DK3577225T1 - Optimized vector for delivery in microbial populations - Google Patents

Optimized vector for delivery in microbial populations Download PDF

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Publication number
DK3577225T1
DK3577225T1 DK18705108.1T DK18705108T DK3577225T1 DK 3577225 T1 DK3577225 T1 DK 3577225T1 DK 18705108 T DK18705108 T DK 18705108T DK 3577225 T1 DK3577225 T1 DK 3577225T1
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Denmark
Prior art keywords
delivery
microbial populations
optimized vector
optimized
vector
Prior art date
Application number
DK18705108.1T
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English (en)
Inventor
Antoine Decrulle
Rodriguez Jesus Fernandez
Xavier Duportet
David Bikard
Original Assignee
Eligo Bioscience
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eligo Bioscience, Pasteur Institut filed Critical Eligo Bioscience
Publication of DK3577225T1 publication Critical patent/DK3577225T1/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • C12N15/73Expression systems using phage (lambda) regulatory sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10311Siphoviridae
    • C12N2795/10332Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/101Plasmid DNA for bacteria
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DK18705108.1T 2017-02-03 2018-02-02 Optimized vector for delivery in microbial populations DK3577225T1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17305126.9A EP3358015A1 (en) 2017-02-03 2017-02-03 Optimized vector for delivery in microbial populations
PCT/EP2018/052662 WO2018141907A1 (en) 2017-02-03 2018-02-02 Optimized vector for delivery in microbial populations

Publications (1)

Publication Number Publication Date
DK3577225T1 true DK3577225T1 (da) 2020-06-29

Family

ID=58428223

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18705108.1T DK3577225T1 (da) 2017-02-03 2018-02-02 Optimized vector for delivery in microbial populations

Country Status (10)

Country Link
US (5) US11905516B2 (da)
EP (2) EP3358015A1 (da)
JP (2) JP7250702B2 (da)
KR (1) KR102563835B1 (da)
CN (1) CN110268062A (da)
CA (1) CA3049511A1 (da)
DE (1) DE18705108T1 (da)
DK (1) DK3577225T1 (da)
IL (2) IL312476A (da)
WO (1) WO2018141907A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3358015A1 (en) 2017-02-03 2018-08-08 Eligo Bioscience Optimized vector for delivery in microbial populations
US11851663B2 (en) 2018-10-14 2023-12-26 Snipr Biome Aps Single-vector type I vectors
WO2020106158A1 (en) * 2018-11-20 2020-05-28 Acd Pharmaceuticals As Serratia liquefaciens variant
CN110129279B (zh) * 2019-04-24 2022-02-18 昆明理工大学 一种粪肠球菌噬菌体及其分离、纯化、富集和应用
US20220233615A1 (en) * 2019-05-21 2022-07-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bacteriophages for the treatment of tuberculosis
CN110484513B (zh) * 2019-08-23 2021-04-16 中国水产科学研究院黑龙江水产研究所 噬菌体pAhMJG及其在治疗嗜水气单胞菌引发的鱼类疾病中的应用
CN110904054A (zh) * 2019-09-29 2020-03-24 中国科学院大学 一种沙门氏菌噬菌体see-1及其应用
WO2021126344A2 (en) * 2019-10-03 2021-06-24 President And Fellows Of Harvard College Compositions and methods comprising engineered bacteriophage
CN111088233A (zh) * 2020-01-08 2020-05-01 中国科学院大学 一株痢疾志贺氏菌噬菌体sse1及其应用
CN111041130B (zh) * 2020-03-13 2020-06-12 圣湘生物科技股份有限公司 检测病原体的组合物、试剂盒及方法
JP2023520729A (ja) * 2020-04-08 2023-05-18 エリゴ・バイオサイエンス マイクロバイオーム関連疾患又は障害を防止、治療、又は治癒するための、マイクロバイオームの遺伝子療法による微生物叢機能のモジュレーション
CN111973616A (zh) * 2020-07-15 2020-11-24 中山大学 副溶血弧菌23S rRNA和/或其保守序列VP13在提高鱼类免疫力中的应用
CN112011563A (zh) * 2020-09-14 2020-12-01 安徽农业大学 一种基于ai-2群体感应自诱导蛋白表达载体及应用
CN112063593B (zh) * 2020-09-17 2021-08-31 扬州大学 一种致病性弧菌噬菌体VmYZU10474及其应用
WO2022140630A1 (en) * 2020-12-23 2022-06-30 Locus Biosciences, Inc. Altering the normal balance of microbial populations
CN113201506B (zh) * 2021-06-07 2023-03-21 西南医科大学 一株高效裂解碳青霉烯耐药肺炎克雷伯菌噬菌体及其应用
WO2023158883A2 (en) * 2022-02-19 2023-08-24 Salvitus, Inc. Probiotic vaccines and related methods of use
CN114634888B (zh) * 2022-03-04 2023-05-26 中南大学 一种铊氧化菌、微生物菌剂及其应用
TW202400783A (zh) * 2022-04-28 2024-01-01 日商安斯泰來製藥股份有限公司 噬菌體
CN116024146B (zh) * 2023-03-28 2023-06-27 中国农业大学 一株高抗菌活性枯草芽孢杆菌及其发酵条件优化
KR102666595B1 (ko) * 2023-06-16 2024-05-16 ㈜에스에이치랩 박테리오파지 유래 펩타이드를 포함하는 피부 주름 개선용 생분해성 고분자 필러 및 이의 제조방법
CN116676324B (zh) * 2023-07-28 2023-10-27 四川大学华西医院 基于Kil蛋白构建释放抗肿瘤效应蛋白的***及方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3442774B2 (ja) * 1991-07-01 2003-09-02 バーレックス ラボラトリーズ,インコーポレイティド 新規な突然変異誘発法および組成物
CA2444819A1 (en) * 2001-04-19 2002-10-31 Biophage, Inc. Methods for generating libraries of therapeutic bacteriophages having desired safety characteristics and methods for labeling and monitoring bacteriophages
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WO2014124226A1 (en) 2013-02-07 2014-08-14 The Rockefeller University Sequence specific antimicrobials
DK3041498T3 (da) * 2013-09-05 2022-05-09 Massachusetts Inst Technology Afstemning af mikrobielle populationer med programmerbare nukleaser
WO2017053327A1 (en) * 2015-09-24 2017-03-30 San Diego State University (Sdsu) Foundation , Dba San Diego State University Research Foundation Antibacterial and protective bacteriophage formulations and methods for making and using them
EP3358015A1 (en) * 2017-02-03 2018-08-08 Eligo Bioscience Optimized vector for delivery in microbial populations

Also Published As

Publication number Publication date
JP2020506726A (ja) 2020-03-05
IL267932B1 (en) 2024-06-01
US20200248192A1 (en) 2020-08-06
WO2018141907A1 (en) 2018-08-09
IL267932A (en) 2019-09-26
KR20190115019A (ko) 2019-10-10
US20240218380A1 (en) 2024-07-04
US11905516B2 (en) 2024-02-20
US11078490B2 (en) 2021-08-03
JP7250702B2 (ja) 2023-04-03
EP3358015A1 (en) 2018-08-08
CA3049511A1 (en) 2018-08-09
DE18705108T1 (de) 2020-08-13
KR102563835B1 (ko) 2023-08-03
CN110268062A (zh) 2019-09-20
US10808254B2 (en) 2020-10-20
US11946056B2 (en) 2024-04-02
US20200040346A1 (en) 2020-02-06
IL312476A (en) 2024-06-01
EP3577225A1 (en) 2019-12-11
US20210380993A1 (en) 2021-12-09
US20200399645A1 (en) 2020-12-24
JP2023073319A (ja) 2023-05-25

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