DK3381469T3 - Anti-erbb2 antistoflægemiddelskonjugat og sammensætning deraf, fremgangsmåde til fremstilling deraf og anvendelse deraf - Google Patents
Anti-erbb2 antistoflægemiddelskonjugat og sammensætning deraf, fremgangsmåde til fremstilling deraf og anvendelse deraf Download PDFInfo
- Publication number
- DK3381469T3 DK3381469T3 DK16867957.9T DK16867957T DK3381469T3 DK 3381469 T3 DK3381469 T3 DK 3381469T3 DK 16867957 T DK16867957 T DK 16867957T DK 3381469 T3 DK3381469 T3 DK 3381469T3
- Authority
- DK
- Denmark
- Prior art keywords
- conjugate
- manufacture
- composition
- erbb2 antibody
- antibody medicines
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/07—Bacillus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510824064.8A CN106729743B (zh) | 2015-11-23 | 2015-11-23 | 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用 |
PCT/CN2016/106802 WO2017088734A1 (zh) | 2015-11-23 | 2016-11-22 | 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3381469T3 true DK3381469T3 (da) | 2021-08-09 |
Family
ID=58762994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16867957.9T DK3381469T3 (da) | 2015-11-23 | 2016-11-22 | Anti-erbb2 antistoflægemiddelskonjugat og sammensætning deraf, fremgangsmåde til fremstilling deraf og anvendelse deraf |
Country Status (15)
Country | Link |
---|---|
US (3) | US20190076438A1 (da) |
EP (1) | EP3381469B1 (da) |
JP (2) | JP6888871B2 (da) |
KR (1) | KR20180080128A (da) |
CN (4) | CN106729743B (da) |
AU (1) | AU2016359514A1 (da) |
CA (1) | CA3000763A1 (da) |
DK (1) | DK3381469T3 (da) |
EA (1) | EA039757B1 (da) |
ES (1) | ES2887349T3 (da) |
HK (1) | HK1243957B (da) |
HU (1) | HUE055671T2 (da) |
PL (1) | PL3381469T3 (da) |
PT (1) | PT3381469T (da) |
WO (1) | WO2017088734A1 (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106729743B (zh) * | 2015-11-23 | 2021-09-21 | 四川科伦博泰生物医药股份有限公司 | 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用 |
CN107857798B (zh) * | 2016-09-22 | 2021-03-23 | 联宁(苏州)生物制药有限公司 | 一种用于抗体药物偶联物的毒素及其制备方法 |
CN107915770B (zh) * | 2016-10-11 | 2020-08-25 | 联宁(苏州)生物制药有限公司 | 一种抗体药物偶联物中间体及其制备方法 |
WO2018158716A1 (en) * | 2017-03-02 | 2018-09-07 | Cadila Healthcare Limited | Novel protein drug conjugate formulation |
US11207420B2 (en) | 2017-04-19 | 2021-12-28 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Cytotoxin and conjugate, uses of same and preparation method therefor |
CA3080236A1 (en) * | 2017-12-15 | 2019-06-20 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Bioactive molecule conjugate, preparation method and use thereof |
WO2019149116A1 (zh) * | 2018-01-30 | 2019-08-08 | 四川科伦博泰生物医药股份有限公司 | 制备偶联物的方法 |
CN111867629A (zh) * | 2018-05-11 | 2020-10-30 | 四川科伦博泰生物医药股份有限公司 | 抗her2抗体-药物偶联物在治疗癌症中的用途 |
CN109692331A (zh) * | 2019-01-07 | 2019-04-30 | 合肥瀚科迈博生物技术有限公司 | 一种抗体偶联药物的制备方法 |
DK3811979T3 (da) * | 2019-03-26 | 2024-01-02 | Remegen Co Ltd | Farmaceutisk præparat med anti-HER2-antistoflægemiddelkonjugat |
IL295312A (en) | 2020-02-28 | 2022-10-01 | Regeneron Pharma | Bispecific antigen binding molecules that bind her2 and methods of using them |
CA3194765A1 (en) | 2020-09-16 | 2022-03-24 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Anti-nectin-4 antibody, conjugate including same, and application thereof |
WO2022233262A1 (zh) * | 2021-05-07 | 2022-11-10 | 四川科伦博泰生物医药股份有限公司 | 抗体药物偶联物治疗癌症的方法及用途 |
CN113521018B (zh) * | 2021-07-20 | 2022-11-18 | 浙江新码生物医药有限公司 | 一种含有抗her2-药物偶联物的冻干组合物、冻干制剂及其制备方法和用途 |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
ES2206447T3 (es) | 1991-06-14 | 2004-05-16 | Genentech, Inc. | Anticuerpo humanizado para heregulina. |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
AU4025193A (en) | 1992-04-08 | 1993-11-18 | Cetus Oncology Corporation | Humanized C-erbB-2 specific antibodies |
ATE149570T1 (de) | 1992-08-17 | 1997-03-15 | Genentech Inc | Bispezifische immunoadhesine |
AU4289496A (en) | 1994-12-02 | 1996-06-19 | Chiron Corporation | Method of promoting an immune response with a bispecific antibody |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
NZ519191A (en) | 1996-10-18 | 2005-04-29 | Univ Texas | Antibodies that bind to domain 1 of ErbB2 useful for inducing cell death via apoptosis, and nucleic acids encoding such antibodies |
EP1189641B1 (en) | 1999-06-25 | 2009-07-29 | Genentech, Inc. | HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
EP1216258A1 (en) | 1999-09-28 | 2002-06-26 | Universität Zürich | Factors having prion-binding activity in serum and plasma and agents to detect transmissible spongiform encephalopathitis |
ES2528794T3 (es) | 2000-04-11 | 2015-02-12 | Genentech, Inc. | Anticuerpos multivalentes y usos de los mismos |
US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
US7129261B2 (en) | 2001-05-31 | 2006-10-31 | Medarex, Inc. | Cytotoxic agents |
CA2525130C (en) | 2003-05-20 | 2014-04-15 | Immunogen, Inc. | Improved cytotoxic agents comprising new maytansinoids |
US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
AU2004284075A1 (en) | 2003-10-22 | 2005-05-06 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto |
KR101520209B1 (ko) | 2003-11-06 | 2015-05-13 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
CA2559870A1 (en) * | 2004-04-07 | 2005-10-27 | Genetech,Inc. | Mass spectrometry of antibody conjugates |
NZ551180A (en) * | 2004-06-01 | 2009-10-30 | Genentech Inc | Antibody drug conjugates and methods |
TW200812615A (en) * | 2006-03-22 | 2008-03-16 | Hoffmann La Roche | Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2 |
EP2441472B1 (en) * | 2006-08-21 | 2015-06-10 | F. Hoffmann-La Roche AG | Tumor therapy with an anti-VEGF antibody |
DK2644194T3 (da) * | 2008-03-18 | 2017-07-03 | Genentech Inc | Kombinationer af et anti-HER2-antistof-lægemiddel-konjugat og docetaxel |
WO2009123894A2 (en) | 2008-04-02 | 2009-10-08 | Macrogenics, Inc. | Her2/neu-specific antibodies and methods of using same |
US8406739B2 (en) * | 2008-11-19 | 2013-03-26 | At&T Mobility Ii Llc | Mediation router |
CN101463344B (zh) * | 2009-01-15 | 2012-06-27 | 协和干细胞基因工程有限公司 | 抗人Her2单克隆抗体杂交瘤细胞系、单克隆抗体、试剂盒及其用途 |
ES2572728T3 (es) | 2009-03-20 | 2016-06-02 | F. Hoffmann-La Roche Ag | Anticuerpos anti-HER biespecíficos |
US9345661B2 (en) * | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
PE20130643A1 (es) | 2010-07-12 | 2013-06-07 | Covx Technologies Ireland Ltd | Conjugados de anticuerpos multifuncionales |
AU2011323316B2 (en) | 2010-11-03 | 2016-02-25 | Immunogen, Inc. | Cytotoxic agents comprising new ansamitocin derivatives |
EP2648753A4 (en) | 2010-12-10 | 2015-06-24 | Merrimack Pharmaceuticals Inc | ASSAY AND ADMINISTRATION OF BISPECIFIC SCFV CONJUGATES |
US9981046B2 (en) * | 2012-05-15 | 2018-05-29 | Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. | Drug-conjugates, conjugation methods, and uses thereof |
US9107960B2 (en) | 2012-12-13 | 2015-08-18 | Immunimedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
EP2927227A4 (en) * | 2013-01-03 | 2015-12-30 | Celltrion Inc | ANTIBODY CONCENTRATOR REMEDY CONJUGATE, METHOD OF MANUFACTURING THEREOF, AND ANTIBODY TOGETHER THEREWITH |
CN103319599B (zh) * | 2013-05-27 | 2015-02-18 | 上海交联药物研发有限公司 | 一种抗人ErbB2抗体—美登木素偶联物及其应用 |
WO2014203898A1 (ja) * | 2013-06-17 | 2014-12-24 | アイシン・エィ・ダブリュ株式会社 | パーキング装置 |
CN104418952B (zh) | 2013-09-04 | 2017-08-08 | 上海张江生物技术有限公司 | 一种用于治疗乳腺癌的抗ErbB2双特异性抗体 |
CA2920192A1 (en) * | 2013-09-27 | 2015-04-02 | Immunomedics, Inc. | Anti-trop-2 antibody-drug conjugates and uses thereof |
AU2014337317A1 (en) * | 2013-10-15 | 2016-09-15 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
AU2015205509B2 (en) * | 2014-01-10 | 2019-08-15 | Byondis B.V. | Duocarmycin ADCs showing improved in vivo antitumor activity |
CN104892763A (zh) * | 2014-03-05 | 2015-09-09 | 中国科学院上海药物研究所 | 抗体-药物偶联物Pertuzumab-MCC-DM1、其与Trastuzumab的组合物及其应用 |
JP6871858B2 (ja) * | 2015-01-28 | 2021-05-19 | ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. | 抗体薬物コンジュゲート |
CN106729743B (zh) | 2015-11-23 | 2021-09-21 | 四川科伦博泰生物医药股份有限公司 | 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用 |
CN107029244B (zh) * | 2016-02-04 | 2021-04-27 | 浙江昭华生物医药有限公司 | 抗her2抗体-药物偶联物及其应用 |
WO2018036438A1 (zh) * | 2016-08-23 | 2018-03-01 | 四川科伦博泰生物医药股份有限公司 | 一种抗体-药物偶联物及其制备方法和应用 |
CN107915770B (zh) * | 2016-10-11 | 2020-08-25 | 联宁(苏州)生物制药有限公司 | 一种抗体药物偶联物中间体及其制备方法 |
-
2015
- 2015-11-23 CN CN201510824064.8A patent/CN106729743B/zh active Active
-
2016
- 2016-11-22 JP JP2017566133A patent/JP6888871B2/ja active Active
- 2016-11-22 CN CN201811298547.9A patent/CN109395089B/zh active Active
- 2016-11-22 AU AU2016359514A patent/AU2016359514A1/en not_active Abandoned
- 2016-11-22 PT PT168679579T patent/PT3381469T/pt unknown
- 2016-11-22 CA CA3000763A patent/CA3000763A1/en active Pending
- 2016-11-22 DK DK16867957.9T patent/DK3381469T3/da active
- 2016-11-22 EA EA201792590A patent/EA039757B1/ru unknown
- 2016-11-22 CN CN201680036760.5A patent/CN107921124B/zh active Active
- 2016-11-22 PL PL16867957T patent/PL3381469T3/pl unknown
- 2016-11-22 WO PCT/CN2016/106802 patent/WO2017088734A1/zh active Application Filing
- 2016-11-22 ES ES16867957T patent/ES2887349T3/es active Active
- 2016-11-22 KR KR1020177036761A patent/KR20180080128A/ko not_active Application Discontinuation
- 2016-11-22 US US15/765,685 patent/US20190076438A1/en active Pending
- 2016-11-22 EP EP16867957.9A patent/EP3381469B1/en active Active
- 2016-11-22 HU HUE16867957A patent/HUE055671T2/hu unknown
- 2016-11-22 CN CN201811298611.3A patent/CN109395090B/zh active Active
-
2018
- 2018-03-15 HK HK18103610.4A patent/HK1243957B/zh unknown
-
2021
- 2021-02-05 US US17/169,087 patent/US11903948B2/en active Active
- 2021-05-17 JP JP2021083093A patent/JP7200454B2/ja active Active
-
2023
- 2023-05-26 US US18/324,511 patent/US20230293536A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EA201792590A1 (ru) | 2019-03-29 |
CN109395090B (zh) | 2022-03-25 |
CN109395089A (zh) | 2019-03-01 |
CN109395089B (zh) | 2022-08-12 |
PL3381469T3 (pl) | 2021-11-29 |
CN106729743A (zh) | 2017-05-31 |
HK1243957B (zh) | 2019-10-04 |
EP3381469B1 (en) | 2021-06-30 |
AU2016359514A1 (en) | 2018-04-26 |
EP3381469A1 (en) | 2018-10-03 |
KR20180080128A (ko) | 2018-07-11 |
JP2019502650A (ja) | 2019-01-31 |
EA039757B1 (ru) | 2022-03-10 |
PT3381469T (pt) | 2021-09-02 |
CN109395090A (zh) | 2019-03-01 |
US20210252006A1 (en) | 2021-08-19 |
JP6888871B2 (ja) | 2021-06-16 |
CN107921124B (zh) | 2018-12-28 |
WO2017088734A1 (zh) | 2017-06-01 |
EP3381469A4 (en) | 2019-07-31 |
US20230293536A1 (en) | 2023-09-21 |
CA3000763A1 (en) | 2017-06-01 |
CN106729743B (zh) | 2021-09-21 |
US20190076438A1 (en) | 2019-03-14 |
HUE055671T2 (hu) | 2021-12-28 |
CN107921124A (zh) | 2018-04-17 |
JP2021152006A (ja) | 2021-09-30 |
US11903948B2 (en) | 2024-02-20 |
ES2887349T3 (es) | 2021-12-22 |
JP7200454B2 (ja) | 2023-01-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3381469T3 (da) | Anti-erbb2 antistoflægemiddelskonjugat og sammensætning deraf, fremgangsmåde til fremstilling deraf og anvendelse deraf | |
DK3453707T3 (da) | Benzazepinderivat, fremgangsmåde til fremstilling, farmaceutisk sammensætning og anvendelse deraf | |
DK3486242T3 (da) | Oxopicolinamidderivat, fremgangsmåde til fremstilling deraf og farmaceutisk anvendelse deraf | |
DK3280441T3 (da) | Anti-sortilin-antistoffer og fremgangsmåder til anvendelse deraf | |
DK3303394T3 (da) | Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf | |
DK3292150T3 (da) | Aktiverbare anti-cd166-antistoffer og fremgangsmåder til anvendelse deraf | |
DK3283106T3 (da) | Terapeutiske antistoffer og anvendelser deraf | |
DK3312177T3 (da) | Tricyklisk derivatforbindelse, fremgangsmåde til at fremstille samme og farmaceutisk sammensætning omfattende samme | |
DK3443009T3 (da) | Anti-tim-3-antistoffer og sammensætninger | |
DK3258951T3 (da) | Anti-pvrig antistoffer og fremgangsmåder for anvendelse | |
DK3643709T3 (da) | Isoindolinderivat, mellemprodukt, fremgangsmåde til fremstilling, farmaceutisk sammensætning og anvendelse deraf | |
DK3524603T3 (da) | Fgfr4-hæmmer, fremgangsmåde til fremstilling deraf og farmaceutisk anvendelse deraf | |
DK3191135T3 (da) | Anti-HER2-antistoffer og immunokonjugater | |
DK3126394T3 (da) | Anti-OX40-antistoffer og fremgangsmåder til anvendelse | |
DK2986304T3 (da) | Farmaceutisk sammensætning, fremgangsmåder til behandling og anvendelser deraf. | |
DK3316909T3 (da) | Anti-ntb-a-antistoffer og relaterede sammensætninger og fremgangsmåder | |
DK3153169T3 (da) | Fremgangsmåde til behandling af tumor, farmaceutisk sammensætning og medicinæskesæt | |
DK3250610T3 (da) | Fcrn-antistoffer og fremgangsmåder til anvendelse heraf | |
DK3557998T3 (da) | Sammensætninger, kompositioner og anvendelsesmetoder | |
DK3390442T3 (da) | Anti-C5 antistoffer og fremgangsmåde til anvendelse deraf | |
DK3113797T3 (da) | Antistoffer, anvendelser og fremgangsmåder | |
DK3074544T3 (da) | Martensitholdigt rustfrit stål, stykke udført i dette stål og fremgangsmåde til fremstilling heraf | |
DK3280440T3 (da) | Humaniserede anti-c1s-antistoffer og fremgangsmåder til anvendelse deraf | |
DK3424924T3 (da) | Ureaforbindelse, fremgangsmåde til fremstilling deraf og medicinsk anvendelse deraf | |
DK3094640T3 (da) | Fremgangsmåder til steril kromatografi og fremstilling |