EA200101108A1 - Полиморфные модификации кристаллического цитрата азабицикло[2.2.2]октан-3-амина и их фармацевтические композиции - Google Patents

Полиморфные модификации кристаллического цитрата азабицикло[2.2.2]октан-3-амина и их фармацевтические композиции

Info

Publication number
EA200101108A1
EA200101108A1 EA200101108A EA200101108A EA200101108A1 EA 200101108 A1 EA200101108 A1 EA 200101108A1 EA 200101108 A EA200101108 A EA 200101108A EA 200101108 A EA200101108 A EA 200101108A EA 200101108 A1 EA200101108 A1 EA 200101108A1
Authority
EA
Eurasian Patent Office
Prior art keywords
azabicyclo
amine
pharmaceutical composition
oktan
pharmaceutical compositions
Prior art date
Application number
EA200101108A
Other languages
English (en)
Other versions
EA003731B1 (ru
Inventor
Майкл Джеймс Касталди
Джордж Джозеф Куоллич
Льюин Теофилус Уинт
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200101108A1 publication Critical patent/EA200101108A1/ru
Publication of EA003731B1 publication Critical patent/EA003731B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Единственная кристаллическая полиморфная форма цитрата (2S,3S)-N-(метокси-5-трет-бутилфенилметил-2-дифенилметил-1-азабицикло[2.2.2]октан-3-амина (моногидрат цитрата) и его фармацевтическая композиция. Фармацевтическая композиция полиморфной формы, если моногидрат цитрата имеет полезную стабильность для приготовления препаратов для лечения рвоты. Введение этой фармацевтической композиции осуществляют в пероральной лекарственной форме с немедленным высвобождением, предпочтительно с помощью таблетки или капсулы либо внутривенно.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200101108A 1999-06-01 2000-05-18 Стабильная полиморфная форма кристаллического моногидрата цитрата (2s,3s)-n-(2-метокси-5-трет-бутилфенил)метил-2-дифенилметил-1-азабицикло[2.2.2]октан-3-амина и фармацевтическая композиция на её основе EA003731B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13699299P 1999-06-01 1999-06-01
PCT/IB2000/000665 WO2000073304A1 (en) 1999-06-01 2000-05-18 Polymorphs of a crystalline azabicyclo (2,2,2) octan-3-amine citrate and their pharmaceutical compositions

Publications (2)

Publication Number Publication Date
EA200101108A1 true EA200101108A1 (ru) 2002-04-25
EA003731B1 EA003731B1 (ru) 2003-08-28

Family

ID=22475338

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200101108A EA003731B1 (ru) 1999-06-01 2000-05-18 Стабильная полиморфная форма кристаллического моногидрата цитрата (2s,3s)-n-(2-метокси-5-трет-бутилфенил)метил-2-дифенилметил-1-азабицикло[2.2.2]октан-3-амина и фармацевтическая композиция на её основе

Country Status (49)

Country Link
US (1) US6255320B1 (ru)
EP (1) EP1181290B1 (ru)
JP (1) JP3830816B2 (ru)
KR (1) KR100476606B1 (ru)
CN (1) CN1146565C (ru)
AP (1) AP2001002349A0 (ru)
AR (1) AR033331A1 (ru)
AT (1) ATE244239T1 (ru)
AU (1) AU767334B2 (ru)
BG (1) BG65240B1 (ru)
BR (1) BR0011094A (ru)
CA (1) CA2372238C (ru)
CO (1) CO5170463A1 (ru)
CY (1) CY2007011I1 (ru)
CZ (1) CZ295819B6 (ru)
DE (1) DE60003679T2 (ru)
DK (1) DK1181290T3 (ru)
DZ (1) DZ3050A1 (ru)
EA (1) EA003731B1 (ru)
EC (1) ECSP003508A (ru)
EE (1) EE200100656A (ru)
ES (1) ES2199825T3 (ru)
GT (1) GT200000087A (ru)
HK (1) HK1046284A1 (ru)
HN (1) HN2000000077A (ru)
HR (1) HRP20010904A2 (ru)
HU (1) HUP0201301A3 (ru)
IL (1) IL146406A0 (ru)
MA (1) MA26742A1 (ru)
MX (1) MXPA01012325A (ru)
MY (1) MY133508A (ru)
NO (1) NO20015848L (ru)
NZ (1) NZ515349A (ru)
OA (1) OA11956A (ru)
PA (1) PA8496101A1 (ru)
PE (1) PE20010209A1 (ru)
PL (1) PL196046B1 (ru)
PT (1) PT1181290E (ru)
SI (1) SI1181290T1 (ru)
SK (1) SK285820B6 (ru)
SV (1) SV2001000093A (ru)
TN (1) TNSN00120A1 (ru)
TR (1) TR200103473T2 (ru)
TW (1) TWI285204B (ru)
UA (1) UA66925C2 (ru)
UY (1) UY26176A1 (ru)
WO (1) WO2000073304A1 (ru)
YU (1) YU81101A (ru)
ZA (1) ZA200109775B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005216707A1 (en) * 2004-01-30 2005-09-09 Pfizer Products Inc. Pharmaceutical compositions of neurokinin receptor antagonists and cyclodextrin and methods for improved injection site toleration
US8183230B2 (en) * 2004-01-30 2012-05-22 Pfizer Inc. Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms
MXPA06007964A (es) * 2004-01-30 2007-01-26 Pfizer Prod Inc Antagonistas del receptor nk-1 para mejorar la recuperacion de anestesia.
DE602005003791T2 (de) * 2004-02-02 2008-05-29 Pfizer Products Inc., Groton Verfahren zur herstellung von 1-(2s,3s)-2-benzhydril-n-(5-tert.-butyl-2-methoxybenzyl)chinuklidin-3-amin
RU2696582C2 (ru) * 2013-03-15 2019-08-05 Перл Терапьютикс, Инк. Способы и системы кондиционирования дисперсных кристаллических материалов
CN110577522B (zh) * 2018-06-07 2022-12-27 东莞市东阳光动物保健药品有限公司 马罗匹坦柠檬酸盐新晶型及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL171379B1 (en) * 1991-05-31 1997-04-30 Pfizer Method of obtaining novel derivatives of quinuclidine
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
US5576317A (en) * 1994-12-09 1996-11-19 Pfizer Inc. NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis

Also Published As

Publication number Publication date
EP1181290B1 (en) 2003-07-02
CA2372238A1 (en) 2000-12-07
PL196046B1 (pl) 2007-11-30
ES2199825T3 (es) 2004-03-01
NZ515349A (en) 2004-03-26
SV2001000093A (es) 2001-11-08
EA003731B1 (ru) 2003-08-28
GT200000087A (es) 2001-11-22
KR20020010688A (ko) 2002-02-04
AR033331A1 (es) 2003-12-17
ZA200109775B (en) 2002-11-28
BG106204A (en) 2002-07-31
AU4424800A (en) 2000-12-18
CY2007011I2 (el) 2010-07-28
EP1181290A1 (en) 2002-02-27
CN1146565C (zh) 2004-04-21
DK1181290T3 (da) 2003-09-29
MY133508A (en) 2007-11-30
TR200103473T2 (tr) 2002-04-22
WO2000073304A1 (en) 2000-12-07
SI1181290T1 (en) 2003-12-31
NO20015848D0 (no) 2001-11-30
CY2007011I1 (el) 2010-07-28
CZ295819B6 (cs) 2005-11-16
IL146406A0 (en) 2002-07-25
HK1046284A1 (en) 2003-01-03
BG65240B1 (bg) 2007-09-28
SK285820B6 (sk) 2007-09-06
CO5170463A1 (es) 2002-06-27
BR0011094A (pt) 2002-03-19
OA11956A (en) 2006-04-13
PE20010209A1 (es) 2001-03-01
HUP0201301A3 (en) 2002-10-28
AU767334B2 (en) 2003-11-06
DE60003679T2 (de) 2004-05-27
CA2372238C (en) 2006-12-19
JP3830816B2 (ja) 2006-10-11
HN2000000077A (es) 2001-02-02
AP2001002349A0 (en) 2001-12-31
PA8496101A1 (es) 2002-07-30
HRP20010904A2 (en) 2003-02-28
NO20015848L (no) 2001-12-18
US6255320B1 (en) 2001-07-03
SK17332001A3 (sk) 2002-07-02
PL352716A1 (en) 2003-09-08
MXPA01012325A (es) 2002-07-22
DE60003679D1 (de) 2003-08-07
CN1353711A (zh) 2002-06-12
KR100476606B1 (ko) 2005-03-18
EE200100656A (et) 2003-02-17
TWI285204B (en) 2007-08-11
HUP0201301A2 (en) 2002-08-28
UY26176A1 (es) 2000-12-29
DZ3050A1 (fr) 2004-03-27
TNSN00120A1 (fr) 2005-11-10
JP2003501354A (ja) 2003-01-14
UA66925C2 (ru) 2004-06-15
YU81101A (sh) 2004-07-15
CZ20014269A3 (cs) 2002-04-17
PT1181290E (pt) 2003-09-30
MA26742A1 (fr) 2004-12-20
ATE244239T1 (de) 2003-07-15
ECSP003508A (es) 2002-02-25

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