EA200870336A1 - Полициклические производные циннамида - Google Patents

Полициклические производные циннамида

Info

Publication number
EA200870336A1
EA200870336A1 EA200870336A EA200870336A EA200870336A1 EA 200870336 A1 EA200870336 A1 EA 200870336A1 EA 200870336 A EA200870336 A EA 200870336A EA 200870336 A EA200870336 A EA 200870336A EA 200870336 A1 EA200870336 A1 EA 200870336A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
substituted
zinnamide
polycyclic derivatives
alkyl group
Prior art date
Application number
EA200870336A
Other languages
English (en)
Other versions
EA016464B1 (ru
Inventor
Тейдзи Кимура
Норитака Китазава
Тосихико Канеко
Нобуаки Сато
Коки Кавано
Коити Ито
Эрико Дои
Мамору Такаиси
Такео Сасаки
Такаси Доко
Такехико Миягава
Хироаки Хагивара
Original Assignee
Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эйсай Ар Энд Ди Менеджмент Ко., Лтд. filed Critical Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
Publication of EA200870336A1 publication Critical patent/EA200870336A1/ru
Publication of EA016464B1 publication Critical patent/EA016464B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Раскрыто соединение, представленное формулой (I), или его фармакологически приемлемая соль, где Arпредставляет собой имидазолильную группу, которая может быть замещена Салкильной группой или тому подобным, Arпредставляет собой фенильную группу, которая может быть замещена Салкоксигруппой или тому подобным, Xпредставляет собой двойную связь или тому подобное и Het представляет собой имидазолильную группу, которая может быть замещена Салкильной группой или тому подобным. Соединение или соль полезно(а) в качестве терапевтического или профилактического средства против заболевания, вызываемого Аβ.
EA200870336A 2006-03-09 2007-03-08 Полициклические производные арилимидазола EA016464B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US78051706P 2006-03-09 2006-03-09
JP2006063562 2006-03-09
US86170206P 2006-11-30 2006-11-30
JP2006322728 2006-11-30
PCT/JP2007/054532 WO2007102580A1 (ja) 2006-03-09 2007-03-08 多環式シンナミド誘導体

Publications (2)

Publication Number Publication Date
EA200870336A1 true EA200870336A1 (ru) 2009-02-27
EA016464B1 EA016464B1 (ru) 2012-05-30

Family

ID=38474999

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870336A EA016464B1 (ru) 2006-03-09 2007-03-08 Полициклические производные арилимидазола

Country Status (16)

Country Link
EP (1) EP1992618B1 (ru)
KR (1) KR101464651B1 (ru)
AR (1) AR059955A1 (ru)
AU (1) AU2007223158B2 (ru)
CA (1) CA2643796A1 (ru)
CY (1) CY1112767T1 (ru)
EA (1) EA016464B1 (ru)
GE (1) GEP20115139B (ru)
HK (2) HK1122027A1 (ru)
HN (1) HN2008001374A (ru)
HR (1) HRP20120174T1 (ru)
IL (1) IL193770A (ru)
MA (1) MA30268B1 (ru)
MX (1) MX2008011221A (ru)
PL (1) PL1992618T3 (ru)
WO (1) WO2007102580A1 (ru)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06013534A (es) 2004-05-26 2007-05-10 Eisai R&D Man Co Ltd Compuesto de cinamida.
CA2580119A1 (en) 2004-10-26 2006-05-04 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
BRPI0618814A2 (pt) 2005-11-24 2014-04-29 Eisai R&D Man Co Ltd Composto ou um sal farmacologicamente aceitável do mesmo, e, agente farmacêutico
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
AR062095A1 (es) 2006-07-28 2008-10-15 Eisai R&D Man Co Ltd Profarmaco de compuesto cinamida
EP2117311A4 (en) * 2007-02-08 2011-05-11 Merck Sharp & Dohme THERAPEUTICS
CL2008000582A1 (es) 2007-02-28 2008-06-27 Eisai R&D Man Co Ltd Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis.
DE602008004769D1 (en) 2007-05-11 2011-03-10 Hoffmann La Roche Hetarylaniline als modulatoren für amyloid beta
RU2009148866A (ru) * 2007-06-01 2011-07-20 Шеринг Корпорейшн (US) Модуляторы гамма-секретазы
WO2009028588A1 (ja) * 2007-08-31 2009-03-05 Eisai R & D Management Co., Ltd. 多環式化合物
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
WO2009061699A1 (en) * 2007-11-05 2009-05-14 Schering Corporation Gamma secretase modulators
WO2009076337A1 (en) * 2007-12-11 2009-06-18 Schering Corporation Gamma secretase modulators
CN101945848A (zh) 2007-12-20 2011-01-12 英维沃医药有限公司 四取代的苯
KR101204213B1 (ko) 2007-12-21 2012-11-26 에프. 호프만-라 로슈 아게 오렉신 수용체 길항제로서의 헤테로아릴 유도체
BRPI0906799A2 (pt) 2008-01-11 2015-07-14 Hoffmann La Roche Moduladores para amiloide beta
CA2713716A1 (en) 2008-02-22 2009-08-27 F. Hoffmann-La Roche Ag Modulators for amyloid beta
MX2011002002A (es) * 2008-08-27 2011-03-29 Eisai R&D Man Co Ltd Proceso para preparar ciertos compuestos de cinnamida.
KR101324414B1 (ko) 2008-10-09 2013-11-01 에프. 호프만-라 로슈 아게 아밀로이드 베타의 조절자
AU2009313538A1 (en) * 2008-11-06 2010-05-14 Merck Sharp & Dohme Corp. Gamma secretase modulators
JP2012508180A (ja) * 2008-11-06 2012-04-05 シェーリング コーポレイション γ−セクレターゼ調節剤
EP2355817A1 (en) 2008-11-10 2011-08-17 F. Hoffmann-La Roche AG Heterocyclic gamma secretase modulators
CA2742472A1 (en) 2008-11-13 2010-05-20 Schering Corporation Gamma secretase modulators
JP2012513399A (ja) 2008-12-22 2012-06-14 シェーリング コーポレイション γ−セクレターゼ調節剤
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
JP2012121809A (ja) * 2009-02-26 2012-06-28 Eisai R & D Management Co Ltd 多環式化合物の製造法およびその中間体
AU2010218667A1 (en) 2009-02-26 2011-07-21 Eisai R&D Management Co., Ltd. Salt of tetrahydrotriazolopyridine derivative and crystal thereof
CA2753696A1 (en) * 2009-02-26 2010-09-02 Noritaka Kitazawa Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
JP2012051805A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd テトラヒドロトリアゾロピリジン誘導体の製造方法
JP2012051807A (ja) * 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
US20120142672A1 (en) 2009-07-13 2012-06-07 Tatsuki Koike Heterocyclic compound and use thereof
US8871760B2 (en) * 2009-09-21 2014-10-28 Roche Palo Alto Llc [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators
MX2012008259A (es) * 2010-01-15 2012-08-17 Janssen Pharmaceuticals Inc Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa.
US8486967B2 (en) 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
JP5816635B2 (ja) 2010-03-05 2015-11-18 カリオファーム セラピューティクス，インコーポレイテッド 核輸送調節剤およびその使用
WO2012029991A1 (en) * 2010-09-02 2012-03-08 Takeda Pharmaceutical Company Limited Fused triazoles for the treatment or prophylaxis of mild cognitive impairment
JP2014012641A (ja) * 2010-10-29 2014-01-23 Dainippon Sumitomo Pharma Co Ltd 新規ピリジン誘導体
EP2665362B1 (en) * 2011-01-17 2016-03-30 Karyopharm Therapeutics, Inc. Olefin containing nuclear transport modulators and uses thereof
US9428490B2 (en) 2011-07-29 2016-08-30 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
KR102022716B1 (ko) 2011-07-29 2019-09-18 카리오팜 쎄라퓨틱스, 인코포레이티드 하이드라지드 함유 핵 수송 조절인자 및 이의 용도
US9708276B2 (en) 2011-10-12 2017-07-18 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
KR102165177B1 (ko) 2012-05-09 2020-10-13 바이오젠 엠에이 인코포레이티드 핵 수송 조절인자 및 이의 용도
SG11201407051XA (en) 2012-05-16 2014-11-27 Janssen Pharmaceuticals Inc Substituted 3, 4 - dihydro - 2h - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) alzheimer's disease
EP2687528A1 (en) * 2012-07-17 2014-01-22 Ares Trading S.A. Fused triazole derivatives as gamma secretase modulators
JP6275161B2 (ja) 2012-12-20 2018-02-07 ヤンセン ファーマシューティカ エヌ．ベー． γセクレターゼ調節剤としての新規な三環式３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体
CA2891755C (en) 2013-01-17 2021-10-26 Janssen Pharmaceutica Nv Substituted pyrido-piperazinone derivatives as gamma secretase modulators
WO2014144772A1 (en) 2013-03-15 2014-09-18 Karyopharm Therapeutics Inc. Methods of promoting wound healing using crm1 inhibitors
CA2915365C (en) 2013-06-21 2022-08-16 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
US20160257657A1 (en) 2013-09-20 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
EP3046561B1 (en) 2013-09-20 2023-02-22 University of Pittsburgh - Of the Commonwealth System of Higher Education Compounds for treating prostate cancer
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
NZ728850A (en) 2014-08-15 2024-03-22 Karyopharm Therapeutics Inc Polymorphs of selinexor
WO2017117535A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
EP3397633A1 (en) 2015-12-31 2018-11-07 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
US10980806B2 (en) 2016-03-24 2021-04-20 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
WO2018098472A1 (en) 2016-11-28 2018-05-31 Karyopharm Therapeutics Inc. Crm1 inhibitors for treating epilepsy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100515549B1 (ko) * 2000-12-04 2005-09-20 에프. 호프만-라 로슈 아게 글루타메이트 수용체 길항제로서의 페닐에테닐 또는페닐에티닐 유도체
JP2006518738A (ja) * 2003-02-12 2006-08-17 トランス　テック　ファーマ，インコーポレイテッド 治療薬としての置換アゾール誘導体
ZA200605526B (en) * 2004-02-12 2007-11-28 Transtech Pharma Inc Substituted azole derivatives, compositions and methods of use
MXPA06013534A (es) * 2004-05-26 2007-05-10 Eisai R&D Man Co Ltd Compuesto de cinamida.

Also Published As

Publication number Publication date
EP1992618B1 (en) 2012-01-18
MA30268B1 (fr) 2009-03-02
IL193770A0 (en) 2009-05-04
AU2007223158B2 (en) 2012-04-12
KR20080108481A (ko) 2008-12-15
AR059955A1 (es) 2008-05-14
EP1992618A1 (en) 2008-11-19
AU2007223158A1 (en) 2007-09-13
MX2008011221A (es) 2008-09-11
KR101464651B1 (ko) 2014-11-24
EP1992618A4 (en) 2010-11-10
WO2007102580A1 (ja) 2007-09-13
IL193770A (en) 2012-10-31
HK1128085A1 (en) 2009-10-16
CY1112767T1 (el) 2016-02-10
PL1992618T3 (pl) 2012-06-29
CA2643796A1 (en) 2007-09-13
HRP20120174T1 (hr) 2012-03-31
HK1122027A1 (en) 2009-05-08
GEP20115139B (en) 2011-01-10
HN2008001374A (es) 2011-03-15
EA016464B1 (ru) 2012-05-30

Similar Documents

Publication Publication Date Title
EA200870336A1 (ru) Полициклические производные циннамида
ATE541836T1 (de) Polycyclische cinnamid-derivate
MY150507A (en) Polycyclic compound
ME01992B (me) Jedinjenje diarilhidantoina
RS52823B (en) NEW UNITS USEFUL FOR TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
WO2010105179A3 (en) Inhibitors of beta-secretase
RS52716B (en) HYDROBENZAMIDE DERIVATIVES AS HEAT SHOCK PROTEIN INHIBITORS HSP90
MA35452B1 (fr) 3-pyrimidin-4-yl-oxazolidin-2-ones comme inhibiteurs d'idh mutante
MX2011008501A (es) Compuestos heterociclicos fusionados que contienen nitrogeno y su uso como inhibidores de la produccion de beta-amiloide.
MX2009009492A (es) Compuestos organicos biciclicos adecuados para el tratamiento de condiciones inflamatorias o alergicas.
EA200801160A1 (ru) Алкоксиалкилзамещённые спироциклические тетрамовые и тетроновые кислоты
RS53142B (en) UNITS THAT HAVE ANTAGONISTIC ACTIVITY ON CRTH2
EA201170176A1 (ru) Ингибитор stat3, содержащий хинолинкарбоксамидное производное в качестве активного ингредиента
EA200801381A1 (ru) Производные пиримидина
TW200612958A (en) Substituted imidazole derivatives
WO2008108386A1 (ja) 医薬組成物
ATE542798T1 (de) Organische verbindungen
RS53003B (en) C7-FLUORO SUBSTITUTED TETRACYCLINE UNITS
EA200900924A1 (ru) Циклизованные производные как ингибиторы eg-5
EA201000104A1 (ru) Производные пиримидина, применимые для лечения воспалительных или аллергических патологических состояний
EA200801596A1 (ru) Новые 11-бета-гидроксиандроста-4-ен-3-оны
EA200801366A1 (ru) Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина
DE602007011434D1 (de) 1h-indol-5-ylpiperazin-1-ylmethanonderivate
WO2008136378A1 (ja) 新規なスルホンアミド誘導体またはその塩
WO2008033757A3 (en) 2-(1-oxo-1h-isoquinolin-2-yl) acetamide derivatives

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU