EA200600609A1 - Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы - Google Patents

Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы

Info

Publication number
EA200600609A1
EA200600609A1 EA200600609A EA200600609A EA200600609A1 EA 200600609 A1 EA200600609 A1 EA 200600609A1 EA 200600609 A EA200600609 A EA 200600609A EA 200600609 A EA200600609 A EA 200600609A EA 200600609 A1 EA200600609 A1 EA 200600609A1
Authority
EA
Eurasian Patent Office
Prior art keywords
imidazopiridin
induced
derivatives
synthase inhibitors
inhibitors
Prior art date
Application number
EA200600609A
Other languages
English (en)
Inventor
Томас Фуксс
Томас Мартин
Райнер Бёр
Андреас Штруб
Манфрид Эльтце
Мартин Ленер
Дегенхард Маркс
Вольф-Рюдигер Ульрих
Original Assignee
Алтана Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алтана Фарма Аг filed Critical Алтана Фарма Аг
Publication of EA200600609A1 publication Critical patent/EA200600609A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

В заявке описаны соединения формулы I, в которой R1, R2, Het1 и А обладают значениями, указанными в описании, являющиеся новыми эффективными ингибиторами iNOS.
EA200600609A 2003-10-01 2004-09-30 Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы EA200600609A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03022064 2003-10-01
PCT/EP2004/052376 WO2005030769A1 (en) 2003-10-01 2004-09-30 Imidazopyridine-derivatives as inducible no-synthase inhibitors

Publications (1)

Publication Number Publication Date
EA200600609A1 true EA200600609A1 (ru) 2006-10-27

Family

ID=34384572

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600609A EA200600609A1 (ru) 2003-10-01 2004-09-30 Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы

Country Status (17)

Country Link
US (1) US20080125460A1 (ru)
EP (1) EP1673371B1 (ru)
JP (1) JP2007507465A (ru)
KR (1) KR20060092222A (ru)
CN (1) CN1856494A (ru)
AT (1) ATE403655T1 (ru)
AU (1) AU2004276013A1 (ru)
BR (1) BRPI0414873A (ru)
CA (1) CA2540242A1 (ru)
DE (1) DE602004015628D1 (ru)
EA (1) EA200600609A1 (ru)
IL (1) IL173809A0 (ru)
MX (1) MXPA06003554A (ru)
NO (1) NO20061316L (ru)
RS (1) RS20060195A (ru)
WO (1) WO2005030769A1 (ru)
ZA (1) ZA200601552B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004014628D1 (de) 2003-10-01 2008-08-07 Nycomed Gmbh Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren
BRPI0414972A (pt) 2003-10-01 2006-11-07 Altana Pharma Ag derivados de imidazopiridinas como inibidores de no-sintase induzìvel
RS20060206A (en) 2003-10-01 2008-08-07 Altana Pharma Ag., Aminopyridine-derivatives as inducible no-synthase inhibitors
CN1856492A (zh) 2003-10-01 2006-11-01 奥坦纳医药公司 咪唑并(4,5－b)吡啶衍生物作为可诱导的no－合酶的抑制剂
WO2009029625A1 (en) * 2007-08-27 2009-03-05 Kalypsys, Inc. 4- [heterocyclyl-methyl] -8-fluoro-quinolin-2-ones useful as nitric oxide synthase inhibitors
CN103038229B (zh) * 2010-05-26 2016-05-11 桑诺维恩药品公司 杂芳基化合物及其使用方法
CA2889906A1 (en) * 2012-11-29 2014-06-05 Sunovion Pharmaceuticals Inc. Triazolo-pyrazine derivatives useful in the treatment of disorders of the central nervous system
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045564A (en) * 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
AUPP873799A0 (en) * 1999-02-17 1999-03-11 Fujisawa Pharmaceutical Co., Ltd. Pyridine compounds
NZ535959A (en) * 2002-03-27 2006-05-26 Altana Pharma Ag Novel alkoxypyridine-derivatives as selective inhibitors of inducible nitric oxidase synthase NOS

Also Published As

Publication number Publication date
CA2540242A1 (en) 2005-04-07
EP1673371B1 (en) 2008-08-06
WO2005030769A1 (en) 2005-04-07
CN1856494A (zh) 2006-11-01
KR20060092222A (ko) 2006-08-22
ATE403655T1 (de) 2008-08-15
RS20060195A (en) 2008-08-07
NO20061316L (no) 2006-03-23
DE602004015628D1 (de) 2008-09-18
US20080125460A1 (en) 2008-05-29
AU2004276013A1 (en) 2005-04-07
JP2007507465A (ja) 2007-03-29
MXPA06003554A (es) 2006-06-05
ZA200601552B (en) 2007-04-25
IL173809A0 (en) 2006-07-05
EP1673371A1 (en) 2006-06-28
BRPI0414873A (pt) 2006-12-12

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