DK3538542T3 - Cykliske peptidmultimerer målrettet alfa-4beta-7-integrin - Google Patents

Cykliske peptidmultimerer målrettet alfa-4beta-7-integrin Download PDF

Info

Publication number
DK3538542T3
DK3538542T3 DK17870529.9T DK17870529T DK3538542T3 DK 3538542 T3 DK3538542 T3 DK 3538542T3 DK 17870529 T DK17870529 T DK 17870529T DK 3538542 T3 DK3538542 T3 DK 3538542T3
Authority
DK
Denmark
Prior art keywords
peptime
multimizes
4beta
alfa
integrin
Prior art date
Application number
DK17870529.9T
Other languages
English (en)
Inventor
Monzur M Morshed
Sai Kumar Chakka
Jennifer L Hickey
Manuel Perez Vazquez
Andrew Roughton
Adam Paul Kafal
Narendrakumar B Patel
Original Assignee
Zealand Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharma As filed Critical Zealand Pharma As
Application granted granted Critical
Publication of DK3538542T3 publication Critical patent/DK3538542T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DK17870529.9T 2016-11-11 2017-11-10 Cykliske peptidmultimerer målrettet alfa-4beta-7-integrin DK3538542T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662421117P 2016-11-11 2016-11-11
PCT/CA2017/000244 WO2018085921A1 (en) 2016-11-11 2017-11-10 CYCLIC PEPTIDES MULTIMERS TARGETING α4β7 INTEGRIN

Publications (1)

Publication Number Publication Date
DK3538542T3 true DK3538542T3 (da) 2021-10-11

Family

ID=62110102

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17870529.9T DK3538542T3 (da) 2016-11-11 2017-11-10 Cykliske peptidmultimerer målrettet alfa-4beta-7-integrin

Country Status (8)

Country Link
US (3) US11111273B2 (da)
EP (2) EP3939989A1 (da)
JP (2) JP7035044B2 (da)
CN (1) CN110088121A (da)
CA (1) CA3042576A1 (da)
DK (1) DK3538542T3 (da)
ES (1) ES2884107T3 (da)
WO (1) WO2018085921A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2884107T3 (es) * 2016-11-11 2021-12-10 Zealand Pharma As Multímeros de péptidos cíclicos con diana en la integrina alfa-4 beta-7
IL270465B (en) 2017-05-10 2022-09-01 Encycle Therapeutics Inc Cyclic peptides targeting alpha4beta7 integrin
EP3810085A1 (en) 2018-06-20 2021-04-28 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
US20230117920A1 (en) * 2019-12-27 2023-04-20 The University Of Tokyo Library Construction Method, Cyclic Peptide, FXIIa Binder and IFNGR1 Binder
US20230295235A1 (en) * 2020-06-29 2023-09-21 Zealand Pharma A/S Compounds targeting alpha4-beta7 integrin
US11957761B2 (en) 2021-12-20 2024-04-16 Zealand Pharma A/S Compounds having α4β7 integrin inhibition activity

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3219113A1 (de) 1982-05-21 1983-11-24 Bayer Ag, 5090 Leverkusen Verwendung von n-substituierten 2,3-diaminocarbonsaeuren in arzneimitteln und ihre herstellung
AU638264B2 (en) 1989-08-10 1993-06-24 Aventis Inc. Cyclic neurokinin a antagonists
US5296604A (en) 1992-05-15 1994-03-22 Miles Inc. Proline derivatives and compositions for their use as inhibitors of HIV protease
US5705481A (en) 1992-11-06 1998-01-06 Merck Patent Gesellschaft Mit Beschrankter Haftung Cyclopeptides
AU681119B2 (en) 1993-05-17 1997-08-21 Fujisawa Pharmaceutical Co., Ltd. New polypeptide compound and a process for preparation thereof
US5693325A (en) 1994-03-15 1997-12-02 Molecumetics, Ltd. Peptide vaccines and methods relating thereto
DE4415310A1 (de) 1994-04-30 1995-11-02 Merck Patent Gmbh Cyclopeptide
CA2193828A1 (en) 1994-06-29 1996-01-11 Timothy P. Kogan Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
GB9524630D0 (en) 1994-12-24 1996-01-31 Zeneca Ltd Chemical compounds
JPH11508583A (ja) * 1995-07-06 1999-07-27 ゼネカ・リミテッド ペプチド系のフィブロネクチン阻害薬
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
US5696084A (en) 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
US6492553B1 (en) 1998-01-29 2002-12-10 Aventis Pharamaceuticals Inc. Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds
US6960597B2 (en) * 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
DE10107707A1 (de) 2001-02-19 2002-08-29 Wilex Biotechnology Gmbh Antagonisten für alpha¶4¶beta¶7¶-Integrin
US6667407B2 (en) 2002-05-03 2003-12-23 Bayer Polymers Llc Process of making polyaziridines
AU2005238445B2 (en) 2004-04-15 2012-05-03 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
US8143375B2 (en) 2006-10-20 2012-03-27 The Governing Council Of The University Of Toronto Aziridine aldehydes, aziridine-conjugated amino derivatives, aziridine-conjugated biomolecules and processes for their preparation
EP1961759A1 (en) 2007-02-21 2008-08-27 Universita'degli Studi Di Milano Integrin targeted cyclopeptide ligands, their preparation and use
CA2724818C (en) 2008-05-22 2015-06-16 Centre National De La Recherche Scientifique (Cnrs) New optically pure compounds for improved therapeutic efficiency
CN102498124B (zh) 2009-03-16 2015-05-13 多伦多大学管理委员会 环状氨基酸分子及其制备方法
US20120045393A1 (en) 2009-03-17 2012-02-23 Linder Karen E Lhrh-ii peptide analogs
WO2011124998A1 (en) 2010-04-08 2011-10-13 Pfizer Inc. Substituted 3,5- di phenyl - isoxazoline derivatives as insecticides and acaricides
US9238056B2 (en) 2011-02-22 2016-01-19 Leo Pharma A/S Cyclic peptide and conjugate thereof for binding to keratinocytes
KR20150009952A (ko) 2012-01-27 2015-01-27 에프. 호프만-라 로슈 아게 알파-v-베타-3 발현 세포로의 표적화 전달을 위한 인테그린 안타고니스트 접합체
PL2842945T3 (pl) * 2012-04-24 2017-04-28 Ea Pharma Co., Ltd. Pochodna sulfonamidowa i jej zastosowanie medyczne
US9273093B2 (en) 2012-10-11 2016-03-01 Protagonist Therapeutics, Inc. α4β7 peptide dimer antagonists
DK3143037T3 (da) 2014-05-16 2021-09-20 Protagonist Therapeutics Inc Alpha4beta7-integrin-thioether-peptidantagonister
EP3201217A4 (en) * 2014-10-01 2018-07-18 Protagonist Therapeutics Inc. Novel cyclic monomer and dimer peptides having integrin antagonist activity
SG11201702553RA (en) * 2014-10-01 2017-04-27 Protagonist Therapeutics Inc NOVEL α4β7 PEPTIDE MONOMER AND DIMER ANTAGONISTS
CN109071602B (zh) 2015-11-11 2022-09-13 西兰制药公司 靶向α4β7整联蛋白的环肽
ES2884107T3 (es) * 2016-11-11 2021-12-10 Zealand Pharma As Multímeros de péptidos cíclicos con diana en la integrina alfa-4 beta-7

Also Published As

Publication number Publication date
US20210324007A1 (en) 2021-10-21
EP3939989A1 (en) 2022-01-19
US20230406884A1 (en) 2023-12-21
EP3538542A4 (en) 2020-08-26
US11111273B2 (en) 2021-09-07
ES2884107T3 (es) 2021-12-10
JP2022078188A (ja) 2022-05-24
JP7035044B2 (ja) 2022-03-14
US20200216501A1 (en) 2020-07-09
CA3042576A1 (en) 2018-05-17
JP2020504080A (ja) 2020-02-06
WO2018085921A1 (en) 2018-05-17
US11713338B2 (en) 2023-08-01
JP7429726B2 (ja) 2024-02-08
EP3538542B1 (en) 2021-08-04
CN110088121A (zh) 2019-08-02
EP3538542A1 (en) 2019-09-18

Similar Documents

Publication Publication Date Title
DK3519420T3 (da) Cykliske dinukleotidforbindelser
DK3405050T3 (da) Børnesikret snusbeholder
DK3436823T3 (da) Antigen-array
FI20160137A (fi) Vikavirtaindikaattori
DK3335532T3 (da) Tandharve
DK3445708T3 (da) Stigbøjle
DK3402792T3 (da) Quinolin-2-on-derivater
DK3538542T3 (da) Cykliske peptidmultimerer målrettet alfa-4beta-7-integrin
DK3509963T3 (da) Pallecontainer
FI20165164A (fi) Kellukekone
FI20165213A (fi) Hyperspektrikuvausjärjestely
DK3528829T3 (da) Bacitracin-alginat-oligomer-konjugater
DK3575238T3 (da) Pallecontainer
DE112017006386A5 (de) Schraubarbeitszylinder
DE112017000734A5 (de) Glycolsensor
DK3471535T3 (da) Dyrelift
DK3323708T3 (da) Bovfender
DK3452590T3 (da) Plademagnet
DK3452587T3 (da) Penicillin-g-acylaser
DK3295800T3 (da) Sandwichkiksindretning
DE112017006474A5 (de) Gargerätevorrichtung
DK3551954T3 (da) Rekuperator
DE112017005767A5 (de) Nasslaufende lamellenkupplung
DK3468607T3 (da) Resveratrolsolubilisat
DK3430609T3 (da) Smartflag