DK3615545T3 - Pyrrolopyrimidinderivativer, der er nyttige som hæmmere af replikation af influenzavirus - Google Patents

Pyrrolopyrimidinderivativer, der er nyttige som hæmmere af replikation af influenzavirus Download PDF

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Publication number
DK3615545T3
DK3615545T3 DK18723298.8T DK18723298T DK3615545T3 DK 3615545 T3 DK3615545 T3 DK 3615545T3 DK 18723298 T DK18723298 T DK 18723298T DK 3615545 T3 DK3615545 T3 DK 3615545T3
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DK
Denmark
Prior art keywords
interventives
pyrrolopyrimidine
inhibitors
replacement
useful
Prior art date
Application number
DK18723298.8T
Other languages
English (en)
Inventor
Irina C Jacobson
Michael David Feese
Sam Sk Lee
Original Assignee
Cocrystal Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Cocrystal Pharma Inc filed Critical Cocrystal Pharma Inc
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Publication of DK3615545T3 publication Critical patent/DK3615545T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK18723298.8T 2017-04-24 2018-04-24 Pyrrolopyrimidinderivativer, der er nyttige som hæmmere af replikation af influenzavirus DK3615545T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762489167P 2017-04-24 2017-04-24
PCT/US2018/028986 WO2018200425A1 (en) 2017-04-24 2018-04-24 Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication

Publications (1)

Publication Number Publication Date
DK3615545T3 true DK3615545T3 (da) 2021-11-22

Family

ID=62117141

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18723298.8T DK3615545T3 (da) 2017-04-24 2018-04-24 Pyrrolopyrimidinderivativer, der er nyttige som hæmmere af replikation af influenzavirus

Country Status (19)

Country Link
US (1) US11014941B2 (da)
EP (1) EP3615545B1 (da)
JP (1) JP7165721B2 (da)
KR (1) KR102598466B1 (da)
CN (1) CN110637022B (da)
AU (1) AU2018257778B2 (da)
BR (1) BR112019022307A2 (da)
CA (1) CA3059449A1 (da)
DK (1) DK3615545T3 (da)
EA (1) EA039181B1 (da)
ES (1) ES2901875T3 (da)
IL (1) IL269900B (da)
MX (1) MX2019012759A (da)
NZ (1) NZ757442A (da)
PH (1) PH12019502376A1 (da)
PL (1) PL3615545T3 (da)
SG (1) SG11201909478UA (da)
TW (1) TWI778052B (da)
WO (1) WO2018200425A1 (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112969457A (zh) * 2018-10-17 2021-06-15 共晶制药公司 流感病毒复制抑制剂的组合
WO2020102270A1 (en) * 2018-11-13 2020-05-22 Cocrystal Pharma, Inc. Formulations of influenza therapeutics
KR20220004096A (ko) 2019-04-26 2022-01-11 닛산 가가쿠 가부시키가이샤 아릴술폰산 에스테르 화합물의 제조 방법
WO2022007966A1 (zh) * 2020-07-10 2022-01-13 四川海思科制药有限公司 Pb2抑制剂及其制备方法和用途
WO2022109495A1 (en) * 2020-11-23 2022-05-27 The Regents Of The University Of California Methods and compositions for linking rna stem loops

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Also Published As

Publication number Publication date
AU2018257778A1 (en) 2019-10-10
US20200123177A1 (en) 2020-04-23
NZ757442A (en) 2022-10-28
KR102598466B1 (ko) 2023-11-03
CA3059449A1 (en) 2018-11-01
IL269900B (en) 2022-05-01
KR20190140971A (ko) 2019-12-20
CN110637022A (zh) 2019-12-31
ES2901875T3 (es) 2022-03-24
SG11201909478UA (en) 2019-11-28
JP7165721B2 (ja) 2022-11-04
PH12019502376A1 (en) 2020-09-14
MX2019012759A (es) 2019-12-16
EA201992543A1 (ru) 2020-03-24
PL3615545T3 (pl) 2022-01-10
BR112019022307A2 (pt) 2020-05-26
AU2018257778B2 (en) 2022-02-17
JP2020517738A (ja) 2020-06-18
EP3615545A1 (en) 2020-03-04
TW201839003A (zh) 2018-11-01
EP3615545B1 (en) 2021-09-01
US11014941B2 (en) 2021-05-25
EA039181B1 (ru) 2021-12-15
WO2018200425A1 (en) 2018-11-01
CN110637022B (zh) 2022-09-16
TWI778052B (zh) 2022-09-21

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