DK437187D0 - Chemiluminescent ACRIDIN DERIVATIVES, THEIR PREPARATION AND USE - Google Patents
Chemiluminescent ACRIDIN DERIVATIVES, THEIR PREPARATION AND USEInfo
- Publication number
- DK437187D0 DK437187D0 DK437187A DK437187A DK437187D0 DK 437187 D0 DK437187 D0 DK 437187D0 DK 437187 A DK437187 A DK 437187A DK 437187 A DK437187 A DK 437187A DK 437187 D0 DK437187 D0 DK 437187D0
- Authority
- DK
- Denmark
- Prior art keywords
- group
- chemiluminescent
- preparation
- hydrogen
- carbon atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Enzymes And Modification Thereof (AREA)
- Liquid Crystal Substances (AREA)
Abstract
The invention relates to novel acridinium derivatives of the formula I: <IMAGE> in which R<1> is hydrogen, an alkyl, alkenyl or alkynyl radical having 1 to 10 carbon atoms, a benzyl or aryl group, R<2> and R<3> are hydrogen, an alkyl group having 1 to 4 carbon atoms, a substituted or unsubstituted amino group, a carboxyl, C1-C4-alkoxy, cyano or nitro group or halogen, R<4> is a radical in which a sulphonamide group is bonded directly to the carbonyl group via the nitrogen and A<(-)> is an anion which does not interfere with the chemiluminescence; and their use in luminescence immunoassays.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK199200684A DK173875B1 (en) | 1986-08-22 | 1992-05-25 | New chemiluminescent 9-carboxy-acridinium cpds. - and their conjugates with biologically interesting substances, used in luminescence immunoassay |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3628573A DE3628573C2 (en) | 1986-08-22 | 1986-08-22 | Chemiluminescent acridine derivatives, processes for their preparation and their use in luminescence immunoassays |
DE3628573 | 1986-08-22 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK437187D0 true DK437187D0 (en) | 1987-08-21 |
DK437187A DK437187A (en) | 1988-02-23 |
DK171437B1 DK171437B1 (en) | 1996-10-28 |
Family
ID=6307971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK437187A DK171437B1 (en) | 1986-08-22 | 1987-08-21 | Chemiluminescent acridine derivatives and process for their preparation |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP0647628B1 (en) |
JP (2) | JPH0699401B2 (en) |
AT (2) | ATE132490T1 (en) |
CA (1) | CA1341402C (en) |
DE (4) | DE3628573C2 (en) |
DK (1) | DK171437B1 (en) |
ES (2) | ES2083949T3 (en) |
FI (1) | FI90542C (en) |
GR (1) | GR3019470T3 (en) |
IE (1) | IE74678B1 (en) |
NO (1) | NO171725C (en) |
PT (1) | PT85563B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0082636B2 (en) * | 1981-12-11 | 2006-10-18 | The Welsh National School of Medicine | Luminescent labelling materials and procedures |
US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
EP0273115B1 (en) * | 1986-10-22 | 1994-09-07 | Abbott Laboratories | Chemiluminescent acridinium and phenanthridinium salts |
FR2625565A1 (en) * | 1987-12-31 | 1989-07-07 | London Diagnostics Inc | Improved chemiluminescent esters, thioesters and amides, and analyses employing them |
NZ227506A (en) * | 1987-12-31 | 1992-06-25 | London Diagnostics Inc | Specific binding assays using chemiluminescent compounds |
DE3844954C2 (en) * | 1988-02-20 | 1998-07-16 | Hoechst Ag | Special chemiluminescent acridine derivatives and their use in luminescent immunoassays |
US6002007A (en) * | 1988-02-20 | 1999-12-14 | Dade Behring Marburg Gmbh | Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays |
US4950613A (en) * | 1988-02-26 | 1990-08-21 | Gen-Probe Incorporated | Proteted chemiluminescent labels |
AU634716B2 (en) * | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
US5227489A (en) * | 1988-08-01 | 1993-07-13 | Ciba Corning Diagnostics Corp. | Stable hydrophilic acridinium esters suitable for liposome encapsulation |
US5241070A (en) * | 1988-09-26 | 1993-08-31 | Ciba Corning Diagnostics Corp. | Nucleophilic polysubstituted aryl acridinium esters and uses thereof |
US5663074A (en) * | 1988-09-26 | 1997-09-02 | Chiron Diagnostics Corporation | Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof |
EP0511366A1 (en) * | 1990-11-21 | 1992-11-04 | Beckman Instruments, Inc. | Chemiluminescent compounds |
DE4041080A1 (en) | 1990-12-21 | 1992-06-25 | Behringwerke Ag | METHOD FOR DETERMINING AN ANALYT |
DE4228839A1 (en) | 1992-08-29 | 1994-03-03 | Behringwerke Ag | Methods for the detection and determination of mediators |
US5491072A (en) * | 1993-05-17 | 1996-02-13 | Lumigen, Inc. | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
BE1008216A4 (en) * | 1994-01-25 | 1996-02-20 | Biocode Sa | HETEROCYCLIC CHEMOLUMINESCENT DERIVATIVES. |
WO1996000284A1 (en) * | 1994-06-24 | 1996-01-04 | Behringwerke Aktiengesellschaft | Method of stabilizing molecules, or parts of molecules, which are sensitive to hydrolysis |
JPH10502958A (en) * | 1994-07-15 | 1998-03-17 | アボツト・ラボラトリーズ | Enhanced chemiluminescence signal |
WO1996027785A1 (en) * | 1995-03-03 | 1996-09-12 | Abbott Laboratories | Article and method for conducting chemiluminescent reaction |
US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
EP0761652A1 (en) * | 1995-08-01 | 1997-03-12 | Mochida Pharmaceutical Co., Ltd. | Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof |
KR100259761B1 (en) * | 1996-03-15 | 2000-07-01 | 타이도 나오카타 | Reagents for labelling sh groups, process for the preparation of them and method for labeling with them |
DK0915851T3 (en) * | 1996-07-16 | 2002-04-29 | Nederlanden Staat | Dibenzodihydropyridine carboxyl esters and their use in chemiluminescence assay methods |
BE1011206A4 (en) * | 1997-06-11 | 1999-06-01 | Biocode Sa | HETEROCYCLIC DERIVATIVES chemiluminescent. |
EP1496050A1 (en) | 2003-07-08 | 2005-01-12 | Roche Diagnostics GmbH | Novel chemiluminescent compounds and their use |
WO2005015215A1 (en) | 2003-07-30 | 2005-02-17 | Roche Diagnostics Gmbh | Novel chemiluminescent compounds and their use |
WO2005015214A1 (en) | 2003-07-30 | 2005-02-17 | Roche Diagnostics Gmbh | Novel chemiluminescent compounds and their use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1461877A (en) * | 1974-02-12 | 1977-01-19 | Wellcome Found | Assay method utilizing chemiluminescence |
GB2008247B (en) * | 1977-11-17 | 1982-12-15 | Welsh Nat School Med | Detecting or quantifying substances using labelling techniques |
EP0082636B2 (en) * | 1981-12-11 | 2006-10-18 | The Welsh National School of Medicine | Luminescent labelling materials and procedures |
-
1986
- 1986-08-22 DE DE3628573A patent/DE3628573C2/en not_active Expired - Lifetime
- 1986-08-22 DE DE3645292A patent/DE3645292C2/en not_active Expired - Lifetime
-
1987
- 1987-08-19 ES ES87112022T patent/ES2083949T3/en not_active Expired - Lifetime
- 1987-08-19 AT AT87112022T patent/ATE132490T1/en not_active IP Right Cessation
- 1987-08-19 ES ES94119395T patent/ES2182835T3/en not_active Expired - Lifetime
- 1987-08-19 DE DE3752357T patent/DE3752357D1/en not_active Expired - Lifetime
- 1987-08-19 AT AT94119395T patent/ATE223903T1/en not_active IP Right Cessation
- 1987-08-19 EP EP94119395A patent/EP0647628B1/en not_active Expired - Lifetime
- 1987-08-19 EP EP87112022A patent/EP0257541B1/en not_active Expired - Lifetime
- 1987-08-19 DE DE3751659T patent/DE3751659D1/en not_active Expired - Lifetime
- 1987-08-20 FI FI873609A patent/FI90542C/en not_active IP Right Cessation
- 1987-08-20 PT PT85563A patent/PT85563B/en unknown
- 1987-08-20 NO NO873520A patent/NO171725C/en not_active IP Right Cessation
- 1987-08-21 IE IE224587A patent/IE74678B1/en not_active IP Right Cessation
- 1987-08-21 DK DK437187A patent/DK171437B1/en not_active IP Right Cessation
- 1987-08-21 CA CA000545036A patent/CA1341402C/en not_active Expired - Lifetime
- 1987-08-21 JP JP62206622A patent/JPH0699401B2/en not_active Expired - Lifetime
-
1994
- 1994-06-14 JP JP6131617A patent/JP2766780B2/en not_active Expired - Lifetime
-
1996
- 1996-03-29 GR GR960400849T patent/GR3019470T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK437187A (en) | 1988-02-23 |
FI90542C (en) | 1994-02-25 |
GR3019470T3 (en) | 1996-06-30 |
EP0257541A3 (en) | 1988-11-30 |
FI873609A (en) | 1988-02-23 |
NO171725C (en) | 1993-04-28 |
NO873520L (en) | 1988-02-23 |
IE960911L (en) | 1988-02-22 |
FI90542B (en) | 1993-11-15 |
JPH0699401B2 (en) | 1994-12-07 |
PT85563A (en) | 1987-09-01 |
NO873520D0 (en) | 1987-08-20 |
EP0647628A1 (en) | 1995-04-12 |
IE74678B1 (en) | 1997-07-30 |
DE3752357D1 (en) | 2002-10-17 |
EP0257541B1 (en) | 1996-01-03 |
JPH07179428A (en) | 1995-07-18 |
ATE132490T1 (en) | 1996-01-15 |
NO171725B (en) | 1993-01-18 |
ES2083949T3 (en) | 1996-05-01 |
CA1341402C (en) | 2002-11-26 |
PT85563B (en) | 1990-05-31 |
JP2766780B2 (en) | 1998-06-18 |
EP0647628B1 (en) | 2002-09-11 |
FI873609A0 (en) | 1987-08-20 |
ATE223903T1 (en) | 2002-09-15 |
DE3751659D1 (en) | 1996-02-15 |
DE3628573C2 (en) | 1994-10-13 |
EP0257541A2 (en) | 1988-03-02 |
JPS6357572A (en) | 1988-03-12 |
DK171437B1 (en) | 1996-10-28 |
DE3628573A1 (en) | 1988-02-25 |
ES2182835T3 (en) | 2003-03-16 |
IE872245L (en) | 1988-02-22 |
DE3645292C2 (en) | 1997-12-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |