EA200100805A1 - Ингибиторы tace на основе гетероарилацетиленсульфонамида и фосфинамида гидроксамовой кислоты - Google Patents

Ингибиторы tace на основе гетероарилацетиленсульфонамида и фосфинамида гидроксамовой кислоты

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Publication number
EA200100805A1
EA200100805A1 EA200100805A EA200100805A EA200100805A1 EA 200100805 A1 EA200100805 A1 EA 200100805A1 EA 200100805 A EA200100805 A EA 200100805A EA 200100805 A EA200100805 A EA 200100805A EA 200100805 A1 EA200100805 A1 EA 200100805A1
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EA
Eurasian Patent Office
Prior art keywords
phosfinamide
heteroyarilacethylene
sulphonamide
basis
hydroxamic acid
Prior art date
Application number
EA200100805A
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English (en)
Inventor
Джереми Ян Левин
Джеймс Минг Чен
Френсиз Кристи Нелсон
Original Assignee
Американ Цианамид Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Американ Цианамид Компани filed Critical Американ Цианамид Компани
Publication of EA200100805A1 publication Critical patent/EA200100805A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/41—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C07C309/42—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/78—Halides of sulfonic acids
    • C07C309/86—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/87—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/42—Benzene-sulfonamido pyrazoles
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
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  • Oncology (AREA)
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  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Соединения формулы (I), используемые для лечения состояний, опосредованных ФНО-α, таких как ревматоидный артрит, остеоартрит, сепсис, СПИД, язвенный колит, рассеянный склероз, болезнь Крона и дегенеративная потеря хряща.Отчет о международном поиске был опубликован 2001.01.25.
EA200100805A 1999-01-27 2000-01-27 Ингибиторы tace на основе гетероарилацетиленсульфонамида и фосфинамида гидроксамовой кислоты EA200100805A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23909199A 1999-01-27 1999-01-27
PCT/US2000/001980 WO2000044740A2 (en) 1999-01-27 2000-01-27 Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors

Publications (1)

Publication Number Publication Date
EA200100805A1 true EA200100805A1 (ru) 2002-02-28

Family

ID=22900572

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100805A EA200100805A1 (ru) 1999-01-27 2000-01-27 Ингибиторы tace на основе гетероарилацетиленсульфонамида и фосфинамида гидроксамовой кислоты

Country Status (22)

Country Link
EP (1) EP1147102B1 (ru)
JP (1) JP2002535399A (ru)
KR (1) KR20010101731A (ru)
CN (1) CN1144785C (ru)
AR (1) AR022422A1 (ru)
AT (1) ATE261955T1 (ru)
AU (1) AU769182B2 (ru)
BR (1) BR0007726A (ru)
CA (1) CA2356481A1 (ru)
CZ (1) CZ20012708A3 (ru)
DE (1) DE60009035T2 (ru)
DK (1) DK1147102T3 (ru)
EA (1) EA200100805A1 (ru)
ES (1) ES2215621T3 (ru)
HU (1) HUP0105434A3 (ru)
IL (1) IL144346A0 (ru)
NO (1) NO20013681L (ru)
NZ (1) NZ512368A (ru)
PL (1) PL349768A1 (ru)
PT (1) PT1147102E (ru)
WO (1) WO2000044740A2 (ru)
ZA (1) ZA200104981B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003304456A1 (en) 2002-12-23 2005-03-16 Wyeth Holdings Corporation Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
AU2019352741A1 (en) 2018-10-04 2021-05-06 Assistance Publique-Hôpitaux De Paris (Aphp) EGFR inhibitors for treating keratodermas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000049197A (ko) * 1996-10-16 2000-07-25 윌리암 에이취 캘넌, 에곤 이 버그 매트릭스 메탈로프로테이나제 및 종양 괴사 인자-α 전환 효소억제제로서의 오르토-설폰아미도 헤테로아릴 하이드록삼산의 제조 및 용도
JP2003524617A (ja) * 1999-01-27 2003-08-19 アメリカン・サイアナミド・カンパニー アセチレンアリールスルホンアミドおよびホスフィン酸アミドヒドロキサム酸ｔａｃｅ阻害剤

Also Published As

Publication number Publication date
DK1147102T3 (da) 2004-06-01
HUP0105434A3 (en) 2002-08-28
AR022422A1 (es) 2002-09-04
PL349768A1 (en) 2002-09-09
CN1144785C (zh) 2004-04-07
NO20013681D0 (no) 2001-07-26
ES2215621T3 (es) 2004-10-16
NO20013681L (no) 2001-07-26
ZA200104981B (en) 2002-10-08
CZ20012708A3 (cs) 2002-04-17
DE60009035D1 (de) 2004-04-22
NZ512368A (en) 2003-11-28
PT1147102E (pt) 2004-07-30
IL144346A0 (en) 2002-05-23
EP1147102A2 (en) 2001-10-24
BR0007726A (pt) 2001-10-30
WO2000044740A2 (en) 2000-08-03
EP1147102B1 (en) 2004-03-17
KR20010101731A (ko) 2001-11-14
CA2356481A1 (en) 2000-08-03
AU3473900A (en) 2000-08-18
JP2002535399A (ja) 2002-10-22
AU769182B2 (en) 2004-01-15
DE60009035T2 (de) 2005-03-31
WO2000044740A3 (en) 2001-01-25
CN1337949A (zh) 2002-02-27
ATE261955T1 (de) 2004-04-15
HUP0105434A2 (en) 2002-06-29

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