EA200700038A1 - Ингибиторы вирусных полимераз - Google Patents
Ингибиторы вирусных полимеразInfo
- Publication number
- EA200700038A1 EA200700038A1 EA200700038A EA200700038A EA200700038A1 EA 200700038 A1 EA200700038 A1 EA 200700038A1 EA 200700038 A EA200700038 A EA 200700038A EA 200700038 A EA200700038 A EA 200700038A EA 200700038 A1 EA200700038 A1 EA 200700038A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- polymerase inhibitors
- viral polymerase
- compound
- polymerases
- rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Соединение формулы (I) или его энантиомер, диастереоизомер или таутомер, где А или В означает азот, а другой А или В означает углерод, и R, R, R, R, R, R, Rи Rопределены в данном описании, или его соль, сложный эфир или производное в качестве ингибиторов вирусной полимеразы. Соединение можно использовать в качестве ингибитора РНК-зависимых РНК полимераз, прежде всего полимераз вирусов семейства Flavoviviridae, предпочтительно полимеразы вируса гепатита С.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58867004P | 2004-07-16 | 2004-07-16 | |
PCT/CA2005/001103 WO2006007693A1 (en) | 2004-07-16 | 2005-07-15 | Viral polymerase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200700038A1 true EA200700038A1 (ru) | 2007-08-31 |
Family
ID=35784831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200700038A EA200700038A1 (ru) | 2004-07-16 | 2005-07-15 | Ингибиторы вирусных полимераз |
Country Status (19)
Country | Link |
---|---|
US (2) | US7241801B2 (ru) |
EP (1) | EP1771442A4 (ru) |
JP (1) | JP2008506638A (ru) |
KR (1) | KR20070035092A (ru) |
CN (1) | CN1984908A (ru) |
AR (1) | AR050172A1 (ru) |
AU (1) | AU2005263135A1 (ru) |
BR (1) | BRPI0513431A (ru) |
CA (1) | CA2573210A1 (ru) |
EA (1) | EA200700038A1 (ru) |
EC (1) | ECSP077171A (ru) |
IL (1) | IL180665A0 (ru) |
MX (1) | MX2007000007A (ru) |
NO (1) | NO20070368L (ru) |
PE (1) | PE20060569A1 (ru) |
TW (1) | TW200617003A (ru) |
UY (1) | UY29017A1 (ru) |
WO (1) | WO2006007693A1 (ru) |
ZA (1) | ZA200609578B (ru) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
CN103304541A (zh) * | 2004-02-20 | 2013-09-18 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
US7348425B2 (en) | 2004-08-09 | 2008-03-25 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
ZA200705872B (en) * | 2005-01-14 | 2008-09-25 | Genelabs Tecnologies Inc | Indole derivatives for treating viral infections |
CN101155801A (zh) * | 2005-02-11 | 2008-04-02 | 贝林格尔·英格海姆国际有限公司 | 2,3-二取代的吲哚的制备方法 |
WO2006127289A1 (en) * | 2005-05-20 | 2006-11-30 | Valeant Research & Development | Treatment of hcv with subtherapeutic doses of ribavirin |
CA2618682C (en) * | 2005-08-12 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
FR2896246B1 (fr) | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2007092000A1 (en) * | 2006-02-06 | 2007-08-16 | Bristol-Myers Squibb Company | Inhibitors of hcv replication |
GB0608928D0 (en) | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
MX2009000882A (es) | 2006-08-17 | 2009-02-04 | Boehringer Ingelheim Int | Inhibidores de la polimerasa virica. |
FR2910813B1 (fr) | 2006-12-28 | 2009-02-06 | Sanofi Aventis Sa | Nouvelle utilisation therapeutique pour le traitement des leucemies |
WO2009008906A2 (en) * | 2007-02-06 | 2009-01-15 | The Trustees Of The University Of Pennsylvania | Therapeutic compounds for blocking dna synthesis of pox viruses |
EP2142215B1 (en) | 2007-05-04 | 2012-03-07 | Vertex Pharmceuticals Incorporated | Combination therapy for the treatment of hcv infection |
JP2010533699A (ja) | 2007-07-17 | 2010-10-28 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | C型肝炎感染症の治療のための大環状インドール誘導体 |
JP2010535156A (ja) | 2007-08-03 | 2010-11-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼ阻害剤 |
US20100286131A1 (en) * | 2007-08-03 | 2010-11-11 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US8940688B2 (en) | 2007-12-05 | 2015-01-27 | Enanta Pharmaceuticals, Inc. | Fluorinated tripeptide HCV serine protease inhibitors |
EA201000948A1 (ru) | 2007-12-19 | 2011-02-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Ингибиторы вирусной полимеразы |
RU2011127080A (ru) | 2009-01-07 | 2013-02-20 | Сайнексис, Инк. | Производное циклоспорина для применения в лечении заражения вирусом гепатита с и вич |
WO2010114896A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
MX2011012155A (es) | 2009-05-13 | 2012-02-28 | Enanta Pharm Inc | Compuestos macrociclicos como inhibidores del virus de hepatitis c. |
MX343275B (es) | 2010-09-21 | 2016-10-31 | Enanta Pharm Inc | Prolina macrociclica derivada de inhibidores de serina proteasa de vhc. |
US9233921B2 (en) | 2013-03-08 | 2016-01-12 | The Trustees Of The University Of Pennsylvania | Potent poxvirus inhibitor |
CN107641121B (zh) * | 2016-07-20 | 2021-02-19 | 上海高驰资产管理有限公司 | 一种荧光探针及其制备方法和用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
CA2439176A1 (en) | 2001-03-08 | 2002-09-12 | Boehringer Ingelheim (Canada) Ltd. | Assay for identifying inhibitors of the rna dependent rna polymerase (ns5b) of hcv |
WO2003007945A1 (en) * | 2001-07-20 | 2003-01-30 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
-
2005
- 2005-07-14 UY UY29017A patent/UY29017A1/es not_active Application Discontinuation
- 2005-07-14 PE PE2005000809A patent/PE20060569A1/es not_active Application Discontinuation
- 2005-07-15 CA CA002573210A patent/CA2573210A1/en not_active Abandoned
- 2005-07-15 CN CNA2005800237228A patent/CN1984908A/zh active Pending
- 2005-07-15 MX MX2007000007A patent/MX2007000007A/es active IP Right Grant
- 2005-07-15 JP JP2007520631A patent/JP2008506638A/ja active Pending
- 2005-07-15 EP EP05768261A patent/EP1771442A4/en not_active Withdrawn
- 2005-07-15 AU AU2005263135A patent/AU2005263135A1/en not_active Abandoned
- 2005-07-15 EA EA200700038A patent/EA200700038A1/ru unknown
- 2005-07-15 US US11/182,987 patent/US7241801B2/en active Active
- 2005-07-15 AR ARP050102935A patent/AR050172A1/es unknown
- 2005-07-15 WO PCT/CA2005/001103 patent/WO2006007693A1/en active Application Filing
- 2005-07-15 KR KR1020077003911A patent/KR20070035092A/ko not_active Application Discontinuation
- 2005-07-15 BR BRPI0513431-5A patent/BRPI0513431A/pt not_active IP Right Cessation
- 2005-07-15 TW TW094124015A patent/TW200617003A/zh unknown
-
2006
- 2006-11-17 ZA ZA200609578A patent/ZA200609578B/xx unknown
-
2007
- 2007-01-11 IL IL180665A patent/IL180665A0/en unknown
- 2007-01-16 EC EC2007007171A patent/ECSP077171A/es unknown
- 2007-01-19 NO NO20070368A patent/NO20070368L/no not_active Application Discontinuation
- 2007-05-25 US US11/753,678 patent/US20070249629A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
UY29017A1 (es) | 2006-02-24 |
EP1771442A1 (en) | 2007-04-11 |
IL180665A0 (en) | 2007-06-03 |
WO2006007693A1 (en) | 2006-01-26 |
BRPI0513431A (pt) | 2008-05-06 |
MX2007000007A (es) | 2007-03-07 |
PE20060569A1 (es) | 2006-06-22 |
JP2008506638A (ja) | 2008-03-06 |
CA2573210A1 (en) | 2006-01-26 |
AR050172A1 (es) | 2006-10-04 |
US20060052418A1 (en) | 2006-03-09 |
ZA200609578B (en) | 2008-08-27 |
AU2005263135A1 (en) | 2006-01-26 |
EP1771442A4 (en) | 2009-12-30 |
NO20070368L (no) | 2007-01-30 |
US7241801B2 (en) | 2007-07-10 |
ECSP077171A (es) | 2007-02-28 |
CN1984908A (zh) | 2007-06-20 |
US20070249629A1 (en) | 2007-10-25 |
KR20070035092A (ko) | 2007-03-29 |
TW200617003A (en) | 2006-06-01 |
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