DK553782A - Cyclohexyl- og phenylsubstituerede enkephaliner og deres fremstilling - Google Patents

Cyclohexyl- og phenylsubstituerede enkephaliner og deres fremstilling Download PDF

Info

Publication number
DK553782A
DK553782A DK553782A DK553782A DK553782A DK 553782 A DK553782 A DK 553782A DK 553782 A DK553782 A DK 553782A DK 553782 A DK553782 A DK 553782A DK 553782 A DK553782 A DK 553782A
Authority
DK
Denmark
Prior art keywords
enkephalines
cyclohexyl
phenyl
substituted
preparation
Prior art date
Application number
DK553782A
Other languages
English (en)
Inventor
Robert Henry Mazur
David Anson Tyner
Eleanor Anne Hallinan
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of DK553782A publication Critical patent/DK553782A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK553782A 1981-12-14 1982-12-13 Cyclohexyl- og phenylsubstituerede enkephaliner og deres fremstilling DK553782A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/330,614 US4407746A (en) 1981-12-14 1981-12-14 Cyclohexyl and phenyl substituted enkephalins

Publications (1)

Publication Number Publication Date
DK553782A true DK553782A (da) 1983-06-15

Family

ID=23290531

Family Applications (1)

Application Number Title Priority Date Filing Date
DK553782A DK553782A (da) 1981-12-14 1982-12-13 Cyclohexyl- og phenylsubstituerede enkephaliner og deres fremstilling

Country Status (10)

Country Link
US (1) US4407746A (da)
EP (1) EP0081838B1 (da)
JP (1) JPS58109460A (da)
DE (1) DE3278401D1 (da)
DK (1) DK553782A (da)
ES (1) ES518189A0 (da)
NO (1) NO824187L (da)
NZ (1) NZ202784A (da)
PT (1) PT75977B (da)
ZA (1) ZA829134B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603121A (en) * 1983-10-06 1986-07-29 G. D. Searle & Co. Enkephalin analogs
US4495178A (en) * 1983-10-06 1985-01-22 G. D. Searle & Co. Enkephalin analogs
US4822775A (en) * 1986-02-14 1989-04-18 G. D. Searle & Co. Phenyl substituted dipeptide amides
US4880829A (en) * 1985-08-14 1989-11-14 G. D. Searle And Company Substituted dipeptide amides #3
US4757153A (en) * 1986-02-14 1988-07-12 G. D. Searle & Co. Sulfide, sulfinyl and sulfone dipeptide amides
US4760180A (en) * 1986-02-14 1988-07-26 G. D. Searle & Co. N-terminally substituted dipeptide amides
US4758675A (en) * 1986-07-14 1988-07-19 G. D. Searle & Co. 3-thiophene-substituted tyrosyl dipeptide amides
US4767744A (en) * 1986-07-14 1988-08-30 G. D. Searle & Co. Substituted tyrosyl methionyl dipeptide amides
US4797470A (en) * 1986-07-14 1989-01-10 G. D. Searle & Co. O-substituted tyrosyl dipeptide amides
FR2687147A1 (fr) * 1992-02-11 1993-08-13 Union Pharma Scient Appl Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant.
CN102653514B (zh) * 2011-03-03 2014-09-17 内蒙古大学 绿原酸类似物及其制备方法和应用
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2732451A1 (de) * 1976-07-27 1978-02-02 Reckitt & Colmann Prod Ltd Peptidverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate
FR2359817A1 (fr) * 1976-07-27 1978-02-24 Reckitt & Colmann Prod Ltd Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant
US4331593A (en) * 1977-10-03 1982-05-25 Smithwick Jr Edward L Analgesic compounds
US4178371A (en) * 1977-12-15 1979-12-11 Reckitt & Colman Products Limited Tetrapeptide derivatives
US4261883A (en) * 1979-07-09 1981-04-14 The Regents Of The University Of California Novel N-aralkyl enkephalin amide analogs are provided having analgesic and opioid properties
NL8005121A (nl) * 1979-09-20 1981-03-24 Erba Farmitalia Biologisch actieve peptiden.
US4273704A (en) * 1979-12-03 1981-06-16 G. D. Searle & Co. N-Adamantane-substituted tetrapeptide amides
US4309343A (en) * 1980-11-25 1982-01-05 Eli Lilly And Company Pharmacologically active peptides

Also Published As

Publication number Publication date
ES8404976A1 (es) 1984-05-16
ES518189A0 (es) 1984-05-16
JPS58109460A (ja) 1983-06-29
EP0081838A1 (en) 1983-06-22
ZA829134B (en) 1984-02-29
US4407746A (en) 1983-10-04
PT75977A (en) 1983-01-01
EP0081838B1 (en) 1988-04-27
NO824187L (no) 1983-06-15
JPH0359920B2 (da) 1991-09-12
DE3278401D1 (en) 1988-06-01
PT75977B (en) 1985-10-04
NZ202784A (en) 1986-08-08

Similar Documents

Publication Publication Date Title
IT1205010B (it) Tetraidronaftalin-derivati e indan-derivati
DK41484A (da) Beta-phenethanolaminer og deres anvendelse
DK543386D0 (da) Thienooxazinoner deres fremstilling og anvendelse
DK446982A (da) Cyanosteroider og fremgangsmaade til deres fremstilling
DK553782A (da) Cyclohexyl- og phenylsubstituerede enkephaliner og deres fremstilling
NO821159L (no) 2-piperazinopyrimidin og deres fremstilling.
DK35884A (da) Lactampeptider samt deres fremstilling og anvendelse
DK413187A (da) Semicarbazoner og thiosemicarbazoner
DK514382A (da) Azolylvinyldithioacetaler, deres fremstilling og anvendelse
NO865055D0 (no) Polyfluorerte alkoholer og deres fremstilling.
DK556483A (da) Benzofuranylderivater og deres fremstilling
DK47985D0 (da) Adhaesionsgrunderlakker og deres anvendelse
DK488185A (da) N6-benzopyrano- og benzothiopyranoadenosiner
NO824312L (no) 4-cyano-2-azetidinoner og fremgangsmaate for deres fremstilling
DK189584D0 (da) (5alfa)-20-spirox-1-en-3-oner samt deres fremstilling og anvendelse
DK295785D0 (da) 1,8-diacyloxy-10-acyl-anthroner, deres fremstilling og anvendelse
DK162979C (da) Polyfluoralkylestere, deres fremstilling og anvendelse
DK358882A (da) Anthracyclinantibiotica samt deres fremstilling og anvendelse
NO851687L (no) Kryssbundne karboksyl-polyelektrolytter og fremgangsmaate for deres fremstilling
DK356481A (da) Hetero-prostaglandinderivater og deres fremstilling
DK538382A (da) P-oxooxazolidinylbenzensulfonamider, deres fremstilling og anvendelse
DK332782A (da) 2-cyanosteroider og fremgangsmaade til deres fremstilling
NO830416L (no) Peptidergotalkaloider og fremgangsmaaten for deres fremstilling
DK35984D0 (da) Lactampeptider samt deres fremstilling og anvendelse
DK162607C (da) Azopigmentpraeparater og deres anvendelse

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment