DK3320338T3 - Barrierefunktionsmålinger - Google Patents

Barrierefunktionsmålinger Download PDF

Info

Publication number
DK3320338T3
DK3320338T3 DK16750529.6T DK16750529T DK3320338T3 DK 3320338 T3 DK3320338 T3 DK 3320338T3 DK 16750529 T DK16750529 T DK 16750529T DK 3320338 T3 DK3320338 T3 DK 3320338T3
Authority
DK
Denmark
Prior art keywords
barrier function
function measurements
measurements
barrier
function
Prior art date
Application number
DK16750529.6T
Other languages
English (en)
Inventor
Paul Vulto
Sebastiaan Johannes Trietsch
Marianne Katharina Vormann
Henriëtte Leonore Lanz
Original Assignee
Mimetas B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mimetas B V filed Critical Mimetas B V
Application granted granted Critical
Publication of DK3320338T3 publication Critical patent/DK3320338T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5032Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on intercellular interactions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B81MICROSTRUCTURAL TECHNOLOGY
    • B81BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00Devices without movable or flexible elements, e.g. microcapillary devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44791Microapparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Plasma & Fusion (AREA)
  • Electrochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK16750529.6T 2015-07-09 2016-07-08 Barrierefunktionsmålinger DK3320338T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2015130A NL2015130B1 (en) 2015-07-09 2015-07-09 Barrier function measurements.
PCT/NL2016/050502 WO2017007325A1 (en) 2015-07-09 2016-07-08 Barrier function measurements

Publications (1)

Publication Number Publication Date
DK3320338T3 true DK3320338T3 (da) 2020-11-30

Family

ID=55077575

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16750529.6T DK3320338T3 (da) 2015-07-09 2016-07-08 Barrierefunktionsmålinger

Country Status (12)

Country Link
US (1) US11662342B2 (da)
EP (1) EP3320338B1 (da)
JP (1) JP6838749B2 (da)
KR (1) KR102579749B1 (da)
CN (1) CN108027366B (da)
AU (1) AU2016291078B2 (da)
BR (1) BR112018000452A2 (da)
CA (1) CA2991876A1 (da)
DK (1) DK3320338T3 (da)
NL (1) NL2015130B1 (da)
RU (1) RU2752085C2 (da)
WO (1) WO2017007325A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2020518B1 (en) 2018-03-02 2019-09-12 Mimetas B V Device and method for performing electrical measurements
WO2020195458A1 (ja) 2019-03-28 2020-10-01 富士フイルム株式会社 測定装置、測定装置の作動プログラム及び測定方法
CN110793735B (zh) * 2019-11-08 2021-02-26 湖南科技大学 一种液态危险化学品泄漏模拟试验装置
NL2024202B1 (en) 2019-11-08 2021-07-20 Mimetas B V Microfluidic cell culture system
JP2022061818A (ja) 2020-10-07 2022-04-19 ウシオ電機株式会社 マイクロ流体デバイス及びマイクロ流体デバイスの使用方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
US4761381A (en) 1985-09-18 1988-08-02 Miles Inc. Volume metering capillary gap device for applying a liquid sample onto a reactive surface
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
EP0907412B1 (en) * 1996-06-28 2008-08-27 Caliper Life Sciences, Inc. High-throughput screening assay systems in microscale fluidic devices
US6637463B1 (en) 1998-10-13 2003-10-28 Biomicro Systems, Inc. Multi-channel microfluidic system design with balanced fluid flow distribution
US6601613B2 (en) 1998-10-13 2003-08-05 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
EP1131431A2 (en) * 1998-11-10 2001-09-12 Digital Gene Technologies Inc. Nucleic acids and polypeptides having altered expression in the t84 gut barrier model
US8231845B2 (en) 2000-10-25 2012-07-31 Steag Microparts Structures for uniform capillary flow
EP1843849A2 (en) 2005-01-12 2007-10-17 Inverness Medical Switzerland GmbH A method of producing a microfluidic device and microfluidic devices
CA2607965A1 (en) * 2005-05-18 2007-02-22 Cornell Research Foundation, Inc. Pharmacokinetic-based culture system with biological barriers
US7312047B2 (en) * 2005-05-24 2007-12-25 University Of Southampton Screening assay for improvement of epithelial barrier function
US20070280856A1 (en) 2006-06-02 2007-12-06 Applera Corporation Devices and Methods for Controlling Bubble Formation in Microfluidic Devices
RU2012157399A (ru) * 2010-06-18 2014-07-27 КсайберСайенс ГмбХ Пептиды в качестве активных агентов для стабилизации биологических барьеров
SG10201601434RA (en) * 2011-02-28 2016-03-30 Harvard College Cell Culture System
GB201103917D0 (en) * 2011-03-08 2011-04-20 Univ Leiden Apparatus for and methods of processing liquids or liquid based substances
WO2013086329A1 (en) * 2011-12-08 2013-06-13 Research Triangle Institute Human emulated response with microfluidic enhanced systems
JP2015509382A (ja) * 2012-03-07 2015-03-30 チルドレンズ メディカル センター コーポレーション 組織構築体およびその使用
US9513280B2 (en) * 2012-08-28 2016-12-06 University Of Utah Research Foundation Microfluidic biological barrier model and associated method
US9588106B2 (en) * 2012-09-05 2017-03-07 The University Of Chicago Methods and compositions for measuring cell permeability
GB2505706A (en) 2012-09-10 2014-03-12 Univ Leiden Apparatus comprising meniscus alignment barriers
US20140363883A1 (en) * 2013-06-11 2014-12-11 BellBrook Labs Device for cell culture and direct imaging
CN104031878A (zh) * 2014-05-16 2014-09-10 浙江大学 通过lps刺激建立的大鼠及猪肠道上皮细胞的综合模型

Also Published As

Publication number Publication date
JP6838749B2 (ja) 2021-03-03
CN108027366A (zh) 2018-05-11
CA2991876A1 (en) 2017-01-12
CN108027366B (zh) 2021-06-08
US11662342B2 (en) 2023-05-30
KR20180028503A (ko) 2018-03-16
WO2017007325A1 (en) 2017-01-12
KR102579749B1 (ko) 2023-09-15
BR112018000452A2 (pt) 2018-09-11
NL2015130B1 (en) 2017-02-01
US20180196035A1 (en) 2018-07-12
AU2016291078B2 (en) 2021-10-07
AU2016291078A1 (en) 2018-02-01
JP2018522586A (ja) 2018-08-16
EP3320338A1 (en) 2018-05-16
RU2752085C2 (ru) 2021-07-22
EP3320338B1 (en) 2020-11-11
RU2017146805A (ru) 2019-08-09
RU2017146805A3 (da) 2019-10-24

Similar Documents

Publication Publication Date Title
DK3331869T3 (da) Muscarinagonister
DK3319956T3 (da) Substituerede oxopyridinderivater
DK3305788T3 (da) Janus-kinase-hæmmer
DK3541332T3 (da) Stomibarriere
DK3360890T3 (da) Genterapi
DK3386954T3 (da) Dimere kontrastmidler
DK3331529T3 (da) Muskarinagonister
DK3310450T3 (da) Olie-vand-separator
DK3270930T3 (da) Præeklampsi
DK3394281T3 (da) Gærcelle
DK3292136T3 (da) Penicillin-g-acylaser
DE112015006486A5 (de) Inkubationsrinne
DK3320338T3 (da) Barrierefunktionsmålinger
DK3274482T3 (da) Stenborsknop
DK3318308T3 (da) Badmintonketsjer
DE112016005599A5 (de) Strahlungsgrill
MA50130A (fr) Détecteur de position
DK3310756T3 (da) Thromboxanreceptorantagonister
DE112015005898A5 (de) Gurtschlossbringer
DE102015206660A8 (de) Plattenaufteilanlage
DK3445296T3 (da) Stomibarriere
FR3035464B1 (fr) Pendule- butee laterale -bimatiere
DE112016001124A5 (de) Spannschutz
DE102015000551A8 (de) Rotationszerstäuberturbine
DK3387052T3 (da) Barrierelag