EA200401335A1 - Производные карбоксимида в качестве уроселективных блокаторов альфа-1a адренорецепторов - Google Patents

Производные карбоксимида в качестве уроселективных блокаторов альфа-1a адренорецепторов

Info

Publication number
EA200401335A1
EA200401335A1 EA200401335A EA200401335A EA200401335A1 EA 200401335 A1 EA200401335 A1 EA 200401335A1 EA 200401335 A EA200401335 A EA 200401335A EA 200401335 A EA200401335 A EA 200401335A EA 200401335 A1 EA200401335 A1 EA 200401335A1
Authority
EA
Eurasian Patent Office
Prior art keywords
addressorceptors
uroselective
blockers
alpha
carboximide derivatives
Prior art date
Application number
EA200401335A
Other languages
English (en)
Inventor
Мохаммад Салман
Гян Чанд Ядав
Сомеш ШАРМА
Гобинд Сингх Капкоти
Анита Чугх
Джанг Бахадур Гупта
Нитья Ананд
Original Assignee
Ранбакси Лабораторис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ранбакси Лабораторис Лимитед filed Critical Ранбакси Лабораторис Лимитед
Publication of EA200401335A1 publication Critical patent/EA200401335A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Предложены новые производные карбоксимида, которые селективно ингибируют связывание с α-адренорецептором, играющим важную роль в лечении доброкачественной гиперплазии простаты. Соединения по настоящему изобретению являются потенциально пригодными для лечения доброкачественной гиперплазии простаты.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401335A 2002-04-08 2002-04-08 Производные карбоксимида в качестве уроселективных блокаторов альфа-1a адренорецепторов EA200401335A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2002/001108 WO2003084541A1 (en) 2002-04-08 2002-04-08 Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers

Publications (1)

Publication Number Publication Date
EA200401335A1 true EA200401335A1 (ru) 2006-02-24

Family

ID=28686909

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401335A EA200401335A1 (ru) 2002-04-08 2002-04-08 Производные карбоксимида в качестве уроселективных блокаторов альфа-1a адренорецепторов

Country Status (8)

Country Link
EP (1) EP1494674A4 (ru)
JP (1) JP2005532282A (ru)
CN (1) CN1627946A (ru)
AU (1) AU2002251409A1 (ru)
BR (1) BR0215686A (ru)
EA (1) EA200401335A1 (ru)
MX (1) MXPA04009821A (ru)
WO (1) WO2003084541A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003259391A1 (en) * 2003-08-25 2005-03-10 Ranbaxy Laboratories Limited Metabolites of 1-{3-4`4-(2-methoxyphenyl) piperazin-1-yl!-propyl}-piperidine-2, 6-dione for use in the treatment of benign prostatic hyperplasia
WO2005037281A1 (en) * 2003-10-15 2005-04-28 Ranbaxy Laboratories Limited 1-alkylpiperazinyl-pyrrolidin-2, 5-dione derivatives as adrenergic receptor antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL329190A1 (en) * 1996-04-05 1999-03-15 Sod Conseils Rech Applic Antagonists of alpha -adrenergic receptor
IT1293807B1 (it) * 1997-08-01 1999-03-10 Recordati Chem Pharm Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
US6083950A (en) * 1997-11-13 2000-07-04 Ranbaxy Laboratories Limited 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers
FR2781220B1 (fr) * 1998-07-17 2000-10-13 Lafon Labor Piperazinones substituees en beta

Also Published As

Publication number Publication date
AU2002251409A1 (en) 2003-10-20
CN1627946A (zh) 2005-06-15
EP1494674A1 (en) 2005-01-12
BR0215686A (pt) 2005-02-22
WO2003084541A1 (en) 2003-10-16
EP1494674A4 (en) 2006-04-12
JP2005532282A (ja) 2005-10-27
MXPA04009821A (es) 2004-12-13

Similar Documents

Publication Publication Date Title
EA200601766A1 (ru) Производные имидазола
EA200601555A1 (ru) Замещенные индазол-о-глюкозиды
ATE554087T1 (de) Neue kinaseinhibitoren
EA200601554A1 (ru) Замещенные индол-о-глюкозиды
DK1682530T3 (da) Pyrrolsubstituerede indoler som inhibitorer af PAI-1
EA200602100A1 (ru) Соединения и способы для ингибирования митотической прогрессии
ATE541571T1 (de) Diarylhydantoin-verbindung
BG66084B1 (bg) Циклопентаноиндоли, състави,съдържащи такива съединения и използването им
EA201100427A1 (ru) Гетероциклические ингибиторы киназы
EA200601553A1 (ru) Замещенные бензимидазол-, бензтриазол- и бензимидазолон-о-глюкозиды
EA200800374A1 (ru) 1,4-дигидропиридин-конденсированные гетероциклы, способы их получения, применение и содержащие их композиции
DE60230890D1 (de) Indolizine als kinaseproteinhemmer
EA200501928A1 (ru) Пирролодигидроизохинолины как ингибиторы pde10
ECSP067099A (es) Compuestos y métodos para inhibir la interacción de las proteínas bcl con los componentes de enlace
ATE484508T1 (de) Furylverbindungen
EA200702110A1 (ru) Ингибитор bcrp/abcg2
MX2010003365A (es) Derivados de tiazol para el tratamiento de cancer.
ATE510822T1 (de) Kaliumkanalinhibitoren
MXPA05013076A (es) Compuestos de isoindolina-1-ona como inhibidores de cinasa.
DK1373220T3 (da) Benzimidazoler, som er nyttige ved behandling af seksuel dysfunktion
DE602006006544D1 (de) Neue pyrrolodihydroisochinoline als pde10-inhibitoren
ATE410235T1 (de) Behandlung von ballastwasser
ATE443044T1 (de) Tace inhibitoren
EA200800203A1 (ru) Замещенные изотопами ингибиторы протонного насоса
DE602004018811D1 (de) Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren