EP1494674A4 - Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers - Google Patents

Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers

Info

Publication number
EP1494674A4
EP1494674A4 EP02720343A EP02720343A EP1494674A4 EP 1494674 A4 EP1494674 A4 EP 1494674A4 EP 02720343 A EP02720343 A EP 02720343A EP 02720343 A EP02720343 A EP 02720343A EP 1494674 A4 EP1494674 A4 EP 1494674A4
Authority
EP
European Patent Office
Prior art keywords
uro
useful
selective alpha
adrenoceptor blockers
carboximide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02720343A
Other languages
German (de)
French (fr)
Other versions
EP1494674A1 (en
Inventor
Mohammad Salman
Gyan Chand Yadav
Somesh Sharma
Gobind Singh Kapkoti
Anita Chugh
Jang Bahadur Gupta
Nitya Anand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of EP1494674A1 publication Critical patent/EP1494674A1/en
Publication of EP1494674A4 publication Critical patent/EP1494674A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP02720343A 2002-04-08 2002-04-08 Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers Withdrawn EP1494674A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2002/001108 WO2003084541A1 (en) 2002-04-08 2002-04-08 Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers

Publications (2)

Publication Number Publication Date
EP1494674A1 EP1494674A1 (en) 2005-01-12
EP1494674A4 true EP1494674A4 (en) 2006-04-12

Family

ID=28686909

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02720343A Withdrawn EP1494674A4 (en) 2002-04-08 2002-04-08 Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers

Country Status (8)

Country Link
EP (1) EP1494674A4 (en)
JP (1) JP2005532282A (en)
CN (1) CN1627946A (en)
AU (1) AU2002251409A1 (en)
BR (1) BR0215686A (en)
EA (1) EA200401335A1 (en)
MX (1) MXPA04009821A (en)
WO (1) WO2003084541A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003259391A1 (en) * 2003-08-25 2005-03-10 Ranbaxy Laboratories Limited Metabolites of 1-{3-4`4-(2-methoxyphenyl) piperazin-1-yl!-propyl}-piperidine-2, 6-dione for use in the treatment of benign prostatic hyperplasia
WO2005037281A1 (en) * 2003-10-15 2005-04-28 Ranbaxy Laboratories Limited 1-alkylpiperazinyl-pyrrolidin-2, 5-dione derivatives as adrenergic receptor antagonist

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037983A1 (en) * 1996-04-05 1997-10-16 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) α1-ADRENERGIC RECEPTOR ANTAGONISTS
WO1999006384A1 (en) * 1997-08-01 1999-02-11 Recordati S.A., Chemical And Pharmaceutical Company 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring
US6083950A (en) * 1997-11-13 2000-07-04 Ranbaxy Laboratories Limited 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2781220B1 (en) * 1998-07-17 2000-10-13 Lafon Labor SUBSTITUTED BETA PIPERAZINONES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037983A1 (en) * 1996-04-05 1997-10-16 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) α1-ADRENERGIC RECEPTOR ANTAGONISTS
WO1999006384A1 (en) * 1997-08-01 1999-02-11 Recordati S.A., Chemical And Pharmaceutical Company 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring
US6083950A (en) * 1997-11-13 2000-07-04 Ranbaxy Laboratories Limited 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO03084541A1 *

Also Published As

Publication number Publication date
AU2002251409A1 (en) 2003-10-20
EA200401335A1 (en) 2006-02-24
JP2005532282A (en) 2005-10-27
WO2003084541A1 (en) 2003-10-16
EP1494674A1 (en) 2005-01-12
MXPA04009821A (en) 2004-12-13
CN1627946A (en) 2005-06-15
BR0215686A (en) 2005-02-22

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