EA200100640A1 - HERPES VIRUS INHIBITORS, PRESENTING ACETAMIDE AND SUBSTITUTED ACETAMIDE-CONTAINING THIOMOVA - Google Patents

HERPES VIRUS INHIBITORS, PRESENTING ACETAMIDE AND SUBSTITUTED ACETAMIDE-CONTAINING THIOMOVA

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Publication number
EA200100640A1
EA200100640A1 EA200100640A EA200100640A EA200100640A1 EA 200100640 A1 EA200100640 A1 EA 200100640A1 EA 200100640 A EA200100640 A EA 200100640A EA 200100640 A EA200100640 A EA 200100640A EA 200100640 A1 EA200100640 A1 EA 200100640A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbon atoms
alkyl
acetamide
perhaloalkyl
sor
Prior art date
Application number
EA200100640A
Other languages
Russian (ru)
Inventor
Джонатан Дэвид Блум
Мартин Джозеф Дигранди
Расселл Джордж Дашин
Стэнли Альберт Лэнг
Брайан Марк О'Хара
Original Assignee
Американ Хоум Продактс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Американ Хоум Продактс Корпорейшн filed Critical Американ Хоум Продактс Корпорейшн
Publication of EA200100640A1 publication Critical patent/EA200100640A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Abstract

Соединения формулы (I), где R-Rнезависимо выбраны из водорода, алкила с 1-6 углеродными атомами, алкенила с 2-6 углеродными атомами, алкинила с 2-6 углеродными атомами, пергалогеналкила с 1-6 углеродными атомами, циклоалкила с 3-10 углеродными атомами, гетероциклоалкила с 3-10 углеродными членами, арила, гетероарила, галогена, -CN, -NO, -COR, -COR, -OR, -SR, -SOR, -SOR, -CONRR, -NRN(RR), -N(RR) или W-Y-(CH)-Z при условии, что, по крайней мере, один из радикалов R-Rне является водородом; или Rи Rили Rи R, взятые вместе, образуют 3-7-членный гетероциклоалкил или 3-7-членный гетероарил; Rи Rнезависимо представляют водород, алкил с 1-6 углеродными атомами, пергалогеналкил с 1-6 углеродными атомами или арил; Rпредставляет водород, алкил с 1-6 углеродными атомами, пергалогеналкил с 1-6 углеродными атомами, циклоалкил с 3-10 углеродными атомами, гетероциклоалкил с 3-10 членами, арил или гетероарил, или Rи R, взятые вместе, могут образовывать 3-7-членный гетероциклоалкил; R-Rнезависимо представляют водород, алкил с 1-4 углеродными атомами, пергалогеналкил с 1-4 углеродными атомами, галоген, алкокси с 1-4 углеродными атомами или циано, или Rи Rили Rи Rмогут быть взяты вместе с образованием арила с 5-7 углеродными атомами; W представляет O, NRили отсутствует; Y представляет -(CO)- или -(CO)- или отсутствует; Z представляет алкил с 1-4 углеродными атомами, -CN, -COR, -COR, -CONRR, -OCOR, -NRCOR, -OCONR, -OR, -SR, -SOR, -SOR, -SRN(RR), -N(RR) или фенил; G представляет алкил с 1-6 углеродными атомами; X представляет связь, -NH, алкил с 1-6 углеродными атомами, алкенил с 1-6 углеродными атомами, алкокси с 1-6 углеродными атомами, тиоалкил с 1-6 углеродными атомами, алкиламино с 1-6 углеродными атомами или (CH)J; J представляет алкил с 1-6 углеродными атомами, циклоалкил с 3-7 углеродными атомами, фенил или бензил; и n представляет целое число от 1 до 6; или их фармацевтические соли полезны для лечения заболеваний, вызванных вирусамиThe compounds of formula (I), where R-R is independently selected from hydrogen, alkyl with 1-6 carbon atoms, alkenyl with 2-6 carbon atoms, alkynyl with 2-6 carbon atoms, perhaloalkyl with 1-6 carbon atoms, cycloalkyl with 3- 10 carbon atoms, heterocycloalkyl with 3-10 carbon members, aryl, heteroaryl, halogen, -CN, -NO, -COR, -COR, -OR, -SR, -SOR, -SOR, -CONRR, -NRN (RR) , -N (RR) or WY- (CH) -Z, with the proviso that at least one of the radicals R — R is not hydrogen; or R1 and R3 or R1 and R7, taken together, form a 3-7 membered heterocycloalkyl or 3-7 membered heteroaryl; R1 and R4 independently represent hydrogen, alkyl with 1-6 carbon atoms, perhaloalkyl with 1-6 carbon atoms, or aryl; R 1 is hydrogen, alkyl with 1-6 carbon atoms, perhaloalkyl with 1-6 carbon atoms, cycloalkyl with 3-10 carbon atoms, heterocycloalkyl with 3-10 members, aryl or heteroaryl, or R1 and R5, taken together, can form 3-7 - member heterocycloalkyl; R-R independently represent hydrogen, alkyl with 1-4 carbon atoms, perhaloalkyl with 1-4 carbon atoms, halogen, alkoxy with 1-4 carbon atoms or cyano, or R and R or R and R can be taken together with the formation of aryl with 5-7 carbon atoms; W is O, NR or is absent; Y is - (CO) - or - (CO) - or absent; Z represents alkyl with 1-4 carbon atoms, -CN, -COR, -COR, -CONRR, -OCOR, -NRCOR, -OCONR, -OR, -SR, -SOR, -SOR, -SRN (RR), - N (RR) or phenyl; G represents alkyl with 1-6 carbon atoms; X represents a bond, -NH, alkyl with 1-6 carbon atoms, alkenyl with 1-6 carbon atoms, alkoxy with 1-6 carbon atoms, thioalkyl with 1-6 carbon atoms, alkylamino with 1-6 carbon atoms or (CH) J; J represents alkyl with 1-6 carbon atoms, cycloalkyl with 3-7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or their pharmaceutical salts are useful for treating diseases caused by viruses.

EA200100640A 1998-12-09 1999-12-06 HERPES VIRUS INHIBITORS, PRESENTING ACETAMIDE AND SUBSTITUTED ACETAMIDE-CONTAINING THIOMOVA EA200100640A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20831698A 1998-12-09 1998-12-09
PCT/US1999/028844 WO2000034237A2 (en) 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses

Publications (1)

Publication Number Publication Date
EA200100640A1 true EA200100640A1 (en) 2001-12-24

Family

ID=22774137

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100640A EA200100640A1 (en) 1998-12-09 1999-12-06 HERPES VIRUS INHIBITORS, PRESENTING ACETAMIDE AND SUBSTITUTED ACETAMIDE-CONTAINING THIOMOVA

Country Status (15)

Country Link
EP (1) EP1137633A2 (en)
JP (1) JP2002531544A (en)
KR (1) KR20010087413A (en)
CN (1) CN1333750A (en)
AU (1) AU3111200A (en)
BR (1) BR9916041A (en)
CA (1) CA2350899A1 (en)
CZ (1) CZ20012060A3 (en)
EA (1) EA200100640A1 (en)
HU (1) HUP0104944A3 (en)
IL (1) IL143204A0 (en)
NO (1) NO20012834L (en)
PL (1) PL349131A1 (en)
WO (1) WO2000034237A2 (en)
ZA (1) ZA200104142B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
WO2001064642A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
JP4690889B2 (en) * 2002-10-24 2011-06-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Methylene urea derivative
US7220768B2 (en) * 2003-02-11 2007-05-22 Wyeth Holdings Corp. Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
EP1660661A2 (en) 2003-08-08 2006-05-31 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
CA2772017C (en) 2003-08-29 2016-05-31 Mitsui Chemicals, Inc. Agricultural/horticultural insecticide and method for using the same
AU2005221151A1 (en) 2004-03-09 2005-09-22 Arriva Pharmaceuticals, Inc. Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor
EP2074085A2 (en) * 2006-10-13 2009-07-01 Lica Pharmaceuticals A/S Anti-infective thiourea compounds
ES2382055T3 (en) 2006-11-02 2012-06-04 Millennium Pharmaceuticals, Inc. Methods for synthesizing pharmaceutical salts of a factor Xa inhibitor
CN108619123A (en) * 2018-03-13 2018-10-09 武汉威立得生物医药有限公司 Tenovin-1 is preparing the application in preventing nerpes vinrus hominis's infection medicine
WO2019193541A1 (en) * 2018-04-06 2019-10-10 Glaxosmithkline Intellectual Property Development Limited Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors
CN112807294B (en) * 2019-11-18 2023-09-05 武汉大学 Application of acyl thiourea compound in preparation of medicines for treating or preventing herpes simplex virus type I infection
WO2022150962A1 (en) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Protease inhibitors, preparation, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69830751T2 (en) * 1997-04-10 2006-05-18 Pharmacia & Upjohn Co. Llc, Kalamazoo Polyaromatic compounds for the treatment of herpes infections

Also Published As

Publication number Publication date
NO20012834L (en) 2001-08-07
CZ20012060A3 (en) 2001-11-14
CN1333750A (en) 2002-01-30
HUP0104944A2 (en) 2002-04-29
CA2350899A1 (en) 2000-06-15
WO2000034237A2 (en) 2000-06-15
KR20010087413A (en) 2001-09-15
AU3111200A (en) 2000-06-26
ZA200104142B (en) 2002-10-25
EP1137633A2 (en) 2001-10-04
NO20012834D0 (en) 2001-06-08
HUP0104944A3 (en) 2003-03-28
BR9916041A (en) 2001-12-04
JP2002531544A (en) 2002-09-24
WO2000034237A3 (en) 2000-11-23
IL143204A0 (en) 2002-04-21
PL349131A1 (en) 2002-07-01

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