EA200701654A1 - Дикетокислоты с каркасом из нуклеинового основания в качестве ингибиторов анти-вич репликации, направленных на вич-интегразу - Google Patents
Дикетокислоты с каркасом из нуклеинового основания в качестве ингибиторов анти-вич репликации, направленных на вич-интегразуInfo
- Publication number
- EA200701654A1 EA200701654A1 EA200701654A EA200701654A EA200701654A1 EA 200701654 A1 EA200701654 A1 EA 200701654A1 EA 200701654 A EA200701654 A EA 200701654A EA 200701654 A EA200701654 A EA 200701654A EA 200701654 A1 EA200701654 A1 EA 200701654A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hiv
- inhibitors
- aids
- compounds
- pharmaceutically acceptable
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 108010002459 HIV Integrase Proteins 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 230000036436 anti-hiv Effects 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000031886 HIV Infections Diseases 0.000 abstract 2
- 208000037357 HIV infectious disease Diseases 0.000 abstract 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229940121357 antivirals Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Приводится описание нового класса дикетокислот, сконструированных на клеточных каркасах нуклеинового основания, предназначенный для применения в качестве ингибиторов репликации ВИЧ путем ингибирования ВИЧ-интегразы. Указанные соединения являются пригодными для профилактики или лечения ВИЧ-инфекции и для лечения СПИДа и СПИД-ассоциированного комплекса либо в виде соединений, либо в виде фармацевтически приемлемых солей с фармацевтически приемлемыми носителями, применяемые отдельно или в сочетании с противовирусными препаратами, иммуномодуляторами, антибиотиками, вакцинами и иными терапевтическими средствами. Также приведено описание способов лечения СПИДа и СПИД-ассоциированного комплекса и способы лечения и профилактики ВИЧ-инфекции. Соединения в соответствии с настоящим изобретением включают соединения формулы I и определяются следующим образом: формула (I), включающая их таутомеры, региоизомеры, геометрические изомеры и оптические изомеры в тех случаях, где это применимо, а также их фармацевтически приемлемые соли, в которых клеточный каркас нуклеиновой кислоты и R группы определены во всех других отношениях в настоящем описании изобретения.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/047,229 US7250421B2 (en) | 2005-01-31 | 2005-01-31 | Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase |
| PCT/US2006/001692 WO2006083553A2 (en) | 2005-01-31 | 2006-01-18 | Diketo acids with nucleobase scaffolds: anti-hiv replication inhibitors targeted at hiv integrase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200701654A1 true EA200701654A1 (ru) | 2008-02-28 |
Family
ID=36757398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200701654A EA200701654A1 (ru) | 2005-01-31 | 2006-01-18 | Дикетокислоты с каркасом из нуклеинового основания в качестве ингибиторов анти-вич репликации, направленных на вич-интегразу |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7250421B2 (ru) |
| EP (1) | EP1848697A4 (ru) |
| JP (1) | JP2008528584A (ru) |
| KR (1) | KR20070112121A (ru) |
| CN (1) | CN101151254A (ru) |
| AU (1) | AU2006211548A1 (ru) |
| CA (1) | CA2596368A1 (ru) |
| EA (1) | EA200701654A1 (ru) |
| IL (1) | IL184926A0 (ru) |
| MX (1) | MX2007009234A (ru) |
| WO (1) | WO2006083553A2 (ru) |
| ZA (1) | ZA200706306B (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888375B2 (en) | 2006-07-19 | 2011-02-15 | The University Of Georgia Research Foundation, Inc | Pyridinone diketo acids: inhibitors of HIV replication |
| NZ573793A (en) * | 2006-07-24 | 2012-01-12 | Korea Res Inst Chem Tech | Hiv reverse transcriptase inhibitors |
| BRPI0813269A2 (pt) * | 2007-06-29 | 2014-12-30 | Korean Res Inst Of Chemical Technology | Inibidores de hiv transcriptase reversa |
| US8354421B2 (en) * | 2007-06-29 | 2013-01-15 | Korea Research Insitute Of Chemical Technology | HIV reverse transcriptase inhibitors |
| WO2009085797A1 (en) * | 2007-12-21 | 2009-07-09 | Gilead Sciences, Inc. | Processes for preparing hiv reverse transcriptase inhibitors |
| EP2254582B1 (en) | 2008-01-25 | 2016-01-20 | Chimerix, Inc. | Methods of treating viral infections |
| EP2509949B1 (en) * | 2009-12-07 | 2014-04-23 | University Of Georgia Research Foundation, Inc. | Pyridinone hydroxycyclopentyl carboxamides: hiv integrase inhibitors with therapeutic applications |
| US9006218B2 (en) | 2010-02-12 | 2015-04-14 | Chimerix Inc. | Nucleoside phosphonate salts |
| CN104185420B (zh) | 2011-11-30 | 2017-06-09 | 埃默里大学 | 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂 |
| US9650360B2 (en) | 2012-03-31 | 2017-05-16 | University Of Georgia Research Foundation, Inc. | Anti-mycobacterial drugs against tuberculosis |
| WO2015130947A1 (en) * | 2014-02-26 | 2015-09-03 | Howard University | Benzende sulfonamide derivatives as hiv integrase inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9816358D0 (en) * | 1998-07-27 | 1998-09-23 | Angeletti P Ist Richerche Bio | Enzyme inhibitors |
| WO2000006529A1 (en) | 1998-07-27 | 2000-02-10 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti S.P.A. | Diketoacid-derivatives as inhibitors of polymerases |
| AP2001002169A0 (en) * | 1998-12-25 | 2001-06-30 | Shionogi & Co | Aromatic heterocycle compounds having hiv intergrase inhibiting activities |
| CN1239472C (zh) * | 2000-06-16 | 2006-02-01 | 布里斯托尔-迈尔斯斯奎布公司 | Hiv整合酶抑制剂 |
| AU2002337765A1 (en) * | 2001-09-26 | 2003-04-07 | Bristol-Myers Squibb Company | Compounds useful for treating hepatitus c virus |
| US20050026902A1 (en) | 2003-01-31 | 2005-02-03 | Timothy Maziasz | Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents |
-
2005
- 2005-01-31 US US11/047,229 patent/US7250421B2/en not_active Expired - Fee Related
-
2006
- 2006-01-18 EP EP06733736A patent/EP1848697A4/en not_active Withdrawn
- 2006-01-18 EA EA200701654A patent/EA200701654A1/ru unknown
- 2006-01-18 AU AU2006211548A patent/AU2006211548A1/en not_active Abandoned
- 2006-01-18 CA CA002596368A patent/CA2596368A1/en not_active Abandoned
- 2006-01-18 JP JP2007553135A patent/JP2008528584A/ja active Pending
- 2006-01-18 MX MX2007009234A patent/MX2007009234A/es active IP Right Grant
- 2006-01-18 CN CNA2006800106832A patent/CN101151254A/zh active Pending
- 2006-01-18 WO PCT/US2006/001692 patent/WO2006083553A2/en active Application Filing
- 2006-01-18 KR KR1020077017676A patent/KR20070112121A/ko not_active Application Discontinuation
-
2007
- 2007-06-19 US US11/820,444 patent/US7569573B2/en not_active Expired - Fee Related
- 2007-07-30 IL IL184926A patent/IL184926A0/en unknown
- 2007-07-30 ZA ZA200706306A patent/ZA200706306B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL184926A0 (en) | 2007-12-03 |
| US7569573B2 (en) | 2009-08-04 |
| WO2006083553A2 (en) | 2006-08-10 |
| KR20070112121A (ko) | 2007-11-22 |
| EP1848697A2 (en) | 2007-10-31 |
| ZA200706306B (en) | 2008-10-29 |
| JP2008528584A (ja) | 2008-07-31 |
| EP1848697A4 (en) | 2011-06-15 |
| WO2006083553A3 (en) | 2007-04-19 |
| MX2007009234A (es) | 2007-10-08 |
| US20070259823A1 (en) | 2007-11-08 |
| AU2006211548A1 (en) | 2006-08-10 |
| US20060172973A1 (en) | 2006-08-03 |
| US7250421B2 (en) | 2007-07-31 |
| CN101151254A (zh) | 2008-03-26 |
| CA2596368A1 (en) | 2006-08-10 |
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