EA200500163A1 - Применение ингибиторов аланиламинопептидаз и содержащие их фармацевтические композиции - Google Patents

Применение ингибиторов аланиламинопептидаз и содержащие их фармацевтические композиции

Info

Publication number
EA200500163A1
EA200500163A1 EA200500163A EA200500163A EA200500163A1 EA 200500163 A1 EA200500163 A1 EA 200500163A1 EA 200500163 A EA200500163 A EA 200500163A EA 200500163 A EA200500163 A EA 200500163A EA 200500163 A1 EA200500163 A1 EA 200500163A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
alynylaminopeptidases
application
pharmaceutical compositions
compositions containing
Prior art date
Application number
EA200500163A
Other languages
English (en)
Other versions
EA008946B1 (ru
Inventor
Зигфрид Анзорге
Янине Тадье
Уве Лендеккель
Original Assignee
Институт Фюр Медицинтехнологи Магдебург (Имтм) Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт Фюр Медицинтехнологи Магдебург (Имтм) Гмбх filed Critical Институт Фюр Медицинтехнологи Магдебург (Имтм) Гмбх
Publication of EA200500163A1 publication Critical patent/EA200500163A1/ru
Publication of EA008946B1 publication Critical patent/EA008946B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к применению одного ингибитора или нескольких ингибиторов аланиламинопептидаз и/или ферментов такой же субстратной специфичности для индукции продуцирования TGF-β1 и экспрессии TGF-β1 в и/или на Treg-клетках и применению для профилактики и/или лечения аутоиммунных заболеваний, аллергий, артериосклероза и для подавления отторжений трансплантатов. Кроме того, изобретение относится к применениям, при которых используют дополнительно пептидные фрагменты патогенных аутоантигенов или синтетические аналоги и/или специфические антигенные компоненты патогенных микроорганизмов.Отчет о международном поиске был опубликован 2004.05.06.
EA200500163A 2002-07-05 2003-07-04 Применение ингибиторов аланиламинопептидаз и содержащие их фармацевтические композиции EA008946B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10230381A DE10230381A1 (de) 2002-07-05 2002-07-05 Verwendung von Inhibitoren der Alanyl-Aminopeptidasen und diese umfassende pharmazeutischen Zubereitungen
PCT/EP2003/007199 WO2004004750A2 (de) 2002-07-05 2003-07-04 Verwendung von inhibitoren der alanyl-aminopeptidasen und diese umfassende pharmazeutischen zubereitungen

Publications (2)

Publication Number Publication Date
EA200500163A1 true EA200500163A1 (ru) 2005-08-25
EA008946B1 EA008946B1 (ru) 2007-10-26

Family

ID=29761689

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500163A EA008946B1 (ru) 2002-07-05 2003-07-04 Применение ингибиторов аланиламинопептидаз и содержащие их фармацевтические композиции

Country Status (9)

Country Link
US (1) US7425532B2 (ru)
EP (2) EP1521588A2 (ru)
JP (1) JP2005532380A (ru)
CN (1) CN1665524B (ru)
AU (1) AU2003250892B2 (ru)
CA (1) CA2490714A1 (ru)
DE (1) DE10230381A1 (ru)
EA (1) EA008946B1 (ru)
WO (1) WO2004004750A2 (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10348044A1 (de) * 2003-10-15 2005-05-19 Imtm Gmbh Duale Alanyl-Aminopeptidase- und Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
DE10348023A1 (de) * 2003-10-15 2005-05-19 Imtm Gmbh Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
DE10348022A1 (de) * 2003-10-15 2005-05-25 Imtm Gmbh Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
US20060063208A1 (en) 2004-08-02 2006-03-23 Woolf Clifford J DRG11-responsive (DRAGON) gene and uses thereof
US7763257B2 (en) 2004-12-09 2010-07-27 Christina Juneau Compositions comprising transforming growth factor (TGF)-β1 and TGF-β2 in admixture of proteins obtained from dairy products
EP1669086A1 (en) * 2004-12-09 2006-06-14 Advitech Solutions Inc. Composition comprising TGF-beta and proteins for treating psoriasis
EP2335719B1 (en) 2005-02-16 2015-06-24 The General Hospital Corporation Use of hemojuvelin fusion proteins to regulate hepcidin-mediated iron metabolism
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
EA026578B1 (ru) * 2007-01-22 2017-04-28 ДЖиТиЭкс, ИНК. Вещества, связывающие ядерные рецепторы
US9604931B2 (en) * 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
ES2308916B1 (es) * 2007-03-22 2009-10-29 Consejo Superior De Investigaciones Cientificas Compuesto inhibidor dual de las enzimas pde7 y/o pde4, composiciones farmaceuticas y sus aplicaciones.
US8895002B2 (en) 2007-04-09 2014-11-25 The General Hospital Corporation Hemojuvelin fusion proteins and uses thereof
DE102007039429A1 (de) 2007-08-21 2009-02-26 Imtm Gmbh Verfahren zur Aktivierung regulatorischer T-Zellen
AU2009313902B9 (en) 2008-11-13 2014-03-27 The General Hospital Corporation Methods and compositions for regulating iron homeostasis by modulation of BMP-6
EP2366394A1 (en) 2010-03-17 2011-09-21 IMTM GmbH Characterization and validation of inhibitors and ligands of dipeptidyl aminopeptidase IV (DP IV)
CN102631664B (zh) * 2011-01-28 2014-10-01 上海来益生物药物研究开发中心有限责任公司 3-氨基-2-羟基-4-苯基-缬氨酰-异亮氨酸的应用
WO2014165573A1 (en) * 2013-04-02 2014-10-09 University Of Connecticut Regulating transplant rejection of donor and embryonic stem cell-derived tissues and organs
WO2017214555A1 (en) * 2016-06-10 2017-12-14 The Regents Of The University Of Michigan Modulation of aminopeptidase n/cd13 and rheumatoid arthritis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347531A1 (de) * 1983-12-30 1985-07-11 Basf Ag, 6700 Ludwigshafen Magnetische aufzeichnungstraeger
DE3568074D1 (en) * 1984-12-22 1989-03-09 Ejot Adolf Bohl Gmbh & Co Kg Fastening device
HUT61487A (en) 1989-12-20 1993-01-28 Brigham & Womens Hospital Process for producing aerosol pharmaceutical composition comprising autoantigens
WO1995004533A2 (en) 1993-08-04 1995-02-16 Andrulis Pharmaceuticals Corporation Treatment of rheumatoid arthritis with thalidomide alone or in combination with other anti-inflammatory agents
CA2203629A1 (en) 1994-10-25 1996-05-02 Dawn Smilek Compositions and treatment for multiple sclerosis
JP3917711B2 (ja) * 1997-05-12 2007-05-23 財団法人微生物化学研究会 フェベスチン誘導体
JP2001131066A (ja) * 1999-08-25 2001-05-15 Nippon Kayaku Co Ltd アポトーシス増強剤
JP2001089360A (ja) * 1999-09-16 2001-04-03 Shionogi & Co Ltd Ｔリンパ球増殖反応の低下剤
DE10002820A1 (de) 2000-01-24 2001-08-23 Walter Schubert Aminopeptidasen-Inhibitor
DE10025464A1 (de) * 2000-05-23 2001-12-06 Inst Medizintechnologie Magdeb Kombinierte Verwendung von Enzyminhibitoren zur Therapie von Autoimmunerkrankungen, bei Transplantationen und Tumorerkrankungen sowie Kombinationen von Enzyminhibitoren umfassende pharmazeutische Zubereitungen
DE10100052A1 (de) * 2001-01-02 2002-07-11 Inst Medizintechnologie Magdeb Kombinierte Verwendung von Enzyminhibitoren und pharmazeutischen Zubereitungen daraus zur Therapie und Prophylaxe der Atheriosklerose
DE10211555A1 (de) * 2002-03-15 2003-10-02 Imtm Inst Fuer Medizintechnolo Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention dermatologischer Erkrankungen mit sebozytärer Hyperproliferation und veränderten Differenzierungszuständen

Also Published As

Publication number Publication date
WO2004004750A2 (de) 2004-01-15
EP2085094A2 (de) 2009-08-05
AU2003250892A1 (en) 2004-01-23
US20060211602A1 (en) 2006-09-21
WO2004004750A3 (de) 2004-05-06
AU2003250892B2 (en) 2006-11-16
CA2490714A1 (en) 2004-01-15
CN1665524B (zh) 2010-08-25
JP2005532380A (ja) 2005-10-27
CN1665524A (zh) 2005-09-07
US7425532B2 (en) 2008-09-16
EP1521588A2 (de) 2005-04-13
DE10230381A1 (de) 2004-01-22
EA008946B1 (ru) 2007-10-26

Similar Documents

Publication Publication Date Title
EA200500163A1 (ru) Применение ингибиторов аланиламинопептидаз и содержащие их фармацевтические композиции
WO2004024097A8 (en) Compositions and methods for the treatment of immune related diseases
ATE267830T1 (de) Als cox-hemmer verwendbare sulfonylphenylpyrazol- verbindungen
DE60330485D1 (de) Zur behandlung von diabetes
BG66084B1 (bg) Циклопентаноиндоли, състави,съдържащи такива съединения и използването им
DK1480961T3 (da) Glutaminylbaserede DPIV-inhibitorer
DE60329316D1 (de) Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
ATE423122T1 (de) Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)
EA200800375A1 (ru) Соединения и способы ингибирования экспрессии vcam-1
EA200300441A1 (ru) Ассоциация антагониста рецептора св1 и сибутрамина, содержащие их фармацевтические композиции и их применение для лечения ожирения
WO2004039956A3 (en) Compositions and methods for the treatment of immune related diseases
DK0705254T3 (da) Phenylheterocykliske forbindelser som cyclooxygenase-2-inhibitorer
MEP90508A (en) New pharmaceutical composition
ATE322902T1 (de) Verwendung von azetogenischen hydrogenotrophischen stämmen zur vorbeugung und behandlung von verdauungskrankheiten
MA31183B1 (fr) Inhibiteurs de mek
EP1673078A4 (en) BENZYL ETHER AND BENZYLAMINO BETA SEKRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER DISEASE
MXPA02006029A (es) Lipopeptidos novedosos como agentes antibacterianos.
DE60122767D1 (de) Indoly-lsulphonyl-verbindungen zur behandlung von störungen des zns
MA27880A1 (fr) Derives de tetrahydrocarbazole et leur utilisation pharmaceutique
DK0705100T3 (da) Terapeutiske substituerede guanidiner
DE69837324D1 (de) Behandlung der multiplen sklerose durch einnahme von copolymer-1
DE60323765D1 (de) Inhibitoren der 17 beta-hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten
ATE414526T1 (de) Zubereitungen zur behandlung von arthritischen erscheinungen
BR0211761A (pt) depsipeptìdeos e processos para preparar os mesmos
PT1060175E (pt) Inibidores de triptase

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU