EA200500683A1 - Новые соединения пирролидина и тиазолидина, способ их получения и фармацевтические композиции, которые их содержат - Google Patents

Новые соединения пирролидина и тиазолидина, способ их получения и фармацевтические композиции, которые их содержат

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Publication number
EA200500683A1
EA200500683A1 EA200500683A EA200500683A EA200500683A1 EA 200500683 A1 EA200500683 A1 EA 200500683A1 EA 200500683 A EA200500683 A EA 200500683A EA 200500683 A EA200500683 A EA 200500683A EA 200500683 A1 EA200500683 A1 EA 200500683A1
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EA
Eurasian Patent Office
Prior art keywords
group
inclusive
integer
optionally substituted
thiazolidine
Prior art date
Application number
EA200500683A
Other languages
English (en)
Other versions
EA009292B1 (ru
Inventor
Гийом Де-Нантей
Ален Бенуа
Мюриелль Комбетт
Элизабет Арле
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200500683A1 publication Critical patent/EA200500683A1/ru
Publication of EA009292B1 publication Critical patent/EA009292B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Соединение формулы (I)в которой Xпредставляет собой атом или группу, выбранную из CRR, O, S(O)и NR, в которой R, R, qи Rимеют значения, указанные в описании,mпредставляет собой 0 или целое число от 1 до 4 включительно,mпредставляет собой целое число от 1 до 4 включительно,nи n, которые могут быть одинаковыми или разными, каждый представляет собой целое число от 1 до 3 включительно,Rпредставляет собой атом водорода или группу, выбранную из карбокси, алкоксикарбонила, необязательно замещенного карбамоила и необязательно замещенного алкила,Rпредставляет собой атом водорода или алкильную группу,Ak представляет собой необязательно замещенную алкиленовую цепь,p представляет собой 0, 1 или 2,Rпредставляет собой атом водорода или цианогруппу,Xи X, которые могут быть одинаковыми или разными, каждый представляет собой или S(O)группу или CRRгруппу, в которой q, Rи Rимеют значения, указанные в описании,его оптические изомеры, если они существуют, и его соли присоединения с фармацевтически приемлемой кислотой. Лекарственные средства.
EA200500683A 2004-05-19 2005-05-18 Новые соединения пирролидина и тиазолидина, способ их получения и фармацевтические композиции, которые их содержат EA009292B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0405454A FR2870538B1 (fr) 2004-05-19 2004-05-19 Nouveaux derives de pyrrolidines et de thiazolidines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
EA200500683A1 true EA200500683A1 (ru) 2005-12-29
EA009292B1 EA009292B1 (ru) 2007-12-28

Family

ID=34942306

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500683A EA009292B1 (ru) 2004-05-19 2005-05-18 Новые соединения пирролидина и тиазолидина, способ их получения и фармацевтические композиции, которые их содержат

Country Status (29)

Country Link
US (1) US7439263B2 (ru)
EP (1) EP1598350B1 (ru)
JP (1) JP4335171B2 (ru)
KR (1) KR100747967B1 (ru)
CN (1) CN100381438C (ru)
AR (1) AR049278A1 (ru)
AT (1) ATE366731T1 (ru)
AU (1) AU2005202180B2 (ru)
BR (1) BRPI0501769A (ru)
CA (1) CA2506491C (ru)
CY (1) CY1106878T1 (ru)
DE (1) DE602005001576T2 (ru)
DK (1) DK1598350T3 (ru)
EA (1) EA009292B1 (ru)
ES (1) ES2290864T3 (ru)
FR (1) FR2870538B1 (ru)
GE (1) GEP20074103B (ru)
HK (1) HK1086259A1 (ru)
HR (1) HRP20070376T3 (ru)
MX (1) MXPA05005256A (ru)
MY (1) MY139481A (ru)
NO (1) NO330294B1 (ru)
NZ (1) NZ540108A (ru)
PL (1) PL1598350T3 (ru)
PT (1) PT1598350E (ru)
RS (1) RS50526B (ru)
SG (1) SG117551A1 (ru)
SI (1) SI1598350T1 (ru)
ZA (1) ZA200504050B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2020413A1 (de) 2007-08-02 2009-02-04 Bayer CropScience AG Oxaspirocyclische-spiro-substituierte Tetram- und Tetronsäure-Derivate
GB2465132B (en) * 2007-09-21 2012-06-06 Lupin Ltd Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
CA2712352C (en) * 2008-01-23 2016-05-10 Jiangsu Hansoh Pharmaceutical Co., Ltd. Dicycloazaalkane derivates, preparation processes and medical uses thereof
US8748457B2 (en) 2009-06-18 2014-06-10 Lupin Limited 2-amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent DPP-IV inhibitors
US8440710B2 (en) * 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
EP2865666B1 (en) * 2012-06-25 2017-05-31 Sunshine Lake Pharma Co., Ltd. Hexahydropentaleno derivatives, preparation method and use in medicine thereof
KR102449196B1 (ko) 2016-01-15 2022-09-29 삼성전자주식회사 비휘발성 메모리 장치 및 비휘발성 메모리 장치의 프로그램 방법

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JPH0618957B2 (ja) * 1988-01-26 1994-03-16 日本合成化学工業株式会社 成形物の製造方法
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
DE4222459C2 (de) * 1992-07-08 1995-09-14 Sigma Tau Ind Farmaceuti 3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
AU7186494A (en) * 1993-07-02 1995-01-24 Bayer Aktiengesellschaft Substituted spiroheterocyclic 1h-3-arylpyrrolidine-2,4-dione derivatives, methods of preparing them and their use as pest-control agents
TW492957B (en) * 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
US6110949A (en) * 1999-06-24 2000-08-29 Novartis Ag N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
TW583185B (en) * 2000-06-13 2004-04-11 Novartis Ag N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
KR100817378B1 (ko) * 2000-08-10 2008-03-27 미츠비시 웰파마 가부시키가이샤 프롤린 유도체 및 그 의약 용도
AU8811401A (en) * 2000-09-25 2002-04-02 Toray Industries Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient
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Also Published As

Publication number Publication date
PL1598350T3 (pl) 2007-10-31
DE602005001576T2 (de) 2008-04-17
ATE366731T1 (de) 2007-08-15
ES2290864T3 (es) 2008-02-16
GEP20074103B (en) 2007-05-10
CA2506491C (fr) 2009-09-01
AU2005202180A1 (en) 2005-12-08
EA009292B1 (ru) 2007-12-28
CY1106878T1 (el) 2012-09-26
FR2870538B1 (fr) 2006-07-14
MXPA05005256A (es) 2005-11-24
EP1598350B1 (fr) 2007-07-11
HK1086259A1 (en) 2006-09-15
KR20060048007A (ko) 2006-05-18
JP4335171B2 (ja) 2009-09-30
DE602005001576D1 (de) 2007-08-23
KR100747967B1 (ko) 2007-08-08
NO330294B1 (no) 2011-03-21
PT1598350E (pt) 2007-10-04
DK1598350T3 (da) 2007-11-12
CA2506491A1 (fr) 2005-11-19
CN1721417A (zh) 2006-01-18
JP2005350456A (ja) 2005-12-22
NO20052414L (no) 2005-11-21
US20050261501A1 (en) 2005-11-24
MY139481A (en) 2009-10-30
EP1598350A1 (fr) 2005-11-23
SI1598350T1 (sl) 2007-10-31
AR049278A1 (es) 2006-07-12
NO20052414D0 (no) 2005-05-19
NZ540108A (en) 2006-04-28
FR2870538A1 (fr) 2005-11-25
RS50526B (sr) 2010-05-07
ZA200504050B (en) 2006-07-26
SG117551A1 (en) 2005-12-29
US7439263B2 (en) 2008-10-21
AU2005202180B2 (en) 2010-10-28
HRP20070376T3 (en) 2007-12-31
CN100381438C (zh) 2008-04-16
BRPI0501769A (pt) 2006-01-10

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