344B2 (ja) * 2007-04-18 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのニトロビニルジアミン誘導体
JP5675343B2 (ja) * 2007-04-18 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としての尿素誘導体
EP2160389B1 (en) * 2007-04-18 2014-03-12 Probiodrug AG Thioxoquinazolinone derivatives as glutaminyl cyclase inhibitors
US8227498B2 (en) * 2007-04-18 2012-07-24 Probiodrug Ag Inhibitors of glutaminyl cyclase
EP2142536B1 (en) * 2007-04-20 2015-10-21 Probiodrug AG Aminopyrimidine derivatives as glutaminyl cyclase inhibitors
US8283517B2 (en) * 2007-09-12 2012-10-09 Probiodrug Ag Transgenic mouse models of Aβ overexpression
NZ586665A (en) 2008-01-14 2011-12-22 Probiodrug Ag MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE GLUTAMINYL CYCLASE GENE (Qpct)
CA2731933A1 (en) * 2008-07-31 2010-02-04 Probiodrug Ag Glutaminyl cyclase as a diagnostic/prognostic indicator for neurodegenerative diseases
EP2344158B1 (en) * 2008-09-04 2017-12-27 Probiodrug AG Use of isoqc inhibitors
BRPI0918564B1 (pt) 2008-09-04 2023-11-28 Vivoryon Therapeutics N.V Derivados de imidazolidina como inibidores, seu processo de preparação e seu uso, e composição farmacêutica
AU2010251176A1 (en) * 2009-05-19 2011-12-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
CA2789091A1 (en) * 2010-02-18 2011-08-25 Probiodrug Ag Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase
EP2606129B1 (en) 2010-08-19 2015-03-25 Probiodrug AG Crystal structure of glutaminyl cyclase
JP2013541938A (ja) 2010-09-02 2013-11-21 プロビオドルグ エージー アイソｑｃ関連障害の治療のためのインビボスクリーニングモデル
WO2012059413A1 (en) 2010-11-02 2012-05-10 Probiodrug Ag Crystal structure of isoglutaminyl cyclase
AU2013292519B2 (en) 2012-07-19 2017-12-07 Drexel University Sigma receptor ligands for modulating cellular protein homeostasis
US20180318260A1 (en) * 2015-11-04 2018-11-08 The Scripps Research Institute Compositions and methods for treating cystic fibrosis
EP3747437A1 (en) * 2017-07-24 2020-12-09 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Treating pathological conditions by direct and indirect targeting of sirpa - cd47 interaction
US11117870B2 (en) 2017-11-01 2021-09-14 Drexel University Compounds, compositions, and methods for treating diseases
GB201918108D0 (en) * 2019-12-10 2020-01-22 Vib Vzw Improved aminopeptiadases for single molecule peptide sequencing

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HK1136603A1 (zh) 2010-07-02
EP2082041A2 (en) 2009-07-29
NZ590631A (en) 2011-12-22
AU2007298929A1 (en) 2008-03-27
AU2007298929B2 (en) 2012-09-27
EA016584B1 (ru) 2012-06-29
US20100009337A1 (en) 2010-01-14
US8129160B2 (en) 2012-03-06
US8647834B2 (en) 2014-02-11
US20120183974A1 (en) 2012-07-19
US20080249083A1 (en) 2008-10-09
KR101432848B1 (ko) 2014-08-27
NZ575727A (en) 2011-12-22
WO2008034891A2 (en) 2008-03-27
EP2581449A2 (en) 2013-04-17
MX2009003090A (es) 2009-04-02
IL197090A0 (en) 2011-08-01
IL214820A (en) 2016-06-30
WO2008034891A3 (en) 2008-05-08
JP2010504088A (ja) 2010-02-12
IL197090A (en) 2016-03-31
KR20090059163A (ko) 2009-06-10
CA2663635A1 (en) 2008-03-27
EP2581449B1 (en) 2016-09-14
EP2082041B1 (en) 2018-03-14
IL214820A0 (en) 2011-09-27

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