DK3354727T3 - Transaminasepolypeptider - Google Patents

Transaminasepolypeptider Download PDF

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Publication number
DK3354727T3
DK3354727T3 DK17208538.3T DK17208538T DK3354727T3 DK 3354727 T3 DK3354727 T3 DK 3354727T3 DK 17208538 T DK17208538 T DK 17208538T DK 3354727 T3 DK3354727 T3 DK 3354727T3
Authority
DK
Denmark
Prior art keywords
transaminase polypeptides
transaminase
polypeptides
Prior art date
Application number
DK17208538.3T
Other languages
English (en)
Inventor
Gregory Miller
Xiyun Zhang
Ish Kumar Dhawan
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42317179&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3354727(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Codexis Inc filed Critical Codexis Inc
Application granted granted Critical
Publication of DK3354727T3 publication Critical patent/DK3354727T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01018—Beta-alanine-pyruvate transaminase (2.6.1.18)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK17208538.3T 2009-01-08 2010-01-08 Transaminasepolypeptider DK3354727T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14340109P 2009-01-08 2009-01-08
EP10729606.3A EP2385983B1 (en) 2009-01-08 2010-01-08 Transaminase polypeptides

Publications (1)

Publication Number Publication Date
DK3354727T3 true DK3354727T3 (da) 2020-11-16

Family

ID=42317179

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10729606.3T DK2385983T3 (da) 2009-01-08 2010-01-08 Transaminase-polypeptider
DK17208538.3T DK3354727T3 (da) 2009-01-08 2010-01-08 Transaminasepolypeptider

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10729606.3T DK2385983T3 (da) 2009-01-08 2010-01-08 Transaminase-polypeptider

Country Status (9)

Country Link
US (11) US8470564B2 (da)
EP (2) EP3354727B1 (da)
CN (1) CN102341494B (da)
DK (2) DK2385983T3 (da)
ES (1) ES2840000T3 (da)
HU (2) HUE036104T2 (da)
IL (2) IL213950A (da)
SG (1) SG172891A1 (da)
WO (1) WO2010081053A2 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG172891A1 (en) 2009-01-08 2011-08-29 Codexis Inc Transaminase polypeptides
WO2010099501A2 (en) 2009-02-26 2010-09-02 Codexis, Inc. Transaminase biocatalysts
EP2446026B1 (en) 2009-06-22 2017-08-09 Codexis, Inc. Transaminase reactions
EP2582799B1 (en) * 2010-06-17 2017-12-20 Codexis, Inc. Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol
US9006460B2 (en) * 2010-08-16 2015-04-14 Cardiome International Ag Process for preparing aminocyclohexyl ether compounds
WO2012024104A2 (en) * 2010-08-16 2012-02-23 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
JP5927178B2 (ja) * 2011-03-11 2016-06-01 株式会社カネカ 改変型アミノ基転移酵素、その遺伝子、およびそれらを利用した光学活性アミノ化合物の製造方法
WO2013036861A1 (en) * 2011-09-08 2013-03-14 Codexis, Inc Biocatalysts and methods for the synthesis of substituted lactams
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
SG11201405990PA (en) 2012-03-23 2014-11-27 Codexis Inc Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
HUE046421T2 (hu) 2012-03-23 2020-02-28 Novartis Ag Kémiai eljárás spiroindolok és intermedierjeik elõállítására
JP2015533501A (ja) * 2012-10-18 2015-11-26 サンド・アクチエンゲゼルシヤフト インドリン誘導体の調製方法
JP6618180B2 (ja) 2012-12-21 2019-12-11 コデクシス， インコーポレイテッド キラルアミンを合成するための操作された生体触媒および方法
SI2978748T1 (sl) * 2013-03-27 2017-07-31 Pfizer Ireland Pharmaceuticals Postopek in intermediati za pripravo pregabalina
ES2857711T3 (es) 2013-09-27 2021-09-29 Codexis Inc Filtración automática de variantes de enzimas
ES2734579T3 (es) 2013-11-26 2019-12-10 Asymchem Lab Tianjin Co Ltd Transaminasa y utilización de la misma
US10370693B2 (en) 2015-06-12 2019-08-06 C-Lecta Gmbh Transaminases
KR20170004510A (ko) 2015-07-02 2017-01-11 씨제이제일제당 (주) 신규 트랜스아미나제 및 이를 이용한 아미노 화합물의 탈아민 방법
ES2830266T3 (es) 2015-12-10 2021-06-03 Novartis Ag Compuestos intermedios para la preparación de sacubitril y su preparación
EP3415630A1 (en) 2017-06-14 2018-12-19 EntreChem, S.L. Method for one-pot production of a primary amine from an alcohol
WO2018231462A1 (en) * 2017-06-14 2018-12-20 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
EP3450566A1 (en) * 2017-09-01 2019-03-06 Vito NV Method for producing chiral amines
ES2931540T3 (es) 2018-02-05 2022-12-30 Asymchem Life Science Tianjin Co Ltd Mutante de transaminasa y aplicación del mismo
CN108384767B (zh) * 2018-02-05 2020-08-14 凯莱英生命科学技术(天津)有限公司 转氨酶突变体及其应用
CN108315365B (zh) * 2018-02-08 2021-01-29 浙江宏元药业股份有限公司 阿托伐他汀中间体的生物合成方法
CN108586346B (zh) 2018-05-10 2019-10-01 北京富盛嘉华医药科技有限公司 一种生物催化合成西他列汀及其中间体的方法
CN113817702B (zh) * 2019-05-30 2023-07-14 凯莱英生命科学技术(天津)有限公司 转氨酶突变体及其应用
IL296841A (en) * 2020-04-10 2022-11-01 Codexis Inc Transaminase transaminase polypeptides
CN112430632B (zh) * 2020-11-18 2022-09-13 上海合全药物研发有限公司 2-((反式)-4-氨基环己烷基)异丙醇的制备方法
CN115975969A (zh) * 2021-10-14 2023-04-18 弈柯莱生物科技(上海)股份有限公司 转氨酶及用于制备西他列汀或其中间体的用途

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600692A (en) 1983-02-10 1986-07-15 Purification Engineering, Inc. Immobilized cells for preparing phenylalanine
US4518692A (en) * 1983-09-01 1985-05-21 Genetics Institute, Inc. Production of L-amino acids by transamination
US4826766A (en) * 1985-09-23 1989-05-02 Genetics Institute, Inc. Production of amino acids using coupled aminotransferases
JPS63273486A (ja) 1987-04-30 1988-11-10 Tanabe Seiyaku Co Ltd １−（４−メトキシフェニル）−２−アミノプロパンの製法
US5316943A (en) * 1988-06-14 1994-05-31 Kidman Gene E Racemic conversion of using a transaminase
US4950606A (en) 1989-06-22 1990-08-21 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5169780A (en) 1989-06-22 1992-12-08 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5300437A (en) * 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5346828A (en) * 1991-03-27 1994-09-13 Celgene Corporation Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase
US5360724A (en) * 1992-12-18 1994-11-01 Celgene Corporation Process for the preparation of chiral 1-aryl-2-aminopropanes
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
DK0765394T3 (da) 1994-06-03 2001-12-10 Novozymes As Oprensede Myceliopthora-laccaser og nukleinsyrer der koder for disse
AU2705895A (en) 1994-06-30 1996-01-25 Novo Nordisk Biotech, Inc. Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein
FI104465B (fi) 1995-06-14 2000-02-15 Valio Oy Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö
WO1997015682A1 (fr) * 1995-10-23 1997-05-01 Kaneka Corporation Procede de production de composes amines actifs sur le plan optique
US5814473A (en) * 1996-02-09 1998-09-29 Diversa Corporation Transaminases and aminotransferases
JPH10165194A (ja) * 1996-12-12 1998-06-23 Sumitomo Chem Co Ltd 光学純度の向上方法
JP4213771B2 (ja) * 1997-04-23 2009-01-21 株式会社カネカ 光学活性アミノ化合物の製造方法
US6197558B1 (en) * 1997-05-19 2001-03-06 Nsc Technologies Transaminase biotransformation process
US6133018A (en) * 1997-06-02 2000-10-17 Celgro Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
CA2313380C (en) 1997-12-08 2008-12-30 California Institute Of Technology Method for creating polynucleotide and polypeptide sequences
US5866512A (en) * 1997-12-19 1999-02-02 Celgene Corporation Plant growth inhibition using the R-isomer of esprocarb
DE69925267T2 (de) 1998-03-11 2006-01-26 Celgro Verbesserung der enzymatischen synthese von chiralen aminen
WO2000023609A1 (en) 1998-10-19 2000-04-27 Nsc Technologies Llc Transaminase biotransformation process employing glutamic acid
DE69939770D1 (da) * 1998-10-30 2008-12-04 Kaneka Corp
JP4221100B2 (ja) 1999-01-13 2009-02-12 エルピーダメモリ株式会社 半導体装置
ATE277170T1 (de) * 1999-03-19 2004-10-15 Sumitomo Chemical Co Stereoselektive transaminase, deren kodierende gen und deren verwendungen
DE19919848A1 (de) 1999-04-30 2000-11-02 Aventis Cropscience Gmbh Verfahren zur Herstellung von L-Phosphinothricin durch enzymatische Transaminierung mit Aspartat
US6107521A (en) * 1999-12-14 2000-08-22 Celgro Process for the preparation of secondary amines
AU4964101A (en) 2000-03-30 2001-10-15 Maxygen Inc In silico cross-over site selection
EP1392639B1 (en) * 2001-05-03 2008-09-17 Galileo Laboratories, Inc. Pyruvate derivatives
CA2452159A1 (en) * 2001-07-23 2003-02-06 Galileo Laboratories, Inc. Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods
US20050009151A1 (en) 2003-07-10 2005-01-13 Pharmacia Corporation Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
JP2007502124A (ja) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド
US7972854B2 (en) * 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
KR100718817B1 (ko) 2004-07-19 2007-05-17 김병기 신규한 오메가아미노트랜스퍼라제, 이의 유전자 및 이의이용 방법
US7172885B2 (en) 2004-12-10 2007-02-06 Cambrex North Brunswick, Inc. Thermostable omega-transaminases
US20080148432A1 (en) * 2005-12-21 2008-06-19 Mark Scott Abad Transgenic plants with enhanced agronomic traits
US20060200878A1 (en) * 2004-12-21 2006-09-07 Linda Lutfiyya Recombinant DNA constructs and methods for controlling gene expression
JP4922929B2 (ja) 2005-05-23 2012-04-25 株式会社カネカ 新規アミノ基転移酵素、およびこれをコードする遺伝子、ならびにこれらの利用法
EP1818411A1 (en) 2006-02-13 2007-08-15 Lonza AG Process for the preparation of optically active chiral amines
US8206970B2 (en) * 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
EP1897956A1 (en) 2006-09-06 2008-03-12 Lonza AG Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase
EP2118281A2 (en) 2007-02-12 2009-11-18 Codexis, Inc. Structure-activity relationships
EP2132322A4 (en) * 2007-03-02 2013-02-20 Richmond Chemical Corp METHOD FOR INCREASING YIELD AND IMPROVING PURIFICATION OF PRODUCTS FROM REACTIONS WITH TRANSAMINASE
WO2008127646A2 (en) 2007-04-11 2008-10-23 Dsm Ip Assets B.V. Transaminase-based processes for preparation of pregabalin
DE102007042600A1 (de) 2007-09-07 2009-03-12 Evonik Degussa Gmbh Verfahren zur Herstellung von enantiomerenangereichten Aminen
SG172891A1 (en) * 2009-01-08 2011-08-29 Codexis Inc Transaminase polypeptides
US8577622B2 (en) 2009-09-02 2013-11-05 Lonza Ag Process for the identification and preparation of a (R)-specific omega-transaminase
CN105408487A (zh) * 2012-12-31 2016-03-16 英威达技术有限责任公司 通过甲酯保护的碳链延伸生产7碳化学物的方法
SI2978748T1 (sl) * 2013-03-27 2017-07-31 Pfizer Ireland Pharmaceuticals Postopek in intermediati za pripravo pregabalina

Also Published As

Publication number Publication date
US9944909B2 (en) 2018-04-17
IL213950A (en) 2016-12-29
DK2385983T3 (da) 2018-02-12
US20170073651A1 (en) 2017-03-16
US10323234B2 (en) 2019-06-18
US9512410B2 (en) 2016-12-06
WO2010081053A3 (en) 2011-01-20
US20130266994A1 (en) 2013-10-10
US20230120624A1 (en) 2023-04-20
IL249285A0 (en) 2017-01-31
US11542485B2 (en) 2023-01-03
US8470564B2 (en) 2013-06-25
CN102341494B (zh) 2014-10-15
ES2840000T3 (es) 2021-07-06
IL249285A (en) 2017-09-28
US20180201911A1 (en) 2018-07-19
CN102341494A (zh) 2012-02-01
HUE052297T2 (hu) 2021-04-28
US20180298355A1 (en) 2018-10-18
EP2385983A2 (en) 2011-11-16
US20150210988A1 (en) 2015-07-30
US20240150732A1 (en) 2024-05-09
IL213950A0 (en) 2011-08-31
US20100209981A1 (en) 2010-08-19
WO2010081053A2 (en) 2010-07-15
US10550370B2 (en) 2020-02-04
US20210230564A1 (en) 2021-07-29
US20200109380A1 (en) 2020-04-09
EP3354727B1 (en) 2020-10-07
US20190249152A1 (en) 2019-08-15
US10995323B2 (en) 2021-05-04
EP2385983B1 (en) 2017-12-20
SG172891A1 (en) 2011-08-29
US10323233B2 (en) 2019-06-18
US9029106B2 (en) 2015-05-12
EP3354727A1 (en) 2018-08-01
US11939602B2 (en) 2024-03-26
EP2385983A4 (en) 2013-07-24
HUE036104T2 (hu) 2018-06-28

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