EA200300187A1 - METHOD FOR OBTAINING N-ARYLANTRANIL ACIDS AND THEIR DERIVATIVES - Google Patents
METHOD FOR OBTAINING N-ARYLANTRANIL ACIDS AND THEIR DERIVATIVESInfo
- Publication number
- EA200300187A1 EA200300187A1 EA200300187A EA200300187A EA200300187A1 EA 200300187 A1 EA200300187 A1 EA 200300187A1 EA 200300187 A EA200300187 A EA 200300187A EA 200300187 A EA200300187 A EA 200300187A EA 200300187 A1 EA200300187 A1 EA 200300187A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- acids
- arylantranil
- derivatives
- obtaining
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Abstract
Настоящее изобретение относится к способу получения N-арилантраниловых кислот и к способу получения N-арилантраниловых сложных эфиров, амидов и гидроксамовых сложных эфиров.Международная заявка была опубликована вместе с отчетом о международном поиске.The present invention relates to a method for producing N-arylanthranilic acids and to a method for producing N-arylanthranyl esters, amides, and hydroxamic esters.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22820600P | 2000-08-25 | 2000-08-25 | |
PCT/US2001/022948 WO2002018319A1 (en) | 2000-08-25 | 2001-07-20 | Process for making n-aryl-anthranilic acids and their derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200300187A1 true EA200300187A1 (en) | 2003-08-28 |
Family
ID=22856235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200300187A EA200300187A1 (en) | 2000-08-25 | 2001-07-20 | METHOD FOR OBTAINING N-ARYLANTRANIL ACIDS AND THEIR DERIVATIVES |
Country Status (31)
Country | Link |
---|---|
EP (1) | EP1313694A1 (en) |
JP (1) | JP2004507518A (en) |
KR (1) | KR20030059115A (en) |
CN (1) | CN1458921A (en) |
AP (1) | AP2001002249A0 (en) |
AR (1) | AR032175A1 (en) |
AU (1) | AU2001277044A1 (en) |
BG (1) | BG107635A (en) |
BR (1) | BR0113520A (en) |
CA (1) | CA2420003A1 (en) |
CZ (1) | CZ2003477A3 (en) |
DO (1) | DOP2001000238A (en) |
EA (1) | EA200300187A1 (en) |
GT (1) | GT200100174A (en) |
HN (1) | HN2001000216A (en) |
HU (1) | HUP0300828A2 (en) |
IL (1) | IL154507A0 (en) |
IS (1) | IS6724A (en) |
MA (1) | MA26949A1 (en) |
MX (1) | MXPA03001654A (en) |
NO (1) | NO20030844L (en) |
PA (1) | PA8526501A1 (en) |
PE (1) | PE20020393A1 (en) |
PL (1) | PL360699A1 (en) |
SK (1) | SK2072003A3 (en) |
SV (1) | SV2002000601A (en) |
TN (1) | TNSN01127A1 (en) |
UY (1) | UY26908A1 (en) |
WO (1) | WO2002018319A1 (en) |
YU (1) | YU14303A (en) |
ZA (1) | ZA200301182B (en) |
Families Citing this family (37)
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US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
PL401637A1 (en) | 2002-03-13 | 2013-05-27 | Array Biopharma Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
KR101013932B1 (en) | 2003-10-21 | 2011-02-14 | 워너-램버트 캄파니 엘엘씨 | Polymorphic form of n-[r-2,3-dihydroxy-propoxy]-3,4-difluoro-2-2-fluoro-4-iodophenylamino-benzamide |
US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
WO2005051302A2 (en) | 2003-11-19 | 2005-06-09 | Array Biopharma Inc. | Bicyclic inhibitors of mek and methods of use thereof |
WO2005051304A2 (en) | 2003-11-21 | 2005-06-09 | Array Biopharma Inc. | Akt protein kinase inhibitors |
UA89035C2 (en) * | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Hydroxamic acid esters and pharmaceutical use thereof |
MX2007012659A (en) | 2005-04-13 | 2008-01-11 | Astex Therapeutics Ltd | Hydroxybenzamide derivatives and their use as inhibitors of hsp90. |
KR20080019236A (en) | 2005-05-18 | 2008-03-03 | 어레이 바이오파마 인크. | Heterocyclic inhibitors of mek and methods of use thereof |
US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
SI2054418T1 (en) | 2006-07-06 | 2012-02-29 | Array Biopharma Inc | Dihydrothieno pyrimidines as akt protein kinase inhibitors |
ATE493418T1 (en) | 2006-07-06 | 2011-01-15 | Array Biopharma Inc | DIHYDROFUROPYRIMIDINES AS ACT PROTEIN KINASE INHIBITORS |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
BRPI0713555A2 (en) | 2006-07-06 | 2012-03-20 | Array Biopharma, Inc. | cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
EP2073803B1 (en) | 2006-10-12 | 2018-09-19 | Astex Therapeutics Limited | Pharmaceutical combinations |
US8277807B2 (en) | 2006-10-12 | 2012-10-02 | Astex Therapeutics Limited | Pharmaceutical combinations |
EP2073804B1 (en) | 2006-10-12 | 2017-09-13 | Astex Therapeutics Limited | Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain |
GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
EP2081891A2 (en) | 2006-10-12 | 2009-07-29 | Astex Therapeutics Limited | Pharmaceutical compounds having hsp90 inhibitory or modulating activity |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
KR20150089099A (en) | 2007-07-05 | 2015-08-04 | 어레이 바이오파마 인크. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
CN101918373B (en) | 2007-07-05 | 2013-06-05 | 阵列生物制药公司 | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
WO2009089453A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
JP5346345B2 (en) | 2008-01-09 | 2013-11-20 | アレイ バイオファーマ、インコーポレイテッド | Hydroxylated pyrimidylcyclopentanes as AKT protein kinase inhibitors |
GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
CN101985428B (en) * | 2009-07-29 | 2014-02-12 | 杭州民生药业有限公司 | O-anilino benzoic acid derivatives or pharmaceutically acceptable salts thereof as well as preparation method and application thereof |
JP2013519714A (en) * | 2010-02-19 | 2013-05-30 | センター ナショナル デ ラ リシェルシェ サイエンティフィック | Process for the preparation of desired chemical compounds by aromatic nucleophilic substitution |
WO2011101604A1 (en) * | 2010-02-19 | 2011-08-25 | Centre National De La Recherche Scientifique | Method for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group |
CN107233343A (en) | 2011-04-01 | 2017-10-10 | 基因泰克公司 | The combination of AKT inhibitor compounds and chemotherapeutics and application method |
EP2694073B1 (en) | 2011-04-01 | 2018-08-08 | Genentech, Inc. | Combinations of akt and mek inhibitors for treating cancer |
SI2909188T1 (en) * | 2012-10-12 | 2018-07-31 | Exelixis, Inc. | Novel process for making compounds for use in the treatment of cancer |
CN112745237B (en) * | 2019-10-29 | 2023-06-20 | 中国科学院上海药物研究所 | 2-arylamine compound and preparation method and application thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3138636A (en) * | 1960-06-23 | 1964-06-23 | Parke Davis & Co | Anthranilic acid derivatives |
WO1998037881A1 (en) * | 1997-02-28 | 1998-09-03 | Warner Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
PT993439E (en) * | 1997-07-01 | 2004-12-31 | Warner Lambert Co | 4-BROMINE OR 4-IODOPHENYLAMINOBENZYDROXYM ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS |
NZ501277A (en) * | 1997-07-01 | 2002-12-20 | Warner Lambert Co | -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
CA2348236A1 (en) * | 1999-01-13 | 2000-07-20 | Stephen Douglas Barrett | 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors |
GEP20033089B (en) * | 1999-04-21 | 2003-10-27 | Warner Lambert Co | Method for Making 2-(N-Phenyl-amino) Benzoic Acids |
-
2001
- 2001-07-20 AP APAP/P/2001/002249A patent/AP2001002249A0/en unknown
- 2001-07-20 YU YU14303A patent/YU14303A/en unknown
- 2001-07-20 JP JP2002523437A patent/JP2004507518A/en active Pending
- 2001-07-20 AU AU2001277044A patent/AU2001277044A1/en not_active Abandoned
- 2001-07-20 BR BR0113520-1A patent/BR0113520A/en not_active Application Discontinuation
- 2001-07-20 SK SK207-2003A patent/SK2072003A3/en unknown
- 2001-07-20 EP EP01954824A patent/EP1313694A1/en not_active Withdrawn
- 2001-07-20 KR KR10-2003-7002675A patent/KR20030059115A/en not_active Application Discontinuation
- 2001-07-20 EA EA200300187A patent/EA200300187A1/en unknown
- 2001-07-20 WO PCT/US2001/022948 patent/WO2002018319A1/en not_active Application Discontinuation
- 2001-07-20 HU HU0300828A patent/HUP0300828A2/en unknown
- 2001-07-20 CZ CZ2003477A patent/CZ2003477A3/en unknown
- 2001-07-20 CA CA002420003A patent/CA2420003A1/en not_active Abandoned
- 2001-07-20 CN CN01815869A patent/CN1458921A/en active Pending
- 2001-07-20 IL IL15450701A patent/IL154507A0/en unknown
- 2001-07-20 MX MXPA03001654A patent/MXPA03001654A/en unknown
- 2001-07-20 PL PL36069901A patent/PL360699A1/en unknown
- 2001-08-15 SV SV2001000601A patent/SV2002000601A/en not_active Application Discontinuation
- 2001-08-22 TN TNTNSN01127A patent/TNSN01127A1/en unknown
- 2001-08-23 PA PA20018526501A patent/PA8526501A1/en unknown
- 2001-08-24 DO DO2001000238A patent/DOP2001000238A/en unknown
- 2001-08-24 UY UY26908A patent/UY26908A1/en not_active Application Discontinuation
- 2001-08-24 PE PE2001000853A patent/PE20020393A1/en not_active Application Discontinuation
- 2001-08-24 GT GT200100174A patent/GT200100174A/en unknown
- 2001-08-24 AR ARP010104047A patent/AR032175A1/en unknown
- 2001-09-26 HN HN2001000216A patent/HN2001000216A/en unknown
-
2003
- 2003-02-12 ZA ZA200301182A patent/ZA200301182B/en unknown
- 2003-02-20 IS IS6724A patent/IS6724A/en unknown
- 2003-02-24 NO NO20030844A patent/NO20030844L/en not_active Application Discontinuation
- 2003-03-13 BG BG107635A patent/BG107635A/en unknown
- 2003-03-14 MA MA27069A patent/MA26949A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA03001654A (en) | 2004-09-10 |
TNSN01127A1 (en) | 2005-11-10 |
NO20030844L (en) | 2003-02-25 |
CZ2003477A3 (en) | 2003-10-15 |
PE20020393A1 (en) | 2002-05-09 |
PL360699A1 (en) | 2004-09-20 |
ZA200301182B (en) | 2004-05-12 |
AR032175A1 (en) | 2003-10-29 |
BR0113520A (en) | 2003-06-24 |
EP1313694A1 (en) | 2003-05-28 |
DOP2001000238A (en) | 2003-01-31 |
AP2001002249A0 (en) | 2001-09-30 |
NO20030844D0 (en) | 2003-02-24 |
IS6724A (en) | 2003-02-20 |
UY26908A1 (en) | 2001-11-30 |
BG107635A (en) | 2004-09-30 |
KR20030059115A (en) | 2003-07-07 |
HUP0300828A2 (en) | 2003-09-29 |
WO2002018319A1 (en) | 2002-03-07 |
PA8526501A1 (en) | 2002-07-30 |
AU2001277044A1 (en) | 2002-03-13 |
SK2072003A3 (en) | 2004-01-08 |
IL154507A0 (en) | 2003-09-17 |
CA2420003A1 (en) | 2002-03-07 |
GT200100174A (en) | 2002-07-18 |
YU14303A (en) | 2006-08-17 |
HN2001000216A (en) | 2002-05-22 |
SV2002000601A (en) | 2002-04-03 |
MA26949A1 (en) | 2004-12-20 |
CN1458921A (en) | 2003-11-26 |
JP2004507518A (en) | 2004-03-11 |
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