DK3354727T3 - Transaminasepolypeptider - Google Patents
Transaminasepolypeptider Download PDFInfo
- Publication number
- DK3354727T3 DK3354727T3 DK17208538.3T DK17208538T DK3354727T3 DK 3354727 T3 DK3354727 T3 DK 3354727T3 DK 17208538 T DK17208538 T DK 17208538T DK 3354727 T3 DK3354727 T3 DK 3354727T3
- Authority
- DK
- Denmark
- Prior art keywords
- transaminase polypeptides
- transaminase
- polypeptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01018—Beta-alanine-pyruvate transaminase (2.6.1.18)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14340109P | 2009-01-08 | 2009-01-08 | |
EP10729606.3A EP2385983B1 (en) | 2009-01-08 | 2010-01-08 | Transaminase polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3354727T3 true DK3354727T3 (da) | 2020-11-16 |
Family
ID=42317179
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10729606.3T DK2385983T3 (da) | 2009-01-08 | 2010-01-08 | Transaminase-polypeptider |
DK17208538.3T DK3354727T3 (da) | 2009-01-08 | 2010-01-08 | Transaminasepolypeptider |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10729606.3T DK2385983T3 (da) | 2009-01-08 | 2010-01-08 | Transaminase-polypeptider |
Country Status (9)
Country | Link |
---|---|
US (11) | US8470564B2 (da) |
EP (2) | EP3354727B1 (da) |
CN (1) | CN102341494B (da) |
DK (2) | DK2385983T3 (da) |
ES (1) | ES2840000T3 (da) |
HU (2) | HUE036104T2 (da) |
IL (2) | IL213950A (da) |
SG (1) | SG172891A1 (da) |
WO (1) | WO2010081053A2 (da) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG172891A1 (en) | 2009-01-08 | 2011-08-29 | Codexis Inc | Transaminase polypeptides |
WO2010099501A2 (en) | 2009-02-26 | 2010-09-02 | Codexis, Inc. | Transaminase biocatalysts |
EP2446026B1 (en) | 2009-06-22 | 2017-08-09 | Codexis, Inc. | Transaminase reactions |
EP2582799B1 (en) * | 2010-06-17 | 2017-12-20 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol |
US9006460B2 (en) * | 2010-08-16 | 2015-04-14 | Cardiome International Ag | Process for preparing aminocyclohexyl ether compounds |
WO2012024104A2 (en) * | 2010-08-16 | 2012-02-23 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine |
JP5927178B2 (ja) * | 2011-03-11 | 2016-06-01 | 株式会社カネカ | 改変型アミノ基転移酵素、その遺伝子、およびそれらを利用した光学活性アミノ化合物の製造方法 |
WO2013036861A1 (en) * | 2011-09-08 | 2013-03-14 | Codexis, Inc | Biocatalysts and methods for the synthesis of substituted lactams |
CN104185634B (zh) * | 2012-03-23 | 2017-05-03 | 诺华股份有限公司 | 制备螺旋吲哚酮和其中间体的化学工艺 |
SG11201405990PA (en) | 2012-03-23 | 2014-11-27 | Codexis Inc | Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs |
HUE046421T2 (hu) | 2012-03-23 | 2020-02-28 | Novartis Ag | Kémiai eljárás spiroindolok és intermedierjeik elõállítására |
JP2015533501A (ja) * | 2012-10-18 | 2015-11-26 | サンド・アクチエンゲゼルシヤフト | インドリン誘導体の調製方法 |
JP6618180B2 (ja) | 2012-12-21 | 2019-12-11 | コデクシス, インコーポレイテッド | キラルアミンを合成するための操作された生体触媒および方法 |
SI2978748T1 (sl) * | 2013-03-27 | 2017-07-31 | Pfizer Ireland Pharmaceuticals | Postopek in intermediati za pripravo pregabalina |
ES2857711T3 (es) | 2013-09-27 | 2021-09-29 | Codexis Inc | Filtración automática de variantes de enzimas |
ES2734579T3 (es) | 2013-11-26 | 2019-12-10 | Asymchem Lab Tianjin Co Ltd | Transaminasa y utilización de la misma |
US10370693B2 (en) | 2015-06-12 | 2019-08-06 | C-Lecta Gmbh | Transaminases |
KR20170004510A (ko) | 2015-07-02 | 2017-01-11 | 씨제이제일제당 (주) | 신규 트랜스아미나제 및 이를 이용한 아미노 화합물의 탈아민 방법 |
ES2830266T3 (es) | 2015-12-10 | 2021-06-03 | Novartis Ag | Compuestos intermedios para la preparación de sacubitril y su preparación |
EP3415630A1 (en) | 2017-06-14 | 2018-12-19 | EntreChem, S.L. | Method for one-pot production of a primary amine from an alcohol |
WO2018231462A1 (en) * | 2017-06-14 | 2018-12-20 | Codexis, Inc. | Engineered transaminase polypeptides for industrial biocatalysis |
EP3450566A1 (en) * | 2017-09-01 | 2019-03-06 | Vito NV | Method for producing chiral amines |
ES2931540T3 (es) | 2018-02-05 | 2022-12-30 | Asymchem Life Science Tianjin Co Ltd | Mutante de transaminasa y aplicación del mismo |
CN108384767B (zh) * | 2018-02-05 | 2020-08-14 | 凯莱英生命科学技术(天津)有限公司 | 转氨酶突变体及其应用 |
CN108315365B (zh) * | 2018-02-08 | 2021-01-29 | 浙江宏元药业股份有限公司 | 阿托伐他汀中间体的生物合成方法 |
CN108586346B (zh) | 2018-05-10 | 2019-10-01 | 北京富盛嘉华医药科技有限公司 | 一种生物催化合成西他列汀及其中间体的方法 |
CN113817702B (zh) * | 2019-05-30 | 2023-07-14 | 凯莱英生命科学技术(天津)有限公司 | 转氨酶突变体及其应用 |
IL296841A (en) * | 2020-04-10 | 2022-11-01 | Codexis Inc | Transaminase transaminase polypeptides |
CN112430632B (zh) * | 2020-11-18 | 2022-09-13 | 上海合全药物研发有限公司 | 2-((反式)-4-氨基环己烷基)异丙醇的制备方法 |
CN115975969A (zh) * | 2021-10-14 | 2023-04-18 | 弈柯莱生物科技(上海)股份有限公司 | 转氨酶及用于制备西他列汀或其中间体的用途 |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
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US4600692A (en) | 1983-02-10 | 1986-07-15 | Purification Engineering, Inc. | Immobilized cells for preparing phenylalanine |
US4518692A (en) * | 1983-09-01 | 1985-05-21 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
US4826766A (en) * | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
JPS63273486A (ja) | 1987-04-30 | 1988-11-10 | Tanabe Seiyaku Co Ltd | 1−(4−メトキシフェニル)−2−アミノプロパンの製法 |
US5316943A (en) * | 1988-06-14 | 1994-05-31 | Kidman Gene E | Racemic conversion of using a transaminase |
US4950606A (en) | 1989-06-22 | 1990-08-21 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
US5169780A (en) | 1989-06-22 | 1992-12-08 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
US5300437A (en) * | 1989-06-22 | 1994-04-05 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
US5346828A (en) * | 1991-03-27 | 1994-09-13 | Celgene Corporation | Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase |
US5360724A (en) * | 1992-12-18 | 1994-11-01 | Celgene Corporation | Process for the preparation of chiral 1-aryl-2-aminopropanes |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
DK0765394T3 (da) | 1994-06-03 | 2001-12-10 | Novozymes As | Oprensede Myceliopthora-laccaser og nukleinsyrer der koder for disse |
AU2705895A (en) | 1994-06-30 | 1996-01-25 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein |
FI104465B (fi) | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
WO1997015682A1 (fr) * | 1995-10-23 | 1997-05-01 | Kaneka Corporation | Procede de production de composes amines actifs sur le plan optique |
US5814473A (en) * | 1996-02-09 | 1998-09-29 | Diversa Corporation | Transaminases and aminotransferases |
JPH10165194A (ja) * | 1996-12-12 | 1998-06-23 | Sumitomo Chem Co Ltd | 光学純度の向上方法 |
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US6133018A (en) * | 1997-06-02 | 2000-10-17 | Celgro | Enzymatic synthesis of chiral amines using -2-amino propane as amine donor |
CA2313380C (en) | 1997-12-08 | 2008-12-30 | California Institute Of Technology | Method for creating polynucleotide and polypeptide sequences |
US5866512A (en) * | 1997-12-19 | 1999-02-02 | Celgene Corporation | Plant growth inhibition using the R-isomer of esprocarb |
DE69925267T2 (de) | 1998-03-11 | 2006-01-26 | Celgro | Verbesserung der enzymatischen synthese von chiralen aminen |
WO2000023609A1 (en) | 1998-10-19 | 2000-04-27 | Nsc Technologies Llc | Transaminase biotransformation process employing glutamic acid |
DE69939770D1 (da) * | 1998-10-30 | 2008-12-04 | Kaneka Corp | |
JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
ATE277170T1 (de) * | 1999-03-19 | 2004-10-15 | Sumitomo Chemical Co | Stereoselektive transaminase, deren kodierende gen und deren verwendungen |
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US7172885B2 (en) | 2004-12-10 | 2007-02-06 | Cambrex North Brunswick, Inc. | Thermostable omega-transaminases |
US20080148432A1 (en) * | 2005-12-21 | 2008-06-19 | Mark Scott Abad | Transgenic plants with enhanced agronomic traits |
US20060200878A1 (en) * | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
JP4922929B2 (ja) | 2005-05-23 | 2012-04-25 | 株式会社カネカ | 新規アミノ基転移酵素、およびこれをコードする遺伝子、ならびにこれらの利用法 |
EP1818411A1 (en) | 2006-02-13 | 2007-08-15 | Lonza AG | Process for the preparation of optically active chiral amines |
US8206970B2 (en) * | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
EP1897956A1 (en) | 2006-09-06 | 2008-03-12 | Lonza AG | Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase |
EP2118281A2 (en) | 2007-02-12 | 2009-11-18 | Codexis, Inc. | Structure-activity relationships |
EP2132322A4 (en) * | 2007-03-02 | 2013-02-20 | Richmond Chemical Corp | METHOD FOR INCREASING YIELD AND IMPROVING PURIFICATION OF PRODUCTS FROM REACTIONS WITH TRANSAMINASE |
WO2008127646A2 (en) | 2007-04-11 | 2008-10-23 | Dsm Ip Assets B.V. | Transaminase-based processes for preparation of pregabalin |
DE102007042600A1 (de) | 2007-09-07 | 2009-03-12 | Evonik Degussa Gmbh | Verfahren zur Herstellung von enantiomerenangereichten Aminen |
SG172891A1 (en) * | 2009-01-08 | 2011-08-29 | Codexis Inc | Transaminase polypeptides |
US8577622B2 (en) | 2009-09-02 | 2013-11-05 | Lonza Ag | Process for the identification and preparation of a (R)-specific omega-transaminase |
CN105408487A (zh) * | 2012-12-31 | 2016-03-16 | 英威达技术有限责任公司 | 通过甲酯保护的碳链延伸生产7碳化学物的方法 |
SI2978748T1 (sl) * | 2013-03-27 | 2017-07-31 | Pfizer Ireland Pharmaceuticals | Postopek in intermediati za pripravo pregabalina |
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2010
- 2010-01-08 SG SG2011049475A patent/SG172891A1/en unknown
- 2010-01-08 CN CN201080010926.9A patent/CN102341494B/zh active Active
- 2010-01-08 HU HUE10729606A patent/HUE036104T2/hu unknown
- 2010-01-08 ES ES17208538T patent/ES2840000T3/es active Active
- 2010-01-08 DK DK10729606.3T patent/DK2385983T3/da active
- 2010-01-08 WO PCT/US2010/020563 patent/WO2010081053A2/en active Application Filing
- 2010-01-08 EP EP17208538.3A patent/EP3354727B1/en active Active
- 2010-01-08 DK DK17208538.3T patent/DK3354727T3/da active
- 2010-01-08 EP EP10729606.3A patent/EP2385983B1/en active Active
- 2010-01-08 HU HUE17208538A patent/HUE052297T2/hu unknown
- 2010-01-08 US US12/684,864 patent/US8470564B2/en active Active
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2011
- 2011-07-06 IL IL213950A patent/IL213950A/en active IP Right Grant
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2013
- 2013-06-18 US US13/920,902 patent/US9029106B2/en active Active
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2015
- 2015-04-13 US US14/684,916 patent/US9512410B2/en active Active
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2016
- 2016-11-02 US US15/341,631 patent/US9944909B2/en active Active
- 2016-11-29 IL IL249285A patent/IL249285A/en active IP Right Grant
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2018
- 2018-03-06 US US15/912,892 patent/US10323233B2/en active Active
- 2018-06-26 US US16/018,247 patent/US10323234B2/en active Active
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2019
- 2019-04-30 US US16/399,488 patent/US10550370B2/en active Active
- 2019-12-17 US US16/717,596 patent/US10995323B2/en active Active
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2021
- 2021-04-06 US US17/224,008 patent/US11542485B2/en active Active
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2022
- 2022-11-30 US US18/060,517 patent/US11939602B2/en active Active
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2024
- 2024-01-10 US US18/409,699 patent/US20240150732A1/en active Pending
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