EA200101108A1 - Полиморфные модификации кристаллического цитрата азабицикло[2.2.2]октан-3-амина и их фармацевтические композиции - Google Patents
Полиморфные модификации кристаллического цитрата азабицикло[2.2.2]октан-3-амина и их фармацевтические композицииInfo
- Publication number
- EA200101108A1 EA200101108A1 EA200101108A EA200101108A EA200101108A1 EA 200101108 A1 EA200101108 A1 EA 200101108A1 EA 200101108 A EA200101108 A EA 200101108A EA 200101108 A EA200101108 A EA 200101108A EA 200101108 A1 EA200101108 A1 EA 200101108A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- azabicyclo
- amine
- pharmaceutical composition
- oktan
- pharmaceutical compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Единственная кристаллическая полиморфная форма цитрата (2S,3S)-N-(метокси-5-трет-бутилфенилметил-2-дифенилметил-1-азабицикло[2.2.2]октан-3-амина (моногидрат цитрата) и его фармацевтическая композиция. Фармацевтическая композиция полиморфной формы, если моногидрат цитрата имеет полезную стабильность для приготовления препаратов для лечения рвоты. Введение этой фармацевтической композиции осуществляют в пероральной лекарственной форме с немедленным высвобождением, предпочтительно с помощью таблетки или капсулы либо внутривенно.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13699299P | 1999-06-01 | 1999-06-01 | |
PCT/IB2000/000665 WO2000073304A1 (en) | 1999-06-01 | 2000-05-18 | Polymorphs of a crystalline azabicyclo (2,2,2) octan-3-amine citrate and their pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200101108A1 true EA200101108A1 (ru) | 2002-04-25 |
EA003731B1 EA003731B1 (ru) | 2003-08-28 |
Family
ID=22475338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200101108A EA003731B1 (ru) | 1999-06-01 | 2000-05-18 | Стабильная полиморфная форма кристаллического моногидрата цитрата (2s,3s)-n-(2-метокси-5-трет-бутилфенил)метил-2-дифенилметил-1-азабицикло[2.2.2]октан-3-амина и фармацевтическая композиция на её основе |
Country Status (49)
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005216707A1 (en) * | 2004-01-30 | 2005-09-09 | Pfizer Products Inc. | Pharmaceutical compositions of neurokinin receptor antagonists and cyclodextrin and methods for improved injection site toleration |
US8183230B2 (en) * | 2004-01-30 | 2012-05-22 | Pfizer Inc. | Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms |
MXPA06007964A (es) * | 2004-01-30 | 2007-01-26 | Pfizer Prod Inc | Antagonistas del receptor nk-1 para mejorar la recuperacion de anestesia. |
DE602005003791T2 (de) * | 2004-02-02 | 2008-05-29 | Pfizer Products Inc., Groton | Verfahren zur herstellung von 1-(2s,3s)-2-benzhydril-n-(5-tert.-butyl-2-methoxybenzyl)chinuklidin-3-amin |
RU2696582C2 (ru) * | 2013-03-15 | 2019-08-05 | Перл Терапьютикс, Инк. | Способы и системы кондиционирования дисперсных кристаллических материалов |
CN110577522B (zh) * | 2018-06-07 | 2022-12-27 | 东莞市东阳光动物保健药品有限公司 | 马罗匹坦柠檬酸盐新晶型及其制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL171379B1 (en) * | 1991-05-31 | 1997-04-30 | Pfizer | Method of obtaining novel derivatives of quinuclidine |
US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
US5576317A (en) * | 1994-12-09 | 1996-11-19 | Pfizer Inc. | NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis |
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2000
- 2000-05-08 US US09/566,307 patent/US6255320B1/en not_active Expired - Lifetime
- 2000-05-17 HN HN2000000077A patent/HN2000000077A/es unknown
- 2000-05-18 MX MXPA01012325A patent/MXPA01012325A/es unknown
- 2000-05-18 WO PCT/IB2000/000665 patent/WO2000073304A1/en active IP Right Grant
- 2000-05-18 IL IL14640600A patent/IL146406A0/xx not_active IP Right Cessation
- 2000-05-18 EP EP00925528A patent/EP1181290B1/en not_active Expired - Lifetime
- 2000-05-18 NZ NZ515349A patent/NZ515349A/xx unknown
- 2000-05-18 CA CA002372238A patent/CA2372238C/en not_active Expired - Lifetime
- 2000-05-18 AP APAP/P/2001/002349A patent/AP2001002349A0/en unknown
- 2000-05-18 ES ES00925528T patent/ES2199825T3/es not_active Expired - Lifetime
- 2000-05-18 CN CNB008082782A patent/CN1146565C/zh not_active Expired - Lifetime
- 2000-05-18 KR KR10-2001-7015494A patent/KR100476606B1/ko not_active IP Right Cessation
- 2000-05-18 PL PL00352716A patent/PL196046B1/pl not_active IP Right Cessation
- 2000-05-18 YU YU81101A patent/YU81101A/sh unknown
- 2000-05-18 OA OA1200100318A patent/OA11956A/en unknown
- 2000-05-18 EA EA200101108A patent/EA003731B1/ru active Protection Beyond IP Right Term
- 2000-05-18 TR TR2001/03473T patent/TR200103473T2/xx unknown
- 2000-05-18 PT PT00925528T patent/PT1181290E/pt unknown
- 2000-05-18 AT AT00925528T patent/ATE244239T1/de not_active IP Right Cessation
- 2000-05-18 SI SI200030161T patent/SI1181290T1/xx unknown
- 2000-05-18 DK DK00925528T patent/DK1181290T3/da active
- 2000-05-18 EE EEP200100656A patent/EE200100656A/xx unknown
- 2000-05-18 CZ CZ20014269A patent/CZ295819B6/cs not_active IP Right Cessation
- 2000-05-18 UA UA2001118214A patent/UA66925C2/ru unknown
- 2000-05-18 AU AU44248/00A patent/AU767334B2/en not_active Expired
- 2000-05-18 BR BR0011094-9A patent/BR0011094A/pt not_active Application Discontinuation
- 2000-05-18 HU HU0201301A patent/HUP0201301A3/hu unknown
- 2000-05-18 SK SK1733-2001A patent/SK285820B6/sk not_active IP Right Cessation
- 2000-05-18 DE DE60003679T patent/DE60003679T2/de not_active Expired - Lifetime
- 2000-05-18 JP JP2001500629A patent/JP3830816B2/ja not_active Expired - Lifetime
- 2000-05-23 PA PA20008496101A patent/PA8496101A1/es unknown
- 2000-05-26 CO CO00039195A patent/CO5170463A1/es not_active Application Discontinuation
- 2000-05-26 TW TW089110206A patent/TWI285204B/zh not_active IP Right Cessation
- 2000-05-29 UY UY26176A patent/UY26176A1/es not_active Application Discontinuation
- 2000-05-30 AR ARP000102663A patent/AR033331A1/es active IP Right Grant
- 2000-05-30 PE PE2000000520A patent/PE20010209A1/es not_active Application Discontinuation
- 2000-05-30 MY MYPI20002409A patent/MY133508A/en unknown
- 2000-05-31 TN TNTNSN00120A patent/TNSN00120A1/fr unknown
- 2000-05-31 GT GT200000087A patent/GT200000087A/es unknown
- 2000-05-31 DZ DZ000101A patent/DZ3050A1/xx active
- 2000-05-31 MA MA25997A patent/MA26742A1/fr unknown
- 2000-05-31 SV SV2000000093A patent/SV2001000093A/es unknown
- 2000-06-01 EC EC2000003508A patent/ECSP003508A/es unknown
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2001
- 2001-11-28 ZA ZA200109775A patent/ZA200109775B/en unknown
- 2001-11-30 NO NO20015848A patent/NO20015848L/no not_active Application Discontinuation
- 2001-12-04 HR HR20010904A patent/HRP20010904A2/hr not_active Application Discontinuation
- 2001-12-10 BG BG106204A patent/BG65240B1/bg unknown
-
2002
- 2002-10-30 HK HK02107879A patent/HK1046284A1/xx not_active IP Right Cessation
-
2007
- 2007-03-27 CY CY2007011C patent/CY2007011I1/el unknown
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PC4A | Registration of transfer of a eurasian patent by assignment | ||
TC4A | Change in name of a patent proprietor in a eurasian patent | ||
PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title |