DK498476A - 2,-dimethyl-3-methoxycarbonyl-4-(2i-nitrophenyl)-1,4-dihydropyridin-5-carboxylsyreisobutylester flere fremgangsmader til fremstilling deraf samt dens anvendelse som coronarterapeutikum - Google Patents

2,-dimethyl-3-methoxycarbonyl-4-(2i-nitrophenyl)-1,4-dihydropyridin-5-carboxylsyreisobutylester flere fremgangsmader til fremstilling deraf samt dens anvendelse som coronarterapeutikum

Info

Publication number: DK498476A
Authority: DK; Denmark
Prior art keywords: therapon; risobutylesters; dihydropyridine; methoxycarbonyl; nitrophenyl
Prior art date: 1975-11-05

Application number

DK498476A

Other languages

English (en)

Other versions

DK146762B (da

DK146762C (da

Inventor

E Wehinger

F Bossert

A Heise

S Kazda

K Stoepel

W Vater

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-11-05

Filing date

1976-11-04

Publication date

1977-05-06

1976-11-04 Application filed by Bayer Ag filed Critical Bayer Ag

1977-05-06 Publication of DK498476A publication Critical patent/DK498476A/da

1983-12-27 Publication of DK146762B publication Critical patent/DK146762B/da

1984-06-12 Application granted granted Critical

1984-06-12 Publication of DK146762C publication Critical patent/DK146762C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK498476A 1975-11-05 1976-11-04 Analogifremgangsmaade til fremstilling af 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridin-5-carboxylsyreisobutylester DK146762C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2549568A DE2549568C3 (de)	1975-11-05	1975-11-05	2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
DE2549568		1975-11-05

Publications (3)

Publication Number	Publication Date
DK498476A true DK498476A (da)	1977-05-06
DK146762B DK146762B (da)	1983-12-27
DK146762C DK146762C (da)	1984-06-12

Family

ID=5960951

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK498476A DK146762C (da)	1975-11-05	1976-11-04	Analogifremgangsmaade til fremstilling af 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridin-5-carboxylsyreisobutylester

Country Status (27)

Country	Link
JP (1)	JPS5259161A (da)
AT (1)	AT352129B (da)
AU (1)	AU498964B2 (da)
BE (1)	BE847968A (da)
BG (6)	BG24805A3 (da)
CA (1)	CA1085406A (da)
CH (2)	CH623038A5 (da)
CS (1)	CS200499B2 (da)
DE (1)	DE2549568C3 (da)
DK (1)	DK146762C (da)
ES (2)	ES452986A1 (da)
FI (1)	FI60704C (da)
FR (1)	FR2330395A1 (da)
GB (1)	GB1516793A (da)
GR (1)	GR61241B (da)
HK (1)	HK12681A (da)
IE (1)	IE43984B1 (da)
IL (1)	IL50817A (da)
LU (2)	LU76133A1 (da)
NL (2)	NL175915C (da)
NO (1)	NO145574C (da)
NZ (1)	NZ182502A (da)
PL (2)	PL105940B1 (da)
PT (1)	PT65797B (da)
RO (1)	RO70295A (da)
SE (1)	SE423542B (da)
ZA (1)	ZA766622B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4146630A (en) *	1976-11-12	1979-03-27	Boehringer Mannheim Gmbh	Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS55301A (en) *	1978-02-14	1980-01-05	Yamanouchi Pharmaceut Co Ltd	1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
DE3212736A1 (de) *	1982-04-06	1983-10-13	Bayer Ag, 5090 Leverkusen	Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
DE3222367A1 (de) *	1982-06-15	1983-12-15	Bayer Ag, 5090 Leverkusen	Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung
JPS5982192U (ja) *	1982-11-27	1984-06-02	エムケ−精工株式会社	扉
DE3312283A1 (de) *	1983-04-05	1984-10-18	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern
DE3312216A1 (de) *	1983-04-05	1984-10-11	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von symmetrischen 1,4-dihydropyridincarbonsaeureestern
US4794111A (en) *	1984-05-23	1988-12-27	Bayer Aktiengesellschaft	Dihydropyridine preparations containing β-blockers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2117571C3 (de) *	1971-04-10	1979-10-11	Bayer Ag, 5090 Leverkusen	Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

1975
- 1975-11-05 DE DE2549568A patent/DE2549568C3/de not_active Expired
1976
- 1976-10-22 NO NO763608A patent/NO145574C/no unknown
- 1976-10-29 JP JP51129540A patent/JPS5259161A/ja active Granted
- 1976-11-01 BG BG7600035345A patent/BG24805A3/xx unknown
- 1976-11-01 BG BG7600034575A patent/BG24668A3/xx unknown
- 1976-11-01 BG BG7600035343A patent/BG24803A3/xx unknown
- 1976-11-01 BG BG7600035342A patent/BG25079A3/xx unknown
- 1976-11-01 BG BG7600035341A patent/BG25078A3/xx unknown
- 1976-11-01 BG BG7600035344A patent/BG24804A3/xx unknown
- 1976-11-02 NZ NZ182502A patent/NZ182502A/xx unknown
- 1976-11-02 RO RO7688294A patent/RO70295A/ro unknown
- 1976-11-02 IL IL50817A patent/IL50817A/xx unknown
- 1976-11-02 CH CH1381976A patent/CH623038A5/de not_active IP Right Cessation
- 1976-11-02 CS CS767068A patent/CS200499B2/cs unknown
- 1976-11-02 GB GB45501/76A patent/GB1516793A/en not_active Expired
- 1976-11-03 NL NLAANVRAGE7612198,A patent/NL175915C/xx not_active IP Right Cessation
- 1976-11-03 PL PL1976201800A patent/PL105940B1/pl unknown
- 1976-11-03 FI FI763160A patent/FI60704C/fi not_active IP Right Cessation
- 1976-11-03 PL PL1976193438A patent/PL106084B1/pl unknown
- 1976-11-03 AT AT814276A patent/AT352129B/de not_active IP Right Cessation
- 1976-11-04 IE IE2458/76A patent/IE43984B1/en not_active IP Right Cessation
- 1976-11-04 CA CA264,921A patent/CA1085406A/en not_active Expired
- 1976-11-04 ES ES452986A patent/ES452986A1/es not_active Expired
- 1976-11-04 DK DK498476A patent/DK146762C/da not_active IP Right Cessation
- 1976-11-04 GR GR52093A patent/GR61241B/el unknown
- 1976-11-04 LU LU76133A patent/LU76133A1/xx active Protection Beyond IP Right Term
- 1976-11-04 LU LU88275C patent/LU88275I2/xx unknown
- 1976-11-04 ZA ZA766622A patent/ZA766622B/xx unknown
- 1976-11-04 SE SE7612308A patent/SE423542B/xx not_active IP Right Cessation
- 1976-11-04 BE BE172063A patent/BE847968A/xx not_active IP Right Cessation
- 1976-11-04 PT PT65797A patent/PT65797B/pt unknown
- 1976-11-05 FR FR7633488A patent/FR2330395A1/fr active Granted
- 1976-11-05 AU AU19358/76A patent/AU498964B2/en not_active Expired
1977
- 1977-10-13 ES ES463166A patent/ES463166A1/es not_active Expired
1980
- 1980-07-23 CH CH567880A patent/CH622779A5/de not_active IP Right Cessation
1981
- 1981-04-02 HK HK126/81A patent/HK12681A/xx unknown
1993
- 1993-05-24 NL NL930035C patent/NL930035I2/nl unknown

Also Published As

Publication number	Publication date
CH622779A5 (en)	1981-04-30
DE2549568B2 (de)	1980-08-21
BG25079A3 (en)	1978-07-12
ZA766622B (en)	1977-10-26
AU1935876A (en)	1978-05-11
CA1085406A (en)	1980-09-09
NO763608L (da)	1977-05-06
NL930035I2 (nl)	1993-10-01
PT65797B (de)	1978-05-12
LU76133A1 (da)	1977-06-02
LU88275I2 (da)	1994-02-03
NO145574B (no)	1982-01-11
ES452986A1 (es)	1977-12-16
CS200499B2 (en)	1980-09-15
FI60704C (fi)	1982-03-10
AT352129B (de)	1979-09-10
NL175915C (nl)	1985-01-16
IL50817A0 (en)	1977-01-31
BE847968A (fr)	1977-05-04
JPS5647185B2 (da)	1981-11-07
PT65797A (de)	1976-12-01
HK12681A (en)	1981-04-10
RO70295A (ro)	1981-08-17
BG24805A3 (en)	1978-05-12
ES463166A1 (es)	1978-07-16
FI60704B (fi)	1981-11-30
SE423542B (sv)	1982-05-10
SE7612308L (sv)	1977-05-06
BG24804A3 (en)	1978-05-12
IL50817A (en)	1979-07-25
BG24803A3 (en)	1978-05-12
BG24668A3 (en)	1978-04-12
AU498964B2 (en)	1979-03-29
ATA814276A (de)	1979-02-15
FR2330395A1 (fr)	1977-06-03
PL106084B1 (pl)	1979-11-30
FR2330395B1 (da)	1978-12-22
IE43984L (en)	1977-05-05
DK146762B (da)	1983-12-27
JPS5259161A (en)	1977-05-16
PL105940B1 (pl)	1979-11-30
DE2549568C3 (de)	1981-10-29
BG25078A3 (en)	1978-07-12
DE2549568A1 (de)	1977-05-18
FI763160A (da)	1977-05-06
GR61241B (en)	1978-10-12
DK146762C (da)	1984-06-12
CH623038A5 (en)	1981-05-15
NL7612198A (nl)	1977-05-09
NL930035I1 (nl)	1993-08-02
IE43984B1 (en)	1981-07-15
NO145574C (no)	1982-04-21
NZ182502A (en)	1978-07-28
GB1516793A (en)	1978-07-05

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Legal Events

Date	Code	Title	Description
1996-12-09	PUP	Patent expired