EA200702510A1 - Способы защиты от апоптоза с применением липопептидов - Google Patents

Способы защиты от апоптоза с применением липопептидов

Info

Publication number
EA200702510A1
EA200702510A1 EA200702510A EA200702510A EA200702510A1 EA 200702510 A1 EA200702510 A1 EA 200702510A1 EA 200702510 A EA200702510 A EA 200702510A EA 200702510 A EA200702510 A EA 200702510A EA 200702510 A1 EA200702510 A1 EA 200702510A1
Authority
EA
Eurasian Patent Office
Prior art keywords
lipopeptides
apoptosis
protection
methods
inducers
Prior art date
Application number
EA200702510A
Other languages
English (en)
Other versions
EA014644B1 (ru
Inventor
Александр Н. Шахов
Андрей В. Гудков
Original Assignee
Кливлэнд Биолабс Инк.
Кливлэнд Клиник Фаундейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кливлэнд Биолабс Инк., Кливлэнд Клиник Фаундейшн filed Critical Кливлэнд Биолабс Инк.
Publication of EA200702510A1 publication Critical patent/EA200702510A1/ru
Publication of EA014644B1 publication Critical patent/EA014644B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Описано применение липопептидов в качестве индукторов NF-κВ для защиты млекопитающих от действий апоптоза.
EA200702510A 2005-06-13 2006-06-13 Способы защиты от апоптоза с применением липопептидов EA014644B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68981005P 2005-06-13 2005-06-13
PCT/US2006/022865 WO2006138238A2 (en) 2005-06-13 2006-06-13 Methods of protecting against apoptosis using lipopeptides

Publications (2)

Publication Number Publication Date
EA200702510A1 true EA200702510A1 (ru) 2008-06-30
EA014644B1 EA014644B1 (ru) 2010-12-30

Family

ID=37571018

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702510A EA014644B1 (ru) 2005-06-13 2006-06-13 Способы защиты от апоптоза с применением липопептидов

Country Status (17)

Country Link
US (4) US8008260B2 (ru)
EP (2) EP2554181B1 (ru)
JP (1) JP5000644B2 (ru)
KR (2) KR101604799B1 (ru)
CN (1) CN101242852B (ru)
AU (1) AU2006259630B2 (ru)
BR (1) BRPI0611586A2 (ru)
CA (1) CA2612102C (ru)
EA (1) EA014644B1 (ru)
ES (2) ES2421447T3 (ru)
HK (2) HK1123495A1 (ru)
IL (1) IL188091A (ru)
MX (1) MX2007015834A (ru)
NZ (1) NZ565063A (ru)
PT (1) PT1904084E (ru)
WO (1) WO2006138238A2 (ru)
ZA (1) ZA200800126B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006133403A2 (en) 2005-06-07 2006-12-14 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of graft rejection and promotion of graft survival
US9457070B2 (en) 2005-06-07 2016-10-04 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses of alpha 1-antitrypsin for early intervention in bone marrow transplantation and treatment of graft versus host disease
AU2006259630B2 (en) * 2005-06-13 2011-10-27 Cleveland Biolabs, Inc. Methods of protecting against apoptosis using lipopeptides
CA2655933C (en) * 2006-06-23 2014-09-09 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
CA2675032A1 (en) * 2007-01-09 2008-07-17 Cleveland Biolabs, Inc. Methods for increasing and mobilizing hematopoietic stem cells
WO2009074569A1 (en) * 2007-12-11 2009-06-18 Bracco International Bv Targeting and therapeutic compounds with a polyproline-comprising spacer and gas-filled microvesicles comprising said compounds
AU2009287339B2 (en) * 2008-08-28 2015-11-26 The University Of Queensland Mutant bacterial glycoproteins and uses thereof
US9150510B2 (en) * 2008-09-18 2015-10-06 Nippon Zoki Pharmaceutical Co., Ltd. Amino acid derivative
CA3050455A1 (en) 2008-11-03 2010-06-03 Adc Therapeutics Sa Antibodies that specifically block the biological activity of a tumor antigen
US8404444B2 (en) * 2009-02-25 2013-03-26 Diacarta Llc Method for predicting the level of damage to cells by measuring free circulating Alu nucleic acid
JP5210405B2 (ja) * 2010-03-17 2013-06-12 日本臓器製薬株式会社 アミノ酸誘導体を含有する医薬及び該誘導体の製造方法
EP2490021A1 (en) 2011-02-18 2012-08-22 Biotempt B.V. Modulators of PRR and GPCR signalling
EP2683398A1 (en) * 2011-03-11 2014-01-15 Omni Bio Pharmaceutical, Inc. Compositions, methods and uses for radioprotectants
PT3173427T (pt) 2011-03-31 2019-09-17 Adc Therapeutics Sa Anticorpos contra antigénio associado ao rim 1 e fragmentos de ligação a antigénio dos mesmos
DE102011018499A1 (de) * 2011-04-23 2012-10-25 Emc Microcollections Gmbh Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut
NZ625758A (en) 2012-01-09 2016-05-27 Alethia Biotherapeutics Inc Method for treating breast cancer
JP5686841B2 (ja) * 2013-04-26 2015-03-18 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 損傷しまたは傷害を受けた組織または臓器の内皮／上皮再生用医薬の製造のための、幹細胞由来微小胞（ｍｖ）の使用ならびにインビトロおよびインビボでの関連した方法
US20160287553A1 (en) 2013-11-22 2016-10-06 Deutsches Krebsforschungszentrum Translation inhibitors in high-dose chemo- and/or high-dose radiotherapy
WO2016073733A1 (en) * 2014-11-06 2016-05-12 Cleveland Biolabs, Inc. Methods of treating cancer using lipopeptides
CN112851755B (zh) * 2021-01-13 2023-09-01 中国人民解放军军事科学院军事医学研究院 一种线性脂肽化合物及其制备方法与应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2860893D1 (en) 1977-06-20 1981-11-05 Ciba Geigy Ag Lipopeptides, process for their preparation and pharmaceutical compositions containing them
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US6024964A (en) 1985-06-24 2000-02-15 Hoechst Aktiengesellschaft Membrane anchor/active compound conjugate, its preparation and its uses
US5192553A (en) 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
EP0604945A1 (en) 1992-12-28 1994-07-06 Takeda Chemical Industries, Ltd. TAN-1511, its derivatives, production and use thereof
AU666789B2 (en) * 1992-12-28 1996-02-22 Takeda Chemical Industries Ltd. 2-amino-6,7-dihydroxy-4-thiaheptanoic acid derivatives, production and use thereof
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
AU1170595A (en) 1993-11-04 1995-05-23 Cytoclonal Pharmaceutics, Inc. A fusion protein and method for making and using same
WO1999035162A1 (en) * 1998-01-07 1999-07-15 Jenner Biotherapies, Inc. Therapeutic liposome-encapsulated immunomodulators
US6239119B1 (en) * 1998-04-27 2001-05-29 Medimmune Oncology, Inc. Topical administration of amifostine and related compounds
DE19822820A1 (de) 1998-05-20 1999-11-25 Biotechnolog Forschung Gmbh Pharmazeutisches Präparat zur Wundbehandlung
US20030170249A1 (en) * 1999-02-19 2003-09-11 Hakomori Sen-Itiroh Vaccines directed to cancer-associated carbohydrate antigens
WO2000064439A1 (en) * 1999-04-26 2000-11-02 Center For Molecular Medicine And Immunology Use of antioxidants to mitigate radioimmunotherapy-induced radiation toxicity
JP2003514828A (ja) * 1999-10-27 2003-04-22 セル−サイ・コーポレーシヨン 自己免疫および移植組織に関連する宿主対移植片症状の処置に有用なペプチド構築物の調製法および組成物
DE10048840A1 (de) * 2000-10-02 2002-04-11 Biotechnolog Forschung Gmbh Verwendung von Lipopeptiden oder Lipoproteinen zur Behandlung von Lungeninfektionen und -tumoren
CN102302493B (zh) 2001-07-31 2015-08-12 健赞股份有限公司 活化祖细胞/干细胞的方法
US20050276813A1 (en) 2002-04-04 2005-12-15 Peter Muhlradt Use of a lipopeptide or lipoprotein as an adjuvant in therapeutic or prophylactic vaccinations
US20030224422A1 (en) * 2002-04-08 2003-12-04 St. Jude Children's Research Hospital, Inc. Pre-and post therapy gene expression profiling to identify drug targets
US20040259790A1 (en) * 2003-01-30 2004-12-23 Bali Pulendran Methods for identifying and administering agents that bias the immune response via dendritic cells
WO2005030133A2 (en) * 2003-09-22 2005-04-07 Yale University Treatment with agonists of toll-like receptors
WO2005057218A2 (en) 2003-12-02 2005-06-23 Cleveland Clinic Foundation Methods of identifying modulators of apoptosis from parasites and uses thereof
WO2005056041A2 (en) 2003-12-02 2005-06-23 Cleveland Clinic Foundation METHODS OF INHIBITING APOPTOSIS USING LATENT TGFβ
US20060039895A1 (en) * 2004-02-28 2006-02-23 Large Scale Biology Corporation Ex-vivo rescue of hematopoietic stem cells after lethal irradiation
AU2006259630B2 (en) 2005-06-13 2011-10-27 Cleveland Biolabs, Inc. Methods of protecting against apoptosis using lipopeptides
CA2675032A1 (en) 2007-01-09 2008-07-17 Cleveland Biolabs, Inc. Methods for increasing and mobilizing hematopoietic stem cells

Also Published As

Publication number Publication date
AU2006259630A1 (en) 2006-12-28
CA2612102A1 (en) 2006-12-28
HK1123495A1 (en) 2009-06-19
CN101242852B (zh) 2012-10-10
ZA200800126B (en) 2009-10-28
AU2006259630B2 (en) 2011-10-27
JP2008543847A (ja) 2008-12-04
CA2612102C (en) 2016-02-09
CN101242852A (zh) 2008-08-13
US20090214467A1 (en) 2009-08-27
US8524668B2 (en) 2013-09-03
US20140045750A1 (en) 2014-02-13
JP5000644B2 (ja) 2012-08-15
EP1904084A4 (en) 2012-03-21
KR101604799B1 (ko) 2016-03-28
US9006183B2 (en) 2015-04-14
EP2554181A2 (en) 2013-02-06
HK1181684A1 (en) 2013-11-15
US9381225B2 (en) 2016-07-05
EP2554181B1 (en) 2015-03-18
WO2006138238A3 (en) 2007-07-19
EP1904084A2 (en) 2008-04-02
US20150306168A1 (en) 2015-10-29
IL188091A (en) 2014-06-30
EP1904084B1 (en) 2013-04-24
KR20140041874A (ko) 2014-04-04
EA014644B1 (ru) 2010-12-30
EP2554181A3 (en) 2013-03-13
IL188091A0 (en) 2008-03-20
KR20080030566A (ko) 2008-04-04
US8008260B2 (en) 2011-08-30
ES2539490T3 (es) 2015-07-01
WO2006138238A2 (en) 2006-12-28
NZ565063A (en) 2011-04-29
ES2421447T3 (es) 2013-09-02
PT1904084E (pt) 2013-07-22
US20110237507A1 (en) 2011-09-29
MX2007015834A (es) 2008-09-15
BRPI0611586A2 (pt) 2010-09-21

Similar Documents

Publication Publication Date Title
EA200702510A1 (ru) Способы защиты от апоптоза с применением липопептидов
MX360301B (es) Moleculas pequeñas que contienen boro como agentes antiinflamatorios.
CL2012000887A1 (es) Mezcla fungicida sinergica que comprende fluorocitosina y otros compuestos fungicos; composicion fungicida que comprende dicha mezcla y un adyuvante agricolamente aceptable o portador.
CL2013000304A1 (es) Compuestos derivados de 2-arilamino-bencimidazoles inhibidores de prostaglandina e2 (mpges-1); composicion farmaceutica que los comprende; compuestos intermediarios; uso en el tratamiento de enfermedades inflamatorias y/o afecciones asociadas, en particular el dolor.
CO6190510A2 (es) Inhibidores del virus de la hepatitis c
MA33803B1 (fr) Inhibiteur de bromodomaine de benzodiazépine
SG10201809390QA (en) Modulators of indoleamine 2,3-dioxygenase and methods of using the same
EA200870415A1 (ru) Хиназолины для ингибирования pdk 1
ECSP10010722A (es) Compuestos orgánicos
CY1115852T1 (el) Φαρμακευτικες συνθεσεις
EA200970737A1 (ru) Оксабициклогептаны и оксабициклогептены, их получение и применение
BRPI1015043A2 (pt) derivados de diazahomoadamantano e métodos de uso dos mesmos
BR112012014082A2 (pt) composições e métodos que compreendem variantes de protease
UY33616A (es) Compuestos con estructura de imidazotriazinona
CL2012001821A1 (es) Compuestos derivados de 5-alquinil-pirimidinas, inhibidores de quinasas; composiciones farmaceuticas que los contienen; y su uso para el tratamiento y/o prevencion de cancer, infecciones, enfermedades inflamatorias y autoinmunitarias.
CL2011000691A1 (es) Compuestos derivados de nicotinamida sustituida; composicion farmaceutica que los comprende; uso para el tratamiento y/o prevencion de cancer, infecciones, enfermedades inflamatorias y autoinmunitarias.
NO20090596L (no) Antivirale fosfinatforbindelser
EA201170288A1 (ru) Оксабициклогептаны и оксабициклогептены, их получение и применение
HK1133642A1 (en) Azaadamantane ester and carbamate derivatives and methods of use thereof
EP2557919A4 (en) STABILIZED FORMULATIONS OF STATIN
EA200601079A1 (ru) Способы защиты от радиации с использованием флагеллина
CY1109992T1 (el) Παραγωγα του αλφα-αμιναμιδιου χρησιμα ως αντιφλεγμονωδη μεσα
SG158091A1 (en) Imidazoazepinone compounds
PA8630801A1 (es) Nuevos imidazoles
EA201170201A1 (ru) Предотвращение и лечение радиационного поражения

Legal Events

Date Code Title Description
TK4A Corrections in published eurasian patents
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU