EA200400213A1 - Новые амиды карбоновых кислот - Google Patents

Новые амиды карбоновых кислот

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Publication number
EA200400213A1
EA200400213A1 EA200400213A EA200400213A EA200400213A1 EA 200400213 A1 EA200400213 A1 EA 200400213A1 EA 200400213 A EA200400213 A EA 200400213A EA 200400213 A EA200400213 A EA 200400213A EA 200400213 A1 EA200400213 A1 EA 200400213A1
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EA
Eurasian Patent Office
Prior art keywords
alkyl
group
oxo
carboxylic acid
formula
Prior art date
Application number
EA200400213A
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English (en)
Other versions
EA010162B1 (ru
Inventor
Дьёрдь Домань
Чилла Хорват
Шандор Фаркаш
Гишелла Бартаней Салаи
Йожеф Надь
Шандор Колок
Эва Ковачней Бозо
Иштван Борза
Иштван Ваго
Аттила Биелик
Дьёрди Игначней Сендрей
Дьёрдь Кешеру
Original Assignee
Рихтер Гедеон Ведьесети Дьяр Рт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from HU0103055A external-priority patent/HU226978B1/hu
Priority claimed from HU0202213A external-priority patent/HU225905B1/hu
Application filed by Рихтер Гедеон Ведьесети Дьяр Рт. filed Critical Рихтер Гедеон Ведьесети Дьяр Рт.
Publication of EA200400213A1 publication Critical patent/EA200400213A1/ru
Publication of EA010162B1 publication Critical patent/EA010162B1/ru

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    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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Abstract

Настоящее изобретение относится к новым производным амидов карбоновых кислот формулы (I)где оба -(CHR)- и -(CHR)- являются -CH-CH- группами; смежные V и U группы образуют вместе друг с другом и с одним или более идентичным или различным дополнительным гетероатомом и -CH= и/или -CH-группами необязательно замещенное 4-7-членное гомо- или гетероциклическое кольцо, предпочтительно морфолин, пиррол, пирролидин, оксо- или тиоксопирролидин, пиразол, пиразолидин, имидазол, имидазолидин, оксо- или тиоксоимидазол или имидазолидин, 1,4-оксазин, оксазол, оксазолидин, оксо- или тиоксооксазолидин или 3-оксо-1,4-оксазиновое кольцо; X является -CO- группой; W является -CO-, -CH- или -CH(-алкильной)- группой, где алкил является C-Cалкильной группой; Y является атомом кислорода, так же как C-Cалкиленом, C-Cалкиниленом, циклоалкиленом, аминокарбонилом, -NH-, -N(алкил)-, -CHO-, -CH(OH)-, -OCH-группой, где алкил является C-Cалкильной группой; Z является водородом или атомом галогена, нитро, амино, C-Cалкилом, C-Cалкокси, циано, трифторметилом, гидроксильной или карбоксильной группой; и к оптическим антиподам или рацематам и/или их фармацевтически приемлемым солям, образованным с кислотами и основаниями, а также к фармацевтическим композициям, содержащим производные амида карбоновой кислоты формулы (I) или их оптические антиподы или рацематы или соли, в качестве активных ингредиентов. Следующим объектом изобретения являются способы получения производных амидов карбоновых кислот формулы (I) и фармацевтическое производство лекарственных средств, содержащих эти соединения, так же как способ лечения при применении указанных соединений, включающий введение нуждающемуся в лечении млекопитающему, включая человека, эффективного количества/количеств
EA200400213A 2001-07-24 2002-07-23 Амидные производные карбоновых кислот EA010162B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0103055A HU226978B1 (en) 2001-07-24 2001-07-24 New carboxylic acid amide compounds, process for their preparation and pharmaceutical compositions containing them and their use
HU0202213A HU225905B1 (en) 2002-07-10 2002-07-10 Solid-supported parallel synthesis of new carboxylic acid amide derivatives
PCT/HU2002/000071 WO2003010159A1 (en) 2001-07-24 2002-07-23 Piperidine derivatives as nmda receptor antagonists

Publications (2)

Publication Number Publication Date
EA200400213A1 true EA200400213A1 (ru) 2004-08-26
EA010162B1 EA010162B1 (ru) 2008-06-30

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EA200400213A EA010162B1 (ru) 2001-07-24 2002-07-23 Амидные производные карбоновых кислот

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EP (1) EP1409477B1 (ru)
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IL159393A0 (en) 2004-06-01
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