DOP2012000006A - Agonista de gpr119 - Google Patents

Agonista de gpr119

Info

Publication number
DOP2012000006A
DOP2012000006A DO2012000006A DO2012000006A DOP2012000006A DO P2012000006 A DOP2012000006 A DO P2012000006A DO 2012000006 A DO2012000006 A DO 2012000006A DO 2012000006 A DO2012000006 A DO 2012000006A DO P2012000006 A DOP2012000006 A DO P2012000006A
Authority
DO
Dominican Republic
Prior art keywords
gpr119 agonist
gpr119
agonist
obesity
diabetes
Prior art date
Application number
DO2012000006A
Other languages
English (en)
Inventor
Kumiko Takeuchi
Ana Belen Bueno Melendo
David Gene Barrett
Jeffry Bernard Franciskovich
Bin Liu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43449712&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2012000006(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DOP2012000006A publication Critical patent/DOP2012000006A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

Los compuestos agonistas de GPR119 de la fórmula: y composiciones farmacéuticas para el tratamiento de diabetes y obesidad.
DO2012000006A 2009-07-15 2012-01-11 Agonista de gpr119 DOP2012000006A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382114 2009-07-15
US24544509P 2009-09-24 2009-09-24

Publications (1)

Publication Number Publication Date
DOP2012000006A true DOP2012000006A (es) 2012-01-31

Family

ID=43449712

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2012000006A DOP2012000006A (es) 2009-07-15 2012-01-11 Agonista de gpr119

Country Status (24)

Country Link
US (1) US8207344B2 (es)
EP (1) EP2454251A1 (es)
JP (1) JP5715127B2 (es)
KR (1) KR101365854B1 (es)
CN (1) CN102471313B (es)
AR (1) AR077638A1 (es)
AU (1) AU2010273642B2 (es)
BR (1) BRPI1015921A2 (es)
CA (1) CA2764906C (es)
CO (1) CO6480977A2 (es)
CR (1) CR20120012A (es)
DO (1) DOP2012000006A (es)
EA (1) EA020540B1 (es)
EC (1) ECSP12011606A (es)
IL (1) IL216776A0 (es)
MA (1) MA33428B1 (es)
MX (1) MX2012000704A (es)
NZ (1) NZ597125A (es)
PE (1) PE20121045A1 (es)
SG (1) SG177646A1 (es)
TN (1) TN2012000002A1 (es)
TW (1) TWI429634B (es)
WO (1) WO2011008663A1 (es)
ZA (1) ZA201200227B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004065380A1 (en) 2003-01-14 2004-08-05 Arena Pharmaceuticals Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
EP2108960A1 (en) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
JP2013522279A (ja) 2010-03-18 2013-06-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及び関連状態の治療で用いるｇｐｒ１１９作動薬とｄｄｐ−ｉｖ阻害薬リナグリプチンの組合せ
PE20131371A1 (es) 2010-09-22 2013-11-25 Arena Pharm Inc Moduladores del receptor gpr119 y el tratamiento de trastornos relacionados con este
WO2012135570A1 (en) * 2011-04-01 2012-10-04 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
EP2693882B1 (en) 2011-04-08 2017-06-28 Merck Sharp & Dohme Corp. Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
WO2012170702A1 (en) * 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
ES2602813T3 (es) 2011-06-09 2017-02-22 Rhizen Pharmaceuticals S.A. Nuevos compuestos como moduladores de GPR-119
EP2720544B1 (en) 2011-06-16 2016-12-21 Merck Sharp & Dohme Corp. Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment
WO2013048916A1 (en) * 2011-09-30 2013-04-04 Merck Sharp & Dohme Corp. Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
WO2013062835A1 (en) * 2011-10-24 2013-05-02 Merck Sharp & Dohme Corp. Substituted piperidinyl compounds useful as gpr119 agonists
WO2013062838A1 (en) 2011-10-24 2013-05-02 Merck Sharp & Dohme Corp. Substituted piperidinyl compounds useful as gpr119 agonists
US9018224B2 (en) 2011-11-15 2015-04-28 Merck Sharp & Dohme Corp. Substituted cyclopropyl compounds useful as GPR119 agonists
ES2759010T3 (es) * 2012-06-12 2020-05-07 Chong Kun Dang Pharmaceutical Corp Derivados de piperidina como agonistas del GPR119
EP2872127A1 (en) 2012-07-11 2015-05-20 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
WO2014052619A1 (en) * 2012-09-27 2014-04-03 Irm Llc Piperidine derivatives and compositions as modulators of gpr119 activity
JP6182269B2 (ja) 2013-11-26 2017-08-16 チョン クン ダン ファーマシューティカル コーポレーション Ｇｐｒ１１９アゴニストとしてのアミド誘導体
KR101651505B1 (ko) * 2014-05-02 2016-08-29 현대약품 주식회사 싸이클로 헥센 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물
KR20230151072A (ko) 2015-01-06 2023-10-31 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 상태의 치료 방법
CA3002551A1 (en) 2015-06-22 2016-12-29 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders
MA47504A (fr) 2017-02-16 2019-12-25 Arena Pharm Inc Composés et méthodes de traitement de l'angiocholite biliaire primitive
AU2021275038A1 (en) 2020-05-19 2022-12-22 Kallyope, Inc. AMPK activators
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004065380A1 (en) * 2003-01-14 2004-08-05 Arena Pharmaceuticals Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
JP2010501629A (ja) * 2006-08-30 2010-01-21 ビオヴィトルム・アクチボラゲット（プブリクト） Ｇｐｒ１１９関連障害を治療するためのピリジン化合物
US7638541B2 (en) * 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
NZ583495A (en) * 2007-09-20 2011-11-25 Irm Llc Compounds and compositions as modulators of gpr119 activity

Also Published As

Publication number Publication date
AU2010273642B2 (en) 2014-03-13
CA2764906C (en) 2014-06-10
ECSP12011606A (es) 2012-02-29
PE20121045A1 (es) 2012-08-09
KR101365854B1 (ko) 2014-02-21
EA020540B1 (ru) 2014-11-28
US20110015199A1 (en) 2011-01-20
JP2012533546A (ja) 2012-12-27
BRPI1015921A2 (pt) 2016-04-26
CN102471313A (zh) 2012-05-23
ZA201200227B (en) 2013-06-26
AU2010273642A1 (en) 2012-01-19
CR20120012A (es) 2012-03-28
KR20120024964A (ko) 2012-03-14
TN2012000002A1 (en) 2013-09-19
JP5715127B2 (ja) 2015-05-07
IL216776A0 (en) 2012-03-01
CA2764906A1 (en) 2011-01-20
MA33428B1 (fr) 2012-07-03
EA201270169A1 (ru) 2012-06-29
NZ597125A (en) 2013-08-30
EP2454251A1 (en) 2012-05-23
AR077638A1 (es) 2011-09-14
TWI429634B (zh) 2014-03-11
TW201114757A (en) 2011-05-01
CN102471313B (zh) 2014-06-04
MX2012000704A (es) 2012-03-07
US8207344B2 (en) 2012-06-26
CO6480977A2 (es) 2012-07-16
WO2011008663A1 (en) 2011-01-20
SG177646A1 (en) 2012-02-28

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