EA200800548A1 - HYBRID POLYPEPTIDES WITH SELECTED PROPERTIES - Google Patents
HYBRID POLYPEPTIDES WITH SELECTED PROPERTIESInfo
- Publication number
- EA200800548A1 EA200800548A1 EA200800548A EA200800548A EA200800548A1 EA 200800548 A1 EA200800548 A1 EA 200800548A1 EA 200800548 A EA200800548 A EA 200800548A EA 200800548 A EA200800548 A EA 200800548A EA 200800548 A1 EA200800548 A1 EA 200800548A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diabetes
- type
- hybrid polypeptides
- disorders
- insulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Данное изобретение главным образом относится к новым, селектируемым гибридным полипептидам, пригодным в качестве агентов для лечения и профилактики заболеваний и нарушений обмена веществ, которые могут быть облегчены контролем уровней глюкозы плазмы, уровней инсулина и/или секреции инсулина, таких как диабет и связанные с диабетом состояния. Такие состояния и нарушения включают, но не ограничены ими, гипертонию, дислипидемию, сердечно-сосудистое заболевание, нарушения питания, резистентность к инсулину, ожирение и сахарный диабет любого типа, включая тип 1, тип 2 и диабет при беременности.This invention mainly relates to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of diseases and metabolic disorders, which can be facilitated by the control of plasma glucose levels, insulin levels and / or insulin secretion, such as diabetes and associated with diabetes states. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, nutritional disorders, insulin resistance, obesity, and diabetes mellitus of any type, including type 1, type 2, and pregnancy diabetes.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20166405A | 2005-08-11 | 2005-08-11 | |
US11/206,903 US8076288B2 (en) | 2004-02-11 | 2005-08-17 | Hybrid polypeptides having glucose lowering activity |
US11/301,744 US7723471B2 (en) | 2004-02-11 | 2005-12-12 | Pancreatic polypeptide family motifs, polypeptides and methods comprising the same |
PCT/US2006/031724 WO2007022123A2 (en) | 2005-08-11 | 2006-08-11 | Hybrid polypeptides with selectable properties |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200800548A1 true EA200800548A1 (en) | 2008-08-29 |
EA014647B1 EA014647B1 (en) | 2010-12-30 |
Family
ID=39662713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200800548A EA014647B1 (en) | 2005-08-11 | 2006-08-11 | Hybrid polypeptides with selectable properties |
Country Status (7)
Country | Link |
---|---|
JP (1) | JP2009504681A (en) |
KR (1) | KR101399178B1 (en) |
CN (1) | CN101296942A (en) |
EA (1) | EA014647B1 (en) |
IL (1) | IL188937A0 (en) |
MX (1) | MX2008002028A (en) |
ZA (1) | ZA200801138B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120071401A1 (en) * | 2009-04-10 | 2012-03-22 | Amylin Pharamaceuticals, Inc. | Amylin agonist compounds for estrogen-deficient mammals |
MX2012005912A (en) * | 2009-11-23 | 2012-10-05 | Amylin Pharmaceuticals Inc | Polypeptide conjugate. |
GB201001333D0 (en) * | 2010-01-27 | 2010-03-17 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
NZ603169A (en) * | 2010-04-27 | 2015-02-27 | Zealand Pharma As | Peptide conjugates of glp-1 receptor agonists and gastrin and their use |
RU2552221C2 (en) * | 2010-07-15 | 2015-06-10 | Общество С Ограниченной Ответственностью "Научно-Производственная Фирма "Материа Медика Холдинг" | Method of treating obesity and accompanying metabolic disorders and medication for treating obesity and accompanying metabolic disorders |
WO2012162547A2 (en) * | 2011-05-25 | 2012-11-29 | Amylin Pharmaceuticals, Inc. | Long duration dual hormone conjugates |
TWI674270B (en) * | 2012-12-11 | 2019-10-11 | 英商梅迪繆思有限公司 | Glucagon and glp-1 co-agonists for the treatment of obesity |
CA2957714A1 (en) * | 2014-08-11 | 2016-02-18 | Albany Medical College | Myristoylated leptin-related peptides and uses thereof |
KR101689803B1 (en) * | 2015-11-17 | 2016-12-27 | 고려대학교 산학협력단 | Composition for preventing or treating of diabetes or obesity containing Apelin-16 |
US11034745B2 (en) * | 2016-01-04 | 2021-06-15 | Adepthera Llc | Superagonist polypeptide analogs of adrenomedullin and intermedin peptide hormones |
JP6889432B2 (en) * | 2016-04-28 | 2021-06-18 | 学校法人甲南学園 | Resin-fixed peptide |
AU2017318610B2 (en) * | 2016-09-02 | 2021-12-09 | The Board Of Trustees Of The University Of Illinois | KIF13B-derived peptide and method of inhibiting Angiogenesis |
CA3075867A1 (en) * | 2017-09-13 | 2019-03-21 | Gene Techno Science Co., Ltd. | Anti-ramp2 antibody |
MX2020011293A (en) * | 2018-04-25 | 2020-11-13 | Janssen Pharmaceutica Nv | Glucagon like peptide 1 (glp-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof. |
US10875902B2 (en) | 2018-04-25 | 2020-12-29 | Janssen Pharmaceutica Nv | Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof |
KR102116944B1 (en) * | 2019-09-23 | 2020-05-29 | 주식회사 차메디텍 | Novel peptide derivatives having melanin production inhibitory activity, pharmaceutically acceptable salts thereof, and composition for inhibiting melanin production comprising the same |
CN117603364A (en) * | 2022-09-30 | 2024-02-27 | 广西医科大学附属肿瘤医院 | GLP-1/glucon/Y 2 Receptor triple agonists and uses thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5739106A (en) * | 1995-06-07 | 1998-04-14 | Rink; Timothy J. | Appetite regulating compositions |
WO1997026321A2 (en) * | 1996-01-19 | 1997-07-24 | Board Of Regents, The University Of Texas System | Recombinant expression of proteins from secretory cell lines |
AU1159897A (en) | 1996-11-13 | 1998-06-03 | University Of Cincinnati, The | Analogs of peptide yy and uses thereof |
EA004790B1 (en) * | 1996-12-20 | 2004-08-26 | Амген Инк. | Ob fusion protein compositions and methods |
US6506724B1 (en) * | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
US6528486B1 (en) * | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
WO2001051078A1 (en) * | 2000-01-10 | 2001-07-19 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia |
CA2716959A1 (en) * | 2000-12-07 | 2002-06-13 | Eli Lilly And Company | Glp-1 fusion proteins |
CA2455963C (en) * | 2001-07-31 | 2017-07-04 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Glp-1, exendin-4, peptide analogs and uses thereof |
US7192922B2 (en) * | 2002-11-19 | 2007-03-20 | Allegheny-Singer Research Institute | Method of treating left ventricular dysfunction |
EP1610811A4 (en) * | 2002-12-17 | 2008-03-26 | Amylin Pharmaceuticals Inc | Prevention and treatment of cardiac arrhythmias |
US7166575B2 (en) | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
US20070027073A1 (en) * | 2003-04-08 | 2007-02-01 | Menachem Rubinstein | Long-acting derivatives of pyy agonists |
CN1961000B (en) * | 2004-02-11 | 2011-05-04 | 安米林药品公司 | Hybrid polypeptides with selectable properties |
-
2006
- 2006-08-11 MX MX2008002028A patent/MX2008002028A/en active IP Right Grant
- 2006-08-11 EA EA200800548A patent/EA014647B1/en not_active IP Right Cessation
- 2006-08-11 CN CNA2006800376649A patent/CN101296942A/en active Pending
- 2006-08-11 JP JP2008526290A patent/JP2009504681A/en active Pending
- 2006-08-11 KR KR1020087005846A patent/KR101399178B1/en not_active IP Right Cessation
-
2008
- 2008-01-22 IL IL188937A patent/IL188937A0/en unknown
- 2008-02-04 ZA ZA200801138A patent/ZA200801138B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200801138B (en) | 2008-12-31 |
KR20080045185A (en) | 2008-05-22 |
IL188937A0 (en) | 2008-04-13 |
EA014647B1 (en) | 2010-12-30 |
JP2009504681A (en) | 2009-02-05 |
CN101296942A (en) | 2008-10-29 |
MX2008002028A (en) | 2008-03-27 |
KR101399178B1 (en) | 2014-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200800548A1 (en) | HYBRID POLYPEPTIDES WITH SELECTED PROPERTIES | |
EA200701704A1 (en) | ANALOGUES AND HYBRID POLYPEPTIDES OF GIP WITH ELECTABLE PROPERTIES | |
WO2007022123A3 (en) | Hybrid polypeptides with selectable properties | |
WO2005077072A3 (en) | Hybrid polypeptides with selectable properties | |
WO2008021560A3 (en) | Dpp-iv resistant gip hybrid polypeptides with selectable properties | |
EP2330125A3 (en) | Hybrid polypeptides with selectable properties | |
IL198922A0 (en) | Chemical compounds and uses | |
WO2007007173A3 (en) | Human anti-madcam antibodies | |
NL301089I2 (en) | imlifidase | |
WO2006012577A3 (en) | Quinazolinone derivatives useful for the regulation of glucose homeostasis and food intake | |
EA200701471A1 (en) | Substituted pyridinyl and pyrimidinyl derivatives, used as modulators of metabolic disease and treatment of disorders associated with it | |
WO2007109354A3 (en) | Peptide-peptidase inhibitor conjugates and methods of using same | |
WO2010123930A3 (en) | Chemosensory receptor ligand-based therapies | |
EA201000515A1 (en) | АКТИВАТОРЫ ГЛЮКОКИНАЗЫ | |
WO2008077145A3 (en) | Treatment of il-1-beta related diseases | |
GEP20084520B (en) | Use of retinyl derivatives and compositions thereof for treating ophthalmic diseases | |
WO2008106429A3 (en) | Methods and compositions for the treatment of heart failure and other disorders | |
EA201300522A1 (en) | PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC DISORDERS | |
EA200501132A1 (en) | 1,2,3-triple substituted aryl and heteroaryl derivatives as modulators of metabolism and prophylaxis and treatment of disorders associated with it, such as diabetes and hyperglycemia | |
EA200700886A1 (en) | CONNECTION OF TIADIAZOLE AND ITS APPLICATION | |
MX2007005590A (en) | Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof. | |
EA200801716A1 (en) | THIAZOLE COMPOUNDS AND THEIR APPLICATION | |
WO2007044591A3 (en) | Vasoactive intestinal polypeptide pharmaceuticals | |
WO2010049678A3 (en) | Treatment of energy utilization diseases | |
WO2007104789A3 (en) | Amylin derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title | ||
PC4A | Registration of transfer of a eurasian patent by assignment | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |