EA200300597A1 - Бифенилкарбоксамиды, полезные в качестве снижающих содержание липидов агентов - Google Patents

Бифенилкарбоксамиды, полезные в качестве снижающих содержание липидов агентов

Info

Publication number
EA200300597A1
EA200300597A1 EA200300597A EA200300597A EA200300597A1 EA 200300597 A1 EA200300597 A1 EA 200300597A1 EA 200300597 A EA200300597 A EA 200300597A EA 200300597 A EA200300597 A EA 200300597A EA 200300597 A1 EA200300597 A1 EA 200300597A1
Authority
EA
Eurasian Patent Office
Prior art keywords
biphenylkarboxamides
lipids
useful
agent
reducing content
Prior art date
Application number
EA200300597A
Other languages
English (en)
Other versions
EA006101B1 (ru
Inventor
Ливен Мерпул
Лео Якобус Йозеф Бакс
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200300597A1 publication Critical patent/EA200300597A1/ru
Publication of EA006101B1 publication Critical patent/EA006101B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Соединения бифенилкарбоксамида формулы (I), способы получения указанных соединений, фармацевтических композиций, включающих указанные соединения, а также применения указанных соединений для лечения гиперлипемии, ожирения и диабета II типа.Отчет о международном поиске был опубликован 2002.11.21.
EA200300597A 2000-11-21 2001-11-15 Бифенилкарбоксамиды, полезные в качестве снижающих содержание липидов агентов EA006101B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00204150 2000-11-21
PCT/EP2001/013316 WO2002042271A2 (en) 2000-11-21 2001-11-15 Biphenylcarboxamides useful as lipid lowering agents

Publications (2)

Publication Number Publication Date
EA200300597A1 true EA200300597A1 (ru) 2003-10-30
EA006101B1 EA006101B1 (ru) 2005-08-25

Family

ID=8172315

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300597A EA006101B1 (ru) 2000-11-21 2001-11-15 Бифенилкарбоксамиды, полезные в качестве снижающих содержание липидов агентов

Country Status (32)

Country Link
US (5) US7135586B2 (ru)
EP (1) EP1339685B1 (ru)
JP (1) JP4190283B2 (ru)
KR (1) KR20030051718A (ru)
CN (1) CN1289481C (ru)
AR (1) AR035072A1 (ru)
AT (1) ATE344243T1 (ru)
AU (2) AU2002219115B2 (ru)
BG (1) BG107805A (ru)
CA (1) CA2427660C (ru)
CZ (1) CZ20031638A3 (ru)
DE (1) DE60124296T2 (ru)
DK (1) DK1339685T3 (ru)
EA (1) EA006101B1 (ru)
EE (1) EE200300234A (ru)
ES (1) ES2275759T3 (ru)
GC (1) GC0000312A (ru)
HK (1) HK1073310A1 (ru)
HU (1) HUP0400926A3 (ru)
IL (2) IL155945A0 (ru)
JO (1) JO2409B1 (ru)
MX (1) MXPA03004465A (ru)
MY (1) MY134167A (ru)
NO (1) NO20032272D0 (ru)
NZ (1) NZ526495A (ru)
PA (1) PA8532001A1 (ru)
PL (1) PL205290B1 (ru)
PT (1) PT1339685E (ru)
SI (1) SI1339685T1 (ru)
SK (1) SK7522003A3 (ru)
WO (1) WO2002042271A2 (ru)
ZA (1) ZA200303910B (ru)

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JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
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US20040102490A1 (en) 2004-05-27
US7135586B2 (en) 2006-11-14
WO2002042271A3 (en) 2002-11-21
DE60124296T2 (de) 2007-05-31
AR035072A1 (es) 2004-04-14
JP4190283B2 (ja) 2008-12-03
DE60124296D1 (de) 2006-12-14
US20080009522A1 (en) 2008-01-10
AU1911502A (en) 2002-06-03
PL205290B1 (pl) 2010-03-31
IL155945A (en) 2009-06-15
CA2427660C (en) 2010-01-19
MXPA03004465A (es) 2003-08-19
HUP0400926A2 (hu) 2004-07-28
SK7522003A3 (en) 2004-04-06
MY134167A (en) 2007-11-30
DK1339685T3 (da) 2007-03-12
SI1339685T1 (sl) 2007-04-30
US7244848B2 (en) 2007-07-17
GC0000312A (en) 2006-11-01
NZ526495A (en) 2004-06-25
KR20030051718A (ko) 2003-06-25
CZ20031638A3 (cs) 2004-02-18
US20060128972A1 (en) 2006-06-15
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US20060128973A1 (en) 2006-06-15
PA8532001A1 (es) 2002-10-28
EP1339685B1 (en) 2006-11-02
EA006101B1 (ru) 2005-08-25
WO2002042271A2 (en) 2002-05-30
NO20032272L (no) 2003-05-20
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CA2427660A1 (en) 2002-05-30
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BG107805A (bg) 2004-01-30
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HUP0400926A3 (en) 2008-03-28
US7538124B2 (en) 2009-05-26
ATE344243T1 (de) 2006-11-15
AU2002219115B2 (en) 2007-01-04
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JO2409B1 (en) 2007-06-17
IL155945A0 (en) 2003-12-23

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