DK3519558T3 - Anvendelse af modificeret nyrevæv i assays - Google Patents
Anvendelse af modificeret nyrevæv i assays Download PDFInfo
- Publication number
- DK3519558T3 DK3519558T3 DK17857412.5T DK17857412T DK3519558T3 DK 3519558 T3 DK3519558 T3 DK 3519558T3 DK 17857412 T DK17857412 T DK 17857412T DK 3519558 T3 DK3519558 T3 DK 3519558T3
- Authority
- DK
- Denmark
- Prior art keywords
- assays
- kidney tissue
- modified kidney
- modified
- tissue
- Prior art date
Links
- 238000003556 assay Methods 0.000 title 1
- 210000005084 renal tissue Anatomy 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/04—Screening or testing on artificial tissues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662400894P | 2016-09-28 | 2016-09-28 | |
| US201762453367P | 2017-02-01 | 2017-02-01 | |
| PCT/US2017/053997 WO2018064323A1 (en) | 2016-09-28 | 2017-09-28 | Use of engineered renal tissues in assays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3519558T3 true DK3519558T3 (da) | 2023-11-13 |
Family
ID=61760966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17857412.5T DK3519558T3 (da) | 2016-09-28 | 2017-09-28 | Anvendelse af modificeret nyrevæv i assays |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11268950B2 (da) |
| EP (1) | EP3519558B1 (da) |
| JP (1) | JP2019537729A (da) |
| AU (2) | AU2017335841A1 (da) |
| DK (1) | DK3519558T3 (da) |
| WO (1) | WO2018064323A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11143659B2 (en) | 2015-01-27 | 2021-10-12 | Arterez, Inc. | Biomarkers of vascular disease |
| WO2018064323A1 (en) | 2016-09-28 | 2018-04-05 | Organovo, Inc. | Use of engineered renal tissues in assays |
| US20210128636A1 (en) * | 2018-05-04 | 2021-05-06 | Figene, Llc | Fibroblast delivery of tumor inhibitory agents |
| DE102018111751A1 (de) * | 2018-05-16 | 2019-11-21 | Cellbricks Gmbh | Verfahren zur Herstellung eines Zellkultureinsatzes mit mindestens einer Membran |
| JP2022521010A (ja) * | 2019-02-21 | 2022-04-04 | イッスム・リサーチ・デベロプメント・カムパニー・オブ・ザ・ヘブリュー・ユニバシティー・オブ・エルサレム リミテッド | 薬物誘導性腎毒性を減少させるための方法 |
| CN109771648A (zh) * | 2019-03-11 | 2019-05-21 | 上海市东方医院（同济大学附属东方医院） | 去泛素化酶usp11的抑制剂在制备预防或治疗尿酸性肾病药物中的用途 |
| GB2599815A (en) * | 2019-05-30 | 2022-04-13 | Discoverybiomed Inc | Human diseased and normal kidney epithelial cell cultures and uses thereof |
| CN114667340A (zh) * | 2019-08-23 | 2022-06-24 | 默多克儿童研究所 | 生物打印肾组织 |
| JPWO2022004718A1 (da) * | 2020-06-29 | 2022-01-06 | ||
| CN112014501B (zh) * | 2020-08-25 | 2021-09-10 | 北京师范大学 | 一种类固醇***在小麦体内迁移过程的研究方法 |
| WO2023230508A2 (en) * | 2022-05-26 | 2023-11-30 | University Of Washington | Systems and methods for characterization of polycystic kidney disease |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6517872B1 (en) | 1995-06-12 | 2003-02-11 | Yeda Research And Development Co., Ltd. | FGFR3 as a marker for mesenchymal skeletal progenitor cells |
| DE69727817T2 (de) | 1996-09-05 | 2005-01-05 | Children's Medical Center Corp., Boston | Nierenprothese und ihre Verwendung zum Behandeln einer Nierenkrankheit |
| JP4533534B2 (ja) | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | グリコーゲンシンターゼキナーゼ３のインヒビター |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| US7439064B2 (en) | 2000-03-09 | 2008-10-21 | Wicell Research Institute, Inc. | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium |
| US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| US7326570B2 (en) | 2000-06-16 | 2008-02-05 | The Regents Of The University Of California | Induction of tubular morphogenesis using pleiotrophin |
| US6477783B1 (en) | 2000-09-19 | 2002-11-12 | The United States Of America As Represented By The Secretary Of Transportation | Gyratory compactor angle measurement device |
| CA2468292A1 (en) | 2001-11-26 | 2003-06-05 | Advanced Cell Technology, Inc. | Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells |
| CN1845987A (zh) | 2003-08-29 | 2006-10-11 | 明尼苏达大学董事会 | 肾来源的干细胞及其分离、分化和使用方法 |
| KR20060114713A (ko) | 2003-12-12 | 2006-11-07 | 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 | 멕신/ＲＡＧＥ/ｉＮＯＳ 발현 질환 모델동물 및 상기 동물을 사용한 화합물의 평가방법 |
| WO2005075636A1 (en) | 2004-02-09 | 2005-08-18 | The University Of Queensland | Molecular markers associated with metanephric development and renal progenitors |
| US8241905B2 (en) | 2004-02-24 | 2012-08-14 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
| US8597947B2 (en) | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
| GB0615327D0 (en) | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
| EP1999249B8 (en) | 2006-03-30 | 2012-02-15 | The University Court Of The University of Edinburgh | Culture medium containing kinase inhibitors. and uses thereof |
| US20100092432A1 (en) | 2006-08-08 | 2010-04-15 | Takenori Ozaki | Cell preparation containing multipotential stem cells originating in fat tissue |
| EP2457997B1 (en) | 2007-01-03 | 2016-08-31 | NeoStem Oncology, LLC | Stem cell growth media and methods of making and using same |
| JP5646990B2 (ja) | 2007-04-23 | 2014-12-24 | ストワーズ インスティテュート フォー メディカル リサーチ | 幹細胞自己複製のための方法及び組成物 |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| ES2587395T3 (es) | 2008-06-04 | 2016-10-24 | Cellular Dynamics International, Inc. | Procedimientos para la producción de células IPS usando un enfoque no vírico |
| US8278105B2 (en) | 2008-09-09 | 2012-10-02 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
| CA2747398C (en) | 2008-12-17 | 2023-06-20 | The Scripps Research Institute | Generation and maintenance of stem cells |
| WO2010108126A2 (en) | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Reprogramming compositions and methods of using the same |
| US10894944B2 (en) | 2009-04-10 | 2021-01-19 | Monash University | Cell culture media |
| CN102597220A (zh) | 2009-08-17 | 2012-07-18 | 株式会社器官再生工学 | 生物人工内脏器官的制造方法 |
| CN102242146B (zh) | 2010-05-10 | 2015-11-25 | 高丽大学校产学协力团 | 组合物和用其产生诱导全能干细胞的方法 |
| EP2569417B1 (en) | 2010-05-13 | 2018-04-18 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Isolated populations of adult renal cells and methods of isolating and using same |
| JP5896360B2 (ja) | 2010-07-21 | 2016-04-13 | 国立大学法人京都大学 | ヒト多能性幹細胞から中間中胚葉細胞への分化誘導方法 |
| EP2598634A1 (en) | 2010-07-26 | 2013-06-05 | The University Of Manchester | Targeted differentiation of stem cells |
| BR112013009744A2 (pt) | 2010-10-21 | 2016-07-19 | Organovo Inc | dispositivo, sistemas e métodos para a fabricação de tecido |
| MX349658B (es) | 2011-06-09 | 2017-08-08 | Hoffmann La Roche | Metodo para la diferenciacion de las celulas madre pluripotentes en celulas de lecho vascular. |
| CA3157246A1 (en) * | 2011-09-12 | 2013-03-21 | Organovo, Inc. | Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same |
| WO2013040087A2 (en) | 2011-09-12 | 2013-03-21 | Organovo, Inc. | Platform for engineered implantable tissues and organs and methods of making the same |
| WO2013056072A1 (en) | 2011-10-13 | 2013-04-18 | Wisconsin Alumni Research Foundation | Generation of cardiomyocytes from human pluripotent stem cells |
| EP3425391A1 (en) * | 2011-11-04 | 2019-01-09 | inRegen | Drug screening and potency assays |
| JP6143268B2 (ja) | 2011-12-19 | 2017-06-07 | 国立大学法人京都大学 | ヒト多能性幹細胞から中間中胚葉細胞への分化誘導方法 |
| KR20130119683A (ko) | 2012-04-24 | 2013-11-01 | 사회복지법인 삼성생명공익재단 | 줄기세포 배양 배지 및 이를 이용한 줄기세포의 배양방법 |
| KR101523040B1 (ko) | 2012-06-26 | 2015-05-26 | 라정찬 | 고농도의 줄기세포 제조방법 |
| US8962322B2 (en) | 2012-12-03 | 2015-02-24 | City Of Hope | Enhancers of induced pluripotent stem cell reprogramming |
| US20150037883A1 (en) | 2013-03-03 | 2015-02-05 | Royan Institute | Method for derivation and long-term establishment of ground state pluripotent embryonic stem cells |
| GB201307310D0 (en) | 2013-04-23 | 2013-05-29 | Ucl Business Plc | Treatment |
| EP3020803B1 (en) | 2013-06-11 | 2020-03-11 | Kyoto University | Method for producing renal precursor cells |
| WO2014197934A1 (en) | 2013-06-14 | 2014-12-18 | The University Of Queensland | Renal progenitor cells |
| WO2015017579A1 (en) | 2013-07-31 | 2015-02-05 | Organovo, Inc. | Automated devices, systems, and methods for the fabrication of tissue |
| CN103555660B (zh) | 2013-09-09 | 2016-03-30 | 依科赛生物科技（太仓）有限公司 | 一种胚胎干细胞无血清培养基及其应用 |
| CN104518333A (zh) | 2013-09-30 | 2015-04-15 | 鸿富锦精密电子(天津)有限公司 | 连接器组合及其固定件 |
| AU2014346959B2 (en) | 2013-11-05 | 2018-07-19 | President And Fellows Of Harvard College | Method of printing a tissue construct with embedded vasculature |
| MA40495A (fr) | 2014-10-06 | 2016-04-14 | Organovo Inc | Tissus rénaux produits par génie génétique, réseaux correspondants, et procédés de production |
| AU2014277667B2 (en) | 2014-12-15 | 2022-07-14 | The University Of Queensland | Differentiation of pluripotent stem cells to form renal organoids |
| US20180258404A1 (en) * | 2015-09-17 | 2018-09-13 | The Brigham And Women's Hospital, Inc. | Methods of generating nephrons from human pluripotent stem cells |
| WO2018064323A1 (en) | 2016-09-28 | 2018-04-05 | Organovo, Inc. | Use of engineered renal tissues in assays |
-
2017
- 2017-09-28 WO PCT/US2017/053997 patent/WO2018064323A1/en unknown
- 2017-09-28 AU AU2017335841A patent/AU2017335841A1/en not_active Abandoned
- 2017-09-28 EP EP17857412.5A patent/EP3519558B1/en active Active
- 2017-09-28 JP JP2019538105A patent/JP2019537729A/ja not_active Withdrawn
- 2017-09-28 US US16/334,937 patent/US11268950B2/en active Active
- 2017-09-28 DK DK17857412.5T patent/DK3519558T3/da active
-
2024
- 2024-02-26 AU AU2024201266A patent/AU2024201266A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018064323A1 (en) | 2018-04-05 |
| US11268950B2 (en) | 2022-03-08 |
| JP2019537729A (ja) | 2019-12-26 |
| US20200018747A1 (en) | 2020-01-16 |
| AU2024201266A1 (en) | 2024-03-14 |
| AU2017335841A1 (en) | 2019-04-04 |
| US20220229045A1 (en) | 2022-07-21 |
| EP3519558A1 (en) | 2019-08-07 |
| EP3519558B1 (en) | 2023-08-09 |
| EP3519558A4 (en) | 2020-08-05 |
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