EA200702468A1 - Новые производные оксадиазола и их применение в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов - Google Patents
Новые производные оксадиазола и их применение в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторовInfo
- Publication number
- EA200702468A1 EA200702468A1 EA200702468A EA200702468A EA200702468A1 EA 200702468 A1 EA200702468 A1 EA 200702468A1 EA 200702468 A EA200702468 A EA 200702468A EA 200702468 A EA200702468 A EA 200702468A EA 200702468 A1 EA200702468 A1 EA 200702468A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- new
- application
- metabotropic glutamate
- positive allosteric
- glutamate receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Настоящее изобретение относится к новым соединениям, которые представляют собой производные оксадиазола формулы (I) в которой значения В, Р, Q, W, Rи Rопределены в описании. Соединения согласно настоящему изобретению пригодны для предотвращения или лечения расстройств центральной или периферической нервной системы, а также других расстройств, регулируемых рецепторами mGluR5.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0510142.3A GB0510142D0 (en) | 2005-05-18 | 2005-05-18 | Novel compounds A1 |
PCT/IB2006/001674 WO2006123249A2 (en) | 2005-05-18 | 2006-05-17 | Novel oxadiazole derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200702468A1 true EA200702468A1 (ru) | 2008-06-30 |
EA015263B1 EA015263B1 (ru) | 2011-06-30 |
Family
ID=34708380
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200702468A EA015263B1 (ru) | 2005-05-18 | 2006-05-17 | Производные оксадиазола и их применение в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов |
Country Status (17)
Country | Link |
---|---|
US (1) | US20090197897A1 (ru) |
EP (1) | EP1896463A2 (ru) |
JP (1) | JP2008540634A (ru) |
KR (1) | KR20080031676A (ru) |
CN (1) | CN101218232B (ru) |
AU (1) | AU2006248649B2 (ru) |
BR (1) | BRPI0610681A2 (ru) |
CA (1) | CA2608012A1 (ru) |
EA (1) | EA015263B1 (ru) |
GB (1) | GB0510142D0 (ru) |
IL (1) | IL187190A0 (ru) |
MX (1) | MX2007014405A (ru) |
NO (1) | NO20076479L (ru) |
NZ (1) | NZ564253A (ru) |
UA (1) | UA92496C2 (ru) |
WO (1) | WO2006123249A2 (ru) |
ZA (1) | ZA200710277B (ru) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0510140D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B2 |
GB0510141D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
NZ564254A (en) * | 2005-05-18 | 2011-04-29 | Addex Pharma Sa | Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
GB0622202D0 (en) * | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
TW200911255A (en) * | 2007-06-07 | 2009-03-16 | Astrazeneca Ab | Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841 |
TWI417100B (zh) * | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-842之用途 |
EA201070143A1 (ru) | 2007-07-13 | 2010-08-30 | Аддекс Фарма С.А. | Новые гетероароматические производные и их использование в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов |
WO2009099177A1 (ja) * | 2008-02-06 | 2009-08-13 | Taisho Pharmaceutical Co., Ltd. | アミノイミダゾール誘導体 |
US7790760B2 (en) | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
US20100222381A1 (en) | 2009-02-27 | 2010-09-02 | Hariprasad Vankayalapati | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors |
AU2010239253A1 (en) * | 2009-04-23 | 2011-11-24 | Merck Sharp & Dohme Corp. | 2-alkyl piperidine mGluR5 receptor modulators |
US8772301B2 (en) | 2009-12-18 | 2014-07-08 | Sunovion Pharmaceuticals, Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
AR080055A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1 |
WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Crf受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
ES2610362T3 (es) * | 2011-01-25 | 2017-04-27 | Viviabiotech, S.L. | Derivados de 1,2,4-oxadiazol como fármacos moduladores del receptor para el péptido glp-1 |
ES2617863T3 (es) | 2012-06-04 | 2017-06-20 | Actelion Pharmaceuticals Ltd. | Derivados de bencimidazol-prolina |
AU2013328301A1 (en) | 2012-10-10 | 2015-05-28 | Actelion Pharmaceuticals Ltd | Orexin receptor antagonists which are [ortho bi (hetero-)aryl]-[2-(meta bi (hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives |
CN105051040A (zh) | 2013-03-12 | 2015-11-11 | 埃科特莱茵药品有限公司 | 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物 |
US9914721B2 (en) | 2013-12-04 | 2018-03-13 | Idorsia Pharmaceuticals Ltd | Use of benzimidazole-proline derivatives |
WO2016153023A1 (ja) * | 2015-03-25 | 2016-09-29 | 国立研究開発法人国立長寿医療研究センター | 新規オキサジアゾール誘導体及びこれを含有する医薬 |
WO2020154431A1 (en) * | 2019-01-25 | 2020-07-30 | Lynch Kevin R | Inhibitors of spinster homolog 2 (spns2) for use in therapy |
EP4210824A1 (en) * | 2020-09-09 | 2023-07-19 | University of Virginia Patent Foundation | Inhibitors of spinster homolog 2 (spns2) for use in therapy |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK162087D0 (da) * | 1987-03-31 | 1987-03-31 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
DE19643037A1 (de) * | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
US6107313A (en) * | 1998-10-02 | 2000-08-22 | Combichem, Inc. | Dopamine receptor antagonists |
EP1119553A1 (en) * | 1998-10-07 | 2001-08-01 | Georgetown University | Monomeric and dimeric heterocycles, and therapeutic uses thereof |
AU5891600A (en) * | 1999-07-01 | 2001-01-22 | Chemrx Advanced Technologies, Inc. | Process for synthesizing oxadiazoles |
DK1210344T3 (da) * | 1999-08-19 | 2006-03-06 | Nps Pharma Inc | Heteropolycykliske forbindelser og anvendelser deraf som metabotrope glutamatreceptorantagonister |
WO2001054503A1 (en) * | 2000-01-28 | 2001-08-02 | Akkadix Corporation | Methods for killing nematodes and nematode eggs using 4-phenoxy-6-aminopyrimidine derivatives |
NZ527691A (en) * | 2001-02-21 | 2007-01-26 | Nps Pharma Inc | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
GB0115862D0 (en) * | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
WO2003037888A1 (en) * | 2001-09-21 | 2003-05-08 | Mitsubishi Pharma Corporation | 3-substituted-4-pyrimidone derivatives |
AU2002337498B2 (en) * | 2001-09-21 | 2006-08-10 | Mitsubishi Pharma Corporation | 3-substituted-4-pyrimidone derivatives |
US6995144B2 (en) * | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
WO2004014881A2 (en) * | 2002-08-09 | 2004-02-19 | Astra Zeneca Ab | '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5 |
EP1581525A2 (en) * | 2002-08-09 | 2005-10-05 | AstraZeneca AB | Compounds having an activity at metabotropic glutamate receptors |
CN1694703A (zh) | 2002-09-06 | 2005-11-09 | 詹森药业有限公司 | 吲哚基衍生物在制备治疗变应性鼻炎的药物中的用途 |
CA2517629C (en) * | 2003-03-12 | 2011-07-12 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
AU2004226450A1 (en) | 2003-03-26 | 2004-10-14 | Merck & Co. Inc. | Benzamide modulators of metabotropic glutamate receptors |
GB0325956D0 (en) * | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
EP1716143A1 (en) * | 2004-02-18 | 2006-11-02 | AstraZeneca AB | Polyheterocyclic compounds and their use as metabotropic glutamate receptor antagonists |
AR051823A1 (es) * | 2004-09-29 | 2007-02-14 | Mitsubishi Pharma Corp | Derivados de piridinil-pirimidonas |
GB0510143D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
GB0510139D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
NZ564254A (en) * | 2005-05-18 | 2011-04-29 | Addex Pharma Sa | Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
GB0510140D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B2 |
GB0622202D0 (en) * | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
-
2005
- 2005-05-18 GB GBGB0510142.3A patent/GB0510142D0/en not_active Ceased
-
2006
- 2006-05-17 NZ NZ564253A patent/NZ564253A/en not_active IP Right Cessation
- 2006-05-17 JP JP2008511819A patent/JP2008540634A/ja active Pending
- 2006-05-17 KR KR1020077029357A patent/KR20080031676A/ko not_active Application Discontinuation
- 2006-05-17 EP EP06779742A patent/EP1896463A2/en not_active Withdrawn
- 2006-05-17 UA UAA200714073A patent/UA92496C2/ru unknown
- 2006-05-17 CA CA002608012A patent/CA2608012A1/en not_active Abandoned
- 2006-05-17 MX MX2007014405A patent/MX2007014405A/es not_active Application Discontinuation
- 2006-05-17 CN CN2006800251728A patent/CN101218232B/zh not_active Expired - Fee Related
- 2006-05-17 BR BRPI0610681-1A patent/BRPI0610681A2/pt not_active IP Right Cessation
- 2006-05-17 US US11/920,489 patent/US20090197897A1/en not_active Abandoned
- 2006-05-17 EA EA200702468A patent/EA015263B1/ru not_active IP Right Cessation
- 2006-05-17 WO PCT/IB2006/001674 patent/WO2006123249A2/en active Application Filing
- 2006-05-17 AU AU2006248649A patent/AU2006248649B2/en not_active Ceased
-
2007
- 2007-11-06 IL IL187190A patent/IL187190A0/en unknown
- 2007-11-28 ZA ZA200710277A patent/ZA200710277B/xx unknown
- 2007-12-17 NO NO20076479A patent/NO20076479L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2006248649B2 (en) | 2012-04-26 |
NO20076479L (no) | 2008-01-29 |
UA92496C2 (ru) | 2010-11-10 |
NZ564253A (en) | 2011-04-29 |
US20090197897A1 (en) | 2009-08-06 |
GB0510142D0 (en) | 2005-06-22 |
EA015263B1 (ru) | 2011-06-30 |
CA2608012A1 (en) | 2006-11-23 |
WO2006123249A3 (en) | 2007-02-08 |
EP1896463A2 (en) | 2008-03-12 |
KR20080031676A (ko) | 2008-04-10 |
CN101218232B (zh) | 2012-06-27 |
WO2006123249A2 (en) | 2006-11-23 |
BRPI0610681A2 (pt) | 2010-07-20 |
IL187190A0 (en) | 2008-02-09 |
JP2008540634A (ja) | 2008-11-20 |
AU2006248649A1 (en) | 2006-11-23 |
MX2007014405A (es) | 2008-04-21 |
ZA200710277B (en) | 2009-03-25 |
CN101218232A (zh) | 2008-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200702468A1 (ru) | Новые производные оксадиазола и их применение в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов | |
EA200702469A1 (ru) | Замещенные производные оксадиазола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов | |
EA200702471A1 (ru) | Новые гетероциклические соединения в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов | |
EA200702470A1 (ru) | Производные пиррола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов | |
DE602005025672D1 (de) | Neuartige tetrazolderivate als positive allosterische modulatoren von metabotropen glutamatrezeptoren | |
EA200700047A1 (ru) | Новые алкильные производные в качестве метаботропных рецепторов глутамата | |
EA201070143A1 (ru) | Новые гетероароматические производные и их использование в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов | |
DK1948606T3 (da) | 3, 5-disubstituerede phenyl-piperidiner som modulatorer af dopaminneurotransmission | |
DE602004017213D1 (de) | Allosterische modulatoren von metabotropen glutamatrezeptoren | |
DE602006017209D1 (de) | Carbamat-derivate als positive allosterische modulatoren von metabotropischen glutamat-rezeptoren | |
EA200970612A1 (ru) | Производные индола в качестве агонистов рецептора s1p1 | |
EA200601568A1 (ru) | Новые гидрокси-8-гетероарилфенантридины и их применение в качестве ингибиторов pde4 | |
EA200700400A1 (ru) | Производные n-(1h-индолил)-1н-индол-2-карбоксамидов, их получение и их применение в терапии | |
ATE467632T1 (de) | Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors | |
SE0401465D0 (sv) | New substituted piperdines as modulators of dopamine neurotransmission | |
EA200701758A1 (ru) | Замещённые арильные производные 1,4-пиразина | |
EA200970573A1 (ru) | Агенты, усиливающие действие амра-рецепторов | |
UA92495C2 (ru) | Замещенные производные оксадиазола как положительные аллостерические модуляторы метаботропных глутаматных рецепторов |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |