EA200300595A1 - Соединения пиперазинилпиразинов в качестве антагонистов серотонин 5-ht2 рецептора - Google Patents

Соединения пиперазинилпиразинов в качестве антагонистов серотонин 5-ht2 рецептора

Info

Publication number
EA200300595A1
EA200300595A1 EA200300595A EA200300595A EA200300595A1 EA 200300595 A1 EA200300595 A1 EA 200300595A1 EA 200300595 A EA200300595 A EA 200300595A EA 200300595 A EA200300595 A EA 200300595A EA 200300595 A1 EA200300595 A1 EA 200300595A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
receptor
piperasinylpirasin
serotonin
antagonists serotonin
Prior art date
Application number
EA200300595A
Other languages
English (en)
Other versions
EA005975B1 (ru
Inventor
Бьерн М. Нильссон
Мартин Скоби
Original Assignee
Биовитрум Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0004244A external-priority patent/SE0004244D0/xx
Application filed by Биовитрум Аб filed Critical Биовитрум Аб
Publication of EA200300595A1 publication Critical patent/EA200300595A1/ru
Publication of EA005975B1 publication Critical patent/EA005975B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Данное изобретение относится к соединениям общей формулы (I), в которой R, Rи Rтакие, как даны в описании, где соединения являются лигандами серотонин 5-HTрецептора.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300595A 2000-11-20 2001-11-20 Соединения пиперазинилпиразинов в качестве антагонистов серотонин 5-ht2 рецептора EA005975B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0004244A SE0004244D0 (sv) 2000-11-20 2000-11-20 Novel compounds and their use
US25370200P 2000-11-28 2000-11-28
PCT/SE2001/002570 WO2002040457A1 (en) 2000-11-20 2001-11-20 Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor

Publications (2)

Publication Number Publication Date
EA200300595A1 true EA200300595A1 (ru) 2003-10-30
EA005975B1 EA005975B1 (ru) 2005-08-25

Family

ID=26655310

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300595A EA005975B1 (ru) 2000-11-20 2001-11-20 Соединения пиперазинилпиразинов в качестве антагонистов серотонин 5-ht2 рецептора

Country Status (19)

Country Link
EP (1) EP1337518B1 (ru)
JP (1) JP4204315B2 (ru)
KR (1) KR100831909B1 (ru)
CN (1) CN1227237C (ru)
AT (1) ATE433962T1 (ru)
AU (1) AU1529402A (ru)
BR (1) BR0115436A (ru)
CA (2) CA2449899C (ru)
DE (1) DE60139021D1 (ru)
DK (1) DK1337518T3 (ru)
EA (1) EA005975B1 (ru)
ES (1) ES2328671T3 (ru)
HK (1) HK1066810A1 (ru)
IL (2) IL155875A0 (ru)
MX (1) MXPA03004391A (ru)
NO (1) NO325321B1 (ru)
NZ (1) NZ525699A (ru)
PL (1) PL360982A1 (ru)
WO (1) WO2002040457A1 (ru)

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Also Published As

Publication number Publication date
CA2449899C (en) 2010-04-06
CA2449899A1 (en) 2002-05-23
BR0115436A (pt) 2004-01-06
WO2002040457A1 (en) 2002-05-23
CN1227237C (zh) 2005-11-16
DK1337518T3 (da) 2009-10-19
IL155875A0 (en) 2003-12-23
HK1066810A1 (en) 2005-04-01
AU1529402A (en) 2002-05-27
ES2328671T3 (es) 2009-11-17
NO20032253D0 (no) 2003-05-19
EA005975B1 (ru) 2005-08-25
JP2004531465A (ja) 2004-10-14
EP1337518A1 (en) 2003-08-27
MXPA03004391A (es) 2004-05-31
IL155875A (en) 2007-06-17
NO325321B1 (no) 2008-03-31
KR100831909B1 (ko) 2008-05-26
NO20032253L (no) 2003-07-18
EP1337518B1 (en) 2009-06-17
NZ525699A (en) 2005-03-24
CN1520404A (zh) 2004-08-11
JP4204315B2 (ja) 2009-01-07
CA2428905A1 (en) 2002-05-23
ATE433962T1 (de) 2009-07-15
PL360982A1 (en) 2004-09-20
DE60139021D1 (de) 2009-07-30
KR20030060946A (ko) 2003-07-16

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