EA035160B9 - Антитела к st2 и их применение - Google Patents

Антитела к st2 и их применение

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Publication number
EA035160B9
EA035160B9 EA201492149A EA201492149A EA035160B9 EA 035160 B9 EA035160 B9 EA 035160B9 EA 201492149 A EA201492149 A EA 201492149A EA 201492149 A EA201492149 A EA 201492149A EA 035160 B9 EA035160 B9 EA 035160B9
Authority
EA
Eurasian Patent Office
Prior art keywords
seq
set forth
antibody
sequence set
chain variable
Prior art date
Application number
EA201492149A
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English (en)
Other versions
EA201492149A8 (ru
EA201492149A1 (ru
EA035160B1 (ru
Inventor
Дирк Е. Смит
Ян ФОЛТЦ
Чэдвик Т. Кинг
Аи Чин Лим
Рутилио Кларк
Майкл Р. Комо
Рэндал Р. Кетчем
Дунхой Си
Сяошань Минь
Чжулунь Ван
Original Assignee
Эмджен Инк.
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Publication date
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA201492149A1 publication Critical patent/EA201492149A1/ru
Publication of EA201492149A8 publication Critical patent/EA201492149A8/ru
Publication of EA035160B1 publication Critical patent/EA035160B1/ru
Publication of EA035160B9 publication Critical patent/EA035160B9/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P19/00—Drugs for skeletal disorders
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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    • C07K2317/515—Complete light chain, i.e. VL + CL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Изобретение относится к выделенному антителу к ST2, содержащему вариабельный домен легкой цепи, который содержит последовательность LCDR1, приведенную в SEQ ID NO: 107, последовательность LCDR2, приведенную в SEQ ID NO: 118, и последовательность LCDR3, приведенную в SEQ ID NO: 129, и вариабельный домен тяжелой цепи, который содержит последовательность HCDR1, приведенную в SEQ ID NO: 41, последовательность HCDR2, приведенную в SEQ ID NO: 52, и последовательность HCDR3, приведенную в SEQ ID NO: 63. Изобретение относится также к нуклеиновой кислоте, кодирующей указанное антитело, вектору экспрессии, рекомбинантной клетке-хозяину, способу лечения аутоиммунного или воспалительного заболевания и способу получения указанного антитела.
EA201492149A 2012-05-18 2013-05-17 Антитела к st2 и их применение EA035160B9 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261649147P 2012-05-18 2012-05-18
US201361792619P 2013-03-15 2013-03-15
PCT/US2013/041656 WO2013173761A2 (en) 2012-05-18 2013-05-17 St2 antigen binding proteins

Publications (4)

Publication Number Publication Date
EA201492149A1 EA201492149A1 (ru) 2015-03-31
EA201492149A8 EA201492149A8 (ru) 2015-10-30
EA035160B1 EA035160B1 (ru) 2020-05-08
EA035160B9 true EA035160B9 (ru) 2020-10-01

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Country Status (37)

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US (5) US9382318B2 (ru)
EP (2) EP2850103B1 (ru)
JP (5) JP6205410B2 (ru)
KR (5) KR102161460B1 (ru)
CN (3) CN104334582B (ru)
AP (1) AP2014008053A0 (ru)
AR (1) AR091069A1 (ru)
AU (2) AU2013262593B2 (ru)
BR (1) BR112014028785B1 (ru)
CA (2) CA3182435A1 (ru)
CL (1) CL2014003131A1 (ru)
CO (1) CO7250445A2 (ru)
CR (2) CR20190225A (ru)
DK (1) DK2850103T3 (ru)
EA (1) EA035160B9 (ru)
ES (1) ES2818571T3 (ru)
HK (1) HK1208479A1 (ru)
HR (1) HRP20201341T1 (ru)
HU (1) HUE052442T2 (ru)
IL (4) IL282226B1 (ru)
JO (1) JO3623B1 (ru)
LT (1) LT2850103T (ru)
MX (1) MX356557B (ru)
MY (1) MY170099A (ru)
NZ (1) NZ700856A (ru)
PE (2) PE20150023A1 (ru)
PH (1) PH12014502527A1 (ru)
PL (1) PL2850103T3 (ru)
PT (1) PT2850103T (ru)
RS (1) RS60819B1 (ru)
SG (1) SG11201407564TA (ru)
SI (1) SI2850103T1 (ru)
TN (1) TN2014000434A1 (ru)
TW (1) TWI600664B (ru)
UY (1) UY34813A (ru)
WO (1) WO2013173761A2 (ru)
ZA (1) ZA201407937B (ru)

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