DK3430022T3 - Forbindelser og fremgangsmåder til syntese af 5-(N-beskyttet-tryptaminocarboxyamid)-2'-deoxyuridin-phosphoramidit til inkorporering i en nukleinsyresekvens - Google Patents
Forbindelser og fremgangsmåder til syntese af 5-(N-beskyttet-tryptaminocarboxyamid)-2'-deoxyuridin-phosphoramidit til inkorporering i en nukleinsyresekvens Download PDFInfo
- Publication number
- DK3430022T3 DK3430022T3 DK17713541.5T DK17713541T DK3430022T3 DK 3430022 T3 DK3430022 T3 DK 3430022T3 DK 17713541 T DK17713541 T DK 17713541T DK 3430022 T3 DK3430022 T3 DK 3430022T3
- Authority
- DK
- Denmark
- Prior art keywords
- tryptaminocarboxyamide
- incorporation
- synthesis
- protected
- compounds
- Prior art date
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4727—Calcium binding proteins, e.g. calmodulin
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30036—Dental; Teeth
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Quality & Reliability (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Theoretical Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dentistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662308132P | 2016-03-14 | 2016-03-14 | |
PCT/US2017/022007 WO2017160672A1 (en) | 2016-03-14 | 2017-03-13 | Compounds and methods for the synthesis of 5-(n-protected-tryptaminocarboxyamide)-2'-deoxyuridine phosphoramidate for incorporation into a nucleic sequence |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3430022T3 true DK3430022T3 (da) | 2020-05-18 |
Family
ID=58410476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17713541.5T DK3430022T3 (da) | 2016-03-14 | 2017-03-13 | Forbindelser og fremgangsmåder til syntese af 5-(N-beskyttet-tryptaminocarboxyamid)-2'-deoxyuridin-phosphoramidit til inkorporering i en nukleinsyresekvens |
Country Status (18)
Country | Link |
---|---|
US (2) | US10634679B2 (da) |
EP (1) | EP3430022B1 (da) |
JP (1) | JP6853265B2 (da) |
KR (1) | KR102269009B1 (da) |
CN (1) | CN108779140B (da) |
AR (1) | AR107867A1 (da) |
AU (1) | AU2017233994B2 (da) |
BR (1) | BR112018017316B1 (da) |
CA (1) | CA3017853A1 (da) |
DK (1) | DK3430022T3 (da) |
ES (1) | ES2784946T3 (da) |
HK (1) | HK1257431A1 (da) |
IL (1) | IL261250A (da) |
MX (1) | MX2018011052A (da) |
RU (1) | RU2750989C2 (da) |
SG (2) | SG10201911357VA (da) |
TW (1) | TWI733772B (da) |
WO (1) | WO2017160672A1 (da) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10049447B2 (en) * | 2013-11-06 | 2018-08-14 | H. Lee Moffitt Cancer Center and Research Insititute, Inc. | Pathology case review, analysis and prediction |
WO2024121253A1 (en) * | 2022-12-06 | 2024-06-13 | Mihkal Gmbh | Novel n,n-dimethyltryptamine (dmt) derivatives and uses thereof |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
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JP4899014B2 (ja) * | 1995-06-02 | 2012-03-21 | イーシー・テクノロジー・エルエルシー | 求核試薬および一酸化炭素を用いるパラジウム触媒ヌクレオシド修飾方法 |
US5945527A (en) * | 1996-05-30 | 1999-08-31 | Nexstar Pharmaceuticals, Inc. | Palladium catalyzed nucleoside modification methods using nucleophiles and carbon monoxide |
IL138825A (en) * | 2000-10-03 | 2006-06-11 | Neurim Pharma 1991 | Pharmaceutical preparations containing tryptamine derivatives and similar compounds, and such new compounds |
US20060063190A1 (en) | 2004-09-22 | 2006-03-23 | Tripath Imaging, Inc | Methods and compositions for evaluating breast cancer prognosis |
EP1960757A1 (en) | 2005-11-25 | 2008-08-27 | British Columbia Cancer Agency Branch | Apparatus and methods for automated assessment of tissue pathology |
CA2604317C (en) * | 2007-08-06 | 2017-02-28 | Historx, Inc. | Methods and system for validating sample images for quantitative immunoassays |
US9684001B2 (en) * | 2008-02-07 | 2017-06-20 | Ranju Ralhan | Biomarkers for head-and-neck cancers and precancers |
ES2573945T3 (es) * | 2008-09-16 | 2016-06-13 | Novartis Ag | Cuantificación reproducible de expresión de biomarcadores |
JP5544833B2 (ja) | 2009-11-17 | 2014-07-09 | 富士通株式会社 | インドール基用保護基 |
ES2905656T3 (es) * | 2010-04-12 | 2022-04-11 | Somalogic Operating Co Inc | Pirimidinas modificadas en posición 5 y su uso |
AU2013202528B2 (en) * | 2010-04-12 | 2015-07-30 | Somalogic Operating Co., Inc. | 5-position modified pyrimidines and their use |
AU2011248632B2 (en) | 2010-04-27 | 2015-07-02 | Prelude Corporation | Cancer biomarkers and methods of use thereof |
US20140235487A1 (en) | 2010-11-12 | 2014-08-21 | William Marsh Rice University | Oral cancer risk scoring |
US10018631B2 (en) | 2011-03-17 | 2018-07-10 | Cernostics, Inc. | Systems and compositions for diagnosing Barrett's esophagus and methods of using the same |
TWI541249B (zh) * | 2011-04-12 | 2016-07-11 | 身體邏輯公司 | 5-位置經修飾之嘧啶類及彼等之用途 |
EP2639238A1 (en) | 2012-03-15 | 2013-09-18 | Universität Bern | Tricyclic nucleosides and oligomeric compounds prepared therefrom |
EP2772882A1 (en) * | 2013-03-01 | 2014-09-03 | Universite D'angers | Automatic measurement of lesions on medical images |
WO2014144657A2 (en) | 2013-03-15 | 2014-09-18 | Metamark Genetics, Inc. | Compositions and methods for cancer prognosis |
LT2984108T (lt) * | 2013-04-09 | 2017-11-10 | Lykera Biomed, S.A. | Anti-s100a7 antikūnai, skirti vėžio gydymui ir diagnozei |
US10983126B2 (en) | 2013-05-31 | 2021-04-20 | The Brigham And Women's Hospital | System and method for analyzing tissue for the presence of cancer using bio-marker profiles |
AU2014326975B2 (en) | 2013-09-24 | 2020-05-07 | Somalogic Operating Co., Inc. | Multiaptamer target detection |
US9598456B2 (en) | 2014-03-30 | 2017-03-21 | Cepheid | Modified cytosine polynucleotide oligomers and methods |
EP2933639A1 (en) * | 2014-04-16 | 2015-10-21 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | S100p and Hyaluronic acid as biomarkers for metastatic breast cancer |
WO2015191303A2 (en) | 2014-06-10 | 2015-12-17 | Agilent Technologies, Inc. | Protecting groups for "z nucleotide" and methods thereof |
WO2015189264A1 (en) * | 2014-06-10 | 2015-12-17 | Ventana Medical Systems, Inc. | Predicting breast cancer recurrence directly from image features computed from digitized immunohistopathology tissue slides |
US9298968B1 (en) * | 2014-09-12 | 2016-03-29 | Flagship Biosciences, Inc. | Digital image analysis of inflammatory cells and mediators of inflammation |
WO2016087592A1 (en) * | 2014-12-03 | 2016-06-09 | Ventana Medical Systems, Inc. | Systems and methods for early-stage cancer prognosis |
WO2017012555A1 (zh) * | 2015-07-20 | 2017-01-26 | 徐敏 | 光子结构和化学计量学病理*** |
-
2017
- 2017-03-13 CA CA3017853A patent/CA3017853A1/en active Pending
- 2017-03-13 BR BR112018017316-9A patent/BR112018017316B1/pt active IP Right Grant
- 2017-03-13 MX MX2018011052A patent/MX2018011052A/es unknown
- 2017-03-13 CN CN201780012492.8A patent/CN108779140B/zh active Active
- 2017-03-13 SG SG10201911357VA patent/SG10201911357VA/en unknown
- 2017-03-13 ES ES17713541T patent/ES2784946T3/es active Active
- 2017-03-13 TW TW106108101A patent/TWI733772B/zh active
- 2017-03-13 AR ARP170100622A patent/AR107867A1/es unknown
- 2017-03-13 DK DK17713541.5T patent/DK3430022T3/da active
- 2017-03-13 RU RU2018135738A patent/RU2750989C2/ru active
- 2017-03-13 US US16/078,859 patent/US10634679B2/en active Active
- 2017-03-13 SG SG11201807079UA patent/SG11201807079UA/en unknown
- 2017-03-13 AU AU2017233994A patent/AU2017233994B2/en active Active
- 2017-03-13 EP EP17713541.5A patent/EP3430022B1/en active Active
- 2017-03-13 KR KR1020187026253A patent/KR102269009B1/ko active IP Right Grant
- 2017-03-13 WO PCT/US2017/022007 patent/WO2017160672A1/en active Application Filing
- 2017-03-13 JP JP2018547892A patent/JP6853265B2/ja active Active
- 2017-03-14 US US16/083,663 patent/US11585816B2/en active Active
-
2018
- 2018-08-20 IL IL261250A patent/IL261250A/en active IP Right Grant
- 2018-12-27 HK HK18116643.7A patent/HK1257431A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
ES2784946T3 (es) | 2020-10-02 |
CN108779140B (zh) | 2022-04-12 |
CN108779140A (zh) | 2018-11-09 |
US11585816B2 (en) | 2023-02-21 |
HK1257431A1 (zh) | 2019-10-18 |
AU2017233994B2 (en) | 2021-02-18 |
JP2019508438A (ja) | 2019-03-28 |
BR112018017316B1 (pt) | 2022-08-02 |
AR107867A1 (es) | 2018-06-13 |
EP3430022A1 (en) | 2019-01-23 |
WO2017160672A1 (en) | 2017-09-21 |
SG10201911357VA (en) | 2020-01-30 |
RU2018135738A3 (da) | 2020-07-22 |
CA3017853A1 (en) | 2017-09-21 |
JP6853265B2 (ja) | 2021-03-31 |
AU2017233994A1 (en) | 2018-08-30 |
TW201734030A (zh) | 2017-10-01 |
RU2018135738A (ru) | 2020-04-15 |
KR102269009B1 (ko) | 2021-06-28 |
TWI733772B (zh) | 2021-07-21 |
SG11201807079UA (en) | 2018-09-27 |
KR20180116312A (ko) | 2018-10-24 |
BR112018017316A2 (pt) | 2019-01-02 |
RU2750989C2 (ru) | 2021-07-07 |
MX2018011052A (es) | 2019-01-24 |
IL261250A (en) | 2018-10-31 |
US20190072559A1 (en) | 2019-03-07 |
US20190031702A1 (en) | 2019-01-31 |
US10634679B2 (en) | 2020-04-28 |
EP3430022B1 (en) | 2020-03-11 |
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