EA200701877A1 - Derivatives of Substituted Pyridines - Google Patents

Derivatives of Substituted Pyridines

Info

Publication number
EA200701877A1
EA200701877A1 EA200701877A EA200701877A EA200701877A1 EA 200701877 A1 EA200701877 A1 EA 200701877A1 EA 200701877 A EA200701877 A EA 200701877A EA 200701877 A EA200701877 A EA 200701877A EA 200701877 A1 EA200701877 A1 EA 200701877A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
substituted pyridines
openers
treatment
general formula
Prior art date
Application number
EA200701877A
Other languages
Russian (ru)
Other versions
EA016244B1 (en
Inventor
Кристиан Венсель Торнее
Николай Ханжин
Марио Роттлендер
Уилльям Патрик Уотсон
Даниель Родригез Греве
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Priority claimed from PCT/DK2006/000123 external-priority patent/WO2006092143A1/en
Publication of EA200701877A1 publication Critical patent/EA200701877A1/en
Publication of EA016244B1 publication Critical patent/EA016244B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к производным пиридина общей формулы I и их применению в качестве открывателей каналов калиевых ионов семейства KCNQ для лечения нарушений ЦНС.The present invention relates to pyridine derivatives of general formula I and their use as openers of potassium ion channels of the KCNQ family for the treatment of CNS disorders.

EA200701877A 2005-03-03 2006-03-02 Substituted pyridine derivatives EA016244B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200500321 2005-03-03
PCT/DK2006/000123 WO2006092143A1 (en) 2005-03-03 2006-03-02 Substituted pyridine derivatives

Publications (2)

Publication Number Publication Date
EA200701877A1 true EA200701877A1 (en) 2008-02-28
EA016244B1 EA016244B1 (en) 2012-03-30

Family

ID=37908541

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701877A EA016244B1 (en) 2005-03-03 2006-03-02 Substituted pyridine derivatives

Country Status (14)

Country Link
KR (2) KR20130088905A (en)
CN (3) CN102276523B (en)
AR (1) AR052931A1 (en)
BR (1) BRPI0608122A2 (en)
DK (1) DK2298766T3 (en)
EA (1) EA016244B1 (en)
ES (1) ES2433593T3 (en)
HK (1) HK1164868A1 (en)
IL (1) IL185113A (en)
NZ (1) NZ556613A (en)
PT (1) PT2298766E (en)
SI (1) SI2298766T1 (en)
UA (1) UA92340C2 (en)
ZA (1) ZA200705987B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114409593B (en) * 2022-01-20 2024-02-23 上海泾维化工科技有限公司 Preparation method of 2-amino-5-methylpyridine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU779034B2 (en) * 1999-08-04 2005-01-06 Icagen, Inc. Benzanilides as potassium channel openers
EP1634594A1 (en) * 2000-06-29 2006-03-15 NeuroSearch A/S Use of 3-substituted oxindole derivatives as KCNQ potassium channel modulators
EP1361879A1 (en) * 2001-02-20 2003-11-19 Bristol-Myers Squibb Company 2,4-disubstituted pyrimidine-5-carboxamide derivatives as kcnq potassium channel modulators
MXPA05010000A (en) * 2003-03-21 2005-11-17 Lundbeck & Co As H Substituted p-diaminobenzene derivatives.
TWI357901B (en) * 2004-03-12 2012-02-11 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivati

Also Published As

Publication number Publication date
PT2298766E (en) 2013-11-07
IL185113A0 (en) 2007-12-03
CN102276523B (en) 2014-12-10
DK2298766T3 (en) 2013-11-11
CN101133053A (en) 2008-02-27
IL185113A (en) 2013-10-31
HK1164868A1 (en) 2012-09-28
KR20070108884A (en) 2007-11-13
EA016244B1 (en) 2012-03-30
BRPI0608122A2 (en) 2010-11-09
ES2433593T3 (en) 2013-12-11
UA92340C2 (en) 2010-10-25
CN102516165A (en) 2012-06-27
AR052931A1 (en) 2007-04-11
SI2298766T1 (en) 2014-05-30
KR20130088905A (en) 2013-08-08
CN102276523A (en) 2011-12-14
NZ556613A (en) 2010-11-26
ZA200705987B (en) 2009-05-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM RU