DK74691A - 4(4-(substitueret phenyl)-1-piperazinyl)phenoler og fremgangsmaade til fremstilling deraf - Google Patents

4(4-(substitueret phenyl)-1-piperazinyl)phenoler og fremgangsmaade til fremstilling deraf Download PDF

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Publication number
DK74691A
DK74691A DK074691A DK74691A DK74691A DK 74691 A DK74691 A DK 74691A DK 074691 A DK074691 A DK 074691A DK 74691 A DK74691 A DK 74691A DK 74691 A DK74691 A DK 74691A
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DK
Denmark
Prior art keywords
preparing
phenoles
piperazinyl
procedures
substituted phenyl
Prior art date
Application number
DK074691A
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English (en)
Other versions
DK74691D0 (da
DK167356B1 (da
Inventor
Jan Heeres
Leo Jacobus Josef Backx
Jozef Bertha August Thijssen
Alfonsus Guilielmus Knaeps
Original Assignee
Jannsen Pharmaceutica N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jannsen Pharmaceutica N V filed Critical Jannsen Pharmaceutica N V
Publication of DK74691D0 publication Critical patent/DK74691D0/da
Publication of DK74691A publication Critical patent/DK74691A/da
Application granted granted Critical
Publication of DK167356B1 publication Critical patent/DK167356B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK074691A 1985-12-23 1991-04-23 4-oe4-(substitueret phenyl)-1-piperazinylaaphenoler og fremgangsmaade til fremstilling deraf DK167356B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81267085A 1985-12-23 1985-12-23
US81267085 1985-12-23

Publications (3)

Publication Number Publication Date
DK74691D0 DK74691D0 (da) 1991-04-23
DK74691A true DK74691A (da) 1991-04-23
DK167356B1 DK167356B1 (da) 1993-10-18

Family

ID=25210297

Family Applications (2)

Application Number Title Priority Date Filing Date
DK625586A DK164167C (da) 1985-12-23 1986-12-22 Oeoe4-oe4-(4-phenyl-1-piperazinyl)phenoxymethylaa-1,3-dioxolan-2-ylaamethylaa-1h-imidazol- og 1h-1,2,4-triazolderivater, fremgangsmaade til fremstilling deraf samt praeparater indeholdende disse til bekaempelse af mikroorganismer
DK074691A DK167356B1 (da) 1985-12-23 1991-04-23 4-oe4-(substitueret phenyl)-1-piperazinylaaphenoler og fremgangsmaade til fremstilling deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK625586A DK164167C (da) 1985-12-23 1986-12-22 Oeoe4-oe4-(4-phenyl-1-piperazinyl)phenoxymethylaa-1,3-dioxolan-2-ylaamethylaa-1h-imidazol- og 1h-1,2,4-triazolderivater, fremgangsmaade til fremstilling deraf samt praeparater indeholdende disse til bekaempelse af mikroorganismer

Country Status (18)

Country Link
EP (1) EP0228125B1 (da)
JP (2) JPH0749428B2 (da)
AT (1) ATE73799T1 (da)
AU (2) AU589726B2 (da)
CA (1) CA1292472C (da)
CY (1) CY1825A (da)
DE (1) DE3684431D1 (da)
DK (2) DK164167C (da)
ES (1) ES2032381T3 (da)
FI (1) FI88505C (da)
GR (1) GR3004114T3 (da)
HK (1) HK46295A (da)
IE (1) IE59564B1 (da)
IL (1) IL81054A (da)
NO (1) NO167917C (da)
NZ (1) NZ218553A (da)
PT (1) PT84007B (da)
ZA (1) ZA869637B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
GR1000297B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000302B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000330B (el) * 1988-07-01 1992-06-25 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4 διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000298B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
CA2076257A1 (en) * 1991-09-13 1993-03-14 Jan Heeres 4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h -1,2,4-triazol-3-one derivatives
TW279864B (da) * 1993-02-19 1996-07-01 Janssen Pharmaceutica Nv
ATE204875T1 (de) * 1993-12-21 2001-09-15 Schering Corp Fungizide tetrahydrofurane
ES2141329T3 (es) * 1994-01-24 2000-03-16 Janssen Pharmaceutica Nv Antifungicos azolicos solubles en agua.
US5571811A (en) * 1994-07-12 1996-11-05 Janssen Pharmaceutica N.V. Sulfonamide derivatives of azolones
AP779A (en) * 1994-10-27 1999-11-03 Janssen Pharmaceutica Nv Apolipoprotein-B synthesis inhibitors.
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
TW457240B (en) * 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
AU6257596A (en) * 1995-06-19 1997-01-15 Schering Corporation Hydroxyalkyl-substituted triazolones antifungals
WO1998021213A2 (en) * 1996-11-12 1998-05-22 Sepracor, Inc. 2r,4s,r,s- and 2s,4r,r,s-hydroxyitraconazole- and hydroxysaperconazole derivatives
AU773405B2 (en) * 1996-11-12 2004-05-27 Sepracor, Inc. Hydroxyitraconazole enantiomer mixtures
CN100343249C (zh) * 1997-07-11 2007-10-17 詹森药业有限公司 2,4,4－三取代的1,3－二氧环戊烷抗真菌剂
TW593312B (en) 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
WO1999018111A1 (en) * 1997-10-07 1999-04-15 Schering Corporation Crystalline antifungal glycine ester polymorph
JP4610744B2 (ja) 1999-05-04 2011-01-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗菌・抗カビ性エーテル類
KR100342383B1 (ko) * 1999-06-17 2002-12-06 한국화학연구원 이소옥사졸리딘 유도체, 그의 제조 방법 및 그를 포함하는 살균제 조성물
CN102906087B (zh) * 2010-05-19 2016-03-23 桑多斯股份公司 制备手性***酮的方法
DK3227277T3 (da) 2014-12-05 2020-04-27 Pulmocide Ltd Antimykotisk forbindelse
MX2017014814A (es) 2015-05-21 2018-02-15 Pulmocide Ltd 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-triazol-1-il)metil)-5-(2,4-difluor ofenil)tetrahidrofuran-3-il)metoxi)-3-metilfenil)piperazin-1-il)- n-(2-hidroxiciclohexil) benzamida antifungica, o una sal farmaceuticamente aceptable de la misma.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles

Also Published As

Publication number Publication date
PT84007B (pt) 1989-06-30
ATE73799T1 (de) 1992-04-15
CY1825A (en) 1995-12-01
DK74691D0 (da) 1991-04-23
DK164167B (da) 1992-05-18
DK625586D0 (da) 1986-12-22
CA1292472C (en) 1991-11-26
NO865235D0 (no) 1986-12-22
DK167356B1 (da) 1993-10-18
AU1607688A (en) 1988-08-04
DE3684431D1 (de) 1992-04-23
JP2574656B2 (ja) 1997-01-22
IL81054A0 (en) 1987-03-31
JPH07285963A (ja) 1995-10-31
IE59564B1 (en) 1994-03-09
FI865257A (fi) 1987-06-24
EP0228125B1 (en) 1992-03-18
EP0228125A1 (en) 1987-07-08
AU6685386A (en) 1987-06-25
FI88505C (fi) 1993-05-25
GR3004114T3 (da) 1993-03-31
DK164167C (da) 1992-10-12
AU593736B2 (en) 1990-02-15
ES2032381T3 (es) 1993-02-16
NO865235L (no) 1987-06-24
NO167917C (no) 1991-12-27
HK46295A (en) 1995-04-07
FI865257A0 (fi) 1986-12-22
IL81054A (en) 1992-03-29
JPH0749428B2 (ja) 1995-05-31
NO167917B (no) 1991-09-16
AU589726B2 (en) 1989-10-19
NZ218553A (en) 1990-06-26
FI88505B (fi) 1993-02-15
JPS62158275A (ja) 1987-07-14
ZA869637B (en) 1988-08-31
PT84007A (en) 1987-01-01
DK625586A (da) 1987-06-24
IE863369L (en) 1987-06-23

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B1 Patent granted (law 1993)
PBP Patent lapsed

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